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Machine learning based on metabolomics unveils neutrophil extracellular trap-related metabolic signatures in non-small cell lung cancer patients undergoing chemoimmunotherapy

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World Journal of Clinical Cases 2024年第20期12卷 4091-4107页

作者： Yu-Ning li Jia-lin Su Shu-Hua Tan Xing-Long Chen tian-li cheng Zhou Jiang Yong-Zhong Luo Le-Meng Zhang School of life and Health Sciences Hunan University of Science and TechnologyXiangtan 411201Hunan ProvinceChina Department of Thoracic Medicine Hunan Cancer HospitalChangsha 410013Hunan ProvinceChina

BACKGROUND Non-small cell lung cancer(NSCLC)is the primary form of lung cancer,and the combination of chemotherapy with immunotherapy offers promising treatment options for patients suffering from this ***,the emergence of drug resistance significantly limits the effectiveness of these therapeutic ***,it is imperative to devise methods for accurately detecting and evaluating the efficacy of these *** To identify the metabolic signatures associated with neutrophil extracellular traps(NETs)and chemoimmunotherapy efficacy in NSCLC *** In total,159 NSCLC patients undergoing first-line chemoimmunotherapy were *** first investigated the characteristics influencing clinical *** levels of NETs and cytokines were measured by commercial *** chromatography tandem mass spectrometry quantified plasma metabolites,and differential metabolites were *** absolute shrinkage and selection operator,support vector machine-recursive feature elimination,and random forest algorithms were *** using plasma metabolic profiles and machine learning algorithms,predictive metabolic signatures were *** First,the levels of circulating interleukin-8,neutrophil-to-lymphocyte ratio,and NETs were closely related to poor efficacy of first-line *** were classed into a low NET group or a high NET group.A total of 54 differential plasma metabolites were *** metabolites were primarily involved in arachidonic acid and purine *** key metabolites were identified as crucial variables,including 8,9-epoxyeicosatrienoic acid,L-malate,and bis(monoacylglycerol)phosphate(18:1/16:0).Using metabolomic sequencing data and machine learning methods,key metabolic signatures were screened to predict NET level as well as chemoimmunotherapy *** The identified metabolic signatures may effectively distinguish NET levels and predict clinical

关键词： Non-small cell lung cancer Chemoimmunotherapy Neutrophil extracellular traps Metabolomics Machine learning

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昆虫病原线虫人工培养技术研究与应用进展

昆虫学报 2024年第6期67卷 872-884页

作者：田成丽张金花朱峰韩日畴李茂海吉林省农业科学院(中国农业科技东北创新中心)植物保护研究所农业部东北作物有害生物综合治理重点实验室公主岭136100 广东省科学院动物研究所广东省动物保护与资源利用重点实验室广东省野生动物保护与利用公共实验室广州510260

昆虫病原线虫是昆虫的专化性寄生天敌,可自主搜寻寄主、杀虫速度快、对环境友好安全,是一类重要的害虫生物防治因子,在害虫可持续治理中具有应用潜力。目前,昆虫病原线虫作为商品化的新型生物杀虫制剂在全球生产销售。然而,昆虫病原线... 详细信息

昆虫病原线虫是昆虫的专化性寄生天敌,可自主搜寻寄主、杀虫速度快、对环境友好安全,是一类重要的害虫生物防治因子,在害虫可持续治理中具有应用潜力。目前,昆虫病原线虫作为商品化的新型生物杀虫制剂在全球生产销售。然而,昆虫病原线虫的商品化需要高效的人工培养技术。由于昆虫病原线虫的专化性较强,一种成熟的商业化昆虫病原线虫人工培养技术需要根据线虫种类优化。除了优化现有技术,还需研发新的人工培养技术。本文综述了国内外昆虫病原线虫人工培养技术研究和应用的历史和现状,详细介绍了活体培养技术和离体培养技术,讨论了影响昆虫病原线虫产量的主要因素,强调了优化人工培养技术并降低培养成本的必要性。未来,随着人工培养技术的不断优化,在丰富了昆虫病原线虫商品化种类的同时,还可降低农业生产的经济损失,改良土壤环境,具有重要的经济和社会价值。

