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Use of Evidence-Based Research Approach in RCTs of Acupuncture-Related Therapies for Primary Dysmenorrhea: A Meta-Research

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Chinese Journal of Integrative Medicine 2024年第6期30卷 551-558页

作者： HU Xiao-yi tian Zi-yu CHEN Huan HU Xiang-yu MING tian-yu PENG Hao-xuan jiao Rui-min SHI Lan-jun XIU Wen-cui YANG Ji-wei GANG Wei-juan JING Xiang-hong Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijingChina Department of Traditional Chinese Medicine Beijing Puren HospitalBeijing100062China

Objective To assess the use of evidence-based research(EBR)approach in randomized controlled trials(RCTs)of acupuncture-related therapies for primary dysmenorrhea(PD).Methods PubMed,EMBASE,Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,Chinese Biomedical Database,and China Science and Technology Journal Database were searched from January 2013 to December 2022 for RCTs of acupuncture on *** full text and references of each RCT were read to assess whether systematic reviews(SRs)or other types of studies with similar research questions and end-users’perspectives were cited to justify and design the *** addition,the discussion section were analyzed to evaluate whether trials placed the new result in the existing SRs to draw a *** logistic regression was used to find variables that associated with 3 aspects of EBR approach:(1)citing clinical studies for justification,(2)citing relevant studies that obtain the perspectives of end users,and(3)citing clinical studies for results *** Of 473 RCTs included,45.67%(216)of the trials cited relevant similar studies,21.56%(102)referenced to the studies that collected end-users’perspectives,and 10.99%(52)placed result in the context of the previous *** RCTs appropriately applied EBR *** all the included studies,3.17%(15)of the trials used SRs to inform study questions but none of them used updated SRs with acceptable quality;1.05%(5)of the trials cited SRs of end-user’s perspectives in the justification and design of the study,and only 1 trial added results in existing SR to draw a *** of publication,language,funding,registration,ethical approval and number of sites were significantly associated with 1 of the 3 aspects of EBR *** Few RCTs in acupuncture-related therapies for PD used the EBR approach to minimize research ***,research institutes,funding agencies,ethics committees,journals and peer

关键词： evidence-based research acupuncture therapy primary dysmenorrhea randomized controlled trial systematic review end-usersperspective meta-research

A review on DFACS(I):System design and dynamics modeling

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Chinese Journal of Aeronautics 2024年第5期37卷 92-119页

作者： Bohan jiao Qifan LIU Zhaohui DANG Xiaokui YUE Yonghe ZHANG Yuanqing XIA Li DUAN Qinglei HU Chenglei YUE Pengcheng WANG Ming GUO Zhansheng DUAN Bing CUI Chu ZHANG Xiaodong shao School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 710699China School of Automation Beijing Institute of TechnologyBeijing 100081China Institute of Mechanics Chinese Academy of SciencesBeijing 710043China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Automation Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

The Drag-Free and Attitude Control System(DFACS)is a critical platform for various space missions,including high precision satellite navigation,geoscience and gravity field measurement,and space scientific *** paper presents a comprehensive review of over sixty years of research on the design and dynamics model of ***,we examine the open literature on DFACS and its applications in Drag-Free missions,providing readers with necessary background information on the ***,we analyze the system configurations and main characteristics of different DFACSs,paying particular attention to the coupling mechanism between the system configuration and dynamics ***,we summarize the dynamics modeling methods and main dynamics models of DFACS from multiple perspectives,including common fundamentals and specific ***,we identify current challenges and technological difficulties in the system design and dynamics modeling of DFACS,while suggesting potential avenues for future *** paper aims to provide readers with a comprehensive understanding of the state-of-the-art in DFACS research,as well as the future prospects and challenges in this field.

关键词： Drag-Free DFACS System Design Dynamics Modeling Control design

Knowledge Distillation via Hierarchical Matching for Small Object Detection

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Journal of Computer Science & Technology 2024年第4期39卷 798-810页

作者： Yong-Chi Ma Xiao Ma tian-Ran Hao Li-Sha Cui shao-Hui Jin Pei Lyu School of Computer Science and Artificial Intelligence Zhengzhou UniversityZhengzhou 450000China

