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Long-term prognosis and its associated predictive factors in patients with eosinophilic gastroenteritis

World Journal of Gastroenterology 2024年第2期30卷 146-157页

作者： Kai-Wen Li Ge-Chong Ruan Shuang Liu tian-ming xu Ye Ma Wei-xun Zhou Wei Liu Peng-Yu Zhao Zhi-Rong Du Ji Li Jing-Nan Li Department of Gastroenterology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Allergy Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Pathology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Radiology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Affairs Office Chinese Academy of Medical Sciences and Peking Union Medical College Hospital(West campus)Beijing 100032China

BACKGROUND Eosinophilic gastroenteritis(EGE)is a chronic recurrent disease with abnormal eosinophilic infiltration in the gastrointestinal *** remain the most common treatment ***,disease relapse and glucocorticoid dependence remain notable *** date,few studies have illuminated the prognosis of EGE and risk factors for disease *** To describe the clinical characteristics of EGE and possible predictive factors for disease relapse based on long-term *** This was a retrospective cohort study of 55 patients diagnosed with EGE admitted to one medical center between 2013 and *** records were collected and ***-Meier curves and log-rank tests were conducted to reveal the risk factors for long-term relapse-free survival(RFS).RESULTS EGE showed a median onset age of 38 years and a slight female predominance(56.4%).The main clinical symptoms were abdominal pain(89.1%),diarrhea(61.8%),nausea(52.7%),distension(49.1%)and vomiting(47.3%).Forty-three(78.2%)patients received glucocorticoid treatment,and compared with patients without glucocorticoid treatments,they were more likely to have elevated serum immunoglobin E(IgE)(86.8%vs 50.0%,P=0.022)and descending duodenal involvement(62.8%vs 27.3%,P=0.046)at *** a median follow-up of 67 mo,all patients survived,and 56.4%had at least one *** variables at baseline might have been associated with the overall RFS rate,including age at diagnosis24 kg/m^(2)(HR 0.3922,95%CI:0.1916-0.8027,P=0.014),disease duration from symptom onset to diagnosis>3.5 mo(HR 2.4725,95%CI:1.220-5.0110,P=0.011),vomiting(HR 3.1259,95%CI:1.5246-6.4093,P=0.001),total serum IgE>300 KU/L at diagnosis(HR 0.2773,95%CI:0.1204-0.6384,P=0.022)and glucocorticoid treatment(HR 6.1434,95%CI:2.8446-13.2676,P=0.003).CONCLUSION In patients with EGE,younger onset age,longer disease c

关键词： Eosinophilic gastroenteritis Prognosis Relapse Glucocorticoid Glucocorticoid dependence

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Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4-oxadiazole motif

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Frontiers of Chemical Science and Engineering 2022年第7期16卷 1090-1100页

作者： Yong-Hui Wen Long Cheng tian-ming xu Xing-Hai Liu Ning-Jie Wu College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China Zhejiang Base of National Southern Pesticide Research Centre Zhejiang Research Institute of Chemical IndustryHangzhou 310023China

Twenty six novel pyrimidin-4-amine derivatives containing the 1,2,4-oxadiazole motif were synthesized. Their chemical structures were confirmed by ^(1)H nuclear magnetic resonance (NMR), ^(13)C NMR, and high-resolution mass spectrography. The insecticidal activity results indicated that some of them possessed excellent insecticidal activity (100%) against Mythimna separate, especially for compounds 6d, 6f, 6o, 6w, 6y and 6z. These compounds exhibited no activity against the insects Aphis medicagini and Tetranychus cinnabarinus. The structure- insecticidal activity relationships are discussed. Density functional theory analysis can potentially be used to design more active compounds. These results provide useful insecticide design information for further optimization.

关键词： synthesis pyrimidin-4-amine derivatives 1,2,4-oxadiazole insecticidal activity structure-activity relationship

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A survey on model-based reinforcement learning

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Science China(Information Sciences) 2024年第2期67卷 59-84页

作者： Fan-ming LUO tian xu Hang LAI Xiong-Hui CHEN Weinan ZHANG Yang YU National Key Laboratory for Novel Software Technology Nanjing University Polixir. ai Department of Computer Science and Engineering Shanghai Jiao Tong University

Reinforcement learning(RL) interacts with the environment to solve sequential decision-making problems via a trial-and-error approach. Errors are always undesirable in real-world applications, even though RL excels at playing complex video games that permit several trial-and-error attempts. To improve sample efficiency and thus reduce errors, model-based reinforcement learning(MBRL) is believed to be a promising direction, as it constructs environment models in which trial-and-errors can occur without incurring actual costs. In this survey, we investigate MBRL with a particular focus on the recent advancements in deep RL. There is a generalization error between the learned model of a non-tabular environment and the actual environment. Consequently, it is crucial to analyze the disparity between policy training in the environment model and that in the actual environment, guiding algorithm design for improved model learning, model utilization, and policy training. In addition, we discuss the recent developments of model-based techniques in other forms of RL, such as offline RL, goal-conditioned RL, multi-agent RL, and meta-RL. Furthermore,we discuss the applicability and benefits of MBRL for real-world tasks. Finally, this survey concludes with a discussion of the promising future development prospects for MBRL. We believe that MBRL has great unrealized potential and benefits in real-world applications, and we hope this survey will encourage additional research on MBRL.

关键词： reinforcement learning model-based reinforcement learning planning model learning model learning with reduced error model usage

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Women’s empowerment and food consumption:Evidence from female-headed households in Tanzania

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Journal of Integrative Agriculture 2024年第2期23卷 457-467页

作者： Mosses Lufuke xu tian College of Economics and Management Nanjing Agricultural UniversityNanjing 210095China Department of Economics The University of DodomaDodoma 41218Tanzania College of Economics and Management China Agricultural UniversityBeijing 100083China Academy of Global Food Economics and Policy China Agricultural UniversityBeijing 100083China

Despite the growing recognition of women’s increasing role in the household and corresponding empowerment programs in sub-Saharan Africa,intensive research on the relationship between women’s influence and household food consumption is *** the most recent(2017-2018)national household survey data from Tanzania,this study examined the influence of women’s empowerment on household food ***,we compared the monthly consumption of eight food categories between female-headed households(FHHs)and male-headed households(MHHs)using both descriptive statistics and the propensity score matching(PSM)***,we adopted the two-stage Linear Expenditure System and Almost Ideal Demand System model(LES-AIDS)to estimate income and price elasticities for the two household *** results show that FHHs consume bread and cereals,fish,oils and fats,vegetables,and confectionery(sugar,jam,honey,chocolate,etc.)more than ***,FHHs have a significantly higher income elasticity of demand for all food groups than *** are also more price elastic than MHHs in meat,fish,oils,fats,sugar,jam,honey,chocolate,etc.

关键词： women’s empowerment food consumption income elasticity price elasticity

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The effects of cool materials,façade orientation,and morphological parameters on energy consumption at the residential neighborhood scale

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Building Simulation 2024年第4期17卷 525-542页

作者： Fusuo xu Dongdong tian Zhi Gao Jianshun Jensen Zhang Department of Mechanical and Aerospace Engineering Syracuse UniversitySyracuseNY13210USA School of Architecture and Urban Planning Nanjing University22 Hankou RoadNanjingJiangsu Province210093China

Building surface cool materials are novel materials that can reduce urban heat island intensity and decrease building energy *** study investigated the impact of radiative properties of materials,façade orientation,and morphological parameters on energy consumption in six typical residential neighborhoods in Nanjing,*** neighborhood energy consumption of 16 application schemes considering the façade orientation factor is compared to determine the best energy-saving *** and annual energy-saving rates,savings in electricity costs,and the price ceiling for materials per unit area are *** results show that for low-rise buildings,using cool materials only on the roof can reduce the annual energy consumption by 1%.When cool or super cool materials are also used on the building façade,the annual energy saving rate can be up to 3.4%and 4.3%,*** cool materials on the south façade of buildings is not recommended due to significant heat loss in *** savings in electricity costs and the price ceiling for materials per unit area,the price of cool and super cool materials should be less than 3.0 and 3.7 RMB/m2,respectively,assuming a lifespan of eight years in Nanjing.

关键词： cool materials building energy saving neighborhood morphology façade orientation

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Synthesis,Structure and Chemical Bonding of Polyantimony Clusters Containing Coinage Metals[M_(2)Sb_(14)]^(4-)(M=Cu,Ag)

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Chinese Journal of Chemistry 2024年第6期42卷 617-622页

作者： Wei-Xing Chen Yu-He xu Cui-Cui Wang Lei Qiao Zi-Yan Guo Wen-Juan tian Zhong-ming Sun State Key Laboratory of Element-Organic Chemistry Tianjin Key Lab for Rare Earth Materials and ApplicationsSchool of Materials Science and EngineeringNankai UniversityTianjin300350 China Institute of Molecular Science Shanxi UniversityTaiyuanShanxi030006 China

Binary polyantimony clusters,namely[Cu_(2)Sb_(14)]^(4–) and [Ag_(2)Sb_(14)]^(4–),containing coinage metals,were successfully synthesized and characterized,in which two homoatomic Sb73–subunits are bridged by two coinage metals in η^(4):η^(1) and η^(1):η^(1) coordination modes,***[M_(2)Sb_(14)]^(4-),two bridging Cu ions and two Sb atoms form a planar rhombic unit,which was revealed to have antiaromatic properties by theoretical *** electron structure and bonding analysis confirmed the presence of delocalized bonds in the rhombic unit and the metallophilic interaction between two formal M^(+) ions.

关键词： Polyantimony cluster Copper Silver Antiaromaticity Metallophilic interaction Quantum chemical calculations

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Analyzing topics in social media for improving digital twinning based product development

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Digital Communications and Networks 2024年第2期10卷 273-281页

作者： Wenyi Tang Ling tian xu Zheng Ke Yan School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

Digital twinning enables manufacturers to create digital representations of physical entities,thus implementing virtual simulations for product *** efforts of digital twinning neglect the decisive consumer feedback in product development stages,failing to cover the gap between physical and digital *** work mines real-world consumer feedbacks through social media topics,which is significant to product *** specifically analyze the prevalent time of a product topic,giving an insight into both consumer attention and the widely-discussed time of a *** primary body of current studies regards the prevalent time prediction as an accompanying task or assumes the existence of a preset ***,these proposed solutions are either biased in focused objectives and underlying patterns or weak in the capability of generalization towards diverse *** this end,this work combines deep learning and survival analysis to predict the prevalent time of *** propose a specialized deep survival model which consists of two *** first module enriches input covariates by incorporating latent features of the time-varying text,and the second module fully captures the temporal pattern of a rumor by a recurrent network ***,a specific loss function different from regular survival models is proposed to achieve a more reasonable *** experiments on real-world datasets demonstrate that our model significantly outperforms the state-of-the-art methods.

关键词： Digital twinning Product development Topic analysis Social media

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Inhibition of Defect-Induced Ice Nucleation, Propagation, and Adhesion by Bioinspired Self-Healing Anti-Icing Coatings

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Research 2024年第1期2023卷 237-246页

作者： Shu tian Ruiqi Li Xinmeng Liu Jiancheng Wang Junyu Yu Sijia xu Yunqing tian Jing Yang Lei Zhang Department of Biochemical Engineering Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(MOE)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Binzhou Institute of Technology Weiqiao-UCAS Science and Technology ParkBinzhou CityShandong Province 256606China

Anti-icing coatings on outdoor infrastructures inevitably suffer from mechanical injuries in numerous icing scenarios such as hailstorms,sandstorms,impacts of foreign objects,and icing–deicing ***,the mechanisms of surface-defect-induced icing are *** the defects,water molecules exhibit stronger adsorption and the heat transfer rate increases,accelerating the condensation of water vapor as well as ice nucleation and ***,the ice–defect interlocking structure increases the ice adhesion ***,a self-healing(at−20℃)antifreeze-protein(AFP)-inspired anti-icing coating is *** coating is based on a design that mimics the ice-binding and non-ice-binding sites in *** enables the coating to markedly inhibit ice nucleation(nucleation temperature<−29.4℃),prevent ice propagation(propagation rate<0.00048 cm^(2)/s),and reduce ice adhesion on the surface(adhesion strength<38.9 kPa).More importantly,the coating can also autonomously self-heal at−20℃,as a result of multiple dynamic bonds in its structure,to inhibit defect-induced icing *** healed coating sustains high anti-icing and deicing performance even under various extreme *** work reveals the in-depth mechanism of defect-induced ice formation as well as adhesion,and proposes a self-healing anti-icing coating for outdoor infrastructures.

关键词： coating defect clarified

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Growth,optical dispersion and magnetic behavior of Dy^(3+) doped yttrium iron garnet crystals

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Journal of Rare Earths 2024年第6期42卷 1110-1117,I0004页

作者： Yating Fang Hui Shen Yudie Ma Shijie Liao Shuang Xia tian tian Ding Zhou Yunfeng Ma Jiayue xu Institute of Crystal Growth School of Materials Science and EngineeringShanghai Institute of Technology National Engineering Center of Electromagnetic Radiation Control Materials School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of China

Y_(3)Fe_(5)O_(12)(YIG)crystals are highly desirable for the fabrication of mid-infrared isolators with the rapid growth of optical communications,although it is rather challenging to grow large size and high-quality single ***^(3+)doping is expected to improve the optical and magneto-optical prope ***,high quality Dy:YIG crystals and the adjustment of Dy^(3+)on the structure and optical behavior of YIG crystal remain unclear,impeding its practical ***,a series of Y_(3-x)Dy_(x)Fe_(5)O_(12)(x=0,0.5,1.0,1.5,3)solid solution crystals was grown by the flux-Bridgman method and single crystals up to 25 mm were *** the introduction of Dy^(3+),lattice parameters are gradually enlarged from 1.2379 nm(YIG)to 1.2420 nm(DyIG).Typical Dy^(3+)absorption peaks are observed around 1070,1265 and 1670 *** refractive index decreases from 2.37(500 nm)to 2.10(2500 nm)for YIG crystal,and it reduces from 2.47(500 nm)to 2.16(2500 nm)for DyIG *** optical bandgaps remain almost unchanged for Dy:YIG *** optical dispersion of the refractive indices was finely fitted by the Wemple and DiDomenico(WDD)and the Sellmeier models,*** the increase of Dy^(3+)content,the saturation magnetization(Ms)decreases significantly from 23.62 emu/g(YIG)to 5.33 emu/g(DyIG).Small coercive field is persisted for this system,endowing small external magnetic *** results provide valuable references for the manipulation of rare earths on the properties of magnetooptical crystals,which is beneficial to the design of high-performance garnet crystals for the application of optical switching and non-reciprocal related devices.

关键词： Magneto-optical crystal Yttrium iron garnet Dy^(3+)doping Crystal growth Optical dispersion Rare earths

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Associations of daily sedentary behavior,physical activity,and sleep with irritable bowel syndrome:A prospective analysis of 362,193 participants

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Journal of Sport and Health Science 2024年第1期13卷 72-80页

作者： xu Gao Sifan tian Ninghao Huang Gang Sun Tao Huang Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Gastroenterology and Hepatology First Medical Center of People's Liberation Army General HospitalBeijing 100853China

Background:Irritable bowel syndrome(IBS)substantially affects quality of life and requires early *** study aimed to elucidate the relationships between IBS and daily behaviors,including sedentary behavior(SB),physical activity(PA),and *** particular,it seeks to identify healthy behaviors to reduce IBS risk,which previous studies have rarely ***:Daily behaviors were retrieved from self-reported data of 362,193 eligible UK Biobank *** cases were determined by self-report or health care data according to RomeⅣ***:A total of 345,388 participants were IBS-free at baseline,during a median follow-up of 8.45 years,19,885 incident IBS cases were *** examined individually,SB and shorter(≤7 h/day)or longer(>7 h/day)sleep duration were each positively associated with increased IBS risk,and PA was associated with lower IBS *** isotemporal substitution model suggested that replacing SB with other activities could provide further protective effects against IBS *** people sleeping≤7 h/day,replacing 1 h of SB with equivalent light PA,vigorous PA,or sleep was associated with 8.1%(95%confidence interval(95%CI):0.901-0.937),5.8%(95%CI:0.896-0.991),and 9.2%(95%CI:0.885-0.932)reduced IBS risk,*** people sleeping>7 h/day,light and vigorous PA were associated with a 4.8%(95%CI:0.926-0.978)and a 12.0%(95%CI:0.815-0.949)lower IBS risk,*** benefits were mostly independent of genetic risk for ***:SB and unhealthy sleep duration are risk factors for IBS.A promising way to mitigate IBS risk for individuals sleeping≤7 h/day and for those sleeping>7 h/day appears to be by replacing SB with adequate sleep or vigorous PA,respectively,regardless of the genetic predisposition of IBS.

关键词： Irritable bowel syndrome Isotemporal substitution model Physical activity Sedentary behavior Sleep

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