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Aero-optical wavefront measurement technique based on BOS and its applications

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Chinese Science Bulletin 2011年第22期56卷 2320-2326页

作者： tian LiFeng yi ShiHe zhao YuXin HE Lin CHEN Zhi College of Aerospace and Material Engineering National University of Defense Technology Changsha 410073 China

A collimated light beam will be refracted if it propagates through a flow-field with index-of-refraction variations,and its wavefront will be *** we measure the deflection angle of the light beam,the gradient of the wavefront can be obtained using the Malus law,and the wavefront aberration can be computed with a reconstruction *** characteristics of background oriented schlieren(BOS) are conducive to wavefront aberration measurement:BOS can be used to measure the deflection angle of a light beam by measuring the displacement field between the reference image and the experiment ***,in a BOS system of Schlieren mode,only the ray perpendicular to the background image can be captured with a *** is helpful to measure wavefront aberrations that occur after a planar wavefront has passed through the *** on these characteristics of BOS of Schlieren mode,a new wavefront measurement technique,which is called the BOS-based wavefront technique(BOS-WT),is proposed in this *** works by constructing the relationship between the displacement of the background image and the aero-optical wavefront gradient and uses the Southwell wavefront reconstruction algorithm.A BOS-WT system was assembled,and its temporal resolution was found to be 6 ns,and its temporal-correlation resolution reached 0.2 μs.A BOS-WT can measure the time-correlation transient wavefront *** is simple and easy to *** this paper,we also present a study of the aero-optical performance of supersonic mixing layer based on our BOS-WT transient wavefronts at an interval of 5 μ*** results showed the wavefront was transient and distorted after it had passed through the mixing *** the analysis of the data at the 5 μs interval,the temporal evolution of wavefront can be obtained.

关键词：波前像差测量技术气动光学超音速混合层时间分辨率应用背景图像折射指数

Role of brahma-related gene 1/brahma-associated factor subunits in neural stem/progenitor cells and related neural developmental disorders

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World Journal of Stem Cells 2023年第4期15卷 235-247页

作者： Nai-Yu Ke tian-yi zhao Wan-Rong Wang Yu-Tong Qian Chao Liu The First Clinical Medical College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Institute of Stem cells and Tissue Engineering School of Basic Medical SciencesAnhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Histology and Embryology School of Basic Medical SciencesAnhui Medical UniversityHefei 230032Anhui ProvinceChina

Different fates of neural stem/progenitor cells(NSPCs)and their progeny are determined by the gene regulatory network,where a chromatin-remodeling complex affects synergy with other ***,we review recent research progress indicating that the BRG1/BRM-associated factor(BAF)complex plays an important role in NSPCs during neural development and neural developmental *** studies based on animal models have shown that mutations in the BAF complex may cause abnormal neural differentiation,which can also lead to various diseases in *** discussed BAF complex subunits and their main characteristics in *** advances in studies of human pluripotent stem cells and the feasibility of driving their differentiation into NSPCs,we can now investigate the role of the BAF complex in regulating the balance between self-renewal and differentiation of *** recent progress in these research areas,we suggest that three approaches should be used in investigations in the near *** of whole human exome and genome-wide association studies suggest that mutations in the subunits of the BAF complex are related to neurodevelopmental *** insight into the mechanism of BAF complex regulation in NSPCs during neural cell fate decisions and neurodevelopment may help in exploiting new methods for clinical applications.

关键词： Neural stem/progenitor cell BRG1/BRM-associated factor complex Subunit Proliferation Differentiation Neural developmental disorde

Effects of Post-weld Heat Treatment on Microstructure, Mechanical Properties and the Role of Weld Reinforcement in 2219 Aluminum Alloy TIG-Welded Joints

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Acta Metallurgica Sinica(English Letters) 2019年第6期32卷 684-694页

作者： Deng-Kui Zhang Guo-Qing Wang Ai-Ping Wu Ji-Guo Shan Yue zhao tian-yi zhao Dan-Yang Meng Jian-Ling Song Zhong-Ping Zhang Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China China Academy of Launch Vehicle Technology Beijing 100076China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationTsinghua UniversityBeijing 100084China tianjin Long March Launch Vehicle Manufacturing Co. Ltd.Tianjin 300462China

In as-welded state,each region of 2219 aluminum alloy TIG-welded joint shows diff erent microstructure and microhardness due to the diff erent welding heat cycles and the resulting evolution of second *** the post-weld heat treatment,both the amount and the size of the eutectic structure orθphases ***,both the Cu content inα-Al matrix and the microhardness increased to a similar level in each region of the joint,and the tensile strength of the entire joint was greatly ***-weld heat treatment played the role of solid solution strengthening and aging *** the post-weld heat treatment,the weld performance became similar to other regions,but weld reinforcements lost their reinforcing eff ect on the weld and their existence was more of an adverse eff *** joint without weld reinforcements after the post-weld heat treatment had the optimal tensile properties,and the specimens randomly crack in the weld zone.

关键词： 2219 Aluminum alloy Tungsten inert gas arc welding Post-weld heat treatment Weld reinforcement Digital image correlation technique

Cardiovascular events in hyperuricemia population and a cardiovascular benefit-risk assessment of urate-lowering therapies:a systematic review and meta-analysis

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Chinese Medical Journal 2020年第8期133卷 982-993页

作者： Li zhao Ling Cao tian-yi zhao Xue Yang Xiao-Xia Zhu He-Jian Zou Wei-Guo Wan Yu Xue Department of Rheumatology Huashan HospitalFudan UniversityShanghai 200040China Institute of Rheumatology Immunology and AllergyFudan UniversityShanghai 200040China

Background:Hyperuricemia and gout have become public health concerns;many important guidelines have recommended xanthine oxidase inhibitors(XOIs)as the first-line urate-lowering therapies(ULTs)to treat chronic gout with ***,whether treating hyperuricemia and gout with ULTs modifies cardiovascular risks remains *** aim of this study was to assess the incident risk of cardiovascular(CV)events(CVE)in hyperuricemia population,assess the cardiovascular benefit-risk of ULTs in hyperuricemia patients with or without gout in diverse cardiovascular risk sub-groups,and specify the safety of different ***:We searched PubMed,Embase,the Cochrane Library,Wanfang,Chongqing VIP(CQVIP,***),and China National Knowledge Infrastructure Database for prospective cohort studies and randomized controlled trials(RCTs)in English and *** medications included XOIs,and *** were divided into sub-groups analysis based on blinding status and patients’history of CV *** ratios(RRs)were calculated and were reported with corresponding 95%confidence intervals(CIs)by fixed-effects or random-effects ***:Seven prospective cohort studies and 17 RCT studies were *** risks of both major adverse cardiovascular events(MACE)(RR=1.72,95%CI 1.28-2.33)and CVE(RR=1.35,95%CI 1.12-1.62)were higher in the hyperuricemia population than non-hyperuricemia *** seven RCT studies where XOIs were compared with no-treatment or placebo,the results of five low CV risk studies showed that XOIs lowered the risks of both MACE(RR=0.35,95%CI 0.20-0.62)and CVE(RR=0.61,95%CI 0.44-0.85);whereas two high CV risk studies showed that XOIs lowered the risk of CVE(RR=0.69,95%CI 0.54-0.88)rather than MACE(RR=0.62,95%CI 0.29-1.35).In nine RCT studies where the cardiovascular safety between febuxostat and allopurinol were compared,no statistical difference was found in the risk of MACE or ***:The hyperuricemia population doe

关键词： Hyperuricemia Gout Cardiovascular event Febuxostat Allopurinol

Efficacy of acupuncture to regain consciousness in patients with traumatic brain injury: a systematic review and meta-analysis

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TMR Integrative Medicine 2023年第31期7卷 1-11页

作者： Lamichhane Narendra yi-Fan Zhang Zi-Chen Zhang Zhi-Fang Xu Yu Luo Mei-Dan zhao tian-yi zhao Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Acupuncture and Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Medical Technology Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Background:Traumatic brain injury(TBI)is a leading cause of death and disability worldwide,and consciousness disorder is a common problem in TBI *** has been used to improve neurological deficits in patients with *** meta-analysis aims to evaluate the effects and safety of acupuncture in improving consciousness in patients with TBI when compared with other ***:A systematic search was conducted in electronic databases PubMed,EMBASE,Web of Science,the Cochrane Central Register of Controlled Trials,Allied and Complementary Medicine Database,WHO International Clinical Trials Registry Platform,***,and Google Scholar for randomized controlled trials that investigated the effect of acupuncture on patients with *** the inception of databases to March ***:A total of 653 participants were included in nine *** found that acupuncture adjunct to routine treatment significantly improved the wakeup rate of patients in TBI when compared with routine treatment alone(relative risk=1.36,95%confidence interval:1.16 to 1.59,I2=4.78%,P=0).Additionally,we found that acupuncture is significantly associated with reduced impaired consciousness after TBI when adjunct to medicine *** a safe intervention,acupuncture can also improve the activities of daily living for people with TBI(mean difference=15.71,95%confidence interval:9.19 to 22.22,I2=0%,P=0).Conclusion:Acupuncture can improve consciousness and braise wakeup of patients with TBI when adjunct to conventional treatment compared with routine treatment *** high-quality studies are needed to confirm these findings and to determine the optimal acupuncture treatment parameter for TBI.

关键词： acupuncture consciousness traumatic brain injury systematic review meta-analysis

Coordinated Control Strategy of New Energy Power Generation System with Hybrid Energy Storage Unit

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Energy Engineering 2025年第1期122卷 167-184页

作者： Yun Zhang ZifenHan Biao tian Ning Chen yi Fan School of Mechano-Electronic Engineering Xidian UniversityXi’an710071China Electric Power Control Center State Grid Gansu Electric Power CompanyLanzhou730030China Electric Power Control Center State Grid Gansu Electric Power Company Zhangye Power Supply BranchZhangye734000China

The new energy power generation is becoming increasingly important in the power *** as photovoltaic power generation has become a research hotspot,however,due to the characteristics of light radiation changes,photovoltaic power generation is unstable and random,resulting in a low utilization rate and directly affecting the stability of the power *** solve this problem,this paper proposes a coordinated control strategy for a newenergy power generation system with a hybrid energy storage unit based on the lithium iron phosphate-supercapacitor hybrid energy storage ***,the variational mode decomposition algorithm is used to separate the high and low frequencies of the power signal,which is conducive to the rapid and accurate suppression of the power fluctuation of the energy storage ***,the fuzzy control algorithm is introduced to balance the power between energy *** this paper,the actual data is used for simulation,and the simulation results show that the strategy realizes the effective suppression of the bus voltage fluctuation and the accurate control of the internal state of the energy storage unit,effectively avoiding problems such as overshoot and over-discharge,and can significantly improve the stability of the photovoltaic power generation systemand the stability of the Direct Current *** is of great significance to promote the development of collaborative control technology for photovoltaic hybrid energy storage units.

关键词： Photovoltaic power suppression hybrid energy storage unit variationalmodal decomposition fuzzy control power distribution control

Core acupoints of acupuncture for hyperplasia of mammary gland: a network analysis

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TMR Non-Drug Therapy 2020年第1期3卷 12-22页

作者： Bao-Min Dou Yuan-Yuan Sun tian-yi zhao Qian-Nan Jia Jiang Liu Bo Chen yi Guo Experimental Acupuncture and Moxibustion Research Center Tianjin University of Traditional Chinese MedicineTianjin 301617China College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Backgroud:Clinical studies on acupuncture treatment of hyperplasia of mammary gland(HMG)have proved its effectiveness,but most studies have paid little attention to acupoints prescription and acupoint *** clinical prescription is not identical,the curative effect also has the ***,through data mining and network analysis,this study explored the core acupoints and the compatibility law of acupoints in acupuncture treatment of ***:To search and select qualified literature according to inclusion and exclusion criteria for relevant clinical research literature on acupuncture treatment of HMG in CNKI,VIP database,WanFang database and PubMed,*** extract relevant information and establish a *** the method of statistical and complex network analysis,this paper studies the core acupoints and the law of acupoint ***:A total of 104 Chinese literatures and 0 English literatures were included and 106 acupuncture prescriptions were *** core acupoints in the treatment of HMG are Danzhong(CV 17),Wuyi(ST 15),Zusanli(ST 36),Jianjing(GB 21).Danzhong(CV 17)and Zusanli(ST 36),Danzhong(CV 17)and Wuyi(ST 15),Jianjing(GB 21)and tianzong(SI 11),Jianjing(GB 21)and Wuyi(ST 15)have the highest correlation *** method of acupoint matching mainly consists of local-remote acupoints,upper-lower acupoints and front-rear ***:The results of a network analysis substantially accord with the general rules of acupuncture theories in traditional Chinese medicine,able to reflect the points-selection principles and features in acupuncture treatment of HMG and provide evidence for the acupoints selection in the treatment of HMG in acupuncture clinic.

关键词： Hyperplasia of mammary glands(HMG) Acupoints compatibility Complex network analysis Traditional Chinese medicine

Identification of Developmentally Regulated Genes by Transposon-mediated Gene Trap Approach in Zebrafish

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Identification of Developmentally Regulated Genes by Transpo...

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

中国遗传学会“发育、遗传和疾病”研讨会

作者： zhao Xin-yi tian tian zhao Long MENG An-Ming Department of Bioscience and Technology,Molecular and Developmental Biology Laboratory,Tsinghua University,Beijing,100084

Zebrafish is an excellent animal model to study vertebrate development by genetic approaches. To identify some key genes in the process of development,we have used the Tol2 transposable element to design and perform gene trapping in ***,we constructed a transposon-based gene trap vector containing a EF1αor vasa splice accepter,a EF1α polyA,and a GFP report gene to performed a pilot screen for gene *** Tol2 transposon vector and the transposase mRNA were coinjected into one-cell stage *** date,we have isolated about 150 transgenic lines expressing GFP in temporally and spatially restricted *** mutants with different phenotypes have also been *** the gene cloning and functional assay are being carried *** propose our gene trap approach should facilitate studies of zebrafish development.

关键词： Tol2 gene trap transposon development

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia tian Yanmei zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells