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Mechanical characteristics and reservoir stimulation mechanisms of the Gulong shale oil reservoirs, the northern Songliao Basin

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Petroleum Science 2024年第3期21卷 2023-2036页

作者： Si-Wei Meng Jia-Ping Tao tian-jiao li Dong-Xu li Su-ling Wang liu Yang Xin liu li-Hao liang He liu PetroChina Research Institute of Petroleum Exploration Development Beijing100083China National Key Laboratory of Continental Shale Oil Daqing 163002HeilongjiangChina Dalian University of Technology Dalian116024LiaoningChina PetroChina Daqing Oilfield Co.Ltd. Daqing163002HeilongjiangChina Northeast Petroleum University Daqing163002HeilongjiangChina China University of Mining and Technology(Beijing) Beijing100083China

Shale oil of the Qingshankou Formation of the Gulong Sag,the northern Songliao Basin,represents the first attempt at large-scale development of pure-shale-type shale oil in *** integrating the multiscale refined reservoir characterization with macro-micro-scale mechanical testing,it is clarified that the Gulong shale is characterized by high clay mineral content,high rock plasticity,highly-developed bedding,and prominent mechanical anisotropy.A three-dimensional(3D)fracture propagation model of hydraulic fracturing was built for the Gulong shale,which fully captures the hydraulic fracture distribution pattern affected by the high bedding density,in-situ stress,and fracturing treatment *** research showed that due to influences of bedding,hydraulic fracturing in the Gulong shale forms a complex fracture morphology featuring the main fracture with multiple perpendicular branches that have different lengths(like the outdoor directional TV antenna);however,the vertical propagation of fractures is inhibited,and the fracture height is commonly less than 10 *** limited stimulated reservoir volume(SRV)is the main problem facing the fracturing stimulation of the Gulong shale *** density has vital effects on fracture morphology,so case-specific fracturing designs shall be developed for shale intervals with different bedding development *** reservoirs with welldeveloped bedding,it is suggested to properly increase the perforation cluster spacing and raise the volume and proportions of viscous fluids of the pad,so as to effectively promote vertical fracture propagation and improve reservoir stimulation *** study integrates multi-scale fine reservoir characterization and macro-micro-scale mechanical testing,as well as the construction and numerical simulation of hydraulic fracturing models for high-density layered shale reservoirs,providing a new approach and methodological framework for the fracturing research of high-density layer

关键词： Shale oil Hydraulic fracturing High bedding density Fracture propagation model

Tumor-infiltrating platelets predict postoperative recurrence and survival in resectable pancreatic neuroendocrine tumor

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World Journal of Gastroenterology 2019年第41期25卷 6248-6257页

作者： Shuai-Shuai Xu Hua-Xiang Xu Wen-Quan Wang Shuo li Hao li tian-jiao li Wu-Hu Zhang liang liu Xian-Jun Yu Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 20032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai Pancreatic Cancer Institute Shanghai 200032China Pancreatic Cancer Institute Fudan UniversityShanghai 200032China

BACKGROUND Platelets have been reported to participate in tumor cell growth,extravasation,epithelial–mesenchymal transition,metastasis,and drug ***,the importance of platelets in pancreatic neuroendocrine tumor(pNET)lacks adequate literature *** predictive value of tumor-infiltrating platelets(TIPs)in pNET remains *** To investigate the relationship between TIPs and the prognosis of patients with pNET following radical *** In total,113 patients who had undergone radical surgical resection with a pathologic diagnosis of pNET were enrolled in this *** analysis of cluster of differentiation 42b(CD42b)expression in the tumor specimens was performed to determine the presence of *** and multivariate analyses were used to analyze the prognostic value of *** TIPs were observed in intratumoral areas in 54 *** basic characteristics nor preoperative platelet-associated indicators showed a significant relationship with the presence of TIPs(all P>0.05).Patients with positive intratumoral CD42b expression had worse overall survival(P=0.005)and recurrence-free survival(P0.05).CONCLUSION TIPs are a useful prognostic biomarker for patients with resectable pNET,and their detection represents a promising tool for pNET treatment strategy decisions.

关键词： Tumor-infiltrating platelets Pancreatic neuroendocrine tumor Survival Recurrence Platelet count Mean platelet volume Platelet-to-lymphocyte ratio

Sclerostin regulation:a promising therapy for periodontitis by modulating alveolar bone

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Chinese Medical Journal 2020年第12期133卷 1456-1461页

作者： tian-jiao li Rui Wang Qin-Yang li Chun-Yu li li Jiang State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China

Periodontitis is one of the most prevalent epidemics affecting human health and life recently,and exploration of the pathogenesis and treatment of periodontitis has been valued by *** recent years,sclerostin,a new factor on bone resorption and reconstruction caused by inflammation and mechanical stimulation,has been a research *** article summarizes the researches on sclerostin in periodontitis development in recent *** them,sclerostin has been shown to be a critical negative regulator of bone formation,thereby inhibiting bone remodeling in periodontitis development,and is closely associated with tooth ***,evidence indicates that the removal of sclerostin seems to reasonably protect the alveolar bone from *** of sclerostin expression is a novel,promising treatment for periodontitis and addresses several complications seen with traditional therapies;accordingly,many drugs with similar mechanisms have ***,the application prospect of sclerostin in periodontal therapy combined with orthodontic treatment is another promising *** are also a lot of drugs that regulate ***-sclerostin antibody(Scl-Ab)is the most direct one that inhibits bone resorption caused by *** present,drugs that inhibit the expression of sclerostin have been applied to the treatment of diseases such as multiple myeloma and ***,the application of sclerostin in the oral field is just around the corner,which provides a new therapeutic bone regulation strategy in oral and general health.

关键词： Sclerostin Periodontitis Orthodontics Tooth movement Mechanical forces Adjunctive therapy

Haemoglobin,albumin,lymphocyte and platelet predicts postoperative survival in pancreatic cancer

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World Journal of Gastroenterology 2020年第8期26卷 828-838页

作者： Shuai-Shuai Xu Shuo li Hua-Xiang Xu Hao li Chun-Tao Wu Wen-Quan Wang He-li Gao Wang Jiang Wu-Hu Zhang tian-jiao li Quan-Xing Ni liang liu Xian-Jun Yu Department of Pancreatic Surgery Fudan UniversityShanghai Cancer CenterShanghai 20032China Pancreatic Cancer Institute Fudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

BACKGROUND Systemic inflammation and nutrition status play an important role in cancer *** combined index of hemoglobin,albumin,lymphocyte,and platelet(HALP),consisting of haemoglobin,albumin,lymphocytes,and platelets,is considered as a novel marker to reflect both systemic inflammation and nutrition ***,no studies have investigated the relationship between HALP and survival of patients with pancreatic cancer following radical *** To evaluate the prognostic value of preoperative HALP in pancreatic cancer *** The preoperative serum levels of hemoglobin,albumin,lymphocyte counts,and platelet counts were routinely detected in 582 pancreatic adenocarcinoma patients who underwent radical *** relationship between postoperative survival and the preoperative level of HALP was *** Low levels of HALP were significantly associated with lymph node metastasis(P=0.002),poor tumor differentiation(P=0.032),high TNM stage(P=0.008),female patients(P=0.005)and tumor location in the head of the pancreas(P<0.001).Low levels of HALP were associated with early recurrence[7.3 mo vs 16.3 mo,P<0.001 for recurrence-free survival(RFS)]and short survival[11.5 mo vs 23.6 mo,P<0.001 for overall survival(OS)]in patients with resected pancreatic adenocarcinoma.A low level of HALP was an independent risk factor for early recurrence and short survival irrespective of sex and tumor *** Low levels of HALP may be a significant risk factor for RFS and OS in patients with resected pancreatic cancer.

关键词： Pancreatic adenocarcinoma HALP Systemic inflammation Nutrition status Postoperative survival

Possible mechanisms associated with immune escape and apoptosis on anti-hepatocellular carcinoma effect of Mu Ji Fang granules

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World Journal of Gastrointestinal Oncology 2023年第3期15卷 504-522页

作者： Yi-Bing Zhang Yong-Rui Bao Shuai Wang tian-jiao li He Tai Jia-Peng Leng Xin-Xin Yang Bo-Cai Wang Xian-Sheng Meng College of Pharmacy Liaoning University of Traditional Chinese MedicineDalian 116600Liaoning ProvinceChina Department of Clinical Trail Institution Office Dalian Municipal Central HospitalDalian 116033Liaoning ProvinceChina Technical Innovation Center of Multidimensional Analysis of Traditional Chinese Medicine of liaoning Province Dalian 116600Liaoning ProvinceChina Engineering Laboratory of Modern Chinese Medicine Research of liaoning Province Dalian 116600Liaoning ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common digestive system cancers with high mortality rates *** main ingredients in Mu Ji Fang Granules(MJF)are alkaloids,flavonoids,and *** has been used in the clinical treatment of hepatitis,cirrhosis and HCC for more than 30 *** previous studies have focused on the mechanism of MJF on tumor immunology in the treatment of *** To explore the mechanism of action of MJF on tumor immunology in the treatment of *** The absorbable ingredients of MJF were identified using Molecule Network related to High Performance liquid Chromatography-Electron Spray Ionization-Time of Flight-Mass Spectrometry,and hub potential anti-HCC targets were screened using network pharmacology and pathway enrichment *** male mice were randomly divided into the Blank,Model,and MJF groups(1.8,5.4,and 10.8 g/kg/d)following 7 d of oral *** body weight gain,spleen and thymus indices were calculated,tumor tissues were stained with hematoxylin and eosin,and Interferon gamma(IFN-γ),Tumor necrosis factorα(TNF-α),Interleukin-2,aspartate aminotransferase,alanine aminotransferase,alpha-fetoprotein(AFP),Fas,and FasL were measured by Enzyme-linked Immunosorbent *** mRNA expression of Bax and Bcl2 was evaluated by Real Time Quantitative PCR(RTqPCR)and protein expression of Transforming growth factorβ1(TGF-β1)and Mothers against decapentaplegic homolog(SMAD)4 was assessed by Western *** HepG2 cell line was treated with 10 mg/mL,20 mg/mL,30 mg/mL,40 mg/mL of MJF,and another 3 groups were treated with TGF-β1 inhibitor(LY364947)and different doses of *** mRNA expression of TNF-α,IFN-γ,Bax and Bcl2 was evaluated by RT-qPCR and protein expression of TGF-β1,SMAD2,p-SMAD2,SMAD4,and SMAD7 was assessed by Western *** It was shown that MJF improved body weight gain and tumor inhibition rate in H22 tumorbearing mice,protected immune organs and liver