关键词：昆虫病原线虫活体培养固体培养液体培养固液双相培养应用技术

敲低卷曲跨膜受体蛋白2抑制小鼠舌鳞癌并增强CTLA4单抗疗效的研究

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中国临床药理学杂志 2024年第16期40卷 2359-2362页

作者：刘慧宇孙晓娇刘振明李天成北京大学第一医院耳鼻咽喉头颈外科北京100034 北京大学药学院天然药物与仿生药物国家重点实验室北京100191

目的探讨卷曲跨膜受体蛋白2(FZD2)在小鼠舌鳞癌中的功能,及其对细胞毒性T淋巴细胞相关抗原4(CTLA4)单抗治疗的影响。方法细胞实验:SCCVII小鼠舌鳞癌细胞分为空白对照组(转染LV-kdCon)和实验组(转染LV-kdFZD2)。用细胞计数试剂盒-8(CCK-8... 详细信息

目的探讨卷曲跨膜受体蛋白2(FZD2)在小鼠舌鳞癌中的功能,及其对细胞毒性T淋巴细胞相关抗原4(CTLA4)单抗治疗的影响。方法细胞实验:SCCVII小鼠舌鳞癌细胞分为空白对照组(转染LV-kdCon)和实验组(转染LV-kdFZD2)。用细胞计数试剂盒-8(CCK-8)检测细胞增殖能力,用Transwell小室实验检测迁移能力,用人脐静脉内皮细胞验证血管生成能力。动物实验:雌性C3H/He小鼠构建荷瘤小鼠模型,分为对照组[给予磷酸盐缓冲液注射(PBS)]、kdFZD组(接种实验组细胞并给予等量PBS注射)、αCTLA4组(小鼠皮下接种空白对照组细胞并给予CTLA4单抗注射)和kdFZD+αCTLA组(小鼠皮下接种实验组细胞并给予CTLA4单抗注射)。用定量聚合酶链反应检测肿瘤组织mRNA相对表达水平,测量肿瘤体积和质量。结果空白对照组和实验组细胞中FZD2 mRNA相对表达水平分别为1.01±0.18和0.52±0.18,细胞迁移数为(466.70±44.10)和(160.00±26.46)个,人脐静脉内皮上皮细胞形成的小管分支节点数分别为(108.70±6.35)和(84.33±10.02)个,总毛细血管长度分别为(20235±2229)和(16549±338)μm,组间比较,在统计学上差异均有统计学意义(P<0.05,P<0.01)。对照组、kdFZD组、αCTLA4组和kdFZD+αCTLA组肿瘤体积分别为(449.50±114.80)、(131.10±13.49)、(83.62±26.47)和(2.45±0.91)mm^(3),肿瘤质量分别为(0.78±0.11)、(0.22±0.06)、(0.13±0.02)和(0.03±0.01)g,组间比较,在统计学上差异均有统计学意义(P<0.001,P<0.0001)。结论FZD2可作为潜在的舌鳞癌治疗靶点,有望成为舌鳞癌辅助免疫治疗优化的关键分子。

关键词：卷曲跨膜受体蛋白2 细胞毒性T淋巴细胞相关抗原4 舌鳞状细胞癌免疫检查点肿瘤治疗

Editorial:Special issue on distributed computing and artificial intelligence

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Frontiers of Information Technology & Electronic Engineering 2016年第4期17卷 281-282页

作者： Juan M.CORCHADO li WEIGANG Javier BAJO Fei WU tian-cheng li University of Salamanca Spain University of Brasilia Brazil Polytechnic University of Madrid Spain Zhejiang University China

4:1!Google’s artificial intelligence(AI)program,Alpha Go,has won Go Master Lee Sedol in a best-of-five competition held in Korean March 9-15,*** by many as a landmark moment for AI,the outcome did not come as a surpr... 详细信息

关键词：人工智能分布式计算编辑计算机科学分布式环境智能算法优良组合蒙特卡洛

光谱卫星LPPT-25微电推进系统飞行试验工作性能评价

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真空 2024年第5期61卷 80-89页

作者：田立成王尚民陈昶文兰州空间技术物理研究所真空技术与物理重点实验室甘肃兰州730000

基于光谱卫星任务需求,兰州空间技术物理研究所开展了脉冲等离子体微电推进系统方案设计,以此完成25W级脉冲等离子体电推进系统飞行样机研制,并开展了地面各项测试,均满足需求。为了进一步验证该系统的空间环境适应性、与航天器的相互... 详细信息

基于光谱卫星任务需求,兰州空间技术物理研究所开展了脉冲等离子体微电推进系统方案设计,以此完成25W级脉冲等离子体电推进系统飞行样机研制,并开展了地面各项测试,均满足需求。为了进一步验证该系统的空间环境适应性、与航天器的相互兼容性、空间工作特性及空间飞行性能与地面数据的差异性,LPPT-25微电推进系统搭载长光卫星公司光谱星一号(GP-1)卫星开展了在轨飞行试验,对脉冲等离子体电推进系统在轨飞行试验结果进行了评价。结果表明:在整个飞行试验期间,脉冲等离子体电推进系统各项工作性能参数符合设计指标要求,电推进分系统工作正常,推力输出稳定,各遥测温度满足推进要求的控温范围;电推进推力标定为306.3μN,相比地面测试推力300μN,偏差在5%以内,体现了良好的天地一致性。

关键词： PPT推力器微电推进系统微小卫星姿态控制和轨道维持

Force-position collaborative optimization of rope-driven snake manipulator for capturing non-cooperative space targets

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Chinese Journal of Aeronautics 2024年第9期37卷 369-384页

作者： Xiaofeng li Jian tian cheng WEI Xibin CAO School of Astronautics Harbin Institute of TechnologyHarbin 150001China Beijing Instiuteof Spacecraft System Engineering China Academy of Space TechnolgyBeijing 100094Chia

With the rapid development of space activities,non-cooperative space targets increase swiftly,such as failed satellites and upper stages,threating normal spacecrafts *** there are some problems in the capture process,such as excessive collision and fast tumbling of targets,manipulator with redundant Degrees of Freedom(DOFs)can be used to improve the compliance and therefore solve these *** Rope-Driven Snake Manipulator(RDSM)is a combina-tion of hyper-redundant DOFs and better compliance,and therefore it is suitable for capturing *** this paper,a snake manipulator mechanism is designed,and the complete kinematic model and system dynamic model considering RDSM,target and contact is ***,to obtain the configuration of joint with hyper-redundant DOFs,an improved motion dexterity index is pro-posed as the joint motion optimization ***,the force-position collaborative optimization index is designed to adjust active stiffness,and the impedance control method based on the modified index is used to capture the space ***,the proposed force-position collaborative opti-mization method is verified by virtual prototype *** results demonstrate that based on the proposed method,the collision force is reduced by about 25%compared to normal impe-dance control,showing higher safety.

关键词： Capturing non-cooperative spacetargets Rope-driven snakemanipu-lator Force-position collaborative optimization Redundant degrees of free-dom Active stiffness adjustment

Recent progress of in situ/operando characterization techniques for electrocatalytic energy conversion reaction

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Chinese Chemical Letters 2024年第9期35卷 92-101页

作者： Zhao li Huimin Yang Wenjing cheng lin tian School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou 221018China University and College Key Lab of Natural Product Chemistry and Application in Xinjiang School of Chemistry and Environmental ScienceYili Normal UniversityYining 835000China

Catalysts can significantly promote the reaction dynamics and are therefore considered crucial components for achieving high electrochemical energy conversion ***,the active sites of the catalysts,particularly for nano-level and atomic-level catalysts commonly undergo reconstruction under practical ***,obtaining an in-depth and systematic understanding on the real active sites through in situ/operando characterization techniques is a prerequisite for establishing the structureperformance relationship and guiding the future design of more efficient ***,we summarize the recent progress of in situ/operando characterization techniques for identifying the nature of active sites of electrocatalysts when used in electrocatalytic energy conversion ***,our focus lies in the fundamental principles of various in situ/operando characterization techniques,with particular emphasis on their applications for electrocatalytic *** that,the challenges and perspective insights are also added in the final section to highlight the future direction of this important field.

关键词： In situ techniques Electrocatalysis Active sites Energy conversion

CO_(2)flooding in shale oil reservoir with radial borehole fracturing for CO_(2)storage and enhanced oil recovery

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Petroleum Science 2024年第1期21卷 519-534页

作者： Jia-cheng Dai tian-Yu Wang Jin-Tao Weng Kang-Jian tian li-Ying Zhu Gen-Sheng li State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China China National Oil and Gas Exploration and Development Company limited Beijing100034China

This study introduces a novel method integrating CO_(2)flooding with radial borehole fracturing for enhanced oil recovery and CO_(2)underground storage,a solution to the limited vertical stimulation reservoir volume in horizontal well fracturing.A numerical model is established to investigate the production rate,reservoir pressure field,and CO_(2)saturation distribution corresponding to changing time of CO_(2)flooding with radial borehole fracturing.A sensitivity analysis on the influence of CO_(2)injection location,layer spacing,pressure difference,borehole number,and hydraulic fractures on oil production and CO_(2)storage is *** CO_(2)flooding process is divided into four *** in layer spacing will significantly improve oil production rate and gas storage ***,serious gas channeling can occur when the spacing is lower than 20 *** the pressure difference between the producer and injector,the borehole number,the hydraulic fracture height,and the fracture width can also increase the oil production rate and gas storage *** analysis shows that layer spacing and fracture height greatly influence gas storage and oil *** outcomes are expected to provide a theoretical basis for the efficient development of shale oil reservoirs in the vertical direction.

关键词： Shale oil Radial borehole fracturing Embedded discrete fracture model Enhanced oil recovery Carbon storage

The effects of various factors on spontaneous imbibition in tight oil reservoirs

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Petroleum Science 2024年第1期21卷 315-326页

作者： cheng liu tian-Ru Wang Qing You Yue-Chun Du Guang Zhao Cai-li Dai School of Energy Resources China University of GeosciencesBeijing100083PR China School of Petroleum Engineering China University of PetroleumQingdao266580ShandongPR China

Slickwater fracturing fluids have gained widespread application in the development of tight oil reservoirs. After the fracturing process, the active components present in slickwater can directly induce spontaneous imbibition within the reservoir. Several variables influence the eventual recovery rate within this procedure, including slickwater composition, formation temperature, degree of reservoir fracture development, and the reservoir characteristics. Nonetheless, the underlying mechanisms governing these influences remain relatively understudied. In this investigation, using the Chang-7 block of the Changqing Oilfield as the study site, we employ EM-30 slickwater fracturing fluid to explore the effects of the drag-reducing agent concentration, imbibition temperature, core permeability, and core fracture development on spontaneous imbibition. An elevated drag-reducing agent concentration is observed to diminish the degree of medium and small pore utilization. Furthermore, higher temperatures and an augmented permeability enhance the fluid flow properties, thereby contributing to an increased utilization rate across all pore sizes. Reduced fracture development results in a lower fluid utilization across diverse pore types. This study deepens our understanding of the pivotal factors affecting spontaneous imbibition in tight reservoirs following fracturing. The findings act as theoretical, technical, and scientific foundations for optimizing fracturing strategies in tight oil reservoir transformations.

关键词： Tight oil reservoir Spontaneous imbibition Nuclear magnetic resonance Slickwater fracturing fluid Fluid utilization degree