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Sequential expression of miR-221-3p and miR-338-3p in Schwann cells as a therapeutic strategy to promote nerve regeneration and functional recovery

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Neural Regeneration Research 2023年第3期18卷 671-682页

作者： Li-Li Wen tian-hao yu Yi-Zhan Ma Xiao-Yan Mao tian-Rang Ao Rabia Javed Hirotomo Ten Akira Matsuno Qiang Ao Department of Tissue Engineering School of Intelligent MedicineChina Medical UniversityShenyangLiaoning ProvinceChina The VIP Department School and Hospital of StomatologyLiaoning Provincial Key Laboratory of Oral DiseasesChina Medical UniversityShenyangLiaoning ProvinceChina Department of Oncology Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of Neurosurgery Teikyo University School of MedicineTokyoJapan NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial&Institute of Regulatory Science for Medical Device&National Engineering Research Center for Biomaterials Sichuan UniversityChengduSichuan ProvinceChina

The functional properties of endogenous Schwann cells(SCs)during nerve repair are *** the functional properties of SCs at different stages of nerve repair may have therapeutic benefit in improving the repair of damaged *** studies showed that miR-221-3p promotes the proliferation and migration of SCs,and miR-338-3p promotes the myelination of *** this study,we established rat models of sciatic nerve injury by bridging the transected sciatic nerve with a silicone *** injected a miR-221 lentiviral vector system together with a doxycycline-inducible Tet-On miR-338 lentiviral vector system into the cavity of nerve conduits of nerve stumps to sequentially regulate the biological function of endogenous SCs at different stages of nerve *** found that the biological function of SCs was sequentially regulated,the diameter and density of myelinated axons were increased,the expression levels of NF200 and myelin basic protein were increased,and the function of injured peripheral nerve was improved using this *** Target Prediction Database prediction,Nanopore whole transcriptome sequencing,quantitative PCR,and dual luciferase reporter gene assay results predicted and verified Cdkn1b and Nrp1 as target genes of miR-221-3p and miR-338-3p,respectively,and their regulatory effects on SCs were confirmed in *** conclusion,here we established a new method to enhance nerve regeneration through sequential regulation of biological functions of endogenous SCs,which establishes a new concept and model for the treatment of peripheral nerve *** findings from this study will provide direct guiding significance for clinical treatment of sciatic nerve injury.

关键词： cdkn1b miR-221 miR-338 miRNA nerve regeneration Nrp1 peripheral nerve injury regulation Schwann cells sequential expression

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Preparation of Self-limiting Heating Cables with Excellent Processability, Mechanical Properties and PTC Effect via Thermal and Electrical Treatments

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Chinese Journal of Polymer Science 2024年第4期42卷 511-520页

作者： tian-hao Yang Tong Wu Qiang Fu State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu610065China

Polymer/conductive filler composites have been widely used for the preparation of self-limiting heating cables with the positive temperature coefficient (PTC) effect. The control of conductive filler distribution and network in polymer matrix is the most critical for performance of PTC materials. In order to compensate for the destruction of the filler network structure caused by strong shearing during processing, an excessive conductive filler content is usually added into the polymer matrix, which in turn sacrifices its processability and mechanical properties. In this work, a facile post-treatment of the as-extruded cable, including thermal and electrical treatment to produce high-density polyethylene (HDPE)/carbon black (CB) cable with excellent PTC effect, is developed. It is found for the as-extruded sample, the strong shearing makes the CB particles disperse uniformly in HDPE matrix, and 25 wt% CB is needed for the formation of conductive paths. For the thermal-treated sample, a gradually aggregated CB filler structure is observed, which leads to the improvement of PTC effect and the notable reduction of CB content to 20 wt%. It is very interesting to see that for the sample with combined thermal and electrical treatment, CB particles are agglomerated and oriented along the electric field direction to create substantial conductive paths, which leads to a further decrease of CB content down to 15 wt%. In this way, self-limiting heating cables with excellent processability, mechanical properties and PTC effect have simultaneously been achieved.

关键词： Self-limiting heating cables Positive temperature coefficient Thermal treatment Electrical treatment

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αDecay in extreme laser fields within a deformed Gamow-like model

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Nuclear Science and Techniques 2024年第2期35卷 131-144页

作者： Qiong Xiao Jun-hao Cheng Yang-Yang Xu You-tian Zou Jun-Gang Deng Tong-Pu yu Department of Physics National University of Defense TechnologyChangsha 410073China College of Science China Three Gorges UniversityYichang 443002China

In this study, the effect of extreme laser fields on the α decay process of ground-state even–even nuclei was *** the deformed Gamow-like model, we found that state-of-the-art lasers can cause a slight change in the α decay penetration probability of most nuclei. In addition, we studied the correlation between the rate of change of the α decay penetration probability and angle between the directions of the laser electric field and α particle emission for different nuclei. Based on this correlation, the average effect of extreme laser fields on the half-life of many nuclei with arbitrary α particle emission angles was calculated. The calculations show that the laser suppression and promotion effects on the α decay penetration probability of the nuclei population with completely random α particle-emission directions are not completely *** remainder led to a change in the average penetration probability of the nuclei. Furthermore, the possibility of achieving a higher average rate of change by altering the spatial shape of the laser is explored. We conclude that circularly polarized lasers may be helpful in future experiments to achieve a more significant average rate of change of the α decay half-life of the nuclei population.

关键词： αDecay Deformed Gamow-like model Half-lives Extreme laser field Penetration probability

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The Role of Processing Solvent on Morphology Optimization for Slot-Die Printed Organic Photovoltaics

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Chinese Journal of Polymer Science 2023年第6期41卷 842-850,I0005页

作者： Lei Wang Jun-Zhe Zhan Wen-Kai Zhong Lei Zhu Guan-Qing Zhou tian-yu hao Ye-Cheng Zou Zhen-Hua Wang Gang Wei Yong-Ming Zhang Feng Liu School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Frontiers Science Center for Transformative Molecules Center of Hydrogen ScienceSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai200240China State Key Laboratory of Fluorinated Functional Membrane Materials and Dongyue Future Hydrogen Energy Materials Company Zibo 256401China

The morphology manipulation of the active layers is important for improving the performance of organic photovoltaics(OPVs).The choice of processing solvent has great impact on the crystallization and phase separation during film formation,since solvent properties,including solvent effect on molecular crystallization,boiling point,and interaction parameters,can directly change the evolution pathways associated with thermodynamics and ***,revealing the underlying solvent-regulated morphology mechanism is potential to provide guiding strategies for device *** this study,chloroform,chlorobenzene,and toluene are used to process PM6:Y6 blends by slot-die printing to fabricate OPV *** chloroform printed film forms a fibrillar network morphology with enhanced crystallization,facilitating exciton dissociation,charge transport and extraction,resulting in an optimal power conversion efficiency of 16.22%.However,the addition of the additive chloronaphthalene in chloroform solution leads to over-crystallization of Y6,and thus,increasing domain size that exceeds the exciton diffusion length,resulting in lower device *** addition,both the chlorobenzene and toluene suppress the crystallization of Y6,which drastically decreased short-circuit current and fill *** results demonstrate the important role of processing solvent in dictating film morphology,which critically connects with the resultant printed OPV performance.

关键词： crystallization chloroform film

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Effect of Fe Addition on Dehydrogenation Performance of Methylcyclohexance over Pt/Al_(2)O_(3)

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 12-18页

作者： Tong Fengya tian hao Wang hao Miao Changxi Song Lei Shanghai Research Institute of Petrochemical Technology SINOPEC Shanghai201208

Catalysts with varying Fe contents were prepared using a sequential impregnation method to investigate the effects of Fe addition on the physicochemical properties of Pt/Al_(2)O_(3) and their performance in methylcyclohexane(MCH)*** results demonstrated that the addition of Fe to Pt/Al_(2)O_(3) enhanced the electron density of Pt and improved catalytic activity,while exhibiting negligible influence on the catalytic selectivity for *** the Fe content was 0.057%,the catalyst exhibited the highest MCH consumption rate,which was approximately two times higher than that of the catalyst without ***,the incorporation of Fe inhibited the formation of coke and reduced the quantity of coke deposits on the catalyst,thereby improving its catalytic ***,Fe shows promise as a prospective secondary element for Pt/Al_(2)O_(3) to enhance the MCH dehydrogenation performance.

