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Effects of acupuncture on hypothalamic–pituitary–adrenal axis:Current status and future perspectives

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Journal of Integrative Medicine 2024年第4期22卷 445-458页

作者： Jia-yuan Zheng Jing Zhu yu Wang Zhan-zhuang tian Department of Integrative Medicine and Neurobiology School of Basic Medical SciencesState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceInstitutes of Brain ScienceInstitute of Acupuncture ResearchAcademy of Integrative MedicineShanghai Key Laboratory for Acupuncture Mechanism and Acupoint FunctionShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Human Anatomy School of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

The hypothalamic–pituitary–adrenal(HPA) axis is a critical component of the neuroendocrine system,playing a central role in regulating the body's stress response and modulating various physiological processes. Dysregulation of HPA axis function disrupts the neuroendocrine equilibrium, resulting in impaired physiological functions. Acupuncture is recognized as a non-pharmacological type of therapy which has been confirmed to play an important role in modulating the HPA axis and thus favorably targets diseases with abnormal activation of the HPA axis. With numerous studies reporting the promising efficacy of acupuncture for neuroendocrine disorders, a comprehensive review in terms of the underlying molecular mechanism for acupuncture, especially in regulating the HPA axis, is currently in need. This review fills the need and summarizes recent breakthroughs, from the basic principles and the pathological changes of HPA axis dysfunction, to the molecular mechanisms by which acupuncture regulates the HPA axis. These mechanisms include the modulation of multiple neurotransmitters and their receptors, neuropeptides and their receptors, and microRNAs in the paraventricular nucleus,hippocampus, amygdala and pituitary gland, which alleviate the hyperfunctioning of the HPA *** review comprehensively summarizes the mechanism of acupuncture in regulating HPA axis dysfunction for the first time, providing new targets and prospects for further exploration of acupuncture.

关键词： Acupuncture Electroacupuncture Hypothalamic-pituitary-adrenal axis Mechanism Neurotransmitter microRNA

Soil disturbance evaluation of soft clay based on stress-normalized smallstrain stiffness

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 990-999页

作者： Yanguo Zhou yu tian Junneng Ye Xuecheng Bian yunmin Chen MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Institute of Geotechnical EngineeringCenter for Hypergravity Experiment and Interdisciplinary ResearchZhejiang UniversityHangzhou310058China Ningbo Rail Transit Group Co. Ltd.Ningbo315010China

Soil disturbance includes the change of stress state and the damage of soil *** field testing indices reflect the combined effect of both changes and it is difficult to identify the soil structure disturbance directly from these *** the present study,the small-strain shear modulus is used to characterize soil structure disturbance by normalizing the effective stress and void ratio based on Hardin *** procedure for evaluating soil sampling disturbance in the field and the further disturbance during the subsequent consolidation process in laboratory test is proposed,and then validated by a case study of soft clay *** seismic testing in the field,portable piezoelectric bender elements for the drilled sample and bender elements in triaxial apparatus for the consolidated sample were used to monitor the shear wave velocity of the soil from intact to disturbed and even remolded *** is found that soil sampling disturbance degree by conventional thin-wall sampler is about 30%according to the proposed procedure,which is slightly higher than that from the modified volume compression method proposed by Hong and Onitsuka(1998).And the additional soil disturbance induced by consolidation in laboratory could reach about 50%when the consolidation pressure is far beyond the structural yield stress,and it follows the plastic volumetric strain quite well.

关键词： Natural clay Soil sample disturbance Shear wave velocity Small-strain shear modulus Hardin equation

APTAnet: an atom-level peptide-TCR interaction affinity prediction model

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Biophysics Reports 2024年第1期10卷 1-14页

作者： Peng Xiong Anyi liang Xunhui Cai tian Xia School of Artificial Intelligence and Automation Huazhong University of Science and Technology Institute of Pathology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

The prediction of affinity between TCRs and peptides is crucial for the further development of TIL(Tumor-Infiltrating Lymphocytes) immunotherapy. Inspired by the broader research of drug-protein interaction(DPI), we propose an atom-level peptide-TCR interaction(PTI) affinity prediction model APTAnet using natural language processing methods. APTAnet model achieved an average ROC-AUC and PR-AUC of 0.893 and 0.877, respectively, in ten-fold cross-validation on 25,675 pairs of PTI ***, experimental results on an independent test set from the McPAS database showed that APTAnet outperformed the current mainstream models. Finally, through the validation on 11 cases of real tumor patient data, we found that the APTAnet model can effectively identify tumor peptides and screen tumor-specific TCRs.

关键词： Immunotherapy TCR Antigen Natural language processing Transfer learning

Multi-Smart Meter Data Encryption Scheme Basedon Distributed Differential Privacy

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Big Data Mining and Analytics 2024年第1期7卷 131-141页

作者： Renwu Yan Yang Zheng Ning yu Cen liang School of Electronic Electrical Engineering and PhysicsFujian University of TechnologyFuzhou 350118China Department of Computing Sciences at The College at Brockport State University of New YorkNew YorkNY 14420USA

Under the general trend of the rapid development of smart grids,data security and privacy are facing serious challenges;protecting the privacy data of single users under the premise of obtaining user-aggregated data has attracted widespread *** this study,we propose an encryption scheme on the basis of differential privacy for the problem of user privacy leakage when aggregating data from multiple smart ***,we use an improved homomorphic encryption method to realize the encryption aggregation of users’***,we propose a double-blind noise addition protocol to generate distributed noise through interaction between users and a cloud platform to prevent semi-honest participants from stealing data by colluding with one ***,the simulation results show that the proposed scheme can encrypt the transmission of multi-intelligent meter data under the premise of satisfying the differential privacy *** if an attacker has enough background knowledge,the security of the electricity information of one another can be ensured.

关键词： smart grid homomorphic encryption data aggregation differential privacy cloud computing

Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice

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Food Science and Human Wellness 2024年第1期13卷 90-100页

作者： Xiaoxiang Gao Chenbo yue Ruocen tian Leilei yu Fengwei tian Jianxin Zhao Wei Chen Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Akkermansia muciniphila play an important in ameliorating obesity but is not allowed for direct consumption in most *** date,microbiota-directed foods selectively promote the targeted human gut microbes,providing a strategy for *** *** studies have indicated the potential regulation of the polyphenol on ***,a polyphenol screening based on *** upregulation was performed in *** acid(CGA)exhibited a greater response to *** ***,we found that CGA did not directly promote *** growth or mucin *** and metabolomics revealed that the increased abundance of *** resulted from the inhibition of CGA on Desulfovibrio and Alistipes and the influence of docosahexaenoic acid,β-hydroxybutyrate,and ***,to confirm the regulation of CGA on *** under disease conditions,high-fat diet-fed mice were *** results showed CGA promoted *** growth,and we expectedly found that CGA suppressed the augment in body weight of mice,significantly attenuated adipose tissue abnormality,provided liver protection and improved gut barrier *** results suggest that CGA inhibits the development of ***,our results indicate that microbiota-directed food is a promising approach for the treatment of obesity.

关键词： Akkermansia muciniphila polyphenol chlorogenic acid obesity

Deformation of Rigid Conjugate Self-dual Galois Representations

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1599-1644页

作者： Yi Feng LIU Yi Chao tian liang XIAO Wei ZHANG Xin Wen ZHU Institute for Advanced Study in Mathematics Zhejiang UniversityHangzhou 310058P.R.China Morningside Center of Mathematics AMSSChinese Academy of SciencesBeijing 100190P.R.China New Cornerstone Lab Beijing International Center for Mathematical ResearchPeking Ui Beijing 100871P.R.China Department of Mathematics Massachusetts Institute of TechnologyCambridge MA 02139United States Department of Mathematics Stanford UniversityStanfordCA 94305United States

In this article,we study deformations of conjugate self-dual Galois *** study is ***,we prove an R=T type theorem for a conjugate self-dual Galois representation with coefficients in a finite field,satisfying a certain property called ***,we study the rigidity property for the family of residue Galois representations attached to a symmetric power of an elliptic curve,as well as to a regular algebraic conjugate self-dual cuspidal representation.

关键词： Galois deformation rigid conjugate self-dual Galois representations

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Research fronts and researchers of World Journal of Psychiatry in 2023: A visualization and analysis of mapping knowledge domains

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World Journal of Psychiatry 2024年第7期14卷 1118-1126页

作者： yun-tian Xie yu-Jing Yang Department of Applied Psychology Changsha Normal UniversityChangsha 410100Hunan ProvinceChina

BACKGROUND In the rapidly evolving landscape of psychiatric research,2023 marked another year of significant progress globally,with the World Journal of Psychiatry(WJP)experiencing notable expansion and *** To conduct a comprehensive visualization and analysis of the articles published in the WJP throughout *** delving into these publications,the aim is to deter-mine the valuable insights that can illuminate pathways for future research endeavors in the field of *** A selection process led to the inclusion of 107 papers from the WJP published in 2023,forming the dataset for the *** advanced visualization techniques,this study mapped the knowledge domains represented in these *** The findings revealed a prevalent focus on key topics such as depression,mental health,anxiety,schizophrenia,and the impact of coronavirus disease ***,through keyword clustering,it became evident that these papers were predominantly focused on exploring mental health disorders,depression,anxiety,schizophrenia,and related *** contributions hailed authors in regions such as China,the United Kingdom,United States,and ***,the paper garnered the highest number of citations,while the American Psychiatric Association was the most cited *** It is recommended that the WJP continue in its efforts to enhance the quality of papers published in the field of ***,there is a pressing need to delve into the potential applications of digital interventions and artificial intelligence within the discipline.

关键词： World Journal of Psychiatry Psychiatry Mapping knowledge domains Visualization Analysis

Understanding and improving Yangtze River Basin summer precipitation prediction using an optimal multi-Physics ensemble

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Frontiers of Earth Science 2024年第1期18卷 256-277页

作者： Yang ZHAO Fengxue QIAO Xin-Zhong liang Jinhua yu Climate Environment and Sustainability CenterNanjing University of Information Science and TechnologyNanjing 210044China Key Laboratory of Geographic Information Science(Ministry of Education) East China Normal UniversityShanghai 200241China School of Geographic Sciences East China Normal UniversityShanghai 200241China Department of Atmospheric and Oceanic Science University of MarylandCollege Park MD 20740USA Earth System Science Interdisciplinary Center University of MarylandCollege Park MD 20740USA Key Laboratory of Meteorological Disaster(KLME)(Ministry of Education)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science and TechnologyNanjing 210044China

This study employs the regional Climate-Weather Research and Forecasting model(CWRF)to first investigate the primary physical mechanisms causing biases in simulating summer precipitation over the Yangtze River Basin(YRB),and then enhance its predictive ability through an optimal multi-physics ensemble *** CWRF 30-km simulations in China are compared among 28 combinations of varying physics parameterizations during 1980−***-term average summer biases in YRB precipitation are remotely correlated with those of large-scale *** teleconnections of biases are highly consistent with the observed correlation patterns between interannual variations of precipitation and circulations,despite minor shifts in their primary action *** YRB precipitation aligns with a southward shifted East Asian westerly jet,an intensified low-level southerly flow south of YRB,and a south-eastward shifted South Asian high,alongside higher moisture availability over ***,decreased YRB precipitation corresponds to an opposite circulation *** CWRF control configuration using the ensemble cumulus parameterization(ECP),compared to other cumulus schemes,best captures the observed YRB precipitation characteristics and associated circulation *** ECP with the Morrison or Morrison-aerosol microphysics and the CCCMA or CAML radiation schemes enhances the overall CWRF *** to the control CWRF,the ensemble average of these skill-enhanced physics configurations more accurately reproduces YRB summer precipitation’s spatial distributions,interannual anomalies,and associated circulation *** Bayesian Joint Probability calibration to these configurations improves the ensemble’s spatial distributions but compromises its interannual anomalies and teleconnection *** findings highlight substantial potential for refining the representation of climate system physics to improve YRB precipitation *** is notabl

关键词： physics parameterization regional climate model downscaling skill enhancement multi-physics ensemble teleconnection bias reduction

Investigating the elliptic anisotropy of identified particles in p-Pb collisions with a multi-phase transport model

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Nuclear Science and Techniques 2024年第2期35卷 160-169页

作者： Si-yu Tang liang Zheng Xiao-Ming Zhang Ren-Zhuo Wan School of Mathematical and Physical Sciences Wuhan Textile UniversityWuhan 430200China School of Mathematics and Physics China University of Geosciences(Wuhan)Wuhan 430074China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China Hubei Key Laboratory of Digital Textile Equipment Wuhan Textile UniversityWuhan 430200China School of Electronic and Electrical Engineering Wuhan Textile UniversityWuhan 430200China

The elliptic azimuthal anisotropy coefficient(v_(2))of the identified particles at midrapidity(|η|<0.8)was investigated in p-Pb collisions at√s_(NN)=5.02 TeV using a multi-phase transport model(AMPT).The calculations of differential v_(2)based on the advanced flow extraction method of light flavor hadrons(pions,kaons,protons,andΛ)in small collision systems were extended to a wider transverse momentum(p_(T))range of up to 8 GeV/c for the first *** string-melting version of the AMPT model provides a good description of the measured p_(T)-differential v_(2)of the mesons but exhibits a slight deviation from the baryon v_(2).In addition,we observed the features of mass ordering at low p_(T)and the approximate number-of-constituentquark(NCQ)scaling at intermediate p_(T).Moreover,we demonstrate that hadronic rescattering does not have a significant impact on v_(2)in p-Pb collisions for different centrality selections,whereas partonic scattering dominates in generating the elliptic anisotropy of the final *** study provides further insight into the origin of collective-like behavior in small collision systems and has referential value for future measurements of azimuthal anisotropy.

关键词： Azimuthal anisotropy Small collision systems Transport model