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A Novel High-Entropy Amorphous Thin Film with High Electrical Resistivity and Outstanding Corrosion Resistance

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Acta Metallurgica Sinica(English Letters) 2021年第11期34卷 1537-1545页

作者： Chuang-Shi Feng tian-Wei Lu tian-li wang Man-Zhen lin Junhua Hou Wenjun Lu Wei-Bing liao College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China

This study explores a novel WNbMoTaV high-entropy thin film(HETF)in amorphous structure via pulsed laser deposition *** formation of amorphous structure of this high-entropy alloy is ascribed to the high cooling rate during the deposition *** HETF shows a smooth surface with a height fl uctuation of less than 13 *** film has a high electrical resistivity of~320.6μΩ·cm and a low corrosion current density of 0.088μA/cm *** corrosion resistance of the HETF at ambient temperature is superior to the conventional AISI 316 L stainless *** high electrical resistivity and excellent corrosion resistance of the HETF are mainly attributed to its chemical disorder,cocktail effect and homogeneous amorphous *** experimental phenomenon not only provides a basis for the preparation of amorphous alloy films with low glass forming ability by pulsed laser deposition system,also promotes the potential application of WNbMoTaV HETF in the microelectronic components as resistivity sensors.

关键词： High-entropy alloys Thin films Electrical resistivity Microstructures Corrosion behaviors

Optimizing SSR-PCR system of Panax ginseng by orthogonal design

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Journal of Forestry Research 2007年第1期18卷 31-34页

作者： YANG tian-tian MU li-qiang wang Jun School of Forestry of Northeast Forestry University Harbin 150040 P. R. China

An orthogonal design was used to optimize SSR-PCR amplification system using Panax ginseng genomic DNA as template. Four levels of five factors （DNA template, Taq DNA polymerase, Mg^2＋, primer, and dNTP） and annealing temperature have been tested separately in this system. The results demonstrated the reaction efficiency was affected by these factors. Based on the results, a stable, productive and reproducible PCR system and cycling program for amplifying a ginseng SSR locus were obtained： 20 μL system containing 1.0 U Taq DNA polymerase, 2.0 mmol·L^-1 Mg^2＋, 0.2 mmol·L^-1 dNTPs, 0.3 μmol·L^-1 SSR primer, 60 ng· μla^-1 DNA template, performed with a program of 94℃ for 5 min, 94℃ for 30 s, annealing at 56.3℃ for 30 s, 72℃ for 1 min, 37 cycles, finishing at 72℃ for 7 min, and storing at 4℃.

关键词： Panax ginseng C.A.Meyer Orthogonal design SSR-PCR

Fecal microbiota in pouchitis and ulcerative colitis

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World Journal of Gastroenterology 2016年第40期22卷 8929-8939页

作者： Kai-Yu li Jian-lin wang Jiang-Peng Wei Sen-Yang Gao Ying-Ying Zhang li-tian wang Gang liu Department of General Surgery Tianjin Medical University General Hospital Department of General Surgery Tianjin NanKai Hospital

AIM To investigate the changes in microbiota in feces of patients with ulcerative colitis(UC) and pouchitis using genomic *** Fecal samples were obtained from UC patients with or without an ileal pouch-anal anastomosis(IPAA) procedure, as well as healthy controls. The touchdown polymerase chain reaction technique was used to amplify the whole V3 region of the 16 S r RNA gene, which was transcribed from DNA extracted from fecal samples. Denaturing gradient gel electrophoresis was used to separate the amplicons. The band profiles and similarity indices were analyzed digitally. The predominant microbiota in different groups was confirmed by sequencing the 16 S rR NA gene. RESULTS Microbial biodiversity in the healthy controls was significantly higher compared with the UC groups(P libacterium prausnitzii and Eubacterium rectale, were reduced in UC. Patients with pouchitis had an altered microbiota composition compared with UC patients. The microbiota from pouchitis patients was less diverse than that from severely active UC patients. Sequencing results showed that similar microbiota, such as Clostridium perfringens, were shared in both UC and *** Less diverse fecal microbiota was present in patients with UC and pouchitis. Increased C. perfringens in feces suggest its role in the exacerbation of UC and pouchitis.

关键词： Pouchitis Intestinal flora Ulcerative colitis Disease activity index Ileal pouch-anal anastomosis

Morphological Measurement and Analysis of Gymnarchus Niloticus

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Journal of Bionic Engineering 2005年第1期2卷 25-31页

作者： Hu tian-jiang li Fei wang Guang-ming Shen lin-cheng College of Mechatronic Engineering and Automation National University of Defense Technology Changsha 410073 P. R. China

Gyrnnarchus niloticus swims by undulations of a long-based dorsal fin, while its body axis is in many cases held straight during swimming. This paper provides a brief relevant introduction to Gyrnnarchus niloticus, which belongs to the African freshwater electric eels but can inspire our bionic interests in propulsion besides its abilities in electric sensing. A special larva of Gyrnnarchus niloticus was morphologically measured by photographing it with a piece of scale-calibrated paper as the background. Then we analyzed the data by a CFD-aided approach. Detailed flow patterns around the larva and a NACA0012 hydrofoil were respectively calculated and visualized at the Reynolds number of 7350 or so. The results show that the profile of Gyrnnarchus niloticus is well streamlined.

关键词： bionic Gymnarchus niloticus morphological measurement CFD-based analysis streamlined profile

Relationship between uric acid and arterial stiffness in the elderly with metabolic syndrome components

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Chinese Medical Journal 2013年第16期126卷 3097-3102页

作者： SUN Ning ZHANG Yun tian Jian-li wang Hui Department of Gerontology Tianjin General Hospital TianjinMedical University Tianjin 300052 China

Background High uric acid （UA） levels and metabolic syndrome （MS） are risk factors for atherosclerotic ***-ankle pulse wave velocity （baPWV） is a valid and reproducible measurement by which to assess arterial stiffness and a surrogate marker of ***,little is known about the relationship between them,especially in elderly Chinese with MS components who are at high risk for atherosclerotic *** One thousand and twenty Chinese subjects （159 women） older than 60 years of age （mean age （70.6±5.7）years） with at least one MS component underwent routine laboratory tests,and baPWV measurements were *** Participants were divided into four groups by MS *** mean age did not significantly differ among the MS component *** found that not only the diagnostic factors （blood pressure,body mass index （BMI）,lipids,glucose） of MS but also baPWV,UA,insulin,homeostasis model of assessment for insulin resistence index （HOMAIR） levels increased,and high density lipoprotein （HDL）-C decreased with an increased number of MS components （test for trend P＜0.05）.The association between UA and baPWV was observed after adjustment for gender,age,blood pressure,BMI,serum creatinine and high density lipoprotein,and insulin resistance （r=0.186,P＜0.0001）.There were increases in the odds ratios for the association between the number of components of MS,UA and baPWV,even after adjustment for traditional risk ***,after adjustment for insulin or HOMA-IR,there were no significant differences in the multivariate odds ratios among the number of MS components for *** The UA level is positively associated with baPWV and MS,but the association between UA and MS is dependent on insulin ***,baPWV is independently associated with MS in our study population.

关键词： uric acid pulse wave velocity metabolic syndrome

Hydrogen sulfide donor regulates alveolar epithelial cell apoptosis in rats with acute lung injury

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Chinese Medical Journal 2013年第3期126卷 494-499页

作者： liU Wen-li liU Zhi-wei li tian-shui wang Cong ZHAO Bin Department of Emergency Medicine Beijing Jishuitan Hospital Beijing 100035 China

Background Acute lung injury （Ali） is a common syndrome associated with high morbidity and mortality in emergency medicine. Cell apoptosis plays a key role in the pathogenesis of ALl. Hydrogen sulfide （H2S） plays a protective role during acute lung injury. We designed this study to examine the role of H2S in the lung alveolar epithelial cell apoptosis in rats with ALl. Methods Sixty-nine male Sprague Dawley rats were used. Ali was induced by intra-tail vein injection of oleic acid （OA）. NariS solution was injected intraperitonally 30 minutes before OA injection as the NariS pretreatment group. Single sodium hydrosulfide pretreatment group and control group were designed. Index of quantitative assessment （IQA）, wet/dry weight （W/D） ratio and the percentage of polymorphonuclear leukocyte （PMN） cells in the bronchoalveolar lavage fluid （BALF） were determined. H2S level in lung tissue was measured by a sensitive sulphur electrode. Apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling （TUNEL） staining and Fas protein was measured by immunohistochemical staining. Results The level of endogenous H2S in lung tissue decreased with the development of ALl induced by OA injection. Apoptosis and Fas protein in alveolar epithelial cells increased in the ALl of rats but NariS lessened apoptosis and Fas protein expression in alveolar epithelial cells of rats with ALl. Conclusion Endogenous H2S protects rats from oleic acid-induced ALl, probably by inhibiting cell apoptosis.

