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Proton beam therapy in apneic oxygenation treatment of an unresectable hepatocellular carcinoma: A case report and review of literature

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World Journal of Hepatology 2018年第10期10卷 772-779页

作者： yi-lan Lin Department of Radiation Oncology Rinecker Proton Therapy Center

Presented here is the clinical course of a 63-yearold patient with a central, large and unresectable hepatocellular carcinoma(HCC) with liver metastases and tumor invasion of the portal and hepatic veins. After the tumor had been diagnosed, the patient was immediately treated with proton beam therapy(PBT), at a total dose of 60 Gy(relative biological effectiveness) in 20 fractions administered within 4 wk. To manage the respiratory movements, at the Rinecker Proton Therapy Center, apneic oxygenation was given daily, under general anesthesia. The patient tolerated both the PBT and general anesthesia very well, and did now show any signs of acute or late toxicity. The treatment was followed by constant reductions in the tumor marker alpha-fetoprotein and the cholestatic parameters gamma-glutamyltransferase and alkaline phosphatase. The patient commenced an adjuvant treatment with sorafenib, given at 6-wk intervals, after the PBT. Follow-up with regular magnetic resonance imaging has continued for 40 mo so far, demonstrating remarkable shrinkage of the HCC(maximal diameter dropping from approximately 13 cm to 2 cm). To date, the patient remains free of tumor recurrence. PBT served as a safe and effective treatment method for an unresectable HCC with vascular invasion.

关键词： Particle therapy Proton beam therapy Apneic oxygenation Unresectable Vascular invasion Hepatocellular carcinoma Intrahepatic metastasis

Reliable and Load Balance-Aware Multi-Controller Deployment in SDN

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China Communications 2018年第11期15卷 184-198页

作者： Tao Hu Peng yi Jianhui Zhang Julong lan National Digital Switching System Engineering & Technological R&D Center Zhengzhou 450002 China

Software Defined Networking(SDN) provides flexible network management by decoupling control plane and data plane. However, such separation introduces the issues regarding the reliability of the control plane and controller load imbalance in the distributed SDN network, which will cause the low network stability and the poor controller performance. This paper proposes Reliable and Load balance-aware Multi-controller Deployment(RLMD) strategy to address the above problems. Firstly, we establish a multiple-controller network model and define the relevant parameters for RLMD. Then, we design the corresponding algorithms to implement this strategy. By weighing node efficiency and path quality, Controller Placement Selection(CPS) algorithm is introduced to explore the reliable deployments of the controllers. On this basis, we design Multiple Domain Partition(MDP) algorithm to allocate switches for controllers according to node attractability and controller load balancing rate, which could realize the reasonable domain planning. Finally, the simulations show that, compared with the typical strategies, RLMD has the better performance in improving the reliability of the control plane and balancing the distribution of the controller loads.

关键词： software defined networking controller reliability load balancing networkoptimization

A Distributed Decision Mechanism for Controller Load Balancing Based on Switch Migration in SDN

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China Communications 2018年第10期15卷 129-142页

作者： Tao Hu Peng yi Jianhui Zhang Julong lan National Digital Switching System Engineering & Technological R&D Center Zhengzhou 450002 China

Software Defined Networking(SDN) provides flexible network management by decoupling control plane from data plane. And multiple controllers are deployed to improve the scalability and reliability of the control plane, which could divide the network into several subdomains with separate controllers. However, such deployment introduces a new problem of controller load imbalance due to the dynamic traffic and the static configuration between switches and controllers. To address this issue, this paper proposes a Distribution Decision Mechanism(DDM) based on switch migration in the multiple subdomains SDN network. Firstly, through collecting network information, it constructs distributed migration decision fields based on the controller load condition. Then we choose the migrating switches according to the selection probability, and the target controllers are determined by integrating three network costs, including data collection, switch migration and controller state synchronization. Finally, we set the migrating countdown to achieve the ordered switch migration. Through verifying several evaluation indexes, results show that the proposed mechanism can achieve controller load balancing with better performance.

