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Targeted delivery of RNAi to cancer cells using RNA-ligand displaying exosome

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1383-1399页

作者： Nasir Uddin Daniel WBinzel Dan Shu tian-min fu Peixuan Guo Center for RNA Nanobiotechnology and Nanomedicine Division of Pharmaceutics and PharmacologyCollege of Pharmacythe Ohio State UniversityColumbusOH 43210USA Dorothy M.Davis Heart and Lung Research Institute the Ohio State UniversityColumbusOH 43210USA James Comprehensive Cancer Center College of Medicinethe Ohio State UniversityColumbusOH 43210USA Department of Biological Chemistry&Pharmacology College of Medicinethe Ohio State UniversityColumbusOH 43210USA

Exosome is an excellent vesicle for in vivo delivery of therapeutics,including RNAi and chemical *** extremely high efficiency in cancer regression can partly be attributed to its fusion mechanism in delivering therapeutics to cytosol without endosome ***,being composed of a lipidbilayer membrane without specific recognition capacity for aimed-cells,the entry into nonspecific cells can lead to potential side-effects and *** engineering approaches for targeting-capacity to deliver therapeutics to specific cells is *** with chemical modification in vitro and genetic engineering in cells have been reported to decorate exosomes with targeting *** nanoparticles have been used to harbor tumor-specific ligands displayed on exosome *** negative charge reduces nonspecific binding to vital cells with negatively charged lipid-membrane due to the electrostatic repulsion,thus lowering the side-effect and *** this review,we focus on the uniqueness of RNA nanoparticles for exosome surface display of chemical ligands,small peptides or RNA aptamers,for specific cancer targeting to deliver anticancer therapeutics,highlighting recent advances in targeted delivery of siRNA and miRNA that overcomes the previous RNAi delivery *** understanding of exosome engineering with RNA nanotechnology promises efficient therapies for a wide range of cancer subtypes.

关键词： RNA interference RNA nanotechnology Endolysosome trapping Exosome engineering Targeted delivery Chemical drug delivery

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煤巷掘进穿越老峒矿山压力规律探讨

煤炭工程 2008年第10期40卷 64-65页

作者：田福民开滦荆欢矿业公司政策研究室河北唐山063000

文章介绍了老峒附近压力分布规律及其计算方法,为掘进巷道穿越老峒安全施工提供了技术基础。类似掘进巷道穿越老峒工程可以借鉴应用。

关键词：煤巷掘进穿越老峒矿压规律

PA-1/UV-531/SBR改性沥青混合料高低温性能评价

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化工管理 2022年第9期 1-3页

作者：闵天府青海大学土木工程学院青海西宁810016

研究0.7%PA-1/1.6%UV-531/1.0%SBR(占基质沥青质量分数)改性沥青混合料低温抗裂性和高温抗车辙性能受温度影响的变化规律,采用半圆弯曲试验(semi-circular bending test,SCB试验)和高温车辙试验分别研究低温抗裂性和高温抗车辙性能。结... 详细信息

研究0.7%PA-1/1.6%UV-531/1.0%SBR(占基质沥青质量分数)改性沥青混合料低温抗裂性和高温抗车辙性能受温度影响的变化规律,采用半圆弯曲试验(semi-circular bending test,SCB试验)和高温车辙试验分别研究低温抗裂性和高温抗车辙性能。结果表明:PA-1/UV-531/SBR改性沥青混合料高温抗车辙能力满足规范对青海地区要求。

关键词：改性沥青混合料 SCB试验高温车辙试验低温抗裂性高温抗车辙性能

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辽朝详稳渊源新论

古代文明（中英文） 2025年第1期19卷 117-127,M0006,M0007页

作者：田富吉林大学历史文化学院吉林长春130012

以往学界多认为辽朝详稳源于突厥语“sangun”,为将军之意。本文通过考证详稳与相温、相公、将军等概念的异同,认为辽朝详稳一词源自汉语“相”,“稳”是指契丹语语法中修饰“详”字的附加成分。辽朝详稳官职来源于突厥、回鹘、吐蕃等... 详细信息

以往学界多认为辽朝详稳源于突厥语“sangun”,为将军之意。本文通过考证详稳与相温、相公、将军等概念的异同,认为辽朝详稳一词源自汉语“相”,“稳”是指契丹语语法中修饰“详”字的附加成分。辽朝详稳官职来源于突厥、回鹘、吐蕃等边疆民族之“相”制,又在“会同改制”过程中脱离其原义,遂成为一种特殊的部族官职。

关键词：辽朝详稳相相温国相

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang Junwu Zhu Yongsheng fu Key Laboratory for Soft Chemistry and functional Materials of ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang fu-min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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面向高速流场成像的聚焦纹影研究进展

中山大学学报（自然科学版）（中英文） 2025年第1期64卷 238-249页

作者：田立丰付双旭中山大学航空航天学院广东深圳518107 深圳市智能微小卫星星座技术与应用重点实验室广东深圳518107

相较于传统的光学流动可视化技术,聚焦纹影技术能对非聚焦区域的流场信息进行模糊化处理,从而反映窄景深内的流场信息,具有高空间分辨率、抗干扰能力强、无需播撒示踪粒子、低成本等特点,这些特点使得聚焦纹影十分适用于高速流场的流动... 详细信息

相较于传统的光学流动可视化技术,聚焦纹影技术能对非聚焦区域的流场信息进行模糊化处理,从而反映窄景深内的流场信息,具有高空间分辨率、抗干扰能力强、无需播撒示踪粒子、低成本等特点,这些特点使得聚焦纹影十分适用于高速流场的流动显示和流场测量。本文在对聚焦纹影系统成像的基本原理进行介绍的基础上,以传统聚焦纹影在格栅对准和非定常流动多平面测量方面面临的挑战为出发点,总结了聚焦纹影的国内外相关研究,并进一步展望了聚焦纹影的未来发展。

关键词：聚焦纹影流动显示流场成像

Green Plant Leaf-inspired Smart Camouflage Fabrics for Visible Light and Near-infrared Stealth

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Journal of Bionic Engineering 2022年第3期19卷 788-798页

作者： Qixin Lu min Li Anli tian Shaohai fu Jiangsu Engineering Research Centre for Digital Textile Inkjet Printing Key Laboratory of Eco-TextileMinistry of EducationJiangnan UniversityWuxi214122China National Manufacturing Innovation Centre of Advanced Dyeing and Finishing Technology Ministry of EducationJiangnan UniversityWuxi214122China

Due to Visible light and Near-Infrared(Vis–NIR)stealth play an important role in the commercial,military,and scientific fields,camouflage materials related to it attracted increasing attention in *** plant leaves,as the most extensive background materials on the earth,were widely simulated in the camouflage ***,difficult full-spectrum simulation(380–2500 nm),low-similarity simulation and the complex preparation have been great challenges for Vis–NIR Camouflage Materials(Vis–NIR-CMs).Herein,basing on the color-matching principle,two novel Vis–NIR-CMs including Dark Green Materials and Light Green Materials(DGM and LGM)were facilely fabricated by simple printing organic disperse dyes including *** Blue 291,*** Yellow 114,and *** Orange 30(B-291,Y-114 and O-30),and titanium dioxide(TiO_(2))on the viscose *** on the excellent red edge property of B-291 and high scattering ability of TiO2,DGM and LGM exhibited generally high spectral correlation coefficients r_(m)(>0.95)with green plant ***,with the great color performance,excellent objects covering performance,low areal density(7.7 MPa),high softness(>81.27),high air permeability(>45.848 mm s^(−1)),DGM and LGM showed good simulation performance and wearing comfort to satisfy the application *** work presents a high-similarity Vis–NIR-CMs as a reference for full-spectrum camouflage materials,as well as low-cost and efficient preparation method is beneficial to the development of camouflage field.

关键词： Vis-NIR Camouflage materials Plant leaves Organic dyes Viscose fabrics

急性心肌梗死相关线粒体基因的生物信息学鉴定与验证

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中国组织工程研究 2025年第31期29卷 6697-6707页

作者：田宇诗付强李冀黑龙江中医药大学基础医学院黑龙江省哈尔滨市150040 黑龙江中医药大学黑龙江省哈尔滨市150040

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性... 详细信息

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性心肌梗死数据集GSE66360,GSE12288,在线粒体蛋白质数据库获取人类线粒体基因集;对急性心肌梗死数据集GSE66360进行差异基因分析及加权基因共表达网络分析,两者取交集后获得基因进行蛋白质-蛋白质相互作用分析、基因本体论和京都基因与基因组百科全书分析;将交集基因与人类线粒体基因取交集以获得差异线粒体基因,对差异线粒体基因进行基因集富集分析和免疫浸润分析,并在外部数据集GSE12288中进行受试者工作特征曲线分析,验证线粒体差异基因的表达特征。结果与结论:①获得急性心肌梗死差异基因548个,差异基因分析及加权基因共表达网络分析显示Blue模块包含基因最多(4992个),二者交集基因共有116个,其中肿瘤坏死因子、白细胞介素1B、白细胞介素6、Toll样受体4和白细胞介素10为核心基因;②基因本体论分析显示生物过程主要涉及炎症反应、肿瘤坏死因子产生的正调控及细胞表面受体信号通路,细胞组成主要涉及三级颗粒膜、质膜外层和质膜等,分子功能主要涉及免疫球蛋白G结合、跨膜信号受体活性及趋化因子活性等,京都基因与基因组百科全书分析显示,这些基因主要涉及肿瘤坏死因子、白细胞介素17及核转录因子κB通路;③共获得8个差异线粒体基因,经过最小绝对收缩和选择算子和比例风险回归模型分析后筛选出4个特征基因,包括佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β,并分别对应了肿瘤蛋白53、氧化磷酸化、硫代谢及甘油磷脂代谢通路;④受试者工作特征曲线分析显示4个特征基因均具有诊断意义,并与静息树突状细胞、幼稚B细胞呈显著负相关性;⑤提示佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β表达特征可作为预测急性心肌梗死中线粒体功能的潜在生物标志物,可进一步提高急性心肌梗死预测的准确性。

关键词：线粒体急性心肌梗死生物信息学机器学习免疫浸润分析氧化应激炎症凋亡

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