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An overview of Chinese multidisciplinary expert consensus on perioperative brain health in elderly patients

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Chinese Medical Journal 2021年第1期134卷 5-7页

作者： Min Li Tian-Long Wang Dong-Xin wang Department of Anesthesiology Peking University Third HospitalBeijing 100191China Department of Anesthesiology and Operating Theater Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Anesthesiology and Critical Care Medicine Peking University First HospitalBeijing 100034China

Goals for Developing This Consensus The rapidly aging populations in China pose serious challenges for anesthesiologists.Comorbidity and functional decline in elderly patients escalate the risks of cerebral complications which might lead to long-term morbidity and overall reduced quality of life after surgery.[1,2]Therefore,it is imperative to implement perioperative brain protection strategies for geriatric patients.

关键词： patients surgery cerebral

Geriatric Anesthesia-related Morbidity and Mortality in China： Current Status and Trend

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Chinese Medical Journal 2017年第22期130卷 2738-2749页

作者： Yang Liu Wei Xiao Ling-Zhong Meng Tian-Long Wang Department of Anesthesiology and Operating Theatre Xuanwu Hospital Capital Medical University Beijing 100053 China Department of Anesthesiology Yale University School of Medicine New Haven CT 06520 USA

Objective： The population of elderly patients and the amount of geriatric anesthesia have been growing rapidly in China. Thus, understanding the morbidity and mortality associated with geriatric anesthesia in China is critical to the improvement of anesthesia quality and outcome. The aim of the review was to discuss the geriatric anesthesia-related morbidity and mortality in China, as well as to point out the future trend. Data Sources： Articles in this review were all searched from Wanfang, China National Knowledge Infrastructure （CNKI）, VIP, PubMed, and Web of Science databases, based on the reports originated in China from January 2011 to December 2016. Study Selection： A total of 57 studies were selected for further study, including 12 retrospective studies, 35 prospective studies, 3 meta-analyses, 4 reviews, 1 viewpoint, and 2 case reports. Of the total studies, 42 studies were in Chinese while 15 were in English. Results： The mortality and morbidity associated with geriatric anesthesia in China are not yet completely reported. Some factors have been recognized, while some are yet to be identified and confirmed. Several studies addressed postoperative cognitive dysfunction and postoperative delirium, whereas only a few studies can be found on renal complications. Thus, a nationwide registry is essential for geriatric anesthesia-associated adverse outcomes. The mortality associated with geriatric anesthesia in China should be reported promptly. In the future, the perspective of geriatric anesthesia needs to be expanded into perioperative geriatric medicine to improve the perioperative management strategy based on the postoperative outcome-directed concept transformation. Conclusions： Anesthesiologists should evaluate the physiological and medical status and focus on the prevention of potential complications in the perioperative setting with the goal to enhance elderly patients＇ long-term well-being and survival quality.

关键词： Anesthesia China Geriatric Morbidity Mortality

Hypothermia selectively protects the anterior forebrain mesocircuit during global cerebral ischemia

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Neural Regeneration Research 2022年第7期17卷 1512-1517页

作者： Xiao-Hua wang Wei Jiang Si-Yuan Zhang Bin-Bin Nie Yi Zheng Feng Yan Jian-Feng Lei Tian-Long Wang Department of Anesthesiology Xuanwu HospitalCapital Medical UniversityBeijingChina National Clinical Research Center for Geriatric Disorders BeijingChina Department of Anesthesiology Third Medical Center of People’s Liberation Army General HospitalBeijingChina Daxing Hospital Affiliated to Capital Medical University BeijingChina Beijing Engineering Research Center of Radiographic Techniques and Equipment Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijingChina Neuroprotection Research Laboratory Departments of Radiology and NeurologyMassachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA Cerebrovascular Research Center Xuanwu HospitalCapital Medical UniversityBeijingChina

Hypothermia is an important protective strategy against global cerebral ischemia following cardiac arrest.However,the mechanisms of hypothermia underlying the changes in different regions and connections of the brain have not been fully elucidated.This study aims to identify the metabolic nodes and connection integrity of specific brain regions in rats with global cerebral ischemia that are most affected by hypothermia treatment.18F-fluorodeoxyglucose positron emission tomography was used to quantitatively determine glucose metabolism in different brain regions in a rat model of global cerebral ischemia established at 31–33℃.Diffusion tensor imaging was also used to reconstruct and explore the brain connections involved.The results showed that,compared with the model rats established at 37–37.5℃,the rat models of global cerebral ischemia established at 31–33℃had smaller hypometabolic regions in the thalamus and primary sensory areas and sustained no obvious thalamic injury.Hypothermia selectively preserved the integrity of the anterior forebrain mesocircuit,exhibiting protective effects on the brain during the global cerebral ischemia.The study was approved by the Institutional Animal Care and Use Committee at Capital Medical University(approval No.XW-AD318-97-019)on December 15,2019.

关键词： anterior forebrain mesocircuit cardiac arrest corpus callosum global cerebral ischemia hypometabolic areas hypothermia magnetic resonance imaging positron emission tomography prefrontal cortex rats thalamus

Ore geology， H–O–C isotopes andAr–Ar dating of the Wutonggou iron deposit， eastern tianshan， NW China: Implications for the source， timing， and genesis of hydrothermal mineralization in a sedimentary iron deposit

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Journal of Earth Science 2022年

作者： Chun-long wang Yi-tian wang State Key Laboratory of Geological Processes and Mineral Resources， Collaborative Innovation Center for Exploration of Strategic Mineral Resources， School of Earth Resources， China University of Geosciences Wuhan MNR Key Laboratory of Metallogeny and Mineral Assessment， Institute of Mineral Resources， Chinese Academy of Geological Sciences

The Wutonggou iron deposit is located in the well-known iron metallogenic belt in the eastern tianshan， NW China， and has been regarded as a sedimentary iron deposit. Hydrothermal overprinting could play indispensable roles in the formation of high-grade iron ores in sedimentary iron deposits， thus the nature and evolution of hydrothermal fluids have important implications on the genesis of these deposits. Consequently， an integrated study of ore geology， H–O–C isotopes andAr–Ar dating， is conducted on the Wutonggou deposit， in order to reveal the features， source， and timing of hydrothermal mineralization. The studied deposit includes two mining sections namely the Jianshan and Wutonggou. The δO values of early magnetite from the Jianshan section range from +3.0‰ to +5.8‰ that nearly consistent with classic magmatic magnetite， while increases to 6.3‰–8.0‰ in the late stage. Quartz from the two sections shows comparable H–O isotopic compositions and identical fractionation trends， and is plotted in or periphery to the primary magmatic water area. Calcites from the two sections are broadly similar in carbon and oxygen isotopic compositions， and siderite from the Wutonggou section is plotted in the same region. Thus， comparable stable isotopic compositions and evolution trends indicate similar magmatic fluids contributed hydrothermal iron mineralization in the two mining sections. Moreover， water-rock interactions of varying degrees generated distinct mineralization styles in the Jianshan and Wutonggou sections， and caused the isotopic fractionation in late stages. Biotite extracted from a hydrothermal siderite ore yielded aAr–Ar plateau age of 299.5 ± 2.0 Ma， indicating the timing of hydrothermal iron mineralization is corresponding to the emplacement of vicinity granitoids. Taken together， the hydrothermal mineralization in the Wutonggou iron deposit was the product of remobilization and upgrading of early sedimentary iron ores， and ore-forming fluids were most probably originated from regional granitic magmatism

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Physical and numerical investigation on fluid flow and inclusion removal behavior in a single-strand tundish

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Journal of Iron and Steel Research(International) 2023年第6期30卷 1182-1198页

作者： Qi Quan Zhi-xiao Zhang tian-peng Qu Xiang-long Li Jun tian De-yong wang School of Iron and Steel Soochow UniversitySuzhou 215137JiangsuChina

Aiming at the problem that the existence of inclusions in the tundish continuous casting process can easily lead to quality defects of the slab,the stainless steel continuous casting tundish was taken as the research object.The effects of flow control device,inclusion density and inclusion size on the mixing characteristics of molten steel and inclusion behavior in tundish were studied.The results showed that compared with the tundish without flow control device,the average residence time of molten steel was prolonged by about 49 s,the dead zone volume fraction was reduced by 8.93%,and the piston fluid integral rate was increased by 12.68%.In the turbulence inhibitor(TI)tundish with weir-dam combination,the removal rate of inclusions with a density of 2700 kg m^(-3) and a particle size of 5 lm is 63.32%,while the removal rate of large inclusions with a density of 150μm could reach 89.04%.When the inclusion particle size was 10-50μm and the density was 2700-4500 kg m^(-3),the effect of inclusion density on inclusion removal rate was small.At the same time,when weir-dam combination TI tundish was set,the inclusions were mainly limited to the slag-metal interface of the first and second chambers of the tundish.The removal rate of inclusions in the first chamber was generally improved,with 10μm inclusions accounting for 47.67% and 150μm inclusions accounting for 60.69%.Furthermore,it has the best effect on the removal of small-size inclusions,especially those less than 70μm.

关键词： Non-metallic inclusion Flow control device Residence time distribution curve Removal behavior Discrete particle model

Mass Spectrometry-Based Targeted Metabolomics Revealed the Regulatory Roles of Magnesium on Biofilm Formation in Escherichia coli by Targeting Functional Metabolites

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Journal of Analysis and Testing 2022年第2期6卷 89-97页

作者： tian-Yu wang Rui Guo long-long Hu Jing-Jing Liu Hai-Tao Lu Key Laboratory of Systems Biomedicine(Ministry of Education) Shanghai Center for Systems BiomedicineShanghai Jiao Tong UniversityShanghai 200240China Laboratory for Functional Metabolomics Science Shanghai Jiao Tong UniversityShanghai 200240China

Biofi lms often impose harmful infl uences in many niches involving food contamination,antibiotics resistance,and environmental issues.However,eradicating biofi lms remains diffi cultly because the formation mechanism of biofi lms is still incompletely clarifi ed.Here,we attempted to explore the regulatory role of magnesium(Mg^(2+))on biofi lm formation in Escherichia coli(E.coli)using phenotype visualization with targeted metabolomics method.We found that Mg^(2+)could exert signifi cant infl uence on biofi lm formation with a concentration dependency by regulating phenotypic morphology and triggering metabolic modifi cations of biofi lm.Phenotypic imaging revealed that increasing concentration of Mg^(2+)gradually inhibited biofi lm formation,Mg^(2+)was observed to restore the microstructure of E.coli strain in biofi lms to that in the relevant planktonic cells.In addition,our metabolomics analysis characterized 20 diff erential metabolites and associated two metabolic pathways including nucleotide metabolism and amino acid metabolism that were notably modifi ed during biofi lm formation under the treatments of varied Mg^(2+).Altogether,our work provides a novel insight into the infl uence of Mg^(2+)on biofi lm formation at a metabolic level,which is implicated in the novel solution to disturb biofi lm formation through the regulation of Mg^(2+)and functional metabolite interaction.

关键词： Biofilms Magnesium Precision-targeted metabolomics Metabolic modifications Escherichia coli

Research on Electromagnetic Loss Characteristics of Submarine Cables

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Energy Engineering 2023年第11期120卷 2651-2666页

作者： Liuhuo wang Qingcui Liu Wenwei Zhu Yanru wang Yi tian long Zhao Guangdong Power Grid Co. Ltd.Guangzhou510600China Guangzhou Yueneng Power Technology Development Co. Ltd.Guangzhou510000China Grid Planning Research Center of Guangdong Power Grid Co. Ltd.Guangzhou510080China Department of Electronics and Information Xi’an Polytechnic UniversityXi’an710048China

