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Combined effects of ultrasonic vibration and FeCoNiCrCu coating on interfacial microstructure and mechanical properties of Al/Mg bimetal by compound casting

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China Foundry 2024年第5期21卷 588-598页

作者： Yuan-cai Xu Wen-ming Jiang Qing-qing Li Ling-hui Yu Xiao-peng Yu Zi-tian fan State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

In this work,a new treatment method combining ultrasonic vibration with FeCoNiCrCu high entropy alloy(HEA)coating was used to prepared Al/Mg bimetal through the lost foam compound *** effects of composite treatment involving ultrasonic vibration and HEA coating on interfacial microstructure and mechanical properties of Al/Mg bimetal were *** demonstrate that the interface thickness of the Al/Mg bimetal with composite treatment significantly decreases to only 26.99%of the thickness observed in the untreated Al/Mg *** HEA coating hinders the diffