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Crack mechanism of ground fissures in loess layer of Fenwei Basin, China

Journal of Mountain Science 2024年第5期21卷 1683-1696页

作者： LI cong LU Quanzhong WANG Feiyong LUO Wenchao XU Qiang School of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China Key Laboratory of Western Mineral Resources and Geological Engineering Ministry of EducationXi’an 710054China Observation and Research Station of Ground Fissure and Land Subsidence Ministry of Natural ResourcesXi’an 710054China School of Engineering and Technology China University of GeosciencesBeijing 100083China

The Fenwei Basin, covered by loess, experiences severe ground fissure disasters. These disasters disrupt the continuity of the loess and pose significant threats to engineering construction safety along transportation routes. Nevertheless, the crack characteristics and the influence zone of ground fissures in the loess layer remain inadequately investigated. To effectively prevent and control ground fissure disasters, physical model tests and the PFC(particle flow code) numerical simulation method are used to investigate the crack mechanism of buried ground fissures in the loess layer. The results show that there are two main cracks in the layer profile, which have a Y-shape morphology. As the dip angle of the preset cracks increased from 60° to 90°, the main deformation zone at the surface gradually shifted towards the footwall. The process of crack propagation from depth to surface is divided into five stages. Additionally, the results confirm the accuracy of the width of the rupture zone d2in the footwall calculated by the cantilever beam theory. These findings can offer theoretical guidance for determining the avoidance distance of ground fissures in loess regions, as well as for implementing disaster prevention and corresponding control measures for various stages of buried ground fissure propagation.

关键词： Ground fissure Fenwei Basin Physical model test Particle flow code Crack propagation

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Progress in the preparation,identification and biological activity of walnut peptides

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未来食品学报(英文) 2024年第3期4卷 205-220页

作者： chang Liu Zijie Zhang Yuting Shang Siting Li Junxi Xia Yiling tian Yingmin Jia Aijin Ma School of Food and Health Beijing Technology and Business UniversityBeijing 100048China Hebei Yangyuan ZhiHui Beverage Co. Ltd.Hengshui 053000China Institution of Chinese Walnut Industry Hengshui 053000China Hebei Key Laboratory of Walnut Nutritional Function and Processing Technology Hengshui 053000China College of Food Science and Technology Hebei Agricultural UniversityBaoding 071000China

Walnuts are rich in protein and are a high-quality plant protein *** recent years,with the growth of consumer demand for functional food and food for special medical purpose,the use of walnut protein for the preparation of functional walnut peptide ingredients or additives and other compositions has received increasing ***,the improvement of the yield of walnut peptides and the clarification of their functional activities are the bottlenecks that limit the development of these *** this end,this article reviews the pretreatment,preparation,purification and identification processes of walnut peptides,as well as their biological activities such as antioxidant activity,antitumour activity,improvement of memory,antihypertension and regulation of metabolic disorders are elaborated to provide a reference for the industrial development of walnut peptides.

关键词： Walnut Peptide Extraction Isolation Purification Identification Biological activity

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Mangrove wetlands distribution status identification, changing trend analyzation and carbon storage assessment of China

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China Geology 2024年第1期7卷 1-11页

作者： chang Li Fu Wang Peng Yang Fei-cui Wang Yun-zhuang Hu Yan-lin Zhao Li-zhu tian Rui-bin Zhao tianjin Center(North China Center of Geoscience Innovation) China Geological Survey(CGS)Tianjin 300170China Tangshan Hydrological Survey and Research Center of Heibei Province Tangshan063000China Key Laboratory of Coast Geo-Environment China Geological SurveyCGSTianjin 300170China tianjin Key Laboratory of Coast Geological Processes and Environmental Safety Tianjin 300170China

This research investigates the ecological importance,changes,and status of mangrove wetlands along China’s *** interpretation,geological surveys,and ISO clustering unsupervised classification methods are employed to interpret mangrove distribution from remote sensing images from 2021,utilizing ArcGIS software ***,the carbon storage capacity of mangrove wetlands is quantified using the carbon storage module of InVEST *** show that the mangrove wetlands in China covered an area of 278.85 km2 in 2021,predominantly distributed in Hainan,Guangxi,Guangdong,Fujian,Zhejiang,Taiwan,Hong Kong,and *** total carbon storage is assessed at 2.11×10^(6) t,with specific regional data *** since the 1950s reveal periods of increase,decrease,sharp decrease,and slight-steady increases in mangrove areas in *** important finding is the predominant replacement of natural coastlines adjacent to mangrove wetlands by artificial ones,highlighting the need for creating suitable spaces for mangrove *** study is poised to guide future mangroverelated investigations and conservation strategies.

关键词： Mangrove Wetland Carbon storage Ecological conservation ArcGIS software platform Restoration InVEST model Quantitative analysis Coastal zone of China

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Anti-hepatocarcinoma effect of polysaccharides extracted from Lactarius hatsudake Tanaka mushroom: in vitro and in vivo studies

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Food Science and Human Wellness 2024年

作者： Qiao Yang Songlin chang Yiming tian Hui Zhang Feijun Luo Wang Li Jiali Ren Hunan Key Laboratory of Forestry Edible Sources Safety and Processing， College of Food Science and Engineering， Central South University of Forestry and Technology

Edible mushroom polysaccharides demonstrate a range of bioactivities and have been investigated as potential adjuvant therapies for cancer treatment. Our prior research found Lactariks hatsudake Tanaka polysaccharide (LHP) effective against hepatocellular carcinoma， but the mechanisms remain unclear. This study aims to clarify the anti-cancer molecular mechanisms by examining the effects on specific signaling pathways through in vivo and in vitro analyses. Animal studies showed that LHP significantly inhibited the growth of transplanted liver cancer without toxicity. Histological and immunohistochemical analyses revealed that LHP increased nuclear cohesion in tumor cells and altered the expression of key regulatory proteins such as Ak strain transformation， nuclear factor kappa B， caspase-3， p21， and p53. These findings suggest that LHP's anticancer effects involve promoting apoptosis and disrupting the cell cycle. At the cellular level， assays such as MTS， flow cytometry， and transwell invasion confirmed that LHP inhibited cancer cell proliferation and induced apoptosis. Polymerase chain reaction and western blot assays revealed that LHP intervention reduced cyclin-dependent kinase 4 activity by upregulating p53 and p21， leading to cell cycle arrest and inhibited cell proliferation. LHP also promoted apoptosis by altering Bcl-2-associated X protein， B-cell lymphoma 2， and cleaved caspase-3 levels. Moreover， LHP could affect the Ak strain transformation， nuclear factor kappa B， and mitogen-activated protein kinase signaling pathways to exert anticancer effects. These findings underscore the potential of LHP as a novel and multifaceted therapeutic agent. Furthermore， the elucidation of LHP-related mechanisms offers a crucial theoretical foundation for developing innovative and effective treatments for hepatocellular carcinoma. Additionally， this supports its potential development as a functional food or adjuvant therapy for cancer， which holds significant implication

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频带禁区:远离共振的管道设计策略

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Acta Mechanica Sinica 2024年第3期40卷 191-201页

作者：邓天昌丁虎 Shanghai Key Laboratory of Mechanics in Energy Engineering School of Mechanics and Engineering ScienceShanghai UniversityShanghai200072China Shanghai Institute of Aircraft Mechanics and Control Shanghai200092China

本文介绍了一种通过调整卡箍使得管道避免发生共振的设计策略.当管道的固有频率在机械设备运作时产生的振动频率范围内,会引发共振现象,给机械设备的正常操作带来严重的灾难.因此,把机械设备操作产生的振动频率范围定义为频带禁区.通常... 详细信息

本文介绍了一种通过调整卡箍使得管道避免发生共振的设计策略.当管道的固有频率在机械设备运作时产生的振动频率范围内,会引发共振现象,给机械设备的正常操作带来严重的灾难.因此,把机械设备操作产生的振动频率范围定义为频带禁区.通常,工程中的管道被简化为多跨输流管道:通过将卡箍简化为线性和扭转刚度,建立了多跨输流管道的整体管道模型.通过采用Galerkin截断方法并应用广义特征值方法,获得了多跨输流管道的固有频率.通过对比不同长度的管道固有频率和频带禁区,定义了管长的安全范围和共振范围分别为频带禁区的外和内,并且通过分析卡箍的影响推导得出了绝对安全长度和绝对共振长度.此外,还确定了卡箍刚度和位置对安全范围的影响.结果表明,通过调整卡箍的线性刚度、扭转刚度和位置,管道的安全范围会发生显著地变化.根据这些结果,提出了一种管道设计策略,从而避免了管道的共振发生,并减少了使用卡箍的数量.最后,以飞机上的一段管道为例进行了设计,结果表明:通过调整卡箍,管道的固有频率成功地远离了频带禁区,因而在飞机的运行过程中不会发生共振.总而言之,通过调整卡箍的刚度或位置,可以获得避免多跨输流管道发生共振的设计策略.

关键词： Pipe conveying fluid Frequency preserve Natural frequency Resonance Multispan Retaining clip

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A Survey of Multimodal Controllable Diffusion Models

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Journal of Computer Science & Technology 2024年第3期39卷 509-541页

作者：江锐郑光聪李藤杨天瑞王井东李玺 College of Computer Science and Technology Zhejiang UniversityHangzhou310007China Department of Mathematics Nanjing UniversityNanjing 210023China Baidu Visual Technology Department Baidu Inc.Beijing 100085China IEEE

Diffusion models have recently emerged as powerful generative models,producing high-fidelity samples across *** this,they have two key challenges,including improving the time-consuming iterative generation process and controlling and steering the generation *** surveys provide broad overviews of diffusion model ***,they lack comprehensive coverage specifically centered on techniques for controllable *** survey seeks to address this gap by providing a comprehensive and coherent review on controllable generation in diffusion *** provide a detailed taxonomy defining controlled generation for diffusion *** generation is categorized based on the formulation,methodologies,and evaluation *** enumerating the range of methods researchers have developed for enhanced control,we aim to establish controllable diffusion generation as a distinct subfield warranting dedicated *** this survey,we contextualize recent results,provide the dedicated treatment of controllable diffusion model generation,and outline limitations and future *** demonstrate applicability,we highlight controllable diffusion techniques for major computer vision tasks *** consolidating methods and applications for controllable diffusion models,we hope to catalyze further innovations in reliable and scalable controllable generation.

关键词： diffusion model controllable generation application personalization

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阿尔茨海默病中BACE1相互作用蛋白筛选及功能分析

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生物化学与生物物理进展 2024年第8期51卷 1904-1919页

作者：刘聪聪王亚琦王培昌首都医科大学宣武医院检验科北京100053

目的β淀粉样蛋白前体蛋白裂解酶1(β-site APP cleaving enzyme 1,BACE1)是阿尔茨海默病(Alzheimer’s disease,AD)中淀粉样斑块形成的限速酶,其表达水平与活性在AD发生发展中起到关键作用。BACE1的相互作用蛋白可以通过直接结合、间... 详细信息

目的β淀粉样蛋白前体蛋白裂解酶1(β-site APP cleaving enzyme 1,BACE1)是阿尔茨海默病(Alzheimer’s disease,AD)中淀粉样斑块形成的限速酶,其表达水平与活性在AD发生发展中起到关键作用。BACE1的相互作用蛋白可以通过直接结合、间接结合、参与各种细胞信号转导通路等方式,直接或间接在BACE1的转录、翻译、修饰、胞内运输等各个环节对BACE1进行调节,从而参与AD的发生与疾病的进程。本研究拟筛选并验证BACE1的相互作用蛋白,为进一步深入阐明淀粉样斑块形成的机制提供新的依据。方法采用免疫共沉淀(co-immunoprecipitation,Co-IP)与质谱联合应用的技术富集并鉴定AD模型小鼠海马组织中BACE1的相互作用蛋白,通过生物信息学分析筛选与BACE1有潜在相互作用的蛋白质,采用Co-IP实验及免疫荧光共聚焦技术进行初步验证,并探究BACE1相互作用蛋白在AD细胞模型中蛋白质表达水平变化。结果本研究在AD组中共鉴定到与BACE1相互作用的差异表达蛋白614个。基因本体(GO)富集分析显示,AD组BACE1相互作用蛋白主要参与细胞内信号转导、靶向高尔基体囊泡的转运、浦肯野细胞层发育等生物学过程;京都基因与基因组百科全书(KEGG)分析显示,AD中BACE1相互作用蛋白主要参与了PI3K-Akt信号通路、mTOR信号通路等神经退行性疾病相关通路。通过构建BACE1相互作用蛋白网络,筛选了12个可信度较高的相互作用蛋白,其中NSF、NUMB、HSP90aa1、SNAP91为首次发现的BACE1相互作用蛋白。经进一步验证,发现NSF与BACE1存在相互作用,并且在AD细胞模型中NSF表达水平上调。结论BACE1相互作用蛋白参与多种AD相关生物途径及信号通路,NSF为新鉴定到的BACE1相互作用蛋白,与BACE1存在相互作用。NSF在AD细胞模型中表达水平上调,预测NSF与BACE1蛋白间相互作用参与调节AD疾病的进程,为疾病的机制研究提供新的靶点和方向。

关键词： β淀粉样蛋白前体蛋白裂解酶1 免疫共沉淀质谱法神经退行性疾病阿尔茨海默病

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Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

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World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： Zhen Huang Fan-Ying Meng Lin-Zhu Lu Qian-Qian Guo chang-Jun Lv Nian-Hua Tan Zhe Deng Jun-Yi Chen Zi-Shu Zhang Bo Zou Hong-Ping Long Qing Zhou Sha tian Si Mei Xue-Fei tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment

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Cerebral arterial blood flow,attention,and executive and cognitive functions in depressed patients after acute hypertensive cerebral hemorrhage

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World Journal of Clinical Cases 2024年第19期12卷 3815-3823页

作者： Ya-Zhao Zhang cong-Yi Zhang Ya-Nan tian Yi Xiang Jian-Hui Wei Department of Neurosurgery Hengshui People's HospitalHengshui 053000Hebei ProvinceChina Department of Ultrasound Second People's Hospital of Hengshui CityHengshui 053000Hebei ProvinceChina Department of Neurology Hengshui People's HospitalHengshui 053000Hebei ProvinceChina

BACKGROUND Intracerebral hemorrhage mainly occurs in middle-aged and elderly patients with hypertension,and surgery is currently the main treatment for hypertensive cerebral hemorrhage,but the bleeding caused by surgery will cause damage to the patient's nerve cells,resulting in cognitive and motor dysfunction,resulting in a decline in the patient's quality of *** To investigate associations between cerebral arterial blood flow and executive and cognitive functions in depressed patients after acute hypertensive cerebral *** Eighty-nine patients with depression after acute hypertensive cerebral hemorrhage who were admitted to our hospital between January 2019 and July 2021 were selected as the observation group,while 100 patients without depression who had acute hypertensive cerebral hemorrhage were selected as the control *** attention span of the patients was assessed using the Paddle Pin Test while executive function was assessed using the Wisconsin Card Sorting Test(WCST)and cognitive function was assessed using the Montreal Cognitive Assessment Scale(MoCA).The Hamilton Depression Rating Scale(HAMD-24)was used to evaluate the severity of depression of involved *** arterial blood flow was measured in both *** The MoCA score,net scores I,II,III,IV,and the total net score of the scratch test in the observation group were significantly lower than those in the control group(P<0.05).Concurrently,the total number of responses,number of incorrect responses,number of persistent errors,and number of completed responses of the first classification in the WCST test were significantly higher in the observation group than those in the control group(P<0.05).Blood flow in the basilar artery,left middle cerebral artery,right middle cerebral artery,left anterior cerebral artery,and right anterior cerebral artery was significantly lower in the observation group than in the control group(P<0.05).The basilar artery,left middle cerebr

关键词： Acute hypertensive cerebral hemorrhage Depression Cerebral arterial blood flow Attention Executive ability Cognitive function

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Myricetin induces M2 macrophage polarization to alleviate renal tubulointerstitial fibrosis in diabetic nephropathy via PI3K/Akt pathway

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World Journal of Diabetes 2024年第1期15卷 105-125页

作者： Wei-Long Xu Pei-Pei Zhou Xu Yu Ting tian Jin-Jing Bao chang-Rong Ni Min Zha Xiao Wu Jiang-Yi Yu Department of Endocrinology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pharmacy Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pneumology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKGROUND Development of end-stage renal disease is predominantly attributed to diabetic nephropathy(DN).Previous studies have indicated that myricetin possesses the potential to mitigate the pathological alterations observed in renal ***-theless,the precise molecular mechanism through which myricetin influences the progression of DN remains *** To investigate the effects of myricetin on DN and explore its potential therapeutic *** Db/db mice were administered myricetin intragastrically on a daily basis at doses of 50 mg/kg or 100 mg/kg for a duration of 12 ***,blood and urine indexes were assessed,along with examination of renal tissue *** morphology and fibrosis were evaluated using various staining techniques including hematoxylin and eosin,periodic acid–Schiff,Masson’s trichrome,and ***,high-glucose culturing was conducted on the RAW 264.7 cell line,treated with 25 mM myricetin or co-administered with the PI3K/Akt inhibitor LY294002 for a period of 24 *** both in vivo and in vitro settings,quantification of inflammation factor levels was conducted using western blotting,real-time qPCR and *** In db/db mice,administration of myricetin led to a mitigating effect on DN-induced renal dysfunction and ***,we observed a significant reduction in expressions of the kidney injury markers kidney injury molecule-1 and neutrophil gelatinase associated lipocalin,along with a decrease in expressions of inflammatory cytokine-related ***,myricetin treatment effectively inhibited the up-regulation of tumor necrosis factor-alpha,interleukin-6,and interluekin-1βinduced by high glucose in RAW 264.7 ***,myricetin modulated the M1-type polarization of the RAW 264.7 *** docking and bioinformatic analyses revealed Akt as the target of *** protective effect of myricetin was nullified upon blocking the polarization of RAW 264.7 via inh

关键词： Myricetin Diabetic nephropathy PI3K/Akt pathway Renal tubulointerstitial fibrosis Macrophage Polarization

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