The electromagnetic losses of submarine cables are mainly caused by the metal shielding layer to prevent the water tree effect and the armor layer that strengthens the strength of the submarine cables.While these losses cause the temperature of submarine cable to rise,and temperature variation will in turn change the conductivity of its metal layer material.In this paper,the electric-magnetic-thermal multi-physical field coupling of the electromagnetic loss variation of the submarine cable is realized by establishing a full coupling system containing Fourier’s law and Maxwell-Ampère’s Law for the photoelectric composite submarine cable.The multi-physical field coupling model is solved and analyzed by using the finite elementmethod.Firstly,the loss of each layer of the optoelectronic composite submarine cable is analyzed,and the lossof eachlayer of the submarine cable and themainfactors leading to the loss of the submarine cable are given.Secondly,the influence of environmental temperature,ampacity and armor layer on the electromagnetic loss of submarine cables is studied,and the main operating factors affecting the electromagnetic loss of submarine cables are summarized.The research shows that the influence of ambient temperature can be ignored,and the loss of shielding layer and armor layer increases with the increase of ampacity,but the impact of shielding layer loss is greater.Finally,this paper studies the electromagnetic loss of each metal layer of the submarine cable and the influence of the laying spacing on the electromagnetic loss.The research results show that the two ways of improving the conductivity of the armor layer and reducing the relative permeability of the armor layer can effectively reduce the loss of each metal layer in the cable structure and increase the current carrying capacity when the tensile strength of the armor layer meets the requirements for single-core and threecore photoelectric composite submarine cables laid horizontally.At the same time,increasing the laying spacing will incr

关键词： Submarine cable multi-physical field coupling electromagnetic loss

Parallel Distance: A New Paradigm of Measurement for Parallel Driving

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IEEE/CAA Journal of Automatica Sinica 2020年第4期7卷 1169-1178页

作者： Teng Liu Hong wang Bin tian Yunfeng Ai long Chen the Vehicle Intelligence Pioneers Inc. Qingdao 266109 the Department of Automotive Engineering Chongqing UniversityChongqing 400044China the Mechanical and Mechatronics Engineering Department Waterloo UniversityN2L 3G1Canada the State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China the School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China the School of Data and Computer Science Sun Yat-sen UniversityGuangzhou 510006China

In this paper, a new paradigm named parallel distance is presented to measure the data information in parallel driving system. As an example, the core variables in the parallel driving system are measured and evaluated in the parallel distance framework. First, the parallel driving 3.0 system included control and management platform, intelligent vehicle platform and remote-control platform is introduced. Then,Markov chain(MC) is utilized to model the transition probability matrix of control commands in these systems. Furthermore, to distinguish the control variables in artificial and physical driving conditions, different distance calculation methods are enumerated to specify the differences between the virtual and real signals. By doing this, the real system can be guided and the virtual system can be im-proved. Finally, simulation results exhibit the merits and multiple applications of the proposed parallel distance framework.

关键词： Artificial and physical system parallel distance parallel driving 3.0 parallel system rotational and accelerator signal

Simulation of inclined dendrites under natural convection by KKS phase field model based on CUDA

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中国铸造:英文版 2023年第5期20卷 432-442页

作者： Chang-sheng Zhu tian-yu Li Bo-rui Zhao Cang-long wang Zi-hao Gao College of Computer and Communication Lanzhou University of TechnologyLanzhou 730050China State Key Laboratory of Gansu Advanced Processing and Recycling of Non-Ferrous Metal Lanzhou University of TechnologyLanzhou 730050China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000GuangdongChina

In this work,Al-4.5wt.%Cu was selected as the research object,and a phase field-lattice Boltzmann method(PF-LBM)model based on compute unified device architecture(CUDA)was established to solve the problem of low serial computing efficiency of a traditional CPU and achieve significant acceleration.This model was used to explore the evolution of dendrite growth under natural convection.Through the study of the tip velocities,it is found that the growth of the dendrite arms at the bottom is inhibited while the growth of the dendrite arms at the top is promoted by natural convection.In addition,research on the inclined dendrite under natural convection was conducted.It is observed that there is a deviation between the actual growth direction and the preferred angle of the inclined dendrite.With the increase of the preferred angle of the seed,the difference between the actual growth direction and the initial preferred angle of the inclined dendrite shows a trend of increasing at first and then decreasing.In the simulation area,the relative deflection directions of the primary dendrite arms in the top right corner and the bottom left corner of the same dendrite are almost counterclockwise,while the relative deflection directions of the other two primary dendrite arms are clockwise.

关键词： PF-LBM natural convection inclined dendrites CUDA