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Six-fold swelling expansion microscopy assisted cell painting for high-content phenotypic screening

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Optoelectronics Letters 2025年

作者： Junfang xie Yipeng DONG Jin WANG Zhichao DENG Jianguo tian Qing YE Key Laboratory of Weak-Light Nonlinear Photonics， Ministry of Education， School of Physics and TEDA Applied Physics， Nankai University

Imaging-based phenotypic screening uses cellular phenotypes to describe the drug performance， which generally focuses on single cellular feature， lacking of a comprehensive characterization. Here， we propose a high content phenotypic screening method based on expansion microscopy (ExM) assisted Cell Painting， which enables multi-channel imaging with approximately 50 nm resolution. As a demonstration， we applied this method to a phenotypic screening involving five drugs. The morphological attributes of three subcellular structures were summarized to consist a “fingerprint” describing the drug effect. The proposed method can provide comprehensive and detailed clues for drug evaluation， enriching the content of phenotypic screening.

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Pt-based intermetallic compound catalysts for the oxygen reduction reaction:From problems to recent developments

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Journal of Energy Chemistry 2024年第12期99卷 302-324页

作者： Heyuan tian Xian Wang Jiawei ge Hao Wan Wei Ma Guanqun xie Junjie ge School of Environment and Civil Engineering Dongguan University of TechnologyDongguan 523808GuangdongChina School of Chemistry and Materials Science Key Laboratory of Precision and Intelligent ChemistryUniversity of Science and Technology of ChinaHefei 230026AnhuiChina State Grid Anhui Electric Power Research Institute Hefei 230601AnhuiChina

Proton exchange membrane fuel cells(PEMFCs)are promising next-generation energy conversion devices with advantages including high energy conversion efficiency,low noise,and environmental *** the PEMFC cathode,the oxygen reduction reaction(ORR)relies heavily on Pt-based catalysts,where PtM_(x)(M stands for transition metal)intermetallic compounds(IMCs)are considered the best choice to enhance the catalytic ***,problems such as inadequate catalytic activity,high cost,and insufficient durability,*** hamper its *** optimizations of the catalyst structure,the improvements in the preparation process,and the understanding of the reaction mechanism are of great *** developments of cathodic oxygen reduction catalysts for PEMFCs will also focus on improving the catalytic activity of intermetallic compound nanoparticles,the utilization rate,and the durability of *** the particle size and particle/carrier interaction remain key issues for future *** catalyst reaction mechanism,the surface changes of the nanoparticles of Pt(111)face before and after the catalytic reaction,and the targeted regulation of the adsorption strength between the IMCs and oxygen-containing intermediates adjusted by transition metals need to be investigated more specifically and *** the application level,the expression of catalyst properties in the catalyst membrane electrode and reactor are the keys to the performance of ***,researches on PEMFCs are still systematic *** paper summarized the recent process toward the optimization of catalyst preparation,the exploration of new catalysts,and the new understanding of the *** the reference to the development of PEMFCs,future research can start from the existing problems,solve the shortcomings of the catalyst,and promote the practical application of PEMFCs.

关键词： Oxygen reduction reaction Platinum PEMFCs Intermetallic compound

A Low-Complexity Key-Recovery Attack on 6-Round Midori64

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Journal of Systems Science & Complexity 2023年第4期36卷 1738-1756页

作者： xie Xiaofeng tian tian Information Engineering University Zhengzhou 450001China

In EUROCRYPT 2017,a new structure-difference property,say“a-multiple-of-8”was proposed on 5-round *** by the idea,yoyo attacks and mixture differential attacks were proposed yielding new records on data and computational complexities for key-recovery attacks against 5-round *** this paper,the authors attempt to apply the idea of mixture differential cryptanalysis to *** is a lightweight block cipher proposed at ASIACRYPT *** the structure of Midori is similar to AES,the MixColumn matrix of Midori is not *** on this observation,the authors present a class of deterministic differential trails on 2-round *** combined with the yoyo trick,a new type of 4-round retracing boomerang distinguishers is obtained on *** on the new 4-round distinguishers,a key-recovery attack on 6-round Midori64 is given that requires only 2^(27)computational complexity,2^(29)chosen plaintexts,2^(20)adaptively chosen *** key-recovery attack has been experimentally verified.

关键词： Boomerang attack Midori mixture differential attack yoyo attack

Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

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Science China Life Sciences 2025年

作者： Xiangping Yao Xudong Mai Ye tian Yifan Liu Guanghui Jin Ze Li Shujie Chen Xiaoshuang Dai Liujing Huang Zijing Fan Guihua Pan Xiaohan Pan Xiangmin Li Michael C Yu Jia Sun Jingxing Ou Hong Chen Liwei xie College of Life and Health Sciences Guangdong Industry Polytechnic Department of Endocrinology and Metabolism Zhujiang Hospital Southern Medical University State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research School of Public Health Xinxiang Medical University BGI Institute of Applied Agriculture BGI-Shenzhen Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Biological Sciences State University of New York at Buffalo Department of Internal Medicine Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

Skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of i WAT, offering potential therapeutic strategies for metabolic syndromes. Leveraging the Chromatin immunoprecipitation(ChIP)-seq and bioinformatics analysis, Bambi gene is shown to be a direct target of HIF2α, which is further confirmed by ChIP-qPCR and promoter luciferase assay. Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters, even under high-fat diet conditions. This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs) into thermogenic adipocytes, contributing to systemic metabolic improvements, potentially through the secretory ***, mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders, highlighting a potential therapeutic pathway for metabolic syndrome management. Thus, skeletal muscle-specific deletion of Bambi triggers muscle growth, enhances metabolic performance, and activates thermogenic adipocytes. These findings suggest Bambi as a novel therapeutic target for metabolic syndromes, providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement. The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism, offering a novel perspective on treating metabolic disorders.

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Multiple Responsive Photonic Prints Through Localized Interpenetrating Polymer Network

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Chemical Research in Chinese Universities 2023年第5期39卷 803-808页

作者： ZHANG tian JIA Xiaolu HOU Zaiyan xie ge ZHANG Lianbin ZHU Jintao Key Laboratory of Material Chemistry for Energy Conversion and Storage of Ministry of Education State Key Laboratory of Materials Processing and Mold TechnologySchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074P.R.China School of Chemistry&Chemical Engineering Zhoukou Normal UniversityZhoukou 466001P.R.China

Multiple responsive photonic prints that can be revealed by a thermal or light stimulus are prepared by locally producing interpenetrating polymer network(IPN)within photonic ***-responsive poly-(N-isopropylacrylamide)(PNIPAM)photonic hydrogels with self-assembled monodisperse carbon-encapsulated Fe_(3)O_(4) nanoparticles(Fe_(3)O_(4)@C NPs)are first prepared by a photopolymerization *** photopolymerization of acrylamide(AM)is carried out within the photonic hydrogel with the help of a mask to generate an IPN structure *** of the regionally different network structure and the resulting varied responsiveness,responsive photonic prints are *** to the thermo-responsive capability of the PNIPAM and the photothermal conversion capability of the incorporated Fe_(3)O_(4)@C NPs,the as-prepared photonic prints with a localized IPN structure can shift the structural color in a broad spectrum range under thermal or light *** current multiple responsive photonic prints with a localized IPN structure can realize full-color pattern display under thermal and light stimulations,providing a new path for anti-counterfeiting,display,and information encoding.

关键词： Photonic crystal Photothermal Hydrogel Patterning Stimuli-responsive

“屈原赋二十五篇”到刘向《楚辞》成书的“聚合之势”考论——兼说今本《楚辞》篇次的来源之二

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三峡大学学报（人文社会科学版） 2025年第1期47卷 18-23,116页

作者：谢天鹏湖南理工学院中国语言文学学院湖南岳阳414006

从屈原《离骚》化用自己《抽思》《涉江》《天问》《远游》《思美人》《惜往日》诸篇,以及宋玉、贾谊、司马迁、东方朔或化用或论及屈作分别达今存七卷中之五卷、六卷、四卷、五卷等情况看,一个共25篇的“屈原集”很可能早已存在,甚至... 详细信息

从屈原《离骚》化用自己《抽思》《涉江》《天问》《远游》《思美人》《惜往日》诸篇,以及宋玉、贾谊、司马迁、东方朔或化用或论及屈作分别达今存七卷中之五卷、六卷、四卷、五卷等情况看,一个共25篇的“屈原集”很可能早已存在,甚至就是屈原自己所编。再从司马迁《屈原列传》、东方朔《七谏》看,今存《楚辞》中宋玉等人的拟屈之作也已围绕着屈原及其作品形成了一个“关系网”。因此,刘向编《楚辞》应是基于这样一个“屈原集”加“关系网”,合并、落实、调适而成的。就其“调适”而言,他主要受了司马迁影响,一是依循“时间”标准排列篇次,二是依据“悲其志”主旨进行再选拔;此外,他还引入了“代屈原设言”的写作标准。

关键词：屈原《楚辞》司马迁刘向

Improved distinguisher search techniques based on parity sets

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Science China(Information Sciences) 2020年第3期63卷 285-287页

作者： Xiaofeng xie tian tian National Digital Switching System Engineering & Technological Research Center

Dear editor,Division property was a technique proposed by Todo at EUROCRYPT 2015 to search integral distinguishers against block ciphers [1]. Todo [2] applied this technique to perform structural evaluation against both the Feistel and the SPN constructions and attacked the full MISTY1. Subsequently, many improved techniques based on the division property were proposed [3,4]. At

关键词： Improved distinguisher search techniques based on parity sets

Bimetallic water oxidation: One-site catalysis with two-sites oxidation

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Journal of Energy Chemistry 2021年第12期30卷 1-7,I0001页

作者： Fei xie Ming-tian Zhang Center of Basic Molecular Science(CBMS) Department of ChemistryTsinghua UniversityBeijing 100084China

Water oxidation is the key half reaction to achieve full splitting of water to hydrogen and ***,a binuclear complex,[(L^(4-))Co_(2)~Ⅲ(OH)]ClO_(4),was reported as a stable and efficient homogenous catalyst for electrocatalytic water oxidation in 0.1 M phosphate buffer(pH 7.0).Cyclic voltammetry experiments indicated that the catalytic process proceed via "one-site catalysis with two-sites oxidation" mechanism in which both two metal sites store the required oxidation equivalents for water oxidation and O-O bond formation occurs by single-site water nucleophilic attack(WNA).

关键词： Water oxidation Bimetallic catalysis O-O bond formation Cobalt catalyst Oxygen evolution

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多目标协同建筑结构消能减震技术研究进展