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DMF-scMT-seq linking methylome and transcriptome within single cells with digital microfluidics

Science China Chemistry 2024年第6期67卷 2070-2078页

作者： xing xu Xi Zeng Xin Lin Shiyan Lin Shanshan Liang tian tian Rui Su Jia Song Chaoyong Yang Collaborative Innovation Center of Chemistry for Energy Materials The MOE Key Laboratory of Spectrochemical Analysis and InstrumentationState Key Laboratory of Physical Chemistry of Solid SurfacesDepartment of Chemical BiologyCollege of Chemistry and Chemical EngineeringThe First Affiliated Hospital of Xiamen UniversityXiamen UniversityXiamen361005China Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai200127China Chemistry and Materials Science College Shanghai Normal UniversityShanghai200234China Chemistry and Biomedicine Innovation Center(ChemBIC) School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China

Single-cell joint analysis of methylome and transcriptome reveals how the methylation regulates the transcriptional ***,traditional bench-top protocols for single-cell DNA methylation and RNA transcription co-detection are laborintensive,cost-ineffective and ***,we establish the DMF-sc MT-seq,a highly-efficient and cost-effective method to simultaneously analyze single-cell DNA methylation and transcriptional activity based on digital *** MT-seq automates the workflow of single-cell isolation,cellular hypotonic lysis,nucleic acid separation and methylome/transcriptome library construction in a contactless and addressable *** system ensures high accuracy(R>0.85),high gene detection ability(14,697 genes per cell at 4 million sequencing depth),and high CpG coverage(677,198 CpG sites per cell at 1million sequencing depth).By using DMF-sc MT-seq,the relationship of DNA methylation and RNA transcription under different genomic contexts is *** further apply DMF-sc MT-seq to study the dynamics of transcription regulation with methylation-inhibiting anti-tumor Decitabine,and identify the methylated promoter/gene body driven genes in response to Decitabine ***-sc MT-seq facilitates the construction of the correlation of DNA methylation and transcriptional activity at the single-cell level in a flexible,sensitive and accurate way,which is anticipated to be a powerful tool in studying single-cell biological systems.

关键词： single-cell analysis digital microfluidics methylome sequencing transcriptome sequencing

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Topologically protected entanglement switching around exceptional points

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Light(Science & Applications) 2024年第8期13卷 1631-1644页

作者： Zan Tang tian Chen xing Tang Xiangdong Zhang Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081 BeijingChina

The robust operation of quantum entanglement states is crucial for applications in quantum information,computing,and communications^(1–3).However,it has always been a great challenge to complete such a task because of decoherence and ***,we propose theoretically and demonstrate experimentally an effective scheme to realize robust operation of quantum entanglement states by designing quadruple degeneracy exceptional *** encircling the exceptional points on two overlapping Riemann energy surfaces,we have realized a chiral switch for entangled states with high *** to the topological protection conferred by the Riemann surface structure,this switching of chirality exhibits strong robustness against perturbations in the encircling ***,we have experimentally validated such a scheme on a quantum walk *** work opens up a new way for the application of non-Hermitian physics in the field of quantum information.

关键词： exceptional quantum Riemann

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Attention mechanisms in computer vision:A survey

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Computational Visual Media 2022年第3期8卷 331-368页

作者： Meng-Hao Guo tian-xing xu Jiang-Jiang Liu Zheng-Ning Liu Peng-Tao Jiang Tai-Jiang Mu Song-Hai Zhang Ralph R.Martin Ming-Ming Cheng Shi-Min Hu BNRist Department of Computer Science and TechnologyTsinghua UniversityBeijing 100084China TKLNDST College of Computer ScienceNankai UniversityTianjin 300350China School of Computer Science and Informatics Cardiff UniversityCardiffUK

Humans can naturally and effectively find salient regions in complex *** by this observation,attention mechanisms were introduced into computer vision with the aim of imitating this aspect of the human visual *** an attention mechanism can be regarded as a dynamic weight adjustment process based on features of the input *** mechanisms have achieved great success in many visual tasks,including image classification,object detection,semantic segmentation,video understanding,image generation,3D vision,multimodal tasks,and self-supervised *** this survey,we provide a comprehensive review of various attention mechanisms in computer vision and categorize them according to approach,such as channel attention,spatial attention,temporal attention,and branch attention;a related repository https://***/MenghaoG uo/Awesome-Vision-Attentions is dedicated to collecting related *** also suggest future directions for attention mechanism research.

关键词： attention transformer computer vision deep learning salience

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Solution-processed all-inorganic lead halide perovskite/layered double hydroxides superlattices

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Science China Chemistry 2024年第9期67卷 2904-2910页

作者： Deyu Li Mingming Zhang Lulu Wei Shubing tian Mingze Sun Kang Liu Jixiang xu Lei Wang Jun xing Key Laboratory of Eco-chemical Engineering Ministry of EducationCollege of Chemistry and Molecular EngineeringQingdao University of Science&TechnologyQingdao 266042China College of Sino-German Science and Technology Qingdao University of Science&TechnologyQingdao 266042China

Quantum wells and superlattices are key building blocks in the semiconductor industry,normally fabricated using epitaxial growth techniques,such as vapor phase epitaxy,metalorganic chemical vapor deposition and molecular beam ***,these complicated preparation processes,as well as their high cost,limit their extensive *** is essential to develop a simple solution process for building ***,we demonstrate an ion exchange strategy for synthesizing an allinorganic superlattice cesium lead bromide/layered double hydroxides(CsPbBr_3/LDH)in *** room temperature,the perovskite ions diffuse into the interlayer of LDH and assemble into layered perovskite with various *** with traditional organic-inorganic hybrid perovskite superlattice,the all-inorganic perovskite superlattice CsPbBr_(3)/LDH has weak quantum confinement,which exhibits narrow emission line-widths of 20 nm,high quantum yields of 55%,and radiative lifetimes of several *** findings offer a new route to synthesize novel perovskite superlattices and enrich the perovskite supercrystal platform for electronics,photonics and optoelectronics devices.

关键词： halide perovskite superlattice layered double hydroxides 2D

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The dynamics of traveling wavefronts for a model describing host tissue degradation by bacteria

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International Journal of Biomathematics 2024年第3期17卷 265-287页

作者： xing-xing Yang Guo-Bao Zhang Ge tian College of Mathematics and Statistics Northwest Normal University Lanzhou Gansu 730070P.R.China

In this paper,we mainly investigate the dynamics of traveling wavefronts for a model describing host tissue degradation by *** first establish the existence of spreading speed,and show that the spreading speed coincides with the minimal wave speed of traveling ***,a lower bound estimate of the spreading speed is ***,we prove that the traveling wavefronts with large speeds are globally exponentially stable,when the initial perturbation around the traveling wavefronts decays exponentially asχ→-∞,but the initial perturbation can be arbitrarily large in other *** adopted methods are the weighted energy and the squeezing technique.

关键词： Host tissue degradation bacterial infection traveling wavefronts minimal wave speed stability

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Unimolecular Self-Assembled Hemicyanine-Oleic Acid Conjugate Acts as a Novel Succinate Dehydrogenase Inhibitor to Amplify Photodynamic Therapy and Eliminate Cancer Stem Cells

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Research 2024年第2期6卷 449-461页

作者： Qiang Wang tian Yang Shiyou Li Chen xu Chong Wang Yuxuan Xiong xing Wang Jiangling Wan Xiangliang Yang Zifu Li National Engineering Research Center for Nanomedicine College of Life Science and Technology.Huazhong University of Science and TechnologyWuhan 430074P.R.China Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China .3Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Bioinformatics and Molecular Imaging Key Laboratory College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China

Photodynamic therapy with reactive oxygen species production is a prospective treatment to combat cancer stem cells(CSCs).However,the innate drawbacks,including short lifetime and diffusion distance of reactive oxygen species and hypoxia within solid tumors,have become bottlenecks for clinical applications of photodynamic ***,we develop a mitochondria-targeting hemicyanine-oleic acid conjugate(CyOA),which can self-assemble into supramolecular nanoparticles(NPs)without any exogenous *** is also shown for targeting the mitochondrial complex II protein succinate dehydrogenase to inhibit oxidative phosphorylation and reverse tumor hypoxia,resulting in 50.4-fold higher phototoxicity against breast cancer stem cells(BCSCs)compared to SO_(3)-CyOA NPs that cannot target to *** 4T1 and BCSC tumor models,CyOA NPs achieve higher tumor inhibition and less lung metastasis nodules compared to the clinically used photosensitizer *** study develops a self-assembled small molecule that can serve as both oxidative phosphorylation inhibitor and photosensitizer for eradication of CSCs and treatment of solid tumors.

关键词： cyanine oxidative treatment

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Women’s empowerment and food consumption:Evidence from female-headed households in Tanzania

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Journal of Integrative Agriculture 2024年第2期23卷 457-467页

作者： Mosses Lufuke xu tian College of Economics and Management Nanjing Agricultural UniversityNanjing 210095China Department of Economics The University of DodomaDodoma 41218Tanzania College of Economics and Management China Agricultural UniversityBeijing 100083China Academy of Global Food Economics and Policy China Agricultural UniversityBeijing 100083China

Despite the growing recognition of women’s increasing role in the household and corresponding empowerment programs in sub-Saharan Africa,intensive research on the relationship between women’s influence and household food consumption is *** the most recent(2017-2018)national household survey data from Tanzania,this study examined the influence of women’s empowerment on household food ***,we compared the monthly consumption of eight food categories between female-headed households(FHHs)and male-headed households(MHHs)using both descriptive statistics and the propensity score matching(PSM)***,we adopted the two-stage Linear Expenditure System and Almost Ideal Demand System model(LES-AIDS)to estimate income and price elasticities for the two household *** results show that FHHs consume bread and cereals,fish,oils and fats,vegetables,and confectionery(sugar,jam,honey,chocolate,etc.)more than ***,FHHs have a significantly higher income elasticity of demand for all food groups than *** are also more price elastic than MHHs in meat,fish,oils,fats,sugar,jam,honey,chocolate,etc.

