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SARS-CoV-2 non-structural protein 13 (nspl3) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1107-1109页

作者： Guijie Guo ming gao Xiaochen gao Bibo Zhu Jinzhou Huang Kuntian Luo Yong Zhang Jie Sun Min Deng Zhenkun Lou Department of Molecular Pharmacology and Experimental Therapeutics Mayo ClinicRochesterMNUSA Department of Oncology Mayo ClinicRochesterMNUSA Thoracic Diseases Research Unit Division of Pulmonary and Critical Care MedicineDepartment of MedicineMayo Clinic College of Medicine and ScienceRochesterMNUSA Department of Immunology Mayo Clinic College of Medicine and ScienceRochesterMNUSA

Dear Editor,COVID-19(Coronavirus Disease-2019),a respiratory disease caused by the novel virus strain,SARS-CoV-2(severe acute respiratory syndrome coronavirus 2),an enveloped,positive-sense,single-stranded RNA betacoronavirus of the family Corona-viridae,has spread worldwide.1 Notably,SARS-CoV-2 infection led to poor induction of typeⅠ interferon response,and the impaired type Ⅰ IFN responses have been shown to be associated with severe COVID-19 disease.2 However,molecular mechanisms by which SARS-CoV-2 suppresses type Ⅰ IFN production,and how host cells respond to the inhibition of type Ⅰ IFN response during SARS-CoV-2 infection,remain largely unknown.

关键词： impaired respiratory interferon

Malignant giant cell tumor in the left upper arm soft tissue of an adolescent:A case report

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World Journal of Clinical Cases 2021年第15期9卷 3704-3710页

作者： Wen-Peng Huang Li-Na Zhu Rui Li Li-ming Li Jian-Bo gao Department of Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Giant cell tumor of soft tissue(GCT-ST)is an extremely rare low-grade soft tissue tumor that is originates in superficial tissue and rarely spreads ***-ST has unpredictable *** is mainly benign,but may sometimes become aggressive and potentially increase in size within a short period of *** SUMMARY A 17-year-old man was suspected of having a fracture,based on radiography following left shoulder *** month later,the swelling of the left shoulder continued to increase and the pain was *** tomography(CT)revealed a soft tissue mass with strip-like calcifications in the left *** mass invaded the adjacent humerus and showed an insect-like area of destruction at the edge of the cortical bone of the upper *** marrow cavity of the upper humerus was enlarged,and a soft tissue density was seen in the medullary *** CT revealed multiple small nodules beneath the pleura of both lungs.A bone scan demonstrated increased activity in the left shoulder joint and proximal *** mass showed mixed moderate hypointensity and hyperintensity on T1-weighted images,and mixed hyperintensity on T2-weighted fat-saturated *** final diagnosis of GCT-ST was confirmed by *** GCT-STs should be considered in the differential diagnosis of soft tissue tumors and monitored for large increases in size.

关键词： Bone scan Giant cell tumor Soft tissue Tomography X-ray computed Magnetic resonance imaging Case report

基于前景理论的园区环境污染第三方治理机会主义行为防治研究

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系统科学与数学 2022年第6期42卷 1580-1595页

作者：黄仁辉高明福州大学经济与管理学院福州350116 福州大学福建绿色发展研究院福州350116

园区环境污染第三方治理模式中治理企业存在的机会主义行为严重影响治污成效,政府如何采取有效监管策略来区分及规制市场中不同技术水平的第三方治理企业是当前的重点问题.文章基于前景理论构建出政府与治理企业间的信号博弈模型,通过... 详细信息

园区环境污染第三方治理模式中治理企业存在的机会主义行为严重影响治污成效,政府如何采取有效监管策略来区分及规制市场中不同技术水平的第三方治理企业是当前的重点问题.文章基于前景理论构建出政府与治理企业间的信号博弈模型,通过比较不同的均衡结果探究了甄别不同技术水平治理企业的实现条件,并借助数值模拟探讨了相关参数的作用程度.研究发现:政府通过设置合理补贴区间与调节伪装成本可对不同层次的第三方治理企业进行有效区分;随技术水平高的第三方治理企业所占市场份额增大,政府补贴力度要相应提升,并需同步提高伪装成本;决策主体受风险态度参数影响较大,需尽力稳定主体的风险偏好.最后,针对相应结论给出政府监管策略建议.

