检索结果-南通市图书馆

Advances in metabolic engineering of yeasts for the production of fatty acid-derived hydrocarbon fuels

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Chemical Engineering 2022年第4期3卷 289-303页

作者： Ran Lu tian-qiong shi Lu Lin Rodrigo Ledesma-Amaro Xiao-Jun Ji He Huang State Key Laboratory of Materials-Oriented Chemical Engineering College of Biotechnology and Pharmaceutical EngineeringNanjing Tech UniversityNanjing211816China School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing210046China Department of Bioengineering and Imperial College Centre for Synthetic Biology Imperial College LondonLondonSW72AZUnited Kingdom

The reliance of the transport sector on fossil fuels has led to increasing concerns related to sustainability and environmental *** petroleum shortages and global climate change caused by greenhouse gas emissions have given an impetus to the development of renewable and low-carbon energy *** acidderived hydrocarbons are an attractive drop-in biofuel to substitute fossil fuels consumed by the transport sector,especially heavy *** to traditional biofuels such as ethanol and biodiesel,fatty acidderived hydrocarbons have higher energy density and better compatibility with existing storage and transport *** a common microbial platform for biofuel production,yeasts have been engineered to produce fatty acid-derived ***,we attempted to comprehensively review the latest advances in metabolic engineering strategies for the production of fatty acid-derived hydrocarbons in the yeasts Saccharomyces cerevisiae and Yarrowia *** heterologous hydrocarbon synthesis pathways and combinational metabolic engineering strategies have been summarized,followed by a discussion of future research directions for the development of yeasts as industrial hydrocarbon producers.

关键词： Biofuel Metabolic engineering Fatty acid Hydrocarbon Yeast

Engineering Yarrowia lipolytica to produce nutritional fatty acids:Current status and future perspectives

在线全文

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2022年第4期7卷 1024-1033页

作者： Lizhen Cao Mingxue Yin tian-qiong shi Lu Lin Rodrigo Ledesma-Amaro Xiao-Jun Ji State Key Laboratory of Materials-Oriented Chemical Engineering College of Biotechnology and Pharmaceutical EngineeringNanjing Tech UniversityNo.30 South Puzhu RoadNanjing211816People’s Republic of China School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNo.1 Wenyuan RoadNanjing210046People’s Republic of China Department of Bioengineering and Imperial College Centre for Synthetic Biology Imperial College LondonLondonSW72AZUnited Kingdom

Due to their vital physiological functions,nutritional fatty acids have great potential as nutraceutical food supplements for preventing an array of diseases such as inflammation,depression,arthritis,osteoporosis,diabetes and *** biosynthesis of fatty acids follows the trend of sustainable development,as it enables green,environmentally friendly and efficient *** a natural oleaginous yeast,Yarrowia lipolytica is especially well-suited for the production of fatty ***,it has a variety of genetic engineering tools and novel metabolic engineering strategies that make it a robust workhorse for the production of an array of value-added *** this review,we summarize recent advances in metabolic engineering strategies for accumulating nutritional fatty acids in ***,including conjugated fatty acids and polyunsaturated fatty *** addition,the future prospects of nutritional fatty acid production using the *** platform are discussed in light of the current progress,challenges,and trends in this ***,guidelines for future studies are also emphasized.

关键词： Yarrowia lipolytica Metabolic engineering Nutritional fatty acids Conjugated fatty acids Polyunsaturated fatty acids

Synthesis of tetrahydroisoquinolines through TiCl4-mediated cyclization and Et3SiH reduction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2020年第3期31卷 729-732页

作者： Zeyu shi qiong Xiao Dali Yin State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China Department of Medicinal Chemistry Beijing Key Laboratory of Active Substances Discovery and Drugability EvaluationInstitute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China

A versatile and efficient telescoped reaction sequence for the synthesis of tetrahydroisoquinolines(THIQs)is reported that uses TiCl4 to promote cyclization of a benzylaminoacetal derivative and Et3SiH for reduction of the intermediate *** method is complimentary to the classical Pomeranz-Fritsch and related reactions since it tolerates electron-withdrawing substituents and allows access to 8-substituted THIQs.