关键词： methylcyclohexane dehydrogenation hydrogen storage deactivation Fe addition

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Study of the multi-physics field-coupled model of the two-stage electrostatic precipitator

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Building Simulation 2024年第3期17卷 387-398页

作者： Wenjia hao yu Guo yukun Wang Tao yu hao Gao Zhengwei Long tianjin Key Laboratory of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityWeijin Road 92Tianjin300072China Wuhan Second Ship Design and Research Institute WuhanChin

The two-stage electrostatic precipitator is widely used to purify oil mist ***,there is limited research on the influences of relative humidity,particle deposition characteristics,and the generation of gaseous ***,this paper established a numerical model of the electrostatic oil mist purifier and applied it to a two-stage electrostatic *** the model was used to investigate the corona discharge characteristics under different relative humidity conditions in the charged zone,the particle deposition characteristics,the purification efficiency,the ozone concentration distribution,and the oil vapor concentration distribution in the collection *** results indicate that,with a constant temperature,the corona current decreases as relative humidity increase,and there is a quadratic relationship between relative humidity and *** variation in relative humidity has little impact on the purification *** maximum ozone concentration occurs near the electrode line,and its concentration is influenced by the discharge current and inlet airflow *** oil vapor concentration reaches its maximum value at the side plates,with a value of 19 ppb,while it reaches the minimum value at the collecting zone electrode plate,with a value of 2 *** temperature is the main factor affecting the volatilization of the oil film,with higher temperatures resulting in higher oil vapor.

关键词： two-stage ESPs particle deposition corona discharge oil vapor

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Differences in the effects and action modes of gut commensals against dextran sulfate sodium-induced intestinal inflammation

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Food Science and Human Wellness 2024年第3期13卷 1201-1211页

作者： Dingwu Qu Zhennan Gu Saisai Feng Leilei yu Fengwei tian hao Zhang Wei Chen Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch Wuxi 214122China

Inflammatory bowel disease(IBD)is a complex relapsing inflammatory disease in the gut and is driven by complicated host-gut microbiome *** commensals have shown different functions in IBD prevention and *** gain a mechanistic understanding of how different commensals affect intestinal inflammation,we compared the protective effects of 6 probiotics(belonging to the genera Akkermansia,Bifidobacterium,Clostridium,and Enterococcus)on dextran sulfate sodium(DSS)-induced colitis in mice with or without gut ***-inflammatory properties(ratio of interleukin(IL)-10 and IL-12)of these strains were also evaluated in an in vitro mesenteric lymph nodes(MLN)co-culture *** showed that 4 probiotics(belonging to the species Bifidobacterium breve,Bifidobacterium bifidum,and Enterococcus faecalis)can alleviate colitis in normal *** probiotic strains differed in regulating the intestinal microbiota,cytokines(IL-10,IL-1βand interferon(IFN)-γ),and tight junction function(Zonulin-1 and Occludin).By constrast,Akkermansia muciniphila AH39 and Clostridium butyricum FHuNHHMY49T1 were not ***,*** JSNJJNM2 with high anti-inflammatory potential in the MLN model could relieve colitis symptoms in antibiotic cocktail(Abx)-treated ***,*** FJSWX25M1induced low levels of cytokines in vitro and showed no beneficial ***,we provided insight into the clinical application of probiotics in IBD treatment.

关键词： Gut commensals Dextran sulfate sodium(DSS)colitis Intestinal barrier Immunoregulation

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Large-inductance superconducting microstrip photon detector enabling 10 photon-number resolution

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Advanced Photonics 2024年第1期6卷 96-105页

作者： Ling-Dong Kong tian-Zhu Zhang Xiao-yu Liu hao Li Zhen Wang Xiao-Ming Xie Li-Xing You Chinese Academy of Sciences(CAS) Shanghai Institute of Microsystem and Information TechnologyNational Key Laboratory of Materials for Integrated CircuitsShanghaiChina CAS Center for Excellence in Superconducting Electronics ShanghaiChina University of Chinese Academy of Sciences Center of Materials Science and Optoelectronics EngineeringBeijingChina

Efficient and precise photon-number-resolving detectors are essential for optical quantum information *** this,very few detectors have been able to distinguish photon numbers with both high fidelity and a large dynamic range,all while maintaining high speed and high timing *** nanostrip-based detectors excel at counting single photons efficiently and rapidly,but face challenges in balancing dynamic range and ***,we have pioneered the demonstration of 10 true photon-number resolution using a superconducting microstrip detector,with readout fidelity reaching an impressive 98%and 90%for 4-photon and 6-photon events,***,our proposed dual-channel timing setup drastically reduces the amount of data acquisition by 3 orders of magnitude,allowing for real-time photon-number *** then demonstrate the utility of our scheme by implementing a quantum random-number generator based on sampling the parity of a coherent state,which guarantees inherent unbiasedness,robustness against experimental imperfections and environmental noise,as well as invulnerability to *** solution boasts high fidelity,a large dynamic range,and real-time characterization for photon-number resolution and simplicity with respect to device structure,fabrication,and readout,which may provide a promising avenue towards optical quantum information science.

关键词： superconducting microstrips single-photon detector photon-number resolution quantum random number

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A new liquid membrane diffusion model for characterizing the adsorption kinetics of europium by using a continuous measurement of adsorption platform

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Nuclear Science and Techniques 2024年第1期35卷 59-72页

作者： hao-Qi yu Tao yu Jian-Hua Ye State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China CGN Cangnan Nuclear Power Co. Ltd.Cangnan 325800China Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

To explore the kinetic adsorption under continuous and nonequilibrium states, an integration of continuous measurement and adsorption platform kinetics method was proposed, which was initially called the ICM-AP kinetics method, and a corresponding kinetic adsorption experimental method was developed. Adsorption experiments of europium(Eu) on Ca-bentonite,Na-bentonite, and the D231 cation exchange resin were performed using the ICM-AP kinetics method and continuous measurements. Because the kinetic experimental results observed in this study were different from those of traditional batch adsorption data, pseudo-first-order or pseudo-second-order kinetic models were unsuitable for fitting the experimental ***, a liquid membrane diffusion(LMD) model was developed based on the assumption of simultaneous adsorption/desorption to discuss the mechanism of kinetic adsorption. The kinetic adsorption mechanism was also studied by using *** results indicated that the proposed adsorption model can fit the experimental data more suitably, and the adsorption/desorption behaviors of Eu on bentonite and the D231 resin were simultaneously observed, suggesting that the adsorption kinetics of Eu(Ⅲ) was mainly dominated by hydrated Eu(Ⅲ) ions on the liquid membrane.

关键词： ICM-AP method LMD model Adsorption mechanism Eu(Ⅲ)

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Equivalent linear model for seismic damage evaluation of single-degree-of-freedom systems representing reinforced concrete structures considering cyclic degradation behavior

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 637-648页

作者： Lulu Yan Ding-hao yu Research Center for Geotechnical and Structural Engineering Technology of Liaoning Province Dalian UniversityDalian116622China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

In this study,a novel equivalent damping ratio model that is suitable for reinforced concrete(RC)structures considering cyclic degradation behavior is developed,and a new equivalent linearization analysis method for implementing the proposed equivalent damping ratio model for use in seismic damage evaluation is *** this end,Ibarra’s peak-oriented model,which incorporates an energy-based degradation rule,is selected for representing hysteretic behavior of RC structure,and the optimized equivalent damping for predicting the maximum displacement response is presented by using the empirical method,in which the effect of cyclic degradation is ***,the relationship between the hysteretic energy dissipation of the inelastic system and the elastic strain energy of the equivalent linear system is established so that the proposed equivalent linear system can be directly integrated with the Park-Ang seismic model to implement seismic damage *** to the simplicity of the equivalent linearization method,the proposed method provides an efficient and reliable way of obtaining comprehensive insight into the seismic performance of RC *** verification demonstrates the validity of the proposed method.

关键词： degrading system equivalent linear system equivalent damping seismic damage RC structures

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