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Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115

Cellular & Molecular Immunology 2024年第3期21卷 275-291页

作者： Zhi-Dong Zhang Chang-Rui Shi Fang-Xu Li Hu Gan Yanhong Wei Qianhui Zhang Xin Shuai Min chen Yu-Lin Lin tian-chen xiong Xiaoqi chen Bo Zhong Dandan Lin Department of Gastrointestinal Surgery Medical Research InstituteFrontier Science Center of Immunology and MetabolismZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan430071China Department of Virology College of Life SciencesWuhan UniversityWuhan430072China TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhan430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan430071China Department of Rheumatology and Immunology Zhongnan Hospital of Wuhan UniversityWuhan430071China Cancer Center Renmin Hospital of Wuhan UniversityWuhan430060China

STING(also known as MITA)is an adaptor protein that mediates cytoplasmic DNA-triggered signaling,and aberrant activation of STING/MITA by cytosolic self-DNA or gain-of-function mutations causes severe ***,we show that STING-mediated inflammation and autoimmunity are promoted by RNF115 and alleviated by the RNF115 inhibitor disulfiram(DSF).Knockout of RNF115 or treatment with DSF significantly inhibit systemic inflammation and autoimmune lethality and restore immune cell development in Trex1^(–/–)mice and STING^(N153S/WT) bone marrow chimeric *** addition,knockdown or pharmacological inhibition of RNF115 substantially downregulate the expression of IFN-α,IFN-γand proinflammatory cytokines in PBMCs from patients with systemic lupus erythematosus(SLE)who exhibit high concentrations of dsDNA in peripheral ***,knockout or inhibition of RNF115 impair the oligomerization and Golgi localization of STING in various types of cells transfected with cGAMP and in organs and cells from Trex1^(–/–)***,knockout of RNF115 inhibits the activation and Golgi localization of STINGN153S as well as the expression of proinflammatory cytokines in myeloid cells but not in endothelial cells or *** together,these findings highlight the RNF115-mediated cell type-specific regulation of STING and STINGN153S and provide potential targeted intervention strategies for STING-related autoimmune diseases.

关键词： STING/MITA Disulfiram RNF115 SLE Autoimmunity

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Evaluation and attribution of trends in compound dry-hot events for major river basins in China

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Science China Earth Sciences 2024年第1期67卷 79-91页

作者： Shaotang xiong Tongtiegang ZHAO chengchao GUO Yu tian Fang YANG Wenlong chen Xiaohong chen Key Laboratory of Water Security Guarantee in Guangdong-Hong Kong-Marco Greater Bay Area of Ministry of Water Resources&Sun Yatsen University/Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Guangzhou 510275China China Institute of Water Resource and Hydropower Research Beijing 100038China Pearl River Hydraulic Research Institute Guangzhou 510611China

Concurrent compound dry and hot events(CDHEs)amplified more damange on the ecosystems and human society than individual *** climate change,compound dry and hot events become more frequent on a global *** paper proposes a mathematical method to quantitatively attribute changes of CDHEs to changes of precipitation,change in temperature and change in the dependence between precipitation and *** attribution is achieved by formulating the total differential equation of the return period of CDHEs among Meta-gaussian model.A case study of China is devised based on monthly precipitation and temperature data during the period from 1921 to 2020 for 80 major river *** is found that temperature is the main driving factor of increases in CDHEs for 49 major river basins in China,except for the upper and middle reaches of the Yangtze *** West China,precipitation changes drove the increase in CDHEs in 18 river basins(23%),particularly in parts of North Xinjiang,Qinghai and *** the other hand,dependence between precipitation and temperature dominated changes of CDHEs in 13 river basins(16%)of China with other factors,including parts of South China,East China and Northwestern ***,changes in both the mean and spread of precipitation and temperature can also contribute to changes in CDHEs.

关键词： Climate extreme Compound dry and hot extreme Precipitation Temperature Return period

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An intelligent active probing and trace-back scheme for IoT anomaly detection

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Digital Communications and Networks 2024年第1期10卷 168-181页

作者： Luying Wang Lingyi chen Neal N.xiong Anfeng Liu tian Wang Mianxiong Dong School of Computer Science and Engineering Central South UniversityChangsha 410083China Department of Computer Science and Mathematics Sul Ross State UniversityAlpineTX 79830USA Artificial Intelligence and Future Networks Beijing Normal University&UICZhuhai 519087China Department of Information and Electronic Engineering Muroran Institute of TechnologyMuroran 050-8585Japan

Due to their simple hardware,sensor nodes in IoT are vulnerable to attack,leading to data routing blockages or malicious tampering,which significantly disrupts secure data *** Intelligent Active Probing and Trace-back Scheme for IoT Anomaly Detection(APTAD)is proposed to collect integrated IoT data by recruiting Mobile Edge Users(MEUs).(a)An intelligent unsupervised learning approach is used to identify anomalous data from the collected data by MEUs and help to identify anomalous nodes.(b)Recruit MEUs to trace back and propose a series of trust calculation methods to determine the trust of nodes.(c)The last,the number of active detection packets and detection paths are designed,so as to accurately identify the trust of nodes in IoT at the minimum cost of the network.A large number of experimental results show that the recruiting cost and average anomaly detection time are reduced by 6.5 times and 34.33%respectively,while the accuracy of trust identification is improved by 20%.

关键词： Anomaly detection Internet of things Integrating data collection Mobile edge users Intelligent

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A survey on model-based reinforcement learning

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Science China(Information Sciences) 2024年第2期67卷 59-84页

作者： Fan-Ming LUO tian XU Hang LAI xiong-Hui chen Weinan ZHANG Yang YU National Key Laboratory for Novel Software Technology Nanjing University Polixir. ai Department of Computer Science and Engineering Shanghai Jiao Tong University

Reinforcement learning(RL) interacts with the environment to solve sequential decision-making problems via a trial-and-error approach. Errors are always undesirable in real-world applications, even though RL excels at playing complex video games that permit several trial-and-error attempts. To improve sample efficiency and thus reduce errors, model-based reinforcement learning(MBRL) is believed to be a promising direction, as it constructs environment models in which trial-and-errors can occur without incurring actual costs. In this survey, we investigate MBRL with a particular focus on the recent advancements in deep RL. There is a generalization error between the learned model of a non-tabular environment and the actual environment. Consequently, it is crucial to analyze the disparity between policy training in the environment model and that in the actual environment, guiding algorithm design for improved model learning, model utilization, and policy training. In addition, we discuss the recent developments of model-based techniques in other forms of RL, such as offline RL, goal-conditioned RL, multi-agent RL, and meta-RL. Furthermore,we discuss the applicability and benefits of MBRL for real-world tasks. Finally, this survey concludes with a discussion of the promising future development prospects for MBRL. We believe that MBRL has great unrealized potential and benefits in real-world applications, and we hope this survey will encourage additional research on MBRL.

关键词： reinforcement learning model-based reinforcement learning planning model learning model learning with reduced error model usage

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Construction of Prediction Model of Foodborne Disease Outbreaks and Its Trend Prediction—Guizhou Province,China,2023-2025

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China CDC weekly 2024年第18期6卷 408-408,I0009,409-412,I0010-I0015页

作者： Li Zhang Sufang xiong Shu Zhu Jigui tian Qingyuan chen Xiaobo Luo Hua Guo Institute of Public Health Surveillance and Evaluation Guizhou Center for Disease Control and PreventionGuiyang CityGuizhou ProvinceChina School of Public Health Guizhou Medical University.Guiyang CityGuizhou ProvinceChina

Objective:Foodborne diseases pose a significant public health concern *** study aims to analyze the correlation between disease prevalence and climatic conditions,forecast the pattern of foodborne disease outbreaks,and offer insights for effective prevention and control strategies and optimizing health resource allocation policies in Guizhou ***:This study utilized theχ^(2) test and four comprehensive prediction models to analyze foodborne disease outbreaks recorded in the Guizhou Foodborne Disease Outbreak system between 2012 and *** best-performing model was chosen to forecast the trend of foodborne disease outbreaks in Guizhou Province,***:Significant variations were observed in the incidence of foodborne disease outbreaks in Guizhou Province concerning various meteorological factors(all P≤0.05).Among all models,the SARIMA-ARIMAX combined model demonstrated the most accurate predictive performance(RMSE:Prophet model=67.645,SARIMA model=3.953,ARIMAX model=26.544,SARIMA-ARIMAX model=26.196;MAPE:Prophet model=42.357%,SARIMA model=37.740%,ARIMAX model=15.289%,SARIMA-ARIMAX model=13.961%).Conclusion:The analysis indicates that foodborne disease outbreaks in Guizhou Province demonstrate distinct seasonal *** is recommended to concentrate prevention efforts during peak *** SARIMA-ARIMAX hybrid model enhances the precision of monthly forecasts for foodborne disease outbreaks,offering valuable insights for future prevention and control strategies.

关键词： Guizhou prevention offering

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Effect of oxide interactions on chromium speciation transformation during simulated municipal solid waste incineration

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Journal of Environmental Sciences 2024年第8期142卷 11-20页

作者： Guodong Zhao Chong tian Peidong Wu Xuguang Zhang Zhikang Wang Xiaoxiang chen Zhuo xiong Yongchun Zhao Junying Zhang State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China National Environmental Protection Engineering Technology Center for Trace Elements Pollution Control and Low Carbon Utilization of Coal Huazhong University of Science and TechnologyWuhan 430074China School of Environmental Engineering Wuhan Textile UniversityWuhan 430200China

Chromium released during municipal solid waste incineration(MSWI)is toxic and *** removal of chromium from simulated MSWI flue gas by four sorbents(CaO,bamboo charcoal(BC),powdered activated carbon(PAC),and Al_(2)O_(3))and the effects of four oxides(SiO_(2),Al_(2)O_(3),Fe_(2)O_(3),and CaO)on chromium speciation transformationwere *** results showed that the removal rates of total Cr by the four sorbents were Al_(2)O_(3)

关键词： Cr(Ⅵ)reduction Cr(Ⅲ)oxidation Alkali oxides Acidic oxides Municipal solid waste incineration

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Metal complexes of bipyridine-functionalized covalent organic frameworks as efficient electrocatalysts for oxygen evolution reaction

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Rare Metals 2024年第7期43卷 3096-3106页

作者： Zhuang-Zhuang Wu tian Xia Ying Liang Yong-Peng Li Zhu-Yin Sui Li-Juan Feng Dao-xiong Wu Xin-Long tian Qi chen State Key Laboratory of Marine Resource Utilization in South China Sea School of Marine Science and EngineeringHainan UniversityHaikou 570228China School of Chemistry and Chemical Engineering Yantai UniversityZhuhai519041China School of Bioengineering Zhuhai Campus of Zunyi Medical UniversityZhuhai519041China

Electrocatalytic water splitting is considered a clean and practic al method for producing *** this study,COF-Bpy,a bipyridine-functionalized covalent organic framework(COF),was prepared via post-synthetic modification,after which electrocatalysts for the oxygen evolution reactions(OER)were formed through coordination to single-or double-transition metals(Fe,Co,Ni,FeCo,FeNi or CoNi).COF-Bpy@FeNi delivered the best OER performance among the studied electrocatalysts,with an overpotential of 399 mV at 10 mA·cm^(-2)in an alkaline electrolyte(1.0 mol·L^(-1)KOH aqueous).Notably,the electrocatalytic performance of COF-Bpy@FeNi showed slight degradation during durability testing,which is ascribable to its irreversible benzoquinoline structure and strong metal *** expected,COF-Bpy@FeNi exhibited a low overpotential of 347 mV at a turnover frequency(TOF)of 0.1 s^(-1),which suggests that COF-Bpy@FeNi possesses excellent intrinsic electroc atalytic OER ***,density functional theory(DFT)calculations reveal that the Ni site plays a major role,while the Fe site adjusts the electronic structure of the Ni ions,which rationalizes the excellent OER properties of COF-Bpy@*** study not only provides a simple and efficient method for complexing COFs with transition metals,but also offers a novel strategy for designing porous organic polymer electrocatalysts.

关键词： Covalent organic framework Oxygen evolution reactions(OER)electrocatalyst Nickel-iron synergy Water splitting

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Achieving dynamic privacy measurement and protection based on reinforcement learning for mobile edge crowdsensing of IoT

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Digital Communications and Networks 2024年第2期10卷 380-388页

作者： Renwan Bi Mingfeng Zhao Zuobin Ying Youliang tian Jinbo xiong Fujian Provincial Key Laboratory of Network Security and Cryptology College of Computer and Cyber SecurityFujian Normal UniversityFuzhou350117China Guangxi Key Laboratory of Trusted Software Guilin University of Electronic TechnologyGuilin541004China Faculty of Data Science City University of Macao999078MacaoChina State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang550025China

With the maturity and development of 5G field,Mobile Edge CrowdSensing(MECS),as an intelligent data collection paradigm,provides a broad prospect for various applications in ***,sensing users as data uploaders lack a balance between data benefits and privacy threats,leading to conservative data uploads and low revenue or excessive uploads and privacy *** solve this problem,a Dynamic Privacy Measurement and Protection(DPMP)framework is proposed based on differential privacy and reinforcement ***,a DPM model is designed to quantify the amount of data privacy,and a calculation method for personalized privacy threshold of different users is also ***,a Dynamic Private sensing data Selection(DPS)algorithm is proposed to help sensing users maximize data benefits within their privacy ***,theoretical analysis and ample experiment results show that DPMP framework is effective and efficient to achieve a balance between data benefits and sensing user privacy protection,in particular,the proposed DPMP framework has 63%and 23%higher training efficiency and data benefits,respectively,compared to the Monte Carlo algorithm.

关键词： Mobile edge crowdsensing Dynamic privacy measurement Personalized privacy threshold Privacy protection Reinforcement learning

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Unimolecular Self-Assembled Hemicyanine-Oleic Acid Conjugate Acts as a Novel Succinate Dehydrogenase Inhibitor to Amplify Photodynamic Therapy and Eliminate Cancer Stem Cells

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Research 2024年第2期6卷 449-461页

作者： Qiang Wang tian Yang Shiyou Li chen Xu Chong Wang Yuxuan xiong Xing Wang Jiangling Wan Xiangliang Yang Zifu Li National Engineering Research Center for Nanomedicine College of Life Science and Technology.Huazhong University of Science and TechnologyWuhan 430074P.R.China Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China .3Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Bioinformatics and Molecular Imaging Key Laboratory College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China

Photodynamic therapy with reactive oxygen species production is a prospective treatment to combat cancer stem cells(CSCs).However,the innate drawbacks,including short lifetime and diffusion distance of reactive oxygen species and hypoxia within solid tumors,have become bottlenecks for clinical applications of photodynamic ***,we develop a mitochondria-targeting hemicyanine-oleic acid conjugate(CyOA),which can self-assemble into supramolecular nanoparticles(NPs)without any exogenous *** is also shown for targeting the mitochondrial complex II protein succinate dehydrogenase to inhibit oxidative phosphorylation and reverse tumor hypoxia,resulting in 50.4-fold higher phototoxicity against breast cancer stem cells(BCSCs)compared to SO_(3)-CyOA NPs that cannot target to *** 4T1 and BCSC tumor models,CyOA NPs achieve higher tumor inhibition and less lung metastasis nodules compared to the clinically used photosensitizer *** study develops a self-assembled small molecule that can serve as both oxidative phosphorylation inhibitor and photosensitizer for eradication of CSCs and treatment of solid tumors.

关键词： cyanine oxidative treatment

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Frost heaving and crack initiation characteristics of tunnel rock mass in cold regions under low-temperature degradation

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Journal of Mountain Science 2024年第8期21卷 2844-2854页

作者： chen Wenhua XIANG tian School of Civil Engineering Beijing Jiaotong UniversityBeijing 202303China

Water freezing in rock fractures causes volumetric expansion and fracture development through frost *** study introduces a novel analytical model to investigate how uneven freezing force and surrounding rock pressure influence fracture initiation,based on mass conservation,elasticity,and water-ice phase transition principles.A model for rock fracture initiation considering freezing temperature,uneven freezing expansion,in-situ stress,and lateral pressure was proposed based on fracture *** for stress intensity factors were developed and validated using the phase field *** effects of rock elastic modulus anisotropy and critical fracture energy density on fracture initiation were also *** results show that the values of KI and KII exhibit an upward trend as the freezing temperature,uneven expansion,in-situ stress,and lateral pressure *** uneven freezing expansion has the most significant influence on KI and KII values among these *** the uneven freezing expansion coefficient increases to 0.5,the fracture initiation mode shifts from tensile fracture to shear *** the lateral pressure coefficient increases to 1,the fracture initiation mode shifts from tensile fracture to shear *** elastic modulus anisotropy causes fractures to propagate in a clockwise direction,forming a'butterfly'*** fracture energy density an isotropy causes counterclockwise deviation in propagation direction,resulting in branching paths and an'H'-shaped pattern.

关键词： Rock fractures Fracture water Uneven freezing expansion Phase field method Initiation angle Anisotropy

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