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Efficacy and safety of ultrasound cycloplasty for the treatment of glaucoma: a Meta-analysis

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1317-1325页

作者： tian-Hong Wu Xue Yin jian-Qing Li Pei-Rong lu Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

AIM:To evaluate the efficacy and safety of ultrasound cycloplasty(UCP)for ***:A comprehensive search of PubMed,Embase,Web of Science,and Google Scholar databases was used to select studies met the inclusion *** was performed by Review Manager and StataCorp ***:A total of 19 articles met the inclusion ***,UCP is effective and safe in the glaucoma treatment,the risk ratio(RR)of the success rate was 2.28(95%CI,1.82-2.84).After UCP,patients had a significant reduction in intraocular pressure(IOP;mm Hg),the weighted mean difference(WMD)was 11.39(95%CI,9.88-12.90).In addition,UCP brings fewer postoperative complications with RR of 0.30(95%CI,0.19-0.49).Most of the complications were short-term and ***,patients’use of IOP-lowering medications reduced,the standardized mean difference(SMD)was 0.78(95%CI,0.40-1.17).However,best corrected visual acuity(BCVA;logMAR)did not have obvious improvement after UCP,the WMD was 0.01(95%CI,-0.06-0.09).This procedure does provide painfulness relief,with RR of 3.06(95%CI,1.95-4.81).CONCluSION:UCP is effective and safe for suitable *** can effectively decrease IOP in glaucoma patients,reduce the patients’dependence on IOP-lowering medications after surgery,relief the painfulness and has fewer long-term or severe postoperative complications,but the BCVA did not improve much.

关键词： ultrasound cycloplasty glaucoma efficacy safety

Electrokinetic flow and energy conversion in a curved microtube

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Applied Mathematics and Mechanics(English Edition) 2022年第8期43卷 1289-1306页

作者： Zhaodong DING Kai tian Yongjun jian School of Mathematical Science Inner Mongolia UniversityHohhot010021China

Curved channels are ubiquitous in microfluidic *** pressure-driven electrokinetic flow and energy conversion in a curved microtube are investigated analytically by using a perturbation analysis method under the assumptions of the small curvature ratio and the Reynolds *** results indicate that the curvature of the microtube leads to a skewed pattern in the distribution of the electrical double layer(EDL)*** EDL potential at the outer side of the bend is larger than that at the inner side of the *** curvature shows an inhibitory effect on the magnitude of the streaming potential field induced by the pressure-driven *** the spanwise pressure gradient is dominant over the inertial force,the resulting axial velocity profile is skewed into the inner region of the curved ***,the flow rate in a curved microtube could be larger than that in a straight one with the same pressure gradient and shape of cross *** asymptotic solutions of the axial velocity and flow rate in the absence of the electrokinetic effect are in agreement with the classical results for low Reynolds number ***,the curved geometry could be beneficial to improving the electrokinetic energy conversion(EKEC)efficiency.

关键词： electrokinetic flow streaming potential electrokinetic energy conversion(EKEC) perturbation analysis method curved microchannel

Observational Subseasonal Variability of the PM_(2.5) Concentration in the Beijing-tianjin-Hebei Area during the January 2021 Sudden Stratospheric Warming

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Advances in Atmospheric Sciences 2022年第10期39卷 1623-1636页

作者： Qian lu jian RAO Chunhua SHI Dong GUO Ji WANG Zhuoqi LIANG tian WANG Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science and TechnologyNanjing 210044China Key Laboratory of Meteorology and Ecological Environment of Hebei Province Shijiazhuang 050021China Beijing Regional Climate Center Beijing 100089China

It is still not well understood if subseasonal variability of the local PM_(2.5) in the Beijing-tianjin-Hebei(BTH)region is affected by the stratospheric *** PM_(2.5) observations and the ERA5 reanalysis,the evolution of the air quality in BTH during the January 2021 sudden stratospheric warming(SSW)is *** subseasonal variability of the PM_(2.5) concentration after the SSW onset is evidently *** circumpolar easterly anomalies lasted for 53 days during the January-February 2021 SSW with two evident stratospheric pulses arriving at the *** the tropospheric wave weakening period and the intermittent period of dormant stratospheric pulses,the East Asian winter monsoon weakened,anomalous temperature inversion developed in the lower troposphere,anomalous surface southerlies prevailed,atmospheric moisture increased,and the boundary layer top height lowered,all of which favor the accumulation of pollutant particulates,leading to two periods of pollution processes in the BTH *** the phase of strengthened East Asian winter monsoon around the very beginning of the SSW and another two periods when stratospheric pulses had reached the near surface,opposite-signed circulation patterns and meteorological conditions were observed,which helped to dilute and diffuse air pollutants in the BTH *** a result,the air quality was excellent during the two periods when the stratospheric pulse had reached the near *** increased subseasonal variation of the regional pollutant particulates after the SSW onset highlights the important role of the stratosphere in the regional environment and provides implications for the environmental prediction.

关键词： sudden stratospheric warming(SSW) PM_(2.5) Beijing-tianjin-Hebei(BTH) East Asian winter monsoon boundary layer meteorological conditions

Analysis of the electron transfer pathway in small laccase by EPR and UV-vis spectroscopy coupled with redox titration

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Magnetic Resonance Letters 2024年第3期4卷 52-59页

作者： lu Yu Aokun Liu jian Kuang Ruotong Wei Zhiwen Wang Changlin tian High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China Department of Endocrinology Institute of Endocrine and Metabolic DiseaseThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineHefei National Research Center for Physical Sciences at the MicroscaleJoint Center for Biological Analytical ChemistryAnhui Engineering Laboratory of Peptide DrugAnhui Laboratory of Advanced Photonic Science and TechnologyUniversity of Science and Technology of ChinaHefei230026China

Bacterial small laccases(SLAC) are promising industrial biocatalysts due to their ability to oxidize a broad range of substrates with exceptional thermostability and tolerance for alkaline p H. Electron transfer between substrate, copper centers, and O2is one of the key steps in the catalytic turnover of SLAC. However, limited research has been conducted on the electron transfer pathway of SLAC and SLAC-catalyzed reactions, hindering further engineering of SLAC to produce tunable biocatalysts for novel applications. Herein, the combinational use of electron paramagnetic resonance(EPR) and ultraviolet-visible(UV-vis) spectroscopic methods coupled with redox titration were employed to monitor the electron transfer processes and obtain further insights into the electron transfer pathway in SLAC. The reduction potentials for type 1 copper(T1Cu), type 2 copper(T2Cu) and type 3copper(T3Cu) were determined to be 367 ± 2 mV, 378 ± 5 m V and 403 ± 2 mV,respectively. Moreover, the reduction potential of a selected substrate of SLAC, hydroquinone(HQ), was determined to be 288 mV using cyclic voltammetry(CV). In this way, an electron transfer pathway was identified based on the reduction potentials. Specifically,electrons are transferred from HQ to T1Cu, then to T2Cu and T3Cu, and finally to ***, superhyperfine splitting observed via EPR during redox titration indicated a modification in the covalency of T2Cu upon electron uptake, suggesting a conformational alteration in the protein environment surrounding the copper sites, which could potentially influence the reduction potential of the copper sites during catalytic processes. The results presented here not only provide a comprehensive method for analyzing the electron transfer pathway in metalloenzymes through reduction potential measurements, but also offer valuable insights for further engineering and directed evolution studies of SLAC in the aim for biotechnological and industrial applications.