Knowledge distillation is often used for model compression and has achieved a great breakthrough in image classification,but there still remains scope for improvement in object detection,especially for knowledge extraction of small *** main problem is the features of small objects are often polluted by background noise and not prominent due to down-sampling of convolutional neural network(CNN),resulting in the insufficient refinement of small object features during *** this paper,we propose Hierarchical Matching Knowledge Distillation Network(HMKD)that operates on the pyramid level P2 to pyramid level P4 of the feature pyramid network(FPN),aiming to intervene on small object features before *** employ an encoder-decoder network to encapsulate low-resolution,highly semantic information,akin to eliciting insights from profound strata within a teacher network,and then match the encapsulated information with high-resolution feature values of small objects from shallow layers as the *** this period,we use an attention mechanism to measure the relevance of the inquiry to the feature *** in the process of decoding,knowledge is distilled to the *** addition,we introduce a supplementary distillation module to mitigate the effects of background *** show that our method achieves excellent improvements for both one-stage and twostage object ***,applying the proposed method on Faster R-CNN achieves 41.7%mAP on COCO2017(ResNet50 as the backbone),which is 3.8%higher than that of the baseline.

关键词： knowledge distillation object detection small object detection machine learning

Interfacial molecular screening of polyimide dielectric towards high-performance organic field-effect transistors

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Chinese Chemical Letters 2024年第2期35卷 268-271页

作者： Yingshuang Zheng Huchao Li Ting Jiang Fei jiao Jie Li Yong Lei Guofeng tian Jinshun Bi Yundong Xuan Liqiang Li Deyang Ji Wenping Hu Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic SciencesInstitute of Molecular Aggregation ScienceTianjin UniversityTianjin 300072China GPL Photonics Laboratory State Key Laboratory of Applied OpticsChangchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic SciencesSchool of ScienceCollaborative Innovation Center of Chemical Science and EngineeringTianjin UniversityTianjin 300072China Joint School of National University of Singapore and tianjin University Fuzhou 350207China Fachgebiet Angewandte Nanophysik Institut für Physik & IMN MacroNanoTechnische Universität IlmenauIlmenau 98693Germany State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100101China

The compatibility of the gate dielectrics with semiconductors is vital for constructing efficient conducting channel for high charge ***,it is still a highly challenging mission to clearly clarify the relationship between the dielectric layers and the chemical structure of semiconductors,especially vacuum-deposited small ***,interfacial molecular screening of polyimide(Kapton)dielectric in organic field-effect transistors(OFETs)is comprehensively *** is found that the semiconducting small molecules with alkyl side chains prefer to form a high-quality charge transport layer on polyimide(PI)dielectrics compared with the molecules without alkyl side *** this basis,the fabricated transistors could reach the mobility of 1.2 cm^(2) V^(−1)s^(−1) the molecule with alkyl side chains on bare PI *** is more,the compatible semiconductor and dielectric would further produce a low activation energy(E_(A))of 3.01 meV towards efficient charge transport even at low temperature(e.g.,100 K,0.9 cm^(2) V^(−1)s^(−1)).Our research provides a guiding scheme for the construction of high-performance thin-film field-effect transistors based on PI dielectric layer at room and low temperatures.

关键词： Interfacial molecular screening Polyimide dielectrics Organic semiconductors Interface engineering Thin-film transistors

Trametinib boosts palbociclib’s efficacy in breast cancer via autophagy inhibition

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Oncology Research 2024年第7期32卷 1197-1207页

作者： ANGUO WU jiao YAN TING SU CHI FENG XIN LONG YIRU PAN RUPEI YE tian XIA HANAN LONG JIANMING WU XIULI XIAO Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaKey Laboratory of Medical Electrophysiology of Ministry of EducationSchool of PharmacySouthwest Medical UniversityLuzhou646000China The Department of Pathology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China The Department of Pathology Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang621000China The Department of Pathology Yongchuan Hospital of Chongqing Medical UniversityChongqing402160China School of Basic Medical Sciences Southwest Medical UniversityLuzhou646000China School of Clinical Medical Sciences Southwest Medical UniversityLuzhou646000China

Breast cancer,a predominant global health issue,requires ongoing exploration of new therapeutic ***(PAL),a well-known cyclin-dependent kinase(CDK)inhibitor,plays a critical role in breast cancer *** its efﬁcacy is recognized,the interplay between PAL and cellular autophagy,particularly in the context of the RAF/MEK/ERK signaling pathway,remains insufﬁciently *** study investigates PAL’s inhibitory effects on breast cancer using both in vitro(MCF7 and MDA-MB-468 cells)and in vivo(tumor-bearing nude mice)*** at elucidating the impact of PAL on autophagic processes and exploring the potential of combining it with trametinib(TRA),an MEK inhibitor,our research seeks to address the challenge of PAL-induced drug ***ﬁndings reveal that PAL signiﬁcantly decreases the viability of MCF7 and MDA-MB-468 cells and reduces tumor size in mice while showing minimal cytotoxicity in MCF10A ***,PAL also induces protective autophagy,potentially leading to drug resistance via the RAF/MEK/ERK pathway *** TRA effectively neutralized this autophagy,enhancing PAL’s anti-tumor efﬁcacy.A combination of PAL and TRA synergistically reduced cell viability and proliferation,and in vivo studies showed notable tumor size *** conclusion,the PAL and TRA combination emerges as a promising strategy for overcoming PAL-induced resistance,offering a new horizon in breast cancer treatment.

关键词： Palbociclib Trametinib Protective autophagy RAF/MEK/ERK MCF7 MDA-MB-468

Preparation of(Lu,Y)_(3)(Al,Sc,Cr)_(2)Al_(3)O_(12)phosphor ceramics with high thermal stability for near-infrared LED/LD

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Journal of Advanced Ceramics 2024年第3期13卷 354-363页

作者： Yuelong Ma Xingcan Li Lan Wu Chenyang shao Boqiang Zhang Tao Pang Lili Lu Hui Qiu Ye tian Guilu Wang Yanbo Hui Qianwen Guo Daqin Chen School of Mechanical and Electrical Engineering Henan University of TechnologyZhengzhou 450001China Huzhou Key Laboratory of Materials for Energy Conversion and Storage College of ScienceHuzhou UniversityHuzhou 313000China College of Physics and Energy Fujian Normal UniversityFuzhou 350117China SongShan Laboratory Zhengzhou 450046China College of Food Science and Engineering Henan University of TechnologyZhengzhou 450046China School of Mechanical Engineering Zhengzhou University of Science and TechnologyZhengzhou 450064China

Near-infrared(NIR)phosphor-converted light-emitting diodes/laser diodes(LEDs/LDs)are prospective lighting sources for NIR ***,developing NIR phosphor materials with desired thermal robustness and high photoelectric efficiency is a crucial challenge for their *** this work,based on the cationic radius matching effect,a series of(Lu,Y)_(3)(Al,Sc,Cr)_(2)Al_(3)O_(12)NIR phosphor ceramics(LuYScCr NIR-PCs)were fabricated by vacuum *** thermal stability(95%@150℃)was obtained in the prepared NIR-PCs,owing to their weak electron-phonon coupling effect(small Huang-Rhys factor).Being excited at 460 nm,NIR-PCs realized a broadband emission(650-850 nm)with internal quantum efficiency(IQE)of 60.68%.Combining NIR-PCs with LED/LD chips,the maximum output power of the encapsulated LED prototype was 447 mW@300 mA with photoelectric efficiency of as high as 18.6%@180 mA,and the maximum output power of the LD prototype was 814 mW@2.5 *** working temperatures of NIR-PCs were 70.8℃@300 mA(LED)and 102.8℃@3 A(LD).Finally,the prepared NIR-PCs applied in food detection were verified in this study,demonstrating their anticipated application prospects in the future.

关键词： thermal stability electron phonon coupling effect photoelectric efficiency near-infrared phosphor ceramics(NIR-PCs) NIR light-emitting diode/laser diode(LED/LD)prototype

LOL: a highly flexible framework for designing stream ciphers

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Science China(Information Sciences) 2024年第09期67卷 62-75页

作者： Dengguo FENG Lin jiao Yonglin HAO Qunxiong ZHENG Wenling WU Wenfeng QI Lei ZHANG Liting ZHANG Siwei SUN tian tian State Key Laboratory of Cryptology PLA Strategic Support Force Information Engineering University Institute of Software Chinese Academy of Sciences Westone Cryptologic Research Center School of Cryptology University of Chinese Academy of Sciences

In this paper, we propose LOL, a general framework for designing blockwise stream ciphers. The proposed framework achieves ultrafast software implementations for ubiquitous virtual networks in 5G/6G environments and high-security levels for post-quantum cryptography. The LOL framework is structurally strong; furthermore, this framework and all its components enjoy high flexibility with various extensions. On the basis of the LOL framework, we propose new stream-cipher designs called LOL-MINI and LOL-DOUBLE with the support of the AES-NI and single instruction multiple data instructions. The former applies the basic LOL single mode, while the latter uses the extended parallel-dual mode. LOL-MINI and LOL-DOUBLE support 256-bit key length. Our thorough evaluations revealed that these cipher designs have 256-bit security margins against all existing cryptanalysis methods, including differential, linear, and integral. The software performances of LOL-MINI and LOL-DOUBLE can reach 89 and 135 Gbps. In addition to pure encryptions,the LOL-MINI and LOL-DOUBLE stream ciphers can be applied in a stream-cipher-then-MAC strategy to make AEAD schemes.