关键词： Mu Ji Fang granules Hepatocellular carcinoma Transforming growth factorβ1/Mothers against decapentaplegic homolog Immune escape H22 tumor-bearing mice HepG2 cells

Dynamic transcriptional atlas of male germ cells during porcine puberty

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Zoological Research 2022年第4期43卷 600-603页

作者： ling-Kai Zhang Hai-Dong Ma Ming Guo ling Wang Yi Zheng Xiao-Dong Wu tian-jiao li Hong-Zhao Lu Wen-Xian Zeng Tao Zhang School of Biological Science and Engineering Shaanxi University of TechnologyHanzhongShaanxi 723001China College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100China

DEAR EDITOR,Spermatogenesis is the process by which male gametes are formed from spermatogonial stem cells(SSCs)and it is essential for the reliable transmission of genetic information between *** birth,prospermatogonia(ProSG)give rise to *** mouse spermatogenesis is relatively well studied,we are only just beginning to unravel this process in larger ***,we analyzed key developmental transitions and differentiation trajectories by profiling neonatal,juvenile,and adult testes through single-cell sequencing(scRNA-seq).We found that SSCs were established at 30 days old,and that CDH1 was a novel cell surface marker for porcine ProSG and undifferentiated spermatogonia.

关键词： neonatal Dynamic birth

Dust-Induced Regulation of Thermal Radiation in Water Droplets

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Chinese Physics Letters 2023年第5期40卷 52-57页

作者：张传新李天骄须留钧黄吉平 Department of Physics State Key Laboratory of Surface Physicsand Key Laboratory of Micro and Nano Photonic Structures(MOE)Fudan UniversityShanghai 200438China MIIT Key Laboratory of Thermal Control of Electronic Equipment School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing 210094China Graduate School of China Academy of Engineering Physics Beijing 100193China

Accurate and fast prediction of thermal radiation properties of materials is crucial for their potential ***,some models assume that the media are made up of pure water droplets,which do not account for the increasing deviations caused by volcanic eruptions,pollution,and human activities that exacerbate dust *** distinct radiation properties of water and dust particles make it challenging to determine the thermal radiation properties of water droplets containing dust *** address this issue,we investigate the influence of dust particles on light transmission and energy distribution in water droplets using the multiple sphere T-matrix *** considering different droplet and dust diameters,volume fractions,and position distributions,we analyze how extinction regulation is achieved in dust-containing water *** results reveal the significant role of dust particles in the thermal radiation effect and provide insights into the electromagnetic properties of colloidal ***,the dust-induced reestablishment of energy balance raises concerns about environmental management and climate *** research highlights the importance of accounting for dust particles in atmospheric models and their potential impact on radiative balance.

关键词： thermal diameters extinction

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货币政策透明度对通胀预期偏差影响的研究

当代财经 2018年第5期 47-58页

作者：谭天骄李亘中国财政科学研究院研究生院北京100142

通过放松理性预期假设,引入有偏性预期构建一个非完美预期模型,采用SVAR方法考察货币政策透明度结构冲击对预期偏差波动的影响在两种货币政策操作框架下是否存在一致性,得出结论:提高货币政策透明度是否有利于降低预期偏差与实际通胀率... 详细信息

通过放松理性预期假设,引入有偏性预期构建一个非完美预期模型,采用SVAR方法考察货币政策透明度结构冲击对预期偏差波动的影响在两种货币政策操作框架下是否存在一致性,得出结论:提高货币政策透明度是否有利于降低预期偏差与实际通胀率偏离均衡通胀率的程度有关。同时,价格型货币政策框架下提高货币政策透明度更能有效锚定通胀预期,降低通胀预期偏差;数量型货币政策框架下通胀预期偏差对政策工具反应呈现较小的粘性,且货币供给量对通胀预期偏差的影响要强于价格型货币政策框架。为此,若要引导公众预期与政策形成合力,应在使用价格型工具时强化货币政策透明度;若要发挥政策工具的逆周期调节作用,应在使用数量型工具时弱化货币政策透明度。

关键词：货币政策工具货币政策透明度通胀预期偏差 SVAR模型

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan jiao lingyan Meng Kang Du Xuezhi li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein