检索结果-南通市图书馆

刃针结合电针治疗对膝关节骨关节炎患者膝关节功能的影响

在线全文

学校读者我要写书评

暂无评论

针刺研究 2024年第4期49卷 398-402页

作者：马洁褚晓彦刘伙生孙吉雅詹红生徐建德何天峰丁金磊周丽艳段希栋王茜邴兴红陶善平上海市嘉定区中医医院针灸科上海201800

目的:比较刃针结合电针与单纯电针治疗膝关节骨关节炎(KOA)的临床疗效及对膝关节功能的影响。方法:将68例KOA患者运用随机数字表法随机分为两组,分别为刃针组34例和电针组34例。其中刃针组采用刃针结合电针治疗,电针组采用单纯电针治疗... 详细信息

目的:比较刃针结合电针与单纯电针治疗膝关节骨关节炎(KOA)的临床疗效及对膝关节功能的影响。方法:将68例KOA患者运用随机数字表法随机分为两组,分别为刃针组34例和电针组34例。其中刃针组采用刃针结合电针治疗,电针组采用单纯电针治疗,两组电针治疗均隔日1次,每周治疗3次,共治疗4周;刃针组在电针基础上增加刃针治疗,每周治疗1次,共治疗4周。治疗前、治疗后、治疗后1个月、治疗后3个月进行计时起立-步行测验(TUG)、9台阶-楼梯攀登测试(9-SCT)、膝关节功能[西安大略和麦马斯特大学骨关节炎指数可视化量表(WOMAC)]评分。结果:通过意向性分析,与治疗前比较,两组患者治疗后、随访1个月和随访3个月时的TUG结果、9-SCT结果、WOMAC评分均显著降低(P<0.05);与同时间点电针组相比,刃针组治疗后和随访1个月时的TUG结果显著降低,刃针组治疗后的WOMAC评分显著降低(P<0.05);与本组治疗后比较,刃针组随访1个月时的WOMAC评分显著降低(P<0.05)。结论:两种治疗均能改善患者膝关节功能,但是刃针结合电针更能明显提高患者的步速,改善患者的关节疼痛、晨僵等不适症状。刃针结合电针治疗KOA安全有效,并且有较好的远期疗效。

关键词：膝关节骨关节炎刃针电针临床疗效关节功能

Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and Microvascular Diseases in the Chinese Population

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2022年第1期35卷 4-12页

作者： WANG Jia Lu CAO Qiu Yu XIN Zhuo Jun LIU Shan Shan xu Min WANG tian Ge LU Jie Li CHEN Yu Hong WANG Shuang Yuan ZHAO Zhi Yun xu Yu NING Guang WANG Wei Qing BI Yu Fang LI Mian Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Objective The association between neutrophil-to-lymphocyte ratio(NLR)with subclinical macrovascular and microvascular diseases has been less *** sought to examine the association between NLR and new-onset subclinical macrovascular and microvascular abnormalities in the Chinese *** From a community cohort,we included 6,430 adults aged≥40 years without subclinical macrovascular and microvascular diseases at *** measured subclinical macrovascular and microvascular abnormalities separately using the ankle-brachial index(ABI),brachial-ankle pulse wave velocity(baPWV),and *** During a mean follow-up of 4.3 years,110 participants developed incident abnormal ABI,746 participants developed incident elevated baPWV,and 503 participants developed incident *** regression analysis indicated that NLR was significantly associated with an increased risk of newonset abnormal ABI,elevated baPWV,and *** to overweight/obese participants,we found a much stronger association between NLR and subclinical vascular abnormalities in participants with normal ***,we found an interaction between the NLR and body mass index(BMI)on the risk of new-onset abnormal ABI(P for interaction:0.01).Conclusion NLR was associated with subclinical macrovascular and microvascular diseases in the Chinese ***,in participants with normal weight,the association between NLR and subclinical vascular abnormalities was much stronger.

关键词： Neutrophil-to-lymphocyte ratio Subclinical macrovascular and microvascular diseases Body mass index Prospective cohort study

黄牛源产气荚膜梭菌分离株基因组的生物信息学分析

在线全文

学校读者我要写书评

暂无评论

畜牧兽医学报 2024年第4期55卷 1707-1715页

作者：田睿徐思翔谢烽刘广锦王刚李庆霞代蕾谢国信张琼文陆亚警王光文王金秀张炜南京农业大学三亚研究院三亚572025 南京农业大学动物医学院南京210095 南京农业大学WOAH猪链球菌参考实验室南京210095 海南省动物疫病预防控制中心海口571100 昌江黎族自治县畜牧兽医技术服务中心昌江572799

本研究自猝死海南黄牛的组织器官中分离到2株A型产气荚膜梭菌,命名为ZWCP209和ZWCP210。基因组拼接结果显示其基因组大小处于3.4~3.5 Mb之间,tRNA和CDS数量稳定。多位点序列分析(MLST)显示,测序菌株属于同种新ST型。从NCBI数据库中获取2... 详细信息

本研究自猝死海南黄牛的组织器官中分离到2株A型产气荚膜梭菌,命名为ZWCP209和ZWCP210。基因组拼接结果显示其基因组大小处于3.4~3.5 Mb之间,tRNA和CDS数量稳定。多位点序列分析(MLST)显示,测序菌株属于同种新ST型。从NCBI数据库中获取27株牛源产气荚膜梭菌的基因组,与测序分离株共同进行生物信息学分析:共检测到13种耐药基因,其中四环素类耐药基因tetA(P)和tetB(P)的携带率最高(79.4%),值得关注的是,本研究中2株海南黄牛分离株均携带了7种以上的耐药基因,其中包括非兽用抗生素噁唑烷酮的耐药基因optrA。泛基因组分析结果显示以上菌株的基因组中共含有7 345个基因,核心基因数量占比22.94%;在核心基因组和plc基因的系统进化分析中,两海南黄牛分离株处于同一分支,并具有相同的毒力因子,具有极高的同源性。本研究为国内首次对海南黄牛产气荚膜梭菌进行全基因组序列测定与生物信息学分析,对牛产气荚膜梭菌病的防治与基因组研究具有参考价值。

关键词：海南黄牛产气荚膜梭菌分离鉴定全基因组测序生物信息学分析

Resequencing of 145 Landmark Cultivars Reveals Asymmetric Sub-genome Selection and Strong Founder Genotype Effects on Wheat Breeding in China

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2020年第12期13卷 1733-1751页

作者： Chenyang Hao Chengzhi Jiao Jian Hou tian Li Hongxia Liu Yuquan Wang Jun Zheng Hong Liu Zhihong Bi Fengfeng xu Jing Zhao Lin Ma Yamei Wang Uzma Majeed xu Liu Rudi Appels Marco Maccaferri Roberto Tuberosa Hongfeng Lu xueyong Zhang Key Laboratory of Crop Gene Resources and Germplasm Enhancement Ministry of Agriculture and Rural Affairs/The National Key Facility for Crop Gene Resources and Genetic Improvement/Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Novogene Bioinformatics Institute Beijing 100083China AgriBio Centre for AgriBioscienceDepartment of Economic DevelopmentJobsTransportand Resources5 Ring RoadLa Trobe UniversityBundooraVIC 3083Australia Department of Agricultural and Food Sciences University of BolognaBolognaItaly

Controlled pedigrees and the multi-decade timescale of national crop plant breeding programs offer a unique experimental context for examining how selection affects plant *** than 3000 wheat cultivars have been registered,released,and documented since 1949 in *** this study,a set of 145 elite cultivars selected from historical points of wheat breeding in China were re-sequenced.A total of 43.75 Tb of sequence data were generated with an average read depth of 17.94x for each cultivar,and more than 60.92 million SNPs and 2.54 million InDels were captured,based on the Chinese Spring RefSeq genome *** years of breeder-driven selection led to dramatic changes in grain yield and related phenotypes,with distinct genomic regions and phenotypes tar-geted by different breeders across the *** are very clear instances illustrating how introduced Italian and otherforeign germplasm was integrated into Chinese wheat programs and reshaped the genomic landscape of local modern ***,the resequencing data also highlighted significant asymmetric breeding selec-tion among the three sub-genomes:this was evident in both the collinear blocks for homeologous chromosomes and among sets of three homeologous *** of more newly assembled genes in newer cultivars implied the potential value of these genes in *** and extended sharing of linkage disequilibrium(LD)blocks was highlighted among pedigree-related cultivars,in which fewer haplotype differences were *** or replacement of haplotypes from founder genotypes after generations of breeding was related to their breeding *** on the haplotype frequency changes in LD blocks of pedigree-related cultivars,we propose a strategy for evaluating the breeding value of any given line on the basis of the accumulation(pyramiding)of bene-ficial ***,our study demonstrates the influence of "founder genotypes" on the output of breeding effort