关键词： stream cipher 5G/6G mobile system fast software implementation

Hepatic arterial infusion chemotherapy with anti-angiogenesis agents and immune checkpoint inhibitors for unresectable hepatocellular carcinoma and meta-analysis

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World Journal of Gastroenterology 2024年第4期30卷 318-331页

作者： Yu-Zhe Cao Guang-Lei Zheng tian-Qi Zhang Hong-Yan shao Jia-Yu Pan Zi-Lin Huang Meng-Xuan Zuo Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy State Key Laboratory of Oncology in South ChinaGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy Guangdong Provincial Clinical Research Center for CancerGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Hepatic arterial infusion chemotherapy(HAIC)has been proven to be an ideal choice for treating unresectable hepatocellular carcinoma(uHCC).HAIC-based treatment showed great potential for treating ***,large-scale studies on HAIC-based treatments and meta-analyses of first-line treatments for uHCC are *** To investigate better first-line treatment options for uHCC and to assess the safety and efficacy of HAIC combined with angiogenesis inhibitors,programmed cell death of protein 1(PD-1)and its ligand(PD-L1)blockers(triple therapy)under real-world *** Several electronic databases were searched to identify eligible randomized controlled trials for this ***-level pooled analyses of hazard ratios(HRs)and odds ratios(ORs)were *** was a retrospective single-center study involving 442 patients with uHCC who received triple therapy or angiogenesis inhibitors plus PD-1/PD-L1 blockades(AIPB)at Sun Yat-sen University Cancer Center from January 2018 to April *** score matching(PSM)was performed to balance the bias between the *** Kaplan-Meier method and cox regression were used to analyse the survival data,and the log-rank test was used to compare the suvival time between the *** A total of 13 randomized controlled trials were *** alone and in combination with sorafenib were found to be effective treatments(P values for ORs:HAIC,0.95;for HRs:HAIC+sorafenib,0.04).After PSM,176 HCC patients were included in the *** triple therapy group(n=88)had a longer median overall survival than the AIPB group(n=88)(31.6 months vs 14.6 months,P<0.001)and a greater incidence of adverse events(94.3%vs 75.4%,P<0.001).CONCLUSION This meta-analysis suggests that HAIC-based treatments are likely to be the best choice for *** findings confirm that triple therapy is more effective for uHCC patients than AIPB.

关键词： Unresectable hepatocellular carcinoma Hepatic arterial infusion chemotherapy Angiogenesis inhibitors Programmed cell death protein 1 Programmed death ligand 1

Anion-induced differential assembly and structural transformation of supramolecular coordination cages

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Chinese Chemical Letters 2024年第3期35卷 268-272页

作者： shao-Ping Zheng Yao-Wei Xu Pei-Yang Su Chen-Hui Liu Yin-Hui Huang Yu-Lin Lu Zhang-Wen Wei Zhiwei jiao Hai-Sen Xu Cheng-Yong Su MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-sen UniversityGuangzhou 510006China Institute of Environmental Research at Greater Bay Area Guangzhou UniversityGuangzhou 510006China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

The intimate host-anion interactions will regulate thermodynamics and kinetics in the self-assembly of cationic cages mimicking biological ***,we report construction and transformation of three Pd(Ⅱ)-based metal-organic cages(MOCs)depending on different *** conversions of the lantern-shaped MOC-34 into either octahedral MOC-35 or tricapped trigonal prism MOC-36 are induced by BF_(4)^(–)or NO_(3)^(–),***-36 is kinetically favored and can undergo quantitative conversion to the thermodynamically preferred MOC-35 upon heating,accelerated by excess BF_(4)^(–)to motivate dissociative dynamics of Pd-vertices and lower activation barrier of cage *** guest encapsulation behaviors of MOC-35 and MOC-36 have also been *** results manifest a significance of host-anion dynamics beyond complementary anion template,shedding light on the understanding of intricate anion recognition in nature.

关键词： Supramolecular coordination cage Dynamic host-anion interactions Structural transformation Anion receptor Guest inclusion