关键词： software defined networking controller load balancing switch migration distributed decision

Adsorption properties of Ⅴ(Ⅳ) on resin-activated carbon composite electrodes in capacitive deionization

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International Journal of Minerals,Metallurgy and Materials 2021年第11期28卷 1777-1787页

作者： Xiao-man tian Shen-xu Bao yi-min Zhang School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China Hubei Key Laboratory of Mineral Resources Processing and Environment Wuhan University of TechnologyWuhan 430070China Hubei Collaborative Innovation Center for High Efficient Utilization of Vanadium Resources Hubei Provincial Engineering Technology Research Center of High Efficient Cleaning Utilization for Shale Vanadium ResourceWuhan University of Science and TechnologyWuhan 430081China

Composite electrodes prepared by cation exchange resins and activated carbon(AC)were used to adsorb Ⅴ(Ⅳ)in capacitive deionization(CDI).The electrode made of middle resin size(D860/AC M)had the largest specific surface area and mesoporous content than two other composite *** analysis showed that D860/AC M presents higher specific capacitance and electrical double layer capacitor than the others,and significantly lower internal diffusion ***,D860/AC M exhibits the highest adsorption capacity and rate of Ⅴ(Ⅳ)among three *** intra-particle diffusion model fits well in the initial adsorption stage,while the liquid film diffusion model is more suitable for fitting at the later *** pseudo-second-order kinetic model is suited for the entire adsorption *** adsorption of Ⅴ(Ⅳ)on the composite electrode follows that of the Freundlich *** analysis indicates that the adsorption of Ⅴ(Ⅳ)is an exothermic process with entropy reduction,and the electric field force plays a dominant role in the CDI *** work aims to improve our understanding of the ion adsorption behaviors and mechanisms on the composite electrodes in CDI.

关键词： capacitive deionization composite electrode vanadium electrochemical behavior kinetics

Single crystal growth and electrochemical studies of garnet-type fast Li-ion conductors

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Tungsten 2022年第4期4卷 263-268页

作者： yi-tian Wang Xi Chen Department of Electrical and Computer Engineering University of CaliforniaRiversideCA92521USA

All-solid-state batteries have attracted much attention due to their improved safety and higher energy density as compared to the conventional *** to the excellent chemical stability against lithium metal and relatively high ionic conductivity at room-temperature,garnet-type fast lithium ion conductors with three-dimensional lithium ion transport channels are promising solid electrolytes for all-solid-state *** order to better understand the intrinsic lithium-ion transport mechanisms and prevent lithium dendrite formation,it is desired to investigate single-crystal solid *** this perspective,we review several methods reported to grow single crystals of garnet-type *** and cons of different growth methods are ***,we introduce some case studies on electrochemical properties of garnet-type single *** addition,we provide some perspectives about potential research directions of single-crystal solid electrolytes for all-solid-state batteries.

关键词： Solid electrolyte Single crystal Garnet-type lithium-ion conductor All-solid-state battery Crystal growth

Mechanism of action of two insect toxins huwentoxin-Ⅲ and hainantoxin-Ⅵ on voltage-gated sodium channels

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第6期11卷 451-457页

作者： Rui-lan WANG Su yi Song-ping LIANG Department of Food Science Guangdong Food and Drug Vocational College Guangzhou 510520 China School of Life Science Hunan Science and Technology University Xiangtan 411201 China Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education College of Life Science Hunan Normal University Changsha 410081 China

Selenocosmia huwena and Selenocosmia hainana are two tarantula species found in southern *** venoms contain abundant peptide *** new neurotoxic peptides,huwentoxin-Ⅲ(HWTX-Ⅲ) and hainantoxin-VI(HNTX-VI),were obtained from the venom using ion-exchange chromatography and reverse-phase high performance liquid chromatography(RP-HPLC).The mechanism of action of HWTX-Ⅲ and HNTX-VI on insect neuronal voltage-gated sodium channels(VGSCs) was studied via whole-cell patch clamp *** a fashion similar to δ-atracotoxins,HNTX-VI can induce a slowdown of current inactivation of the VGSC and reduction in the peak of Na+ current in cockroach dorsal unpaired median(DUM) ***,10 μmol/L HNTX-IV caused a positive shift of steady-state inactivation of sodium ***-ⅡI inhibited VGSCs on DUM neurons(concentration of toxin at half-maximal inhibition(IC50)≈1.106 μmol/L) in a way much similar to tetrodotoxin(TTX).HWTX-Ⅲ had no effect on the kinetics of activation and *** shift in the steady-state inactivation curve was distinct from other depressant spider *** diverse effect and the mechanism of action of the two insect toxins illustrate the diverse biological activities of spider toxins and provide a fresh theoretical foundation to design and develop novel insecticides.