关键词： wheat breeding asymmetric selection founder genotype haplotype block

槐花外泌体减轻低氧诱导的胃和小肠黏膜急性氧化应激损伤研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

胃肠病学和肝病学杂志 2024年第5期33卷 539-542页

作者：张恒王德智廖星晨张明杰王梦琪许俊锋王昕金鹏盛剑秋解放军医学院北京100853 中国人民解放军总医院第七医学中心消化内科中国人民解放军总医院第一医学中心消化内科医学部

目的分析槐花外泌体在低氧诱导的胃和小肠黏膜急性氧化应激损伤中的作用。方法通过超速离心法提取槐花外泌体并完成电镜和粒径鉴定,采用低压氧环境控制系统构建小鼠低氧急性胃肠损伤模型,在低氧第1天给予槐花外泌体灌胃,第3天安乐死小鼠... 详细信息

目的分析槐花外泌体在低氧诱导的胃和小肠黏膜急性氧化应激损伤中的作用。方法通过超速离心法提取槐花外泌体并完成电镜和粒径鉴定,采用低压氧环境控制系统构建小鼠低氧急性胃肠损伤模型,在低氧第1天给予槐花外泌体灌胃,第3天安乐死小鼠,收集消化道组织进行HE染色,收集胃和小肠黏膜进行ROS检测。期间记录小鼠的进食量、体质量、粪便性状和便血情况。结果口服槐花外泌体可改善低氧导致的小鼠血便、稀便和体质量下降,减轻低氧引起的胃和小肠黏膜损伤,降低ROS水平。结论口服槐花外泌体可有效缓解低氧引起的胃和小肠黏膜急性氧化应激损伤。

关键词：槐花外泌体低氧氧化应激胃小肠

The absolute paleoposition of the North China Block during the Middle Ordovician

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2016年第1期59卷 573-582页

作者： WANG Hong Hao LI Jiang Hai ZHANG Hua tian xu Li LI Wei Bo Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of Education School of Earth and Space SciencesPeking University

Present-day hot spots and Phanerozoic large igneous provinces(LIPs) and kimberlites mainly occur at the edges of the projections of Large Low Shear Wave Velocity Provinces(LLSVPs) on the earth's surface. If a plate contains accurately dated LIPs or kimberlites, it is possible to obtain the absolute paleoposition of the plate from the LIP/kimberlite and paleomagnetic data. The presence of Middle Ordovician kimberlites in the North China Block provides an opportunity to determine the absolute paleoposition of the block during the Middle Ordovician. In addition to paleobiogeographical information and the results of previous work on global plate reconstruction for the Ordovician Period, we selected published paleomagnetic data for the North China Block during the Middle Ordovician and determined the most reasonable absolute paleoposition of the North China Block during the Middle Ordovician: paleolatitude of approximately 16.6°S to 19.1°S and paleolongitude of approximately 10°W. The block was located between the Siberian Plate and Gondwana, close to the Siberian Plate. During the Cambrian and Ordovician periods, the North China Block may have moved toward the Siberian Plate and away from the Australian Plate.

关键词： North China Block Middle Ordovician Absolute paleoposition Plume Generation Zone

同方期刊数据库

9NiCrMoV钢淬火过程传热系数仿真分析与试验

在线全文

学校读者我要写书评

暂无评论

材料热处理学报 2022年第4期43卷 156-161,169页

作者：李亨田开国李健合肥工业大学航空结构件成形制造与装备安徽省重点实验室安徽合肥230009 北京钢铁研究总院船舶及海工用钢项目部北京100081

船用中厚钢板在淬火过程中因截面冷速差异极易造成表面至心部组织性能不均匀,导致心部韧性波动或不达标。要明确不同冷速对组织性能的影响以调控钢材的性能,冷速的定量化测定就极为重要。鉴于实际测量工业厚板淬火冷速难度很大,可通过... 详细信息

