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Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

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Science China Life Sciences 2025年

作者： Xiangping Yao Xudong Mai Ye tian Yifan Liu Guanghui Jin Ze Li Shujie chen Xiaoshuang Dai Liujing Huang Zijing Fan Guihua Pan Xiaohan Pan Xiangmin Li Michael C Yu Jia Sun Jingxing Ou Hong chen Liwei Xie College of Life and Health Sciences Guangdong Industry Polytechnic Department of Endocrinology and Metabolism Zhujiang Hospital Southern Medical University State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research School of Public Health Xinxiang Medical University BGI Institute of Applied Agriculture BGI-Shenzhen Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Biological Sciences State University of New York at Buffalo Department of Internal Medicine Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

Skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of i WAT, offering potential therapeutic strategies for metabolic syndromes. Leveraging the Chromatin immunoprecipitation(ChIP)-seq and bioinformatics analysis, Bambi gene is shown to be a direct target of HIF2α, which is further confirmed by ChIP-qPCR and promoter luciferase assay. Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters, even under high-fat diet conditions. This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs) into thermogenic adipocytes, contributing to systemic metabolic improvements, potentially through the secretory ***, mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders, highlighting a potential therapeutic pathway for metabolic syndrome management. Thus, skeletal muscle-specific deletion of Bambi triggers muscle growth, enhances metabolic performance, and activates thermogenic adipocytes. These findings suggest Bambi as a novel therapeutic target for metabolic syndromes, providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement. The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism, offering a novel perspective on treating metabolic disorders.

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Modulation of the octahedral structure and potential superconductivity of La3Ni2O7 through strain engineering

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： Zihao Huo Zhihui luo Peng Zhang Aiqin Yang Zhengtao Liu Xiangru Tao Zihan Zhang Shumin Guo Qiwen Jiang Wenxuan chen Dao-Xin Yao Defang Duan tian Cui Key Laboratory of Material Simulation Methods & Software of Ministry of Education State Key Laboratory of Superhard Materials College of Physics Jilin University Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices State Key Laboratory of Optoelectronic Materials and Technologies School of Physics Sun Yat-sen University MOE Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter Shaanxi Province Key Laboratory of Advanced Functional Materials and Mesoscopic Physics School of Physics Xi'an Jiaotong University Institute of High Pressure Physics School of Physical Science and Technology Ningbo University

The recent transport measurements of La3Ni2O7uncovered a“right-triangle”shape of the superconducting dome in the pressure-temperature （P-T） phase *** by this,we perform theoretical first-principles studies of La3Ni2O7with the pressure ranging from 0 to 100 ***,we reveal a pressure dependence of the Ni-d2zelectron density at the Fermi energy (nE Fz) that highly coincides with such *** this basis,we further explore the electronic structure under uniaxial *** tracking the stress response of nE Fz,we propose that superconductivity can be achieved by applying only～2 GPa of compression along the c *** idea is further exemplified from the perspectives of lattice distortion,band structure,Fermi surface and superconducting phase *** also discuss the possible charge modulation under the stress and provide an insight into the relation between nE Fzand the superconducting Tcin *** study provides new routes to the search of high-Tcsuperconductors in future experiments.

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Synchronization of networks with time-varying couplings

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Applied Mathematics(A Journal of Chinese Universities) 2013年第4期28卷 438-454页

作者： lu Wen-lian chen tian-ping School of Mathematical Sciences Fudan University Department of Computer Science The University of WarwickCoventry CV4 7AL UK School of Computer Science and School of Mathematical Sciences Fudan Unicersity

In this paper, we present a review of our recent works on complete synchro-nization analyses of networks of the coupled dynamical systems with time-varying cou-plings. The main approach is composed of algebraic graph theory and dynamic system method. More precisely, the Hajnal diameter of matrix sequence plays a key role in in-vestigating synchronization dynamics and the joint graph across time periods possessing spanning tree is a doorsill for time-varying topologies to reach synchronization. These techniques with proper modification count for diverse models of networks of the cou-pled systems, including discrete-time and continuous-time models, linear and nonlinear models, deterministic and stochastic time-variations. Alternatively, transverse stability analysis of general time-varying dynamic systems can be employed for synchronization study as a special case and proved to be equivalent to Hajnal diameter.

关键词： Synchronization coupled dynamical system network time-varying coupling

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住房产权归属何以影响城市家庭教育投资

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山西财经大学学报 2025年第1期47卷 60-71页

作者：陈荣赓李天峰复旦大学国际关系与公共事务学院中南大学人文学院

基于家庭内部议价能力与社会规范两种解释，探究夫妻间住房产权归属与家庭教育投资的关系。利用CFPS数据实证发现，通过女性劳动参与和家庭收入两种机制，女性拥有住房产权促进了家庭教育投资绝对数额增加。异质性分析显示，伴随女性受... 详细信息

基于家庭内部议价能力与社会规范两种解释，探究夫妻间住房产权归属与家庭教育投资的关系。利用CFPS数据实证发现，通过女性劳动参与和家庭收入两种机制，女性拥有住房产权促进了家庭教育投资绝对数额增加。异质性分析显示，伴随女性受教育水平提升与受教育水平性别差距缩小，住房产权对家庭教育投资的影响得以增强，另外二者间影响仅在男孩子代与独生子女样本中表现明显。进一步分析显示，相较于女性独有产权，夫妻共享住房产权对家庭教育投资的影响更大。

关键词：住房产权性别差异家庭教育投资家庭内部议价能力社会规范劳动参与家庭收入夫妻财产约定

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Impacts of Multigrid NLS-4DVar-based Doppler Radar Observation Assimilation on Numerical Simulations of Landfalling Typhoon Haikui (2012)

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Advances in Atmospheric Sciences 2020年第8期37卷 873-892页

作者： lu ZHANG Xiangjun tian Hongqin ZHANG Feng chen International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China Zhejiang Institute of Meteorological Sciences Hangzhou 310008China

We applied the multigrid nonlinear least-squares four-dimensional variational assimilation(MG-NLS4DVar)method in data assimilation and prediction experiments for Typhoon Haikui(2012)using the Weather Research and Forecasting(WRF)*** data included radial velocity(Vr)and reflectivity(Z)data from a single Doppler radar,quality controlled prior to *** prediction results were evaluated and compared between the NLS-4DVar and MG-NLS4DVar *** with a forecast that began with NCEP analysis data,our radar data assimilation results were clearly improved in terms of structure,intensity,track,and precipitation prediction for Typhoon Haikui(2012).The results showed that the assimilation accuracy of the NLS-4DVar method was similar to that of the MG-NLS4DVar method,but that the latter was more *** assimilation of Vr alone and Z alone each improved predictions of typhoon intensity,track,and precipitation;however,the impacts of Vr data were significantly greater that those of Z *** window-length sensitivity experiments showed that a 6-h assimilation window with 30-min assimilation intervals produced slightly better results than either a 3-h assimilation window with 15-min assimilation intervals or a 1-h assimilation window with 6-min assimilation intervals.

关键词： MG-NLS4DVar NLS-4DVar radar data assimilation typhoon forecast

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Accurate theoretical evaluation of strain energy of all-carboatomic ring(cyclo[2n]carbon),boron nitride ring,and cyclic polyacetylene

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Chinese Physics B 2022年第12期31卷 357-363页

作者： tian lu Zeyu Liu Qinxue chen Beijing Kein Research Center for Natural Sciences Beijing 100024China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Cyclocarbon fully consists of sp-hybridized carbon atoms,which shows quite unusual electronic and geometric structures compared to common *** this work,we systematically studied strain energy(SE)of cyclocarbons of different sizes using regression analysis method based on electronic energies evaluated at the very accurate DLPNO-CCSD(T)/ccp VTZ theoretical *** addition,ring strain of two systems closely related to cyclocarbon,boron nitride(BN)ring,and cyclic polyacetylene(c-PA),is also *** ideal relationships between SE and number of repeat units(n)are built for cyclo[2n]carbon,B_(n)N_(n),and[2n]c-PA as SE=555.0·n^(-1),145.1·n^(-1),and 629.8·n^(-1)kcal·mol^(-1),respectively,and the underlying reasons of the difference and similarity in their SEs are discussed from electronic structure *** addition,force constant of harmonic potential of C-C-C angles in cyclocarbon is derived based on SE values,the result is found to be 56.23 kcal·mol^(-1)·rad^(-2).The possibility of constructing homodesmotic reactions to calculate SEs of cyclocarbons is also explored in this work,although this method is far less rigorous than the regression analysis method,its result is qualitatively correct and has the advantage of much lower computational *** addition,comparisons show thatωB97XD/def2-TZVP is a good inexpensive alternative to the DLPNO-CCSD(T)/cc-p VTZ for evaluating energies used in deriving SE,while the popular and very cheap B3LYP/6-31G(d)level should be used with caution for systems with global electron conjugation such as c-PA.

关键词： strain energy ring strain cyclocarbon boron nitride ring cyclic polyacetylene quantum chemistry

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An exploratory study of multimodal interaction modeling based on neural computation

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Science China(Information Sciences) 2016年第9期59卷 63-78页

作者： lu lu Fei LYU Feng tian Yineng chen Guozhong DAI Hongan WANG Beijing Key Laboratory of Human-Computer Interaction Institute of SoftwareChinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Computer Science Institute of SoftwareChinese Academy of Sciences

Multimodal interaction serves an important role in human-computer interaction. In this paper we propose a multimodal interaction model based on the latest cognitive research findings. The proposed model combines two proven neural computations, and helps to reveal the enhancement or depression influence of multimodal presentation upon the corresponding interaction task performance. A set of experiments is designed and conducted within the constraints of the model, which demonstrates the observed performance enhancement and depression effects. Our exploration and the experimental results help to further solve the question about how tactile feedback signal contribute the multimodal interaction efficiency which could provide guidelines for designing the tactile feedback in multimodal interaction.

关键词： human-computer interaction multimodal integration interaction model touch-included interac tion cognition multisensory integration neural computation brain coding

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Adaptive allocation strategy for cooperatively jamming netted radar system based on improved cuckoo search algorithm

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Defence Technology（防务技术） 2023年第6期24卷 285-297页

作者： De-jiang lu Xing Wang Xiao-tian Wu You chen Aviation Engineering School Air Force Engineering UniversityXi'an710038China

The jamming resource allocation problem of the aircraft formation cooperatively jamming netted radar system is *** adaptive allocation strategy based on dynamic adaptive discrete cuckoo search algorithm(DADCS)is proposed,whose core is to adjust allocation scheme of limited jamming resource of aircraft formation in real time to maintain the best jamming effectiveness against netted radar ***,considering the information fusion rules and different working modes of the netted radar system,a two-factor jamming effectiveness evaluation function is constructed,detection probability and aiming probability are adopted to characterize jamming effectiveness against netted radar system in searching and tracking mode,*** a nonconvex optimization model for cooperatively jamming netted radar system is ***,a dynamic adaptive discrete cuckoo search algorithm(DADCS)is constructed by improving path update strategies and introducing a global learning mechanism,and a three-step solution method is proposed *** results are provided to demonstrate the advantages of the proposed optimization strategy and the effectiveness of the improved algorithm.

关键词： Cuckoo search algorithm Netted radar system Radar countermeasures Resource allocation Information fusion

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A micromachined electrochemical angular accelerometer with highly integrated sensitive microelectrodes

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Microsystems & Nanoengineering 2022年第5期8卷 61-67页

作者： tian Liang Bowen Liu Mingwei chen Yulan lu Jian chen Deyong chen Junbo Wang State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

This paper presents a micromachined electrochemical angular accelerometer with highly integrated sensitive *** analyses and numerical simulations were conducted to model the angular accelerometer with key geometrical parameters(e.g.,electrode spacing,via spacing and via size)*** integrated sensitive microelectrodes were manufactured based on microfabrication and assembled to form MEMS-based electrochemical angular *** characterization was conducted,locating a sensitivity of 80 V/(rad/s^(2)),a bandwidth of 0.01–18 Hz and a noise level of 3.98×10^(−8)(rad/s^(2))/√*** comparison to a previously reported electrochemical angular microaccelerometer,a significant improvement in sensitivity(80 V/(rad/s^(2))vs.10 V/(rad/s^(2)))was achieved due to the new structure of sensitive *** results indicated the potential of the developed MEMS-based electrochemical angular accelerometer in seismology,including natural disaster monitoring and resource exploration.

关键词： angular electrochemical spacing

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考虑消费者异质性和在线购物信任度的双渠道公益营销决策

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管理工程学报 2025年第2期39卷 175-189页

作者：吴传良田中俊陈静上海财经大学商学院上海200433 淮南师范学院经济与管理学院安徽淮南232038 东南大学经济管理学院江苏南京211189

当制造商在实体和网络两个渠道销售同质产品时,实体和网络间会产生渠道竞争。相关主体在网络渠道实施公益营销可以提升消费者的在线购物信任度从而增强网络渠道产品竞争力。公益营销的成功实施离不开异质性消费者(亲社会和非亲社会消费... 详细信息

当制造商在实体和网络两个渠道销售同质产品时,实体和网络间会产生渠道竞争。相关主体在网络渠道实施公益营销可以提升消费者的在线购物信任度从而增强网络渠道产品竞争力。公益营销的成功实施离不开异质性消费者(亲社会和非亲社会消费者)中亲社会消费者产生的温情效应。温情效应的产生影响了产品定价。网络渠道可通过决策单位捐赠金额的大小改变温情效应的强度。本文以一个制造商和一个实体分销商组成的双渠道供应链为研究对象,通过构建Stackelberg动态博弈模型研究消费者异质性和在线购物信任度对双渠道供应链公益营销决策的影响问题。研究表明:制造商在网络渠道实施公益营销加剧了渠道之间的竞争。当温情效应较大时,网络渠道可以利用公益营销,采用定高价的方式仅服务于亲社会消费者,高价产生的边际收益增加足以弥补放弃非亲社会消费者转移至实体分销渠道的利润损失;当温情效应较小时,网络渠道应该兼顾两种异质性消费者,且与不实施公益营销时相比,制造商利润以及社会福利都会增加;捐赠总金额随着消费者在线购物信任度的提高先减少后增加,当温情效应较小时,单位捐赠金额与亲社会消费者比例以及公益营销偏好程度有关,而当温情效应较大时,单位捐赠金额只与公益营销偏好程度有关。

关键词：公益营销消费者异质性信任度双渠道温情效应

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