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IKIP downregulates THBS1/FAK signaling to suppress migration and invasion by glioblastoma cells

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Oncology Research 2024年第7期32卷 1173-1184页

作者： ZHAOYING ZHU YANJIA HU FENG ye HAIBO TENG GUOLIANG YOU YUNHUI ZENG MENG tian JIANGUO XU JIN LI ZHIYONG LIU HAO LIU NIANDONG ZHENG Department of Neurosurgery The Affiliated Hospital of Southwestern Medical UniversityLuzhouChina Department of Neurosurgery Sichuan University West China HospitalChengduChina

Background:Inhibitor of NF-κB kinase-interacting protein(IKIP)is known to promote proliferation of glioblastoma(GBM)cells,but how it affects migration and invasion by those cells is ***:We compared levels of IKIP between glioma tissues and normal brain tissue in clinical samples and public *** examined the effects of IKIP overexpression and knockdown on the migration and invasion of GBM using transwell and wound healing assays,and we compared the transcriptomes under these different conditions to identify the molecular mechanisms ***:Based on data from our clinical samples and from public databases,IKIP was overexpressed in GBM tumors,and its expression level correlated inversely with *** overexpression in GBM cells inhibited migration and invasion in transwell and wound healing assays,whereas IKIP knockdown exerted the opposite *** overexpression in GBM cells that were injected into mouse brain promoted tumor growth but inhibited tumor invasion of surrounding *** effects of IKIP were associated with downregulation of THBS1 mRNA and concomitant inhibition of THBS1/FAK ***:IKIP inhibits THBS1/FAK signaling to suppress migration and invasion of GBM cells.

关键词： Inhibitor of NF-κB kinase-interacting protein(IKIP) Glioblastoma(GBM) Migration Thrombospondin 1(THBS1) FAK signaling

Molecular Conformational Isomerization:An Efficient Way to Design Novel Emitters with Dual-Thermally Activated Delayed Fluorescence Characteristics and Their Optoelectronic and Bioimaging Applications

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CCS Chemistry 2024年第4期6卷 912-922页

作者： Yi-Zhong Shi Ya-Fang Xiao Hao Wu Shao-Li Zhang Xiao-Chun Fan ye tian Chang-Qing ye Kai Wang Jia Yu Chun-Sing Lee Xiao-Hong Zhang School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009 Institute of Functional Nano and Soft Materials(FUNSOM) Joint International Research Laboratory of Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123Jiangsu Center of Super-Diamond and Advanced Films(COSDAF) Department of ChemistryCity University of Hong KongHong Kong SAR School of Biomedical Engineering The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260 Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow UniversitySuzhou 215123Jiangsu Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123Jiangsu

Single-molecule luminophores with dual-thermally activated delayed fluorescence(TADF)properties are receiving increasing ***,how to achieve these goals requires more in-depth ***,we demonstrate a novel example emitter,10-(5-(2-(pyridin-3-yl)-[4,5′-bipyrimidin]-6-yl)pyridin-2-yl)-10Hphenoxazine(PmPy-PXZ),enabling dual-TADF properties due to its key feature of conformational *** a pyridine bridge can greatly reduce the steric hindrance and facilitate dual-stable conformations in the ground state,where the quasi-axial(QA)forms ***,unlike previously reported TADF molecules with dual confirmations,both theoretical and experimental measurements show that not only the quasi-equatorial(QE)forms but also the QA forms exhibit distinct TADF characteristics,which can be attributed to an additional higher reverse intersystem crossing *** is the first time that dual-TADF properties of single molecules have been achieved based on conformational *** applications in“self-doping”organic light-emitting diode and biomedical imaging have further been *** these results show the good potential of such dual-band TADF emitters based on molecular conformational isomerization.

关键词： dual-thermally activated delayed fluorescence conformational isomerization organic light-emitting diode biomedical imaging self-doping

Robust Cross-Linked Na_(3)V_(2)(PO_(4))_(2)F_(3) Full Sodium-Ion Batteries

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Energy & Environmental Materials 2024年第1期7卷 9-20页

作者： Jinqiang Gao ye tian Lianshan Ni Baowei Wang Kangyu Zou Yingchang Yang Ying Wang Craig E.Banks Dou Zhang Kechao Zhou Huan Liu Wentao Deng Guoqiang Zou Hongshuai Hou Xiaobo Ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China College of Material and Chemical Engineering Tongren UniversityTongren 554300China Department of Chemistry The Chinese University of Hong KongShatinN.T.Hong Kong S.A.R.China Faculty of Science and Engineering Manchester Metropolitan UniversityManchester UK State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China School of Materials Science and Engineering Hunan Provincial Key Lab of Advanced Materials for New Energy Storage and ConversionHunan University of Science and TechnologyXiangtan 411201China School of Materials and Engineering Zhengzhou UniversityZhengzhou 450001China

Sodium-ion batteries(SIBs)have rapidly risen to the forefront of energy storage systems as a promising supplementary for Lithium-ion batteries(LIBs).Na_(3)V_(2)(PO_(4))_(2)F_(3)(NVPF)as a common cathode of SIBs,features the merits of high operating voltage,small volume change and favorable specific energy ***,it suffers from poor cycling stability and rate performance induced by its low intrinsic ***,we propose an ingenious strategy targeting superior SIBs through cross-linked NVPF with multi-dimensional nanocarbon frameworks composed of amorphous carbon and carbon nanotubes(NVPF@C@CNTs).This rational design ensures favorable particle size for shortened sodium ion transmission pathway as well as improved electronic transfer network,thus leading to enhanced charge transfer kinetics and superior cycling *** from this unique structure,significantly improved electrochemical properties are obtained,including high specific capacity(126.9 mAh g^(-1)at 1 C,1 C=128 mA g^(-1))and remarkably improved long-term cycling stability with 93.9%capacity retention after 1000 cycles at 20 *** energy density of 286.8 Wh kg^(-1)can be reached for full cells with hard carbon as anode(NVPF@C@CNTs//HC).Additionally,the electrochemical performance of the full cell at high temperature is also investigated(95.3 mAh g^(-1)after 100 cycles at 1 C at 50℃).Such nanoscale dual-carbon networks engineering and thorough discussion of ion diffusion kinetics might make contributions to accelerating the process of phosphate cathodes in SIBs for large-scale energy storages.

关键词： dual-nanocarbon networks full sodium-ion battery ion transfer kinetics Na_(3)V_(2)(PO_(4))_(2)F_(3) NASICON structure

Incorporating mesopelagic fish into the evaluation of conservation areas for marine living resources under climate change scenarios

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Marine Life Science & Technology 2024年第2期6卷 68-83页

作者： Shuhao Liu Yang Liu Katharina Teschke Mark AHindell Rachel Downey Briannyn Woods Bin Kang Shuyang Ma Chi Zhang Jianchao Li Zhenjiang ye Peng Sun Jianfeng He Yongjun tian Research Centre for Deep Sea and Polar Fisheries and Key Laboratory of MaricultureMinistry of EducationOcean University of ChinaQingdao 266003China Frontiers Science Center for Deep Ocean Multispheres and Earth System Ocean University of ChinaQingdao 266100China Alfred Wegener Institute Helmholtz Centre for Polar and Marine ResearchAm Handelshafen 1227570 BremerhavenGermany Helmholtz Institute for Functional Marine Biodiversity at the University Oldenburg Ammerländer Heerstraße 23123129 OldenburgGermany Institute for Marine and Antarctic Studies University of TasmaniaHobart 7004Australia Fenner School of Environment and Society Australian National UniversityCanberraACT 2602Australia College of Fisheries Ocean University of ChinaQingdao 266003China Polar Research Institute of China Shanghai 200136China

Mesopelagic fish(meso-fish)are central species within the Southern Ocean(SO).However,their ecosystem role and adaptive capacity to climate change are rarely integrated into protected areas *** is a pity given their importance as crucial prey and predators in food webs,coupled with the impacts of climate ***,we estimate the habitat distribution of nine meso-fish using an ensemble model approach(MAXENT,random forest,and boosted regression tree).Four climate model simulations were used to project their distribution under two representative concentration pathways(RCP4.5 and RCP8.5)for short-term(2006–2055)and long-term(2050–2099)*** addition,we assess the ecological representativeness of protected areas under climate change scenarios using meso-fish as indicator *** models show that all species shift poleward in the ***(family Myctophidae)are predicted to migrate poleward more than other families(Paralepididae,Nototheniidae,Bathylagidae,and Gonostomatidae).In comparison,lanternfishes were projected to increase habitat area in the eastern SO but lose area in the western SO;the opposite was projected for species in other *** areas(IAs)of meso-fish are mainly distributed near the Antarctic Peninsula and East *** protected area cover 23% of IAs at present and 38%of IAs in the future(RCP8.5,long-term future).Many IAs of meso-fish still need to be included in protected areas,such as the Prydz Bay and the seas around the Antarctic *** results provide a framework for evaluating protected areas incorporating climate change adaptation strategies for protected areas management.

关键词： Myctophids Mesopelagic fish Species distribution model Southern Ocean Antarctic Peninsula

Association of Human Whole-blood NAD+Levels with Nabothian Cyst

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Biomedical and Environmental Sciences 2024年第5期37卷 471-478页

作者： XU Ling WANG Yue Xuan WANG Wei FAN Xue CHEN Xue Yu ZHOU tian Yun LIU Yu He YU ye YANG Fan JU Zhen Yu ZHOU Yong WANG Deng Liang Clinical Research Institute Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China NHC Key Lab of Reproduction Regulation Shanghai Engineering Research Center of Reproductive Health Drugs and DevicesShanghai Institute for Biomedical and Pharmaceutical TechnologiesShanghai 200237China Department of Applied Statistics Johannes Kepler University LinzLinz 4040Austria Hematology Center Beijing Key Laboratory of Pediatric Hematology OncologyNational Key Discipline of Pediatrics(Capital Medical University)Key Laboratory of Major Diseases in ChildrenMinistry of EducationBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Biostatistics School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Clinical Medicine School of Basic MedicineShanghai Medical College Fudan UniversityShanghai 200032China Department of Biochemistry and Molecular Biology Hengyang Medical SchoolUniversity of South ChinaHengyang 421001HunanChina Administrative Office Total Quality Management OfficeTotal Quality Management InstituteShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China The First Affiliated Hospital of Jinan University Institute of Aging and Regenerative MedicineJinan UniversityJinan 510632GuangzhouChina Department of Scientific Research The First Affiliated Hospital of Huzhou UniversityHuzhou 313000ZhejiangChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005FujianChina Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou 350209FujianChina Fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated HospitalFujian Medical UniversityFuzhou 350005FujianChina Fujian Provincial Clinical Research Center for Neurological

Objective Little is known about the association between whole-blood nicotinamide adenine dinucleotide(NAD^(+))levels and nabothian *** study aimed to assess the association between NAD^(+)levels and nabothian cysts in healthy Chinese *** Multivariate logistic regression analysis was performed to analyze the association between NAD^(+)levels and nabothian *** The mean age was 43.0±11.5 years,and the mean level of NAD^(+)was 31.3±5.3μmol/*** cysts occurred in 184(27.7%)participants,with single and multiple cysts in 100(15.0%)and84(12.6%)participants,*** total nabothian cyst prevalence gradually decreased from37.4%to 21.6%from Q1 to Q4 of NAD^(+)and the prevalence of single and multiple nabothian cysts also decreased across the NAD^(+)*** compared with the highest NAD^(+)quartile(≥34.4μmol/L),the adjusted odds ratios with 95%confidence interval of the NAD^(+)Q1 was 1.89(1.14–3.14)for total nabothian *** risk of total and single nabothian cysts linearly decreased with increasing NAD^(+)levels,while the risk of multiple nabothian cysts decreased more rapidly at NAD^(+)levels of 28.0 to35.0μmol/***:Low NAD^(+)levels were associated with an increased risk of total and multiple nabothian cysts.

关键词： Nicotinamide adenine dinucleotide Nabothian cyst Female Risk factor

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基于管道应变的应力弱磁检测模型

油气储运 2024年第1期43卷 67-74页

作者：田野国家管网集团西部管道有限责任公司

【目的】金属磁记忆(Metal Magnetic Memory,MMM)应力检测技术支持非接触、在线检测,在以钢制油气管道为代表对象的铁磁性材料应力损伤检测领域具有很好的应用潜力,现有研究缺乏对磁力学关系的全面分析,需要建立一套完整的磁力学关系体... 详细信息

【目的】金属磁记忆(Metal Magnetic Memory,MMM)应力检测技术支持非接触、在线检测,在以钢制油气管道为代表对象的铁磁性材料应力损伤检测领域具有很好的应用潜力,现有研究缺乏对磁力学关系的全面分析,需要建立一套完整的磁力学关系体系,明确MMM检测信号与弹塑性阶段应力集中的对应关系。【方法】基于J-A理论,建立管道磁化强度与应变关系数值模型,计算分析管道变形过程中MMM检测信号特征,研究了应力影响下的无磁滞磁化曲线形状参数、钉扎系数对MMM信号的影响规律,并对应变与磁信号的关系开展全尺寸水压试验验证。【结果】管道在受力过程中,应变逐渐增大,磁化强度曲线在弹性变形阶段发生第1次翻转,翻转位置位于近屈服处,且随无磁滞磁化曲线形状参数的增大而提前;当管体发生塑性变形时,位错引起材料磁学特性改变,磁化强度曲线出现第2次翻转,翻转位置位于屈服点附近,且受钉扎系数影响较大,随着钉扎系数增大,翻转位置延后,翻转处应变呈2次函数减小趋势,第1次翻转与第2次翻转方向相反。【结论】利用该特征,根据磁记忆信号翻转规律与被检管道相同材料标定试验结果的相位对比分析,可判断钢制油气管道应力集中处是否发生塑性应变,实现对管道应力集中区域的快速定性检测。(图8,参30)

关键词：管道应变应力检测磁记忆磁-力学关系

油气管道工程用X80三通优化设计及增材制造技术

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油气储运 2024年第7期43卷 787-795页

作者：田野国家管网集团西部管道有限责任公司

【目的】传统热挤压三通制造工艺复杂,组织性能与质量水平不稳定,容易出现三通本体强度或韧性不满足标准要求等问题,严重制约油气管道的安全平稳运行,因此亟需对三通的性能提升与质量控制方法开展研究。【方法】通过对油气管道工程用X8... 详细信息

【目的】传统热挤压三通制造工艺复杂,组织性能与质量水平不稳定,容易出现三通本体强度或韧性不满足标准要求等问题,严重制约油气管道的安全平稳运行,因此亟需对三通的性能提升与质量控制方法开展研究。【方法】通过对油气管道工程用X80钢级、直径1219 mm等径三通的结构进行优化设计与安全性评价,改善局部应力集中的问题。采用京雷焊丝与电弧增材技术实现了等径三通的增材制造,对产品开展微观组织、力学性能、缺陷与残余应力测试,并对等径增材三通及其环焊缝进行耐压试验与往复循环压力波动试验。【结果】在控制总质量的前提下,优化改进三通结构后,设计压力下三通所受最大应力降低了38 MPa,三通主管连接区域应力降低约50%。增材制造的X80三通力学性能稳定,各部位、方向心部与表面的性能及组织均匀,强度、韧性各向异性小,无厚度效应。相控阵超声与常规超声适用于增材制造三通的缺陷检测,整体热处理可显著降低增材制造三通生产过程中的残余应力。【结论】X80增材制造三通及其连接环焊缝性能远高于同钢级热挤压三通,整体可承受的最大压力超过57.5 MPa,焊接短节爆破裂纹扩展至增材三通管件肩部后停止,具有良好的韧性与止裂能力。增材制造技术提高了三通的安全性与稳定性,为低温服役环境等特殊场景适用的三通设计与制造提供了新的思路与方法。

关键词：油气管道高强度三通增材制造 X80钢

The shaping of milk-flavored white tea: More than a change in appearance

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Journal of Integrative Agriculture 2024年第11期23卷 3912-3922页

作者： Jiao Feng Weisu tian Jinyuan Wang Shuping ye Guanjun Pan Bugui Yu Fang Wang Hongzheng Lin Zhilong Hao College of Horticulture Fujian Agriculture and Forestry University Zhenghe Ruiming Tea Co. Ltd. Tea Sensory Evaluation Research Center Ningde Normal University Key Laboratory of Tea Science in Universities of Fujian Province

Tea’s popularity and flavor are influenced by factors like cultivation and processing methods and shaping techniques also have an impact on tea *** study employed targeted metabolomics and chemometrics to investigate how shaping techniques affect the flavor of milk-flavored white tea (MFWT).The results showed that the tea cake sample with the shortest pressing time (Y90) has the highest amino acid content and milky aroma *** were variations in amino acids,catechins,and soluble sugars among MFWT samples with different shaping *** total contents of amino acids and catechins in tea cake sample (Y90) were significantly lower than those in the loose tea sample (SC) and bundle-like tea sample (SG),while the total sugar content was significantly higher than that in SC (P1) in Y90 remained lower relative to SC and SG (P<0.05),but the proportion was not different from that in SC and SG,minimally affecting the overall *** short-time pressing method might be suitable for mass production of *** findings provide insights into improving the tightness of the appearance of MFWT with minimal impact on tea flavor.

关键词： shaping milk-flavored white tea Camellia sinensis tea processing tea flavor

Lighting up aggregate emission of perylene diimide by leveraging polymerization-mediated through-space charge transfer and π-π stacking

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Science China Chemistry 2024年

作者： Suiying ye Désirée Füglistaller tian tian Anjay Manian Sudhir Kumar Celine Nardo Andrew J.Christofferson Salvy P.Russo Chih-Jen Shih Jean-Christophe Leroux Yinyin Bao Institute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 3 Institute for Chemical and Bioengineering Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 1-5 ARC Centre of Excellence in Exciton Science School of Science RMIT University School of Science STEM College RMIT University

The molecular engineering of fluorescent organic/polymeric materials, specifically those emitting in the deep red to near-infrared spectrum, is vital for advancements in optoelectronics and biomedicine. Perylene diimide(PDI), a well-known fluorescent scaffold, offers high thermal and photophysical stability but suffers from fluorescence quenching in solid or aggregate states due to intense π-π interactions. To mitigate this, simple and versatile methods for strong PDI aggregate emission without extensive synthetic demands are highly desirable but still lacking. Here, we report a straightforward strategy to enhance the solid-state emission of PDI by introducing certain degree of through-space charge transfer(TSCT) via controlled radical polymerization,which can efficiently distort the typical face-to-face PDI stacking, enabling greatly enhanced deep red emission. This is achieved by growing electron-donating star-shape styrenic(co)polymers from a multidirectional electron-accepting PDI initiator. The incorporation of polycyclic aromatic monomers further shifted the emission into the near-infrared region, albeit with a reduced intensity. Overall, the emission of the PDI-based TSCT polymers can be systematically manipulated by leveraging the balance between PDI stacking and the TSCT degree, as confirmed by both experimental study and theoretical calculations. Our approach circumvents complex synthetic procedures, offering highly emissive materials with large Stokes shifts and showing broad potential for optoelectronic technology.

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