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Effect and safety of sorafenib in patients with intermediate hepatocellular carcinoma who received transarterial chemoembolization: A retrospective comparative study

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World Journal of Clinical Cases 2018年第5期6卷 74-83页

作者： Xue-Fen Lei Yang Ke tian-hao bao hao-Ran Tang Xue-Song Wu Zhi-tian Shi Jie Lin Zhi-Xian Zhang Hou Gu Lin Wang Department of Medical Oncology The Second Affiliated Hospital of Kunming Medical University Department of Hepatobiliary Surgery The Second Affiliated Hospital of Kunming Medical University The Mental Health Center of Kunming Medical University Department of Hepatobiliary Surgery The Second Affiliated Hospital of Kunming Medical University Department of Gastro- enterological Surgery The Second Affiliated Hospital of Kunming Medical University

AIM To evaluate the safety and efficacy of sorafenib plus transarterial chemoembolization(TACE) treatment for intermediate hepatocellular carcinoma(HCC).METHODS Sixty-seven patients with intermediate-stage [Barcelona Clinic liver cancer stage B(BCLC-B)] HCC who were treated with sorafenib plus TACE or TACE alone between 2009 and 2011 were included in the study. Follow-up was until 2014 or patient death. Two groups were defined in the experiment: The experimental group, treated with sorafenib plus TACE, and the control group, treated with standard TACE *** The Kaplan-Meier survival analysis showed that the median overall survival(m OS) of the experimental group was 35.2 mo, while that of the control group was 22.0 mo(P < 0.05). Sorafenib plus TACE showed higher incidence rates of rash, hand-foot syndrome(HFS), and hypertension(P < 0.05) than TACE treatment *** Sorafenib plus TACE treatment for BCLC-B HCC significantly prolonged the m OS of patients compared to TACE treatment alone. The most common toxicities with sorafenib were rash(31.6%), HFS(39.5%) and hypertension(31.6%), but there were no intolerable adverse events. The Cox multivariate analysis showed that the survival of patients with BCLC-B HCC depended on the Child-Pugh classification, tumor diameter, and treatment with sorafenib plus TACE compared to TACE alone.

关键词： Sorafenib Hepatocellular carcinoma Transarterial chemoembolization Overall survival Adverse reaction

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1.3-μm 4×25-Gb/s hybrid integrated TOSA and ROSA

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Frontiers of Information Technology & Electronic Engineering 2019年第4期20卷 490-497页

作者： Yu LIU hao-tian bao Yi-ming ZHANG Zhi-ke ZHANG Yun-shan ZHANG Xiang-fei CHEN Jun LU Yue-chun SHI Jia-shun ZHANG Liang-liang WANG Jun-ming AN Ning-hua ZHU State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences School of Electronic Electrical and Communication Engineering University of Chinese Academy of Sciences State Key Laboratory of Advanced Optical Communications System and Networks School of Electronics Engineering and Computer Science Peking University Microwave-Photonics Technology Laboratory College of Engineering and Applied Sciences Nanjing University

The design and fabrication of a compact and low-cost 4×25-Gb/s transmitter optical sub-assembly(TOSA) and receiver optical sub-assembly(ROSA) using a hybrid integrated technique are reported. TOSA and ROSA are developed without thermoelectric cooler for coarse wavelength division multiplexing applications. Physical dimension of the packaged optical subassembly is limited to 11.5 mm×5.4 mm×5.4 mm. The design of TOSA and ROSA is employed using a silica-based arrayed waveguide grating chip to select the specific channel wavelength at O-band. In TOSA, the wavelength of four 1.3-μm discrete directly modulated laser chips is well controlled based on the reconstruction equivalent chirp technique. In the back-to-back transmission test, bit error rates for all lanes of cascade of the TOSA and ROSA are small. A clear opening eye diagram is obtained.

关键词： Reconstruction equivalent chirp Arrayed waveguide grating Transmitter optical subassembly Hybrid integrated

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Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie Wang Wei Wang Xuheng Chen Junfang bao Qiuyue hao Heng Zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

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Ultra‑High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health Monitoring and Robotic Perception

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Nano-Micro Letters 2025年第2期17卷 432-446页

作者： hao Yin Yanting Li Zhiying tian Qichao Li Chenhui Jiang Enfu Liang Yiping Guo State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Beijing Vacuum Electronics Research Institute Beijing 100015People’s Republic of China Fundamental Science On Vibration Shock and Noise LaboratoryState Key Laboratory of Mechanical System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Monitoring minuscule mechanical signals,both in magnitude and direction,is imperative in many application scenarios,e.g.,structural health monitoring and robotic sensing ***,the piezoelectric sensor struggles to satisfy the requirements for directional recognition due to the limited piezoelectric coefficient matrix,and achieving sensitivity for detecting micrometer-scale deformations is also ***,we develop a vector sensor composed of lead zirconate titanate-electronic grade glass fiber composite filaments with oriented arrangement,capable of detecting minute anisotropic *** as-prepared vector sensor can identify the deformation directions even when subjected to an unprecedented nominal strain of 0.06%,thereby enabling its utility in accurately discerning the 5μm-height wrinkles in thin films and in monitoring human pulse *** ultra-high sensitivity is attributed to the formation of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate ***,when integrated with machine learning techniques,the sensor’s capability to recognize multi-signals enables it to differentiate between 10 types of fine textures with 100%*** structural design in piezoelectric devices enables a more comprehensive perception of mechanical stimuli,offering a novel perspective for enhancing recognition accuracy.

关键词： Flexible piezoelectric filaments Anisotropic Ultra-high sensitivity Structural health detection Texture recognition

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Uncertainty analysis and probabilistic design optimization of hybrid rocket motors for manned lunar landing

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Science China(Technological Sciences) 2015年第7期58卷 1234-1241页

作者： ZHU hao tian Hui CAI GuoBiao bao WeiMin School of Astronautics Beihang University China Aerospace Science and Technology Corporation

To obtain a conceptual design for a hybrid rocket motor(HRM)to be used as the Ascent Propulsion System in the Apollo lunar module,the deterministic design optimization(DDO)method is applied to the HRM *** on the results of an uncertainty analysis of HRMs,an uncertainty-based design optimization(UDO)method is also adopted to improve the design *** HRM design process,which is a multidisciplinary system,is analyzed,and a mathematical model for the system design is established to compute the motor performance from the input parameters,including the input variables and model *** input parameter uncertainties are quantified,and a sensitivity analysis of the model parameter uncertainties is conducted to identify the most important model parameter uncertainties for *** DDO and probabilistic UDO methods are applied to conceptual designs for an HRM to be used as a substitute for the liquid rocket motor(LRM)of the Ascent Propulsion *** conceptual design results show that HRMs have several advantages as an alternative to the LRM of the Ascent Propulsion System,including nontoxic propellant combination,small motor volume,and comparable functions,such as restarting and *** of the DDO and UDO results indicate that the UDO method achieves more robust and reliable optimal designs than the DDO *** probabilistic UDO method can be used to develop better conceptual designs for HRMs.

关键词： hybrid rocket motor deterministic design optimization uncertainty-based design optimization sensitivity analysis manned lunar landing

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Uncertainty analysis and design optimization of hybrid rocket motor powered vehicle for suborbital flight

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Chinese Journal of Aeronautics 2015年第3期28卷 676-686页

作者： Zhu hao tian Hui Cai Guobiao bao Weimin School of Astronautics Beihang University China Aerospace Science and Technology Corporation

Abstract In this paper, we propose an uncertainty analysis and design optimization method and its applications on a hybrid rocket motor （HRM） powered vehicle. The multidisciplinary design model of the rocket system is established and the design uncertainties are quantified. The sensitivity anal- ysis of the uncertainties shows that the uncertainty generated from the error of fuel regression rate model has the most significant effect on the system performances. Then the differences between deterministic design optimization （DDO） and uncertainty-based design optimization （UDO） are discussed. Two newly formed uncertainty analysis methods, including the Kriging-based Monte Carlo simulation （KMCS） and Kriging-based Taylor series approximation （KTSA）, are carried out using a global approximation Kriging modeling method. Based on the system design model and the results of design uncertainty analysis, the design optimization of an HRM powered vehicle for suborbital flight is implemented using three design optimization methods： DDO, KMCS and KTSA. The comparisons indicate that the two UDO methods can enhance the design reliability and robustness. The researches and methods proposed in this paper can provide a better way for the general design of HRM powered vehicles.

关键词： Design optimization Hybrid rocket motor Kriging model Uncertainty analysis Uncertainty-based designoptimization

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Systematic study of the synthesis of heavy and superheavy nuclei in 48Ca-induced fusion-evaporation reactions

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Nuclear Science and Techniques 2024年第7期35卷 157-172页

作者： Shi-hao Zhu tian-Liang Zhao Xiao-Jun bao Department of Physics Collaborative Innovation Center for Quantum EffectsKey Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of EducationHunan Normal UniversityChangsha410081China School of Nuclear Science and Technology Lanzhou UniversityLanzhou730000China School of Physics Xi’an Jiaotong UniversityXi’an710049China

We systematically studied the evaporation residue cross sections of ^(48)Ca-induced reactions on lanthanide and actinide target nuclei under the Dinuclear System(DNS)model framework to check the reliability and applicability of the *** produce new proton-rich Fl and Lv isotopes through hot fusion reactions in the superheavy element region with Z≥104,we utilized the reactions ^(48)Ca+^(236,238,239) Pu and ^(48)Ca+^(242,243,244,250) ***,owing to the detection limit of available equipment(0.1 pb),only 283Fl and 287−289Lv,which have the maximum evaporation residue cross section values of 0.149,0.130,9.522,and 0.309 pb,respectively,can be ***,to produce neutron-deficient isotopes of actinides near the proton drip line with Z=93−100,we attempted to generate the new isotopes(224−227Pu,228−232,237Cm)using the reactions ^(48)Ca+180,182,183 W and ^(48)Ca+^(184,186,187,192) *** maximum evaporation residue cross section values are 0.07,0.06,0.26,and 0.30 nb for the former set of reactions,and 1.96 pb,5.73 pb,12.16 pb,19.39 pb,54.79 pb,and 6.45 nb for the latter,*** results are expected to provide new information for the future synthesis of unknown neutron-deficient isotopes.

关键词： Dinuclear system(DNS)model Evaporation residue cross section Neutron-deficient isotopes

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等离子体改性聚酰亚胺热老化的分子模拟

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原子与分子物理学报 2025年第1期42卷 95-100页

作者：丁璨田浩博陈琛三峡大学电气与新能源学院宜昌443002

通过反应分子动力学方法模拟聚酰亚胺的热老化过程,以模拟仿真等离子体改性后的聚酰亚胺材料在热裂解后的性能变化情况.通过研究老化过程中气体产生的情况,研究发现随着温度升高,分子链之间的相互作用力减弱,导致材料的致密性下降,弹性... 详细信息

通过反应分子动力学方法模拟聚酰亚胺的热老化过程,以模拟仿真等离子体改性后的聚酰亚胺材料在热裂解后的性能变化情况.通过研究老化过程中气体产生的情况,研究发现随着温度升高,分子链之间的相互作用力减弱,导致材料的致密性下降,弹性模量降低,材料抵抗外应力的能力减弱.同时,由于温度升高使得聚酰亚胺材料相对介电常数上升,材料绝缘性能下降,击穿强度也被削弱.

关键词：反应分子动力学聚酰亚胺热老化

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Consolidation mechanism of fluxed hematite pellets

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Journal of Iron and Steel Research International 2022年第10期29卷 1526-1534页

作者： hao Wu Tie-jun Chun Ping Wang Song Zhou tian-bao Zhou School of Metallurgical Engineering Anhui University of TechnologyMa’anshan243002AnhuiChina

Fluxed pellets are becoming a popular burden for the blast furnace in *** basicity(wCaO/wSiO_(2))ranging from 0.33 to 1.33 was prepared by adding CaO analytical *** phase change of pellets during roasting was analyzed by the FactSage software,and the consolidation mechanism of fluxed hematite pellets was also *** results show that the increase in basicity gradually increases the diameter,volume,and porosity of *** diameter,volume,and porosity of pellets change slightly when the basicity is greater than *** increase in roasting temperature gradually decreases the volume and porosity of *** the increase in pellet basicity,the compressive strength of pellets reaches the maximum at the basicity of *** higher the roasting temperature is,the more the slag phase is produced,thereby accelerating Fe^(3+)diffusion and promoting Fe_(2)O_(3) *** addition,the consolidation effect of the slag phase after cooling improves the consolidation strength of fluxed *** the basicity is higher than 0.83,the slag phase decreases with the increase in basicity,and the high-temperature solid solution,such as melilite and spinel,increases,thereby hindering Fe2O3 recrystallization.

关键词： Fluxed pellet Consolidation Porosity Recrystallization Basicity

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Possibility of synthesizing Z=119 superheavy nuclei with Z>20 projectiles

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Chinese Physics C 2024年第12期48卷 151-157页

作者： hao Zhu tian-Liang Zhao Xiao Jun bao Department of Physics Collaborative Innovation Center for Quantum Effectsand Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of EducationHunan Normal UniversityChangsha 410081China

We employ the dinuclear system(DNS)model combined with a statistical model to calculate the evaporation residue cross sections of the reaction systems ^(48)Ca+^(243)Am,^(48)Ca+^(248)Cm,and ^(48)Ca+^(249)*** theoretical results successfully reproduce the experimental trends in the 3n and 4n evaporation channels of these reaction *** synthesize the new element,we predict the evaporation residue cross sections for three reaction systems(^(54)Cr+^(243)Am,^(51)V+^(248)Cm,and ^(50)Ti+^(249)Bk)to select the most promising projectile-target *** also note that the maximum cross sections predicted by our model and other methods appear to be below the detection limits of current experimental facilities,given the projectile-target combinations feasible under current experimental ***,synthesizing superheavy nuclei with Z=119 will require improvements in beam intensity,detection techniques,and effective separation methods.

关键词： superheavy nuclei evaporation residue cross sections dinuclear system model

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