关键词： Insect neurotoxin Dorsal unpaired median neurons Sodium channel Whole-cell patch clamp technique

GHM-FKNN:a generalized Heronian mean based fuzzy k-nearest neighbor classifier for the stock trend prediction

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High Technology Letters 2023年第2期29卷 122-129页

作者：吴振峰 WANG Mengmeng lan tian ZHANG Anyuan Institute of Scientific and Technical Information of China Beijing 100038P.R.China School of Economics Renmin University of ChinaBeijing 100872P.R.China Shandong Provincial Center for Quality Control of Feed and Veterinary Drug Jinan 250022P.R.China

Stock trend prediction is a challenging problem because it involves many *** at the problem that some existing machine learning techniques, such as random forest(RF), probabilistic random forest(PRF), k-nearest neighbor(KNN), and fuzzy KNN(FKNN), have difficulty in accurately predicting the stock trend(uptrend or downtrend) for a given date, a generalized Heronian mean(GHM) based FKNN predictor named GHM-FKNN was ***-FKNN combines GHM aggregation function with the ideas of the classical FKNN *** evaluation, the comparison results elucidated that GHM-FKNN outperformed the other best existing methods RF, PRF, KNN and FKNN on independent test datasets corresponding to three stocks, namely AAPL, AMZN and *** with RF, PRF, KNN and FKNN, GHM-FKNN achieved the best performance with accuracy of 62.37% for AAPL, 58.25% for AMZN, and 64.10% for NFLX.

关键词： stock trend prediction Heronian mean fuzzy k-nearest neighbor(FKNN)

Silvestrol alleviates glioblastoma progression through ERK pathway modulation and MANBA and NRG-1 expression

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BIOCELL 2024年第7期48卷 1081-1093页

作者： lan ZHOU QI ZHANG BO tian FENG YANG Neurosurgery Department The First Affiliated Hospital of Chongqing Medical and Pharmaceutical CollegeChongqingChina Neurosurgery Department Changdu People’s Hospital of TibetChangduChina

Background:Glioblastoma,a notably malignant tumor within the central nervous system,is distinguished by its aggressive ***,a robust inhibitor of the RNA helicase eukaryotic initiation factor 4A(eIF4A),has shown significant potential as an anticancer ***,the impact of silvestrol on glioblastoma,especially its molecular mechanisms,has not been fully ***:This investigation employed a variety of in vitro assays,such as cell counting kit-8(CCK-8),clonogenic,5-ethynyl-2′-deoxyuridine(EDU),wound healing,and flow cytometry,to evaluate cell cycle progression,apoptosis,cell viability,and *** blot analysis was also performed to study the apoptosis and extracellular regulated kinase(ERK)*** the ERK pathway was inhibited,differentially expressed genes(DEGs)in U87 cells were identified,followed by an analysis of target genes using the gene expression profiling interactive analysis(GEPIA)***:Silvestrol significantly suppressed the proliferation,migration,and colony formation of glioma *** caused cell cycle arrest and enhanced apoptosis in these ***,silvestrol stimulated the ERK pathway,with these effects being reversible by an ERK phosphorylation *** combined with GEPIA,GSCA,UALCAN,TIMER database screened 4 potential drug targets of silvestrol:chromosome 1 open reading frame 226(C1ORF226),mannosidase beta A(MANBA),IQ motif and Sec7 domain 2(IQSEC2),neuregulin 1(NRG-1).Among them,C1ORF226 was lower risk gene while MANBA,IQSEC2,and NRG-1 were high-risk ***,silvestrol notably reduced MANBA mRNA levels,which could be reversed by inhibiting ERK ***,silvestrol markedly decreased NRG-1 protein levels,with an additional reduction observed when the ERK pathway was ***:Silvestrol’s anti-glioma effects are primarily due to the suppression of MANBA expression via the ERK pathway and possibly by hindering the translation of N

关键词： Glioblastoma Silvestrol ERK pathway MANBA NRG-1

Preparation of Nylon MXD6/EG/CNTs Ternary Composites with Excellent Thermal Conductivity and Electromagnetic Interference Shielding Effectiveness

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Chinese Journal of Polymer Science 2017年第12期35卷 1497-1507页

作者： yi-lan Guo Run-zhi Zhang Kai Wu 陈枫傅强 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan University

In this article, hybrid fillers with different dimensions, namely, 2-dimensional（2-D） expanded graphite（EG） and 1-dimensional（1-D） multi-walled carbon nanotubes（CNTs）, were added to aromatic nylon MXD6 matrix via melt-blending, to enhance its thermal and electrical conductivity as well as electromagnetic interference shielding effectiveness（EMI SE）. For ternary composites of MXD6/EG/CNTs, the electrical conductivity reaches up nine orders of magnitude higher compared to that of the neat MXD6 sample, which turned the polymer-based composites from an insulator to a conductor, and the thermal conductivity has been enhanced by 477% compared with that of neat MXD6 sample. Meanwhile, the EMI SE of ternary composite reaches ~50 d B at the overall filler loading of only 18 wt%. This work can provide guidance for the preparation of polymer composites with excellent thermal and electrical conductivity via using hybrid filler.

关键词： Thermal and electrical conductivity Electromagnetic interference shielding Hybrid filler Synergistic effect