关键词： Tetrahydroisoquinoline TiCl4 Cyclization Et3SiH Telescoped reaction

Hydrothermal Synthesis and Characterization of a Novel Two-dimensional Framework Materials Constructed from Polyoxometalate and Coordination Groups: [H_2Mo_(5.5)V_(10.5)O_(40)(PO_4)][Cu(en)_2]_4·7H_2O

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2004年第1期20卷 10-14页

作者： CUIXiao-bing ZHENGShou-tian SUNYan-qiong YANGGuo-yu CoordinationandHydrothermalChemistryGroup StateKeyLaboratoryofStructuralChemistryFujianInstituteofResearchontheStructureofMatterChineseAcademyofSciencesFuzhou350002P.R.China StateKeyLaboratoryofCoordinationChemistry NajingUniversityNanjing210093P.R.China

A novel compound [H_2Mo_ 5.5V_ 10.5O_ 40(PO_4)][Cu(en)_2]_4·7H_2O(1) was synthesized from V_2O_5, MoO_3, CuCl_2·2H_2O, en, H_3PO4 and H_2O in an aqueous solution via the hydrothermal method and characterized by means of single-crystal X-ray diffraction, elemental analyses, IR, EPR spectra and thermal analyses. C_ 16H_ 80Cu_4Mo_ 5.5N_ 16O_ 51PV_ 10.5 crystallized in a triclinic system, the space group is P1 with M=2660.63, a= 1.283590(10) nm, b=1.289910(10) nm, c=1.387870(10) nm, V=1.80942(2) nm 3, Z=2, D_x=4.883 g/cm 3, F(000)=2599, μ=6.956 mm -1, (Δ/σ)=0.000, S=1.089. The crystal structure was solved by the direct methods with the final R=0.0752 and wR=0.1988 for 6311 observed reflections with I≥2σ(I). The X-ray crystallography reveals that compound 1 is a novel two-dimensional framework material constructed from the mixed Mo/V polyoxometalate and coordination groups.

关键词： Hydrothermal synthesis Two-dimensional framework Mixed Mo/V tetra-capped pseudo-Keggin structure Polyoxometalate

Hydrothermal Synthesis and Characterization of [V_(16)O_(38)(Cl)][Cu(enMe)_2]_(3.5)·2H_2O Containing {V_(16)O_(38)} Cluster

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2004年第3期20卷 266-269页

Compound [V_ 16 O_ 38 (Cl)][Cu(enMe)_2]_ 3.5 ·2H_2O(1) has been hydrothermally synthesized and characterized by means of single-crystal X-ray diffraction,elemental analysis,IR,EPR and TGA analysis. The X-ray crystallography shows that compound 1 contains a new {V_ 16 O_ 38 } cluster shell,which is connected by [Cu(enMe)_2] 2+ coordination fragments into a 3-D framework. The compound crystallized in a monoclinic system with space group P2(1)/n,M =2235.82,a =1.26076(3) nm,b =2.55802(6) nm,c =2.14742(4) nm,β =90.7380(10)°, V =6.9250(3) nm 3,Z =4,F (000)=4418,D _c=2.145 g·cm -3 , μ =3.227 mm -1 ,( Δ/σ )=0.000,S =1.066.

关键词： Hydrothermal synthesis Polyoxovanadate Crystal structure Three-dimensional structure Open-framework

Concepts, processing, and recent developments in encapsulating essential oils

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2021年第2期34卷 255-271页

作者： Qirui tian Weiqing Zhou qiong Cai Guanghui Ma Guoping Lian Department of Chemical and Process Engineering University of SurreyGuildford GU27XHUK State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences School of Chemical SciencesBeijing 100049China Unilever Research Colworth Colworth ParkSharnbrookBedfordshire MK441LQUK

By the virtue of their olfactory,physicochemical,and biological characteristics,essential oils(EOs)have drawn wide attention as additives in daily chemicals like perfume or personal care ***,they are physicochemically unstable and susceptible to degradation or *** offers a feasible strategy to stabilize and prolong release of *** review summarizes the recognized benefits and functional properties of various preparation and characterization methods,wherein innovative fabrication strategies and their formation mechanisms are especially *** in combining detecting/measuring technologies with kinetic modelling are discussed,to give an integral approach of controlling the dynamic release of encapsulated ***,new development trends of EOs capsules are also highlighted.

关键词： Essential oils Encapsulation Sustained release

Nano-enabled cellular engineering for bioelectric studies

在线全文

学校读者我要写书评

暂无评论

Nano Research 2020年第5期13卷 1214-1227页

作者： Jiuyun shi Clementene Clayton Bozhi tian Department of Chemistry University of ChicagoChicagoIL 60637USA The James Franck Institute University of ChicagoChicagoIL 60637USA The Institute for Biophysical Dynamics University of ChicagoChicagoIL 60637USA

Engineered cells have opened up a new avenue for scientists and engineers to achieve specialized biological ***,such as silicon nanowires and quantum dots,can establish tight interfaces with cells either extra-or intracellularly,and they have already been widely used to control cellular *** future exploration of nanomaterials in cellular engineering may reveal numerous opportunities in both fundamental bioelectric studies and clinic *** this review,we highlight several nanomaterials-enabled non-genetic approaches to fabricating engineered ***,we briefly review the latest progress in engineered or synthetic cells,such as protocells that create cell-like behaviors from nonliving building blocks,and cells made by genetic or chemical ***,we illustrate the need for non-genetic cellular engineering with semiconductors and present some examples where chemical synthesis yields complex morphology or functions needed for *** then provide discussions in detail about the semiconductor nanostructure-enabled neural,cardiac,and microbial *** also suggest the need to integrate tissue engineering with semiconductor devices to carry out more complex *** end this review by providing our perspectives for future development in non-genetic cellular engineering.

关键词： cellular engineering nano-bio interface biological modulation tissue engineering

Molecular Population Genetics of Rice Domestication

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2007年第6期49卷 769-775页

作者： tian Tang Suhua shi State Key Laboratory of Biocontrol School of Life Sciences Sun Yat-sen (Zhongshan) University Guangzhou 510275 China

Domestication is a selection process that genetically modifies species to meet human needs. A most intriguing feature of domestication is the extreme phenotypic diversification among breeds. What could be the ultimate source of such genetic variations？ Another notable outcome of artificial selection is the reduction In the fitness of domesticated species when they live In the wild without human assistance. The complete sequences of the two subspecies of rice cultlvars provide an opportunity to address these questions. Between the two subspecies, we found much higher rates of non-synonymous （N） than synonymous （S） substitutions and the N/S ratios are higher between cultivars than between wild species. Most interestingly, substitutions of highly dissimilar amino acids that are deleterious and uncommon between natural species are disproportionately common between the two subspecies of rice. We suggest strong selection in the absence of effective recombination may be the driving force, which we called the domestication-associated Hill-Robertson effect. These hitchhiking mutations may contribute to some fitness reduction in cultivars. Comparisons of the two genomes also reveal the existence of highly divergent regions in the genomes. Haplotypes in these regions often form highly polymorphic linkage blocks that are much older than speciation between wild species. Genes from such regions could contribute to the differences between indica and japonica and are likely to be involved in the diversifying selection under domestication. Their existence suggests that the amount of genetic variation within the single progenitor species Oryza rufipogon may be insufficient to account for the variation among rice cultivars, which may come from a more inclusive gene pool comprising most of the A-genome wild species. Genes from the highly polymorphic regions also provide strong support for the Independent domestication of the two subspecies. The genomic variation in rice has revealing i

关键词： rice population genetics domestication artificial selection admixture.

Responses of plant diversity and species composition to the cessation of fertilization in a sandy grassland

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2014年第2期25卷 337-342页

作者： Sheng-nan shi Zhan-yuan Yu qiong Zhao State Key Laboratory of Forest and Soil Ecology Institute of Applied Ecology Chinese Academy of Sciences University of Chinese Academy of Sciences Daqinggou Ecological Station Institute of Applied EcologyChinese Academy of Sciences

Nitrogen was the main limiting nutrient of net primary production in the southeastern Keerqin Sandy Lands, Northeast China. Species richness declined and biomass increased after five consecutive years of nitrogen fertilization of these sandy grasslands （2004-2008）. After fertilization had been stopped for three years （2009-2011）, we surveyed vegetation on previously fertilized plots to quantify changes in commu- nity composition. Respect species richness showed an increasing trend over time since the cessation of fertilization. Respect vegetation height and coverage showed decreasing trends over time since the cessation of fertilization. Species composition changed after fertilization ceased, the dominant species shifting from Cannabis sativa, Phragmites communis and Chenopodium acuminaturn in 2008 to Cannabis sativa, Phragmites communis and Artemisia scoparia in 2011. Dominance of dominant species declined from 66.2% in 2008 to 57.5% in 2011. The importance value of annual plants in the earlier nitrogen addition plots was higher than in control plots, but the differences were not significant in 2011. The importance value of perennial plants differed significantly between treatments from 2009 to 2011. The reversion rate not only differed be- tween community characteristics, but also between functional groups in the same community characteristic. Although the residual effect of nitrogen addition on vegetation was still observed three years after fertilization ceased, the vegetation showed signs of recovery.

关键词： nitrogen fertilization recovery Keerqin Sandy Lands vegetation