关键词： women’s empowerment food consumption income elasticity price elasticity

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Numerical Study on Reduction in Aerodynamic Drag and Noise of High-Speed Pantograph

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2155-2173页

作者： Deng Qin xing Du tian Li Jiye Zhang State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu610031China School of Electrical Engineering Southwest Jiaotong UniversityChengdu610031China

Reducing the aerodynamic drag and noise levels of high-speed pantographs is important for promoting environmentally friendly,energy efficient and rapid advances in train *** computational fluid dynamics theory and the K-FWH acoustic equation,a numerical simulation is conducted to investigate the aerodynamic characteristics of high-speed pantographs.A component optimization method is proposed as a possible solution to the problemof aerodynamic drag and noise in high-speed *** results of the study indicate that the panhead,base and insulator are the main contributors to aerodynamic drag and noise in high-speed ***,a gradual optimization process is implemented to improve the most significant components that cause aerodynamic drag and *** optimizing the cross-sectional shape of the strips and insulators,the drag and noise caused by airflow separation and vortex shedding can be *** aerodynamic drag of insulator with circular cross section and strips with rectangular cross section is the *** insulators and optimizing the chamfer angle and height of the windward surface of the strips can improve the aerodynamic performance of the *** addition,the streamlined fairing attached to the base can eliminate the complex flow and shield the radiated *** contrast to the original pantograph design,the improved pantograph shows a 21.1%reduction in aerodynamic drag and a 1.65 dBA reduction in aerodynamic noise.

关键词： High-speed pantograph aerodynamic drag aerodynamic noise reduction optimizing

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Cage-confinement synthesis of MoC nanoclusers as efficient sulfiphilic and lithiophilic regulator for superior Li–S batteries

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Rare Metals 2024年第2期43卷 624-634页

作者： xing-Yuan Zhang Mei-Na Lei Shan tian Jian-Gan Wang State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU)Xi’an710072China

High-energy-density Li-S batteries are subjected to serious sulfur deactivation and short cycle lifetime caused by undesirable polysulfide shuttle effect and frantic lithium dendrite *** this work,a controllable cage-confinement strategy to fabricate molybdenum carbide(MoC)nanoclusters as a high-efficient sulfiphilic and lithiophilic regulator to mitigate the formidable issues of Li-S batteries is *** sub-2 nm MoC nanoclusters not only guarantee robust chemisorption and fast electrocatalytic conversion of polysulfides to enhance the sulfur electrochemistry,but also homogenize Li^(+) flux to suppress the lithium dendrite *** a consequence,the MoC-modified separator endows the batteries with boosted reaction kinetics,promoted sulfur utilization,and improved cycling stability.A reversible capacity of 701 mAh·g^(−1) at a high rate of 5.0C and a small decay rate of 0.076%per cycle at 1.0C over 600 cycles are *** study offers a rational route for design and synthesis of bifunctional nanoclusers with both sulfiphilicity and lithiophilicity for high-performance Li-S batteries.

关键词： Li-S batteries Nanocluster Electrocatalyst Polysulfide shuttle Li dendrites

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Synthesis,Structure and Chemical Bonding of Polyantimony Clusters Containing Coinage Metals[M_(2)Sb_(14)]^(4-)(M=Cu,Ag)

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Chinese Journal of Chemistry 2024年第6期42卷 617-622页

作者： Wei-xing Chen Yu-He xu Cui-Cui Wang Lei Qiao Zi-Yan Guo Wen-Juan tian Zhong-Ming Sun State Key Laboratory of Element-Organic Chemistry Tianjin Key Lab for Rare Earth Materials and ApplicationsSchool of Materials Science and EngineeringNankai UniversityTianjin300350 China Institute of Molecular Science Shanxi UniversityTaiyuanShanxi030006 China

Binary polyantimony clusters,namely[Cu_(2)Sb_(14)]^(4–) and [Ag_(2)Sb_(14)]^(4–),containing coinage metals,were successfully synthesized and characterized,in which two homoatomic Sb73–subunits are bridged by two coinage metals in η^(4):η^(1) and η^(1):η^(1) coordination modes,***[M_(2)Sb_(14)]^(4-),two bridging Cu ions and two Sb atoms form a planar rhombic unit,which was revealed to have antiaromatic properties by theoretical *** electron structure and bonding analysis confirmed the presence of delocalized bonds in the rhombic unit and the metallophilic interaction between two formal M^(+) ions.

关键词： Polyantimony cluster Copper Silver Antiaromaticity Metallophilic interaction Quantum chemical calculations

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