关键词： hydrogen sulfide acute lung injury cell apoptosis

Protective Effect of Low-dose Sevoflurane Inhalation and Propofol Anesthesia on the Myocardium after Carotid Endarterectomy： A Randomized Controlled Trial

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Chinese Medical Journal 2015年第14期128卷 1862-1866页

作者： Qianwang Yan-Hong li tian-Long wang Hua Feng Bing Cai Department of Anesthesiology Xuan Wu Hospital Capital Medical University Beijing 100053 China

Background： Myocardial infarction is an important cause of mortality after carotid endarterectomy （CEA）. Sevoflurane provides myocardial protection to patients undergoing coronary surgery, but whether it also reduces the incidence of myocardial injury in CEA patients is unclear. In this study, we evaluated the cardioprotective effect of low-dose sevoflurane with propofol in patients undergoing CEA. Methods： This was a single-center, prospective, randomized study conducted between November 2011 and December 2013. The study population of 122 patients who underwent CEA were randomly assigned to two groups. Group A （n = 62） received propofol for anesthetic maintenance, and Group B （n = 60） additionally received 0.8% end-tidal sevoflurane. The bispectral index was kept at 40-60. Myocardial injury, defined as cardiac troponin 1 （cTnl） levels 〉0.04 ng/ml, was the primary end-point. Levels ofcTnl were measured before anesthesia, and at 4, 24, and 7211 after surgery. Perioperative hemodynamic parameters and adverse cardiovascular events after surgery were also recorded. Results： Myocardial injury was detected in 18 patients in Group A and 7 in Group B. The difference was statistically signifcant （29.0% vs. 11.7%, P= 0.018）. The hemodynamic parameters were comparable between the groups, as were adverse cardiovascular events （P = 0.619）. Conclusions： Low-dose sevoflurane inhalation along with propofol reduces the incidence of myocardial injury in symptomatic patients after CEA.

关键词： Carotid Endarterectomy Myocardial Injury Propofol Sevoflurane

Targeting glutamine metabolism enhances responses to platinum-based chemotherapy in triple-negative breast cancers(TNBC)

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Genes & Diseases 2022年第6期9卷 1408-1411页

作者： Jiaxin Hong Yao-An Shen Chih-Yi Hsu Peng Huang Alicja Tomaszewski Edward Gabrielson Ie-Ming Shih Stephanie Gaillard tian-li wang Sidney Kimmel Comprehensive Cancer Center and Department of Oncology BaltimoreMD 21231USA Department of Pathology Johns Hopkins University School of MedicineBaltimoreMD 21231USA Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022PR China Department of Gynecology and Obstetrics Johns Hopkins University School of MedicineBaltimoreMD 21231USA

Reprogramming of metabolic pathways,a hallmark of human cancer,results from a process in which cancer cells become dependent on specific metabolic pathways such as glutamine catabolism or glutaminolysis for growth and *** studies have demonstrated that triplenegative breast cancers(TNBC)may use glutamine as an extracellular nutrient source to generate lipids,proteins,and nucleic acids.1 Glutamine catabolism in cancer cells also contributes to the production of the antioxidant,glutathione(GSH),which is critical for redox homeostasis and for protection of cells from oxidative stress elicited by reactive oxygen species(ROS).2 Considering TNBC cell lines are often dependent on glutamine for growth and survival,we sought to determine whether targeting glutaminolysis with a small molecule inhibitor,CB-839,in combination with platinum-based chemotherapy drug,would elicit significant anti-tumor activity.

关键词： metabolism TNBC chemotherapy

Fabrication of Tl_(2)Ba_(2)CaCu_(2)O_(8) superconducting films without thallium pellets

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Chinese Physics B 2018年第5期27卷 464-468页

作者： Teng-Da Xu Jian Xing li-tian wang Jin-li Zhang Sheng-Hui Zhao Yang Xiong Xin-Jie Zhao Lu Ji Xu Zhang Ming He College of Electronic Information and Optical Engineering Nankai UniversityTianjin 300350China Key Laboratory of Photoelectronic Thin Film Devices and Technology of tianjin Tianjin 300350China

A new improved two-step method in fabricating Tl_(2)Ba_(2)CaCu_(2)O_(8)(Tl-2212)thin films is presented in this *** the first process of dc magnetron sputtering,the thallium content in the precursor film is largely increased by adjusting the ratio of thallium in the sputtering *** the second annealing process in the absence of additional thallium pellets or powder source,high-quality Tl-2212 thin films can be *** proper content of thallium in the precursor film provides a relatively stable atmosphere to guarantee the growth of Tl-2212 *** method avoids the repeated production of the thallium pellets in the post-annealing process,the repeatability and controllability of the experiment are greatly improved.X-ray diffraction(XRD)scans show that all of the sharp peaks of the sample films can be assigned to the(00 l)peaks of Tl-2212 *** highest superconducting critical temperature(T_(c))of the films is 105 K and the critical current density(J_(c))can achieve 1.93 MA/cm^(2) in zero magnetic field at 77 K for a 600 nm film.

关键词： Tl-2212 superconducting films post-annealing critical temperature critical current density