关键词：园区环境污染第三方治理机会主义行为信号博弈前景理论

Relationship between traditional Chinese medicine syndrome differentiation and imaging characterization to the radiosensitivity of nasopharyngeal carcinoma

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Chinese Journal of Cancer 2010年第11期29卷 937-945页

作者： Hong Bao Jing gao Tao Huang Zi-ming Zhou Bei Zhang Yun-Fei Xia Department of Medical Imaging Yueyang Hospital of Integrated Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Shanghai 200437 P. R. China Department of Radiation Oncology Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Department of Internal Traditional Chinese Medicine Yueyang Hospital of Integrated Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Shanghai 200437 P. R. China Department of Traditional Chinese Medicine Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China

Background and Objective: Traditional Chinese medicine (TCM) is a well established and time-honored practice in China, employing syndrome differentiation as a basis for the treatment of disease. According to different TCM syndrome typing findings, combining modern medical methods with TCM approaches can improve the quality of life and comprehensive effect on patients with nasopharyngeal carcinoma (NPC). This study investigated the relationship between TCM syndrome typing and imaging characterization to radiosensitivity as to provide objective evidence for the integration of Chinese and modern medical approaches in the treatment of NPC. Methods: Prior to treatment, TCM syndrome typing, computed tomography (CT) and magnetic resonance imaging (MRI) were performed on 147 patients pathologically classified with NPC. The status of tumor remission was radiologically evaluated at accumulated doses of 20 Gy, 40 Gy and 60 Gy, and at 3 months after completion of radiotherapy. Statistical results were analyzed by the Friedman and K-W test procedures. Results: Prior to treatment, TCM syndrome typing of NPC included Lung Heat, Blood Stasis, Phlegm Congealment and Blood Stasis-Phlegm Congealment. Lung Heat typing accounted for the highest proportion at 34.7% (51/147), followed by Phlegm Congealment at 32.7% (48/147), Blood Stasis at 17.0% (25/147) and Blood Stasis-Phlegm Congealment at 15.7% (23/147). Radiological imaging demonstrated a higher incidence of cervical lymph node metastases in Phlegm Congealment and Blood Stasis-Phlegm Congealment types (P < 0.05), while Blood Stasis and Blood Stasis-Phlegm Congealment types were more prone to skull base invasion (P < 0.05). Residual tumor size was larger in Blood Stasis and Blood Stasis-Phlegm Congealment types than in Lung Heat and Phlegm Congealment types after 3 months of treatment (P < 0.05). Conclusions: Different radiological manifestations were observed in TCM syndrome typed NPC patients, with lesser radiosensitivity demonstra

关键词：放射敏感性中医证候鼻咽癌成像特性放射影像学放射治疗辨证血瘀证

Effect of Transcatheter Embolization by Autologous Fat Particles in the Treatment of Coronary Artery Perforation During Percutaneous Coronary Intervention

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Chinese Medical Journal 2015年第6期128卷 745-749页

作者： Li-Yun He Jiang-Li Han Li-Jun Guo Fu-Chun Zhang ming Cui Wei gao Department of Cardiology Peking University Third Hospital Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing 100191 China

Background:Coronary artery perforation (CAP) is a rare but severe complication of percutaneous coronary intervention (PCI).The aim of our study was to evaluate the effect and safety of transcatheter embolization by autologous fat particles in the treatment of ***:Once the CAP was confirmed,a little autologous subcutaneous fatty tissue was obtained from the groin of the patient and then was made into 1 mm× 1 mm fat *** perforated vessel was embolized by fat particles via a *** were eight patients undergoing transcatheter embolization by autologous fat particles in the treatment of CAP during PCI in Peking University Third Hospital from February 2009 to June 2014,and the clinical data of these patients were collected and analyzed ***:The lesion morphology of the patients was classified based on the American College of Cardiology/American Heart Association Task Force classification,there were one patient with Class B2 lesion and seven patients with Class C lesions (there were five patients with chronic total occlusion lesions).According to the Ellis classification of CAP,there were six patients with Class Ⅱ perforations and two patients with Class Ⅲ *** causes of perforation included that seven patients induced by guide wire and one patient by balloon *** patients had pericardial *** of the eight patients with CAP underwent transcatheter embolization by autologous fat *** angiography confirmed that all of them were embolized *** was no severe complication after the *** coronary angiography of one patient at l week and another patient at 2 years after the embolization showed that the embolized arteries had *** median follow-up time was 20.3 months (8.8-50.2 months),the event-free survival rate was 100％.Conclusions:Transcatheter embolization by autologous fat particles was an effective,safe,cheap,and easy way to treat the perforat

关键词： Autologous Fat Particles Coronary Artery Perforation Embolization Percutaneous Coronary Intervention

Sclerosing cholangitis in critically ill patients： an important and easily ignored problem based on a German experience

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Frontiers of Medicine 2014年第1期8卷 118-126页

作者： Ting Lin Kai Qu Xinsen Xu Min tian Jie gao Chun Zhang Ying Di Yuelang Zhang Chang Liu Department of Hepatobiliary Surgery Surgical Intensive Care Unit Department of Imaging the First Affiliated Hospital School ofMedicine Xi 'an Jiaotong University Xi 'an 710061 China

Intensive care unit （ICU） is important in the rehabilitation of critically ill patients. In the past decades, many patients who received aggressive treatment in ICU developed sclerosing cholangitis in multiple centers. Sclerosing cholangitis in critically ill patients （SC-CIP） is a relatively new issue. To investigate the causes, clinical manifestation, treatment, and prognosis of SC-CIP, we searched for published cases in the databases of PubMed, Highwire, and Elsevier from 2001 to 2012. Data were extracted using a standard form and retrospectively analyzed. Twelve eligible studies covering 88 patients, with 64 men and 24 women, were mainly reported by German centers. The mean age was 49.8 years. All of the patients recovered from critical illnesses, such as trauma, infection, burn, and major surgeries. High pressure positive end-expiratory pressure （PEEP, peak level at 12.8 cm H20） was utilized for all patients, with the average duration of 36.3 d. In addition, vasopressor agents were administered in approximately 60% of SC-CIE A rapid increase in cholestasis and irregular strictures in the intrahepatic bile ducts was observed in the following months. With an average follow-up period of 17.9 months, poor outcomes were observed in 54 patients, including 34 deaths. In conclusion, ischemic injury of the biliary tree, which may be affected by PEEP and/or vasopressor administration, affects cholangiopathic procedure. As a newly discovered type of secondary sclerosing cholangitis, SC-CIP is a severe progressive complication of patients in ICU and should be carefully monitored by clinicians.

关键词： intensive care unit sclerosing cholangitis ischemic injury prognosis systemic review

气候变化情景下茶角胸叶甲在中国的潜在适生区预测

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茶叶学报 2024年第1期65卷 1-10页

作者：勒尔阿都钟文玉姜明鑫胡海琴冯艳田丽娟周子钦孙威江陈李林福建农林大学安溪茶学院福建泉州362406 闽台作物有害生物生态防控国家重点实验室福建农林大学植物保护学院福建福州350002 中国白茶研究院福建福鼎355200 中国农业专业技术协会尤溪红茶科技小院福建尤溪365199 福建农林大学园艺学院福建福州350002

【目的】研究当前及未来气候情景下茶树上重要的鞘翅目害虫茶角胸叶甲潜在适生区的变化,可为其监控和预警提供科学指导,有效防止其大范围扩散造成更大危害。【方法】通过搜集整理茶角胸叶甲在中国的分布点数据,利用MaxEnt模型预测其在... 详细信息

【目的】研究当前及未来气候情景下茶树上重要的鞘翅目害虫茶角胸叶甲潜在适生区的变化,可为其监控和预警提供科学指导,有效防止其大范围扩散造成更大危害。【方法】通过搜集整理茶角胸叶甲在中国的分布点数据,利用MaxEnt模型预测其在中国当前及未来气候变化情景下的潜在适生区分布范围及适生程度。【结果】模型重复运行10次的平均AUC值为0.907,标准差为0.007,测试样本遗漏率与预测遗漏率基本吻合,预测效果表现为非常好。当前气候条件下,茶角胸叶甲的潜在适生区均主要集中在中国华南、华东、华中、西南大部分地区,总适生区面积为267.73万km^(2)。未来气候情景下沿当前适生区继续向北方扩张,最北扩散至黑龙江省,在2061—2080年SSP5_85情景下总适生区面积达到最大,为376.58万km^(2),占中国总面积的39.23%。影响茶角胸叶甲潜在适生区分布的主要环境变量是最干月份降水量、最湿月份降水量、最热月份最高温、温度变化方差。【结论】茶角胸叶甲当前在中国的潜在适生区模拟结果与其实际分布区域相符;未来气候变化情景下茶角胸叶甲在中国的潜在适生区呈明显扩张趋势,中国更多地区均有可能成为其适生区。

关键词：茶角胸叶甲气候变化潜在适生区最大熵模型

基于Nystrom柯西核共轭梯度算法的混沌时间序列预测

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物理学报 2022年第10期71卷 392-401页

作者：齐乐天王世元沈明琳黄刚毅西南大学电子信息工程学院重庆400715 非线性电路与智能信息处理重庆市重点实验室重庆400715

混沌时间序列能够较好反映真实环境的非线性和非平稳性特性,然而具有二阶统计特性的核自适应滤波器(kernel adaptive filter,KAF)在处理含噪声和异常值的混沌时间序列时,其预测性能显著下降.为提高核自适应滤波器的鲁棒性,本文提出了一... 详细信息

混沌时间序列能够较好反映真实环境的非线性和非平稳性特性,然而具有二阶统计特性的核自适应滤波器(kernel adaptive filter,KAF)在处理含噪声和异常值的混沌时间序列时,其预测性能显著下降.为提高核自适应滤波器的鲁棒性,本文提出了一种用于测量非线性相似度的柯西核损失(Cauchy kernel loss,CKL),并采用半平方(half-quadratic,HQ)方法保证了CKL的全局凸性.为改善随机梯度下降法收敛速度较慢且容易陷入局部最优的不足,采用共轭梯度(conjugate gradient,CG)方法优化CKL.进一步,为解决核矩阵网络增长的问题,采取Nystrom稀疏策略近似核矩阵,并利用概率密度秩量化(probability density rank-based quantization,PRQ)提高逼近精度.基于此,本文提出了一种新的基于Nystrom和PRQ的柯西核共轭梯度(Nystrom Cauchy kernel conjugate gradient with PRQ,NCKCG-PRQ)算法有效实现了混沌时间序列的预测.基于合成和真实两类混沌时间序列验证了所提NCKCG-PRQ算法在稳态性能,鲁棒性和计算存储复杂度上的优势.

关键词：混沌时间序列预测核自适应滤波柯西核函数 Nystrom方法

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面向异质信息网络的双通道协同聚类算法

计算机学报 2023年第11期46卷 2416-2430页

作者：邱林山房子荃陈璐张天明李天义浙江大学计算机科学与技术学院杭州310027 浙江大学软件学院浙江宁波315048 浙江工业大学计算机科学与技术学院杭州310023 奥尔堡大学计算机学院奥尔堡9220丹麦

网络聚类广泛应用于现实世界的各个领域,受到了越来越多的关注.由于保留了节点和链接关系的异质性,异质信息网络聚类相较于同质网络聚类具有更优的性能.然而,现有基于图神经网络的异质信息网络聚类忽略了节点属性以及拓扑结构对聚类的... 详细信息

网络聚类广泛应用于现实世界的各个领域,受到了越来越多的关注.由于保留了节点和链接关系的异质性,异质信息网络聚类相较于同质网络聚类具有更优的性能.然而,现有基于图神经网络的异质信息网络聚类忽略了节点属性以及拓扑结构对聚类的权重不同的问题.此外,这些方法仅对单一类型的目标节点聚类,而没有考虑其余类型节点的辅助作用.为此,提出了面向异质信息网络的双通道协同聚类算法(B3C),其能够有效地融合节点属性和拓扑结构,并挖掘异质节点间的潜在相关性,从而提高聚类性能.首先,设计了一个简单有效的双通道编码器以聚合拓扑结构及相似矩阵的邻域信息;接着,应用自训练聚类的同时学习异质信息网络表示以及优化聚类分配,并采用协同聚类机制,以对不同类型节点同时聚类;最后,利用三元中心损失(Triplet-Center Loss)学习具有区分度的节点表示,以凝聚相似节点,分离不相似节点.在公开数据集上进行了大量实验,验证了本文提出的双通道编码器性能相较于广泛使用的图神经网络编码器有显著提升,并且B3C精度优于现有的基于学习的异质信息网络聚类方法.

关键词：异质信息网络网络聚类协同聚类网络表示学习图神经网络