船用中厚钢板在淬火过程中因截面冷速差异极易造成表面至心部组织性能不均匀,导致心部韧性波动或不达标。要明确不同冷速对组织性能的影响以调控钢材的性能,冷速的定量化测定就极为重要。鉴于实际测量工业厚板淬火冷速难度很大,可通过实验室小样物理模拟9NiCrMoV船用厚板钢不同厚度部位,对其进行不同冷速淬火处理,对比相同淬火工艺处理后的试样和工业厚板不同部位的组织性能,从而反推出厚板不同部位的淬火冷速和综合传热系数。试验采用在试样内部封装热电偶外接高频数据采集仪的办法,精确计算了实验室小样的淬火冷速。结果表明:尺寸为20 mm×20 mm×230 mm的试样在850和800℃淬火时冷速最大值分别可达85和64℃/s,通过DEFORM反传热模型确定的综合传热系数分别为12000 W/(m^(2)·℃)和8000 W/(m^(2)·℃)。

关键词： 9NiCrMoV钢淬火冷速反传热法传热系数

Web Databases Sampling Approach Based on Valid Probability of Query Attributes

在线全文

学校读者我要写书评

暂无评论

Web Databases Sampling Approach Based on Valid Probability o...

赛沃替尼治疗MET基因突变非小细胞肺癌的药物浓度与疗效和不良反应的关系

2010 3rd International Conference on Computer and Electrical Engineering(ICCEE 2010)

作者： tian Jian-Wei xu Yang School of Computer Wuhan University International School of Software Wuhan University

A great portion of information is hidden behind in the query restricted Web databases, which makes it difficult to obtain these high-quality data samples. The existing hidden database samplers are very inefficient for the underflow in the sampling walk. Aiming at this problem, in this paper we propose a new approach for sampling data from deep Web based on the valid probability of query. In order to get the valid query result, we leverage the historical valid paths to calculate the valid probability of attribute value combinations in the queries, and then we give priority to the query with largest valid probability. The experimental results indicate that our approach can efficiently extracting data from the deep, and the extraction result set can well cover the deep web database.

关键词： valid probability data sampling deep Web web database

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国肿瘤临床 2024年第3期51卷 113-117页

作者：韩森马旭聂鋆戴玲胡维亨陈筱玲张洁马向娟田广明吴頔龙皆然韩金娣张自然张攀攀郝倩云方健北京大学肿瘤医院暨北京市肿瘤防治研究所恶性肿瘤发病机制及转化研究教育部重点实验室北京市100142

目的:探讨药物浓度与疗效和不良反应之间的关系,了解赛沃替尼治疗MET14外显子跳跃突变晚期非小细胞肺癌患者的疗效和安全性。方法:回顾性分析2018年4月至2019年9月北京大学肿瘤医院收治的携带MET14外显子跳跃突变,并且接受赛沃替尼治疗... 详细信息

目的:探讨药物浓度与疗效和不良反应之间的关系,了解赛沃替尼治疗MET14外显子跳跃突变晚期非小细胞肺癌患者的疗效和安全性。方法:回顾性分析2018年4月至2019年9月北京大学肿瘤医院收治的携带MET14外显子跳跃突变,并且接受赛沃替尼治疗的16例局部晚期或转移性非小细胞肺癌患者的临床资料及其血浆药物浓度,评估赛沃替尼治疗的疗效和安全性,分析药物浓度与疗效及不良反应的相关性。随访患者的无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS),采用Kaplan-Meier法计算中位PFS和OS。结果:16例患者中男性9例(56.3%),年龄范围51~84岁。肺癌病理类型包括:腺癌11例,肉瘤样癌5例,鳞癌1例。赛沃替尼的客观缓解率为50.0%(8/16),疾病控制率达到87.5%(14/16)。评效达到部分缓解患者和未达到者相比,赛沃替尼的药物谷浓度分别为77.2 ng/mL和146.7 ng/mL(P=0.06)。治疗中出现过2级以上不良反应的患者和仅出现过1级不良反应者,其药物谷浓度分别为116.5 ng/mL和93.2 ng/mL(P=0.59)。所有患者的中位PFS为8.5个月,中位OS为14.1个月。结论:赛沃替尼治疗MET基因突变非小细胞肺癌的效果较好,不良反应可耐受。常规用药剂量下,赛沃替尼的血浆药物谷浓度与疗效可能存在一定负相关,但药物浓度与不良反应的程度无明显相关性。

关键词：非小细胞肺癌 MET14外显子跳跃突变赛沃替尼药物浓度治疗药物监测