关键词： Electron paramagnetic resonance Redox titration Electron transfer Reduction Potential Small laccase

EXPLAINING THE CHANGES IN ALPS BY IDENTIFYING ALPS-IMPORTANT COEFFICIENTS:AN EMPIRICAL APPLICATION OF CHINA

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Journal of Systems Science & Complexity 2013年第3期26卷 383-406页

作者： lu Xiaolin XU jian Management School University of Chinese Academy of Sciences

This paper establishes the relation between APLs and direct input coefficients through Sherman-Morrison *** such a basis,elasticity matrix can be calculated for each element of the APLs matrix,which measures the percentage change in the APLs-matrix element brought by one percentage change in every direct input ***,the percentage change in each APLs-matrix element caused by the real percentage change in each coefficient with other coefficients fixed can be drawn,from which it is easily to find out the APLs-important coefficients and is useful to explain the reason for change in the *** empirical application studies the Chinese ***'s more,the method is applied under different level of *** comparison between the APLs matrix of 1997 and 2002 allows the authors to visualize the elements that change *** the methodology above is applied to explain the change from the perspective of direct input coefficients and find out the important coefficients to the Chinese APLs matrix.

关键词： APLs-important coefficients APLs matrix direct input coefficients elasticity matrix Sherman-Morrison formulation.

解淀粉芽孢杆菌wxy-b3产脂肽类物质对苹果斑点落叶病菌的抑菌活性研究

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陕西科技大学学报 2025年第1期43卷 46-51页

作者：崔皓玥田露胡乐梅龚国利陕西科技大学食品科学与工程学院陕西西安710021

苹果斑点落叶病菌是苹果生产过程中常见的病害,严重危害苹果农作物的产量.脂肽作为一种主要来源于微生物次生代谢产物的抗菌剂,具有广谱抑菌、低耐药性、安全低毒等优势.本研究发现,解淀粉芽孢杆菌wxy-b3产生的脂肽类物质能够抑制苹果... 详细信息

苹果斑点落叶病菌是苹果生产过程中常见的病害,严重危害苹果农作物的产量.脂肽作为一种主要来源于微生物次生代谢产物的抗菌剂,具有广谱抑菌、低耐药性、安全低毒等优势.本研究发现,解淀粉芽孢杆菌wxy-b3产生的脂肽类物质能够抑制苹果斑点落叶病菌的生长,对苹果斑点落叶病菌的最小抑菌浓度为16 mg/mL,此浓度可造成该病原菌细胞膜电位超极化、线粒体膜电位去极化、大分子蛋白质和核酸泄露,以及胞内活性氧和丙二醛含量分别累积增加0.33倍和5.44倍,并通过扫描电镜进一步观察到MIC处理组的细胞形态起皱、细胞膜破损.上述结果表明,脂肽可能通过破坏细胞膜系统,导致细胞形态发生变化,细胞膜破裂,改变细胞膜通透性来达到抑菌效果.该研究将为脂肽作为抑制苹果斑点落叶病菌的抗菌剂奠定理论基础.

关键词：解淀粉芽孢杆菌脂肽类物质苹果斑点落叶病菌抑菌活性

In situ regulating intimately connected heterostructure by decomposition of solid solution oxides toward high-efficient water oxidation

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Rare Metals 2024年第4期43卷 1557-1569页

作者： Shao-Fei Zhang Xiao-lu Yin Jin Wang jian-Li Kang tian-tian Li Jin-Feng Sun Yong-Qiang Meng jian-jiang Wang Dian-Long Wang Kai-Qiang Qin Hebei Key Laboratory of Flexible Functional Materials/Hebei Key Laboratory of Material Near-Net Forming Technology School of Materials Science and EngineeringHebei University of Science and TechnologyShijiazhuang050018China Key Laboratory of Advanced Ceramics and Machining Technology/Ministry of Education School of Materials Science and EngineeringTianjin UniversityTianjin300072China Electrochemical Engine Center Department of Mechanical EngineeringPennsylvania State UniversityUniversity ParkPA16802USA

Heterogeneous interfaces produced by interdomain interactions on a nanoscale performs a crucial role in boosting the properties of an electrocatalyst toward oxygen evolution reaction(OER)***,a series of dual-phase electrodes with intimately connected heterointerfaces are prepared by in situ decomposing solid solution oxide of Ni_(x)Co_(y)Fe_(100-x-y)O,which grew on Ni foam massively via an ultrafast combustion ***,with high-reaction kinetics caused by the reduction treatment at 450℃,the less electronegative Fe and Co are more oxyphilic than Ni,which facilitated their co-exsolution and formation of CoFe_2O_4/NiO oxide with enriched oxygen *** from the nanoporous framework,heterojunction structure,and oxygen defects,the self-supporting electrodes present rapid charge/mass transmission and provide abundant active sites for *** optimized sample(R-SNCF4.5)shows low overpotentials of 226 and 324 mV at 10 and100 mA·cm^(-2),a small Tafel slope(46.7 mV·dec^(-1)),and excellent *** assembled R-SNCF4.5//Pt/C/NF electrolyzer demonstrates continuous electrolysis over 50 h at a current density of 10 mA·cm^(-2),under 1.51 *** functional theory(DFT)calculations verify that the strong electronic modulation plays a critical part in the CoFe_2O_4/NiO hybrid by lowering the energy barriers for the ratedetermining steps,and Fe sites are the most active OER sites.

关键词： Rapid combustion Decomposition of solid solution oxide Dual-phase heterostructure Oxygen evolution reaction Theoretical calculation

Superlinear Elliptic Equation with Mixed Boundary Value in Annular Domain

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Acta Mathematica Sinica,English Series 2021年第10期37卷 1549-1559页

作者： jian tian Yuan Hong WEI School of Mathematics Jilin UniversityChangchun 130012P.R.China

In this paper,we study superlinear elliptic equations with mixed boundary value conditions in annular *** is assumed that the nonlinearities depend on the derivative *** results about existence of solutions are establ... 详细信息

关键词： Mixed boundary value annular domain radial solution gradient term iterative method

旧金山果实乳杆菌生物学特性及其对发酵面食影响的研究进展

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食品工业科技 2025年第1期46卷 431-438页

作者：张国华贺霞霞路婷孙天王灿烂周世伟山西大学生命科学学院山西太原030031 乐斯福管理(上海)有限公司上海200235

旧金山果实乳杆菌(Fructilactobacillus sanfranciscensis)作为酸面团中常见的菌种,是具有良好应用价值的酸面团乳酸菌之一,该菌种通过自身的生长代谢及其与酸面团中酵母菌间的相互作用对发酵面食的风味、营养及质构等方面产生重要影响... 详细信息

旧金山果实乳杆菌(Fructilactobacillus sanfranciscensis)作为酸面团中常见的菌种,是具有良好应用价值的酸面团乳酸菌之一,该菌种通过自身的生长代谢及其与酸面团中酵母菌间的相互作用对发酵面食的风味、营养及质构等方面产生重要影响。自1971年分离该菌株以来,其分类学地位经历多次变迁,命名从Lactobacillus sanfrancisco变更为Lactobacillus sanfranciscensis,在2020年确定为Fructilactobacillus sanfranciscensis,至今,该菌种相关的研究文献已达500余篇。目前,该菌种已列入欧洲食品安全局的可食用菌种名单和韩国的限制性使用的微生物菌种名单,但尚不在我国可食用菌种名单中。本文系统综述了旧金山果实乳杆菌目前的分类学地位及其在酸面团中的普遍性,菌种的生化特性及基因特性,并阐述了其对发酵面食的影响,探索旧金山果实乳杆菌在酸面团中的应用潜力,以期开发用于酸面团的标准化发酵剂,为传统发酵面食产业化提供理论基础。

关键词：酸面团旧金山果实乳杆菌发酵面食酿酒酵母矮小哈萨克斯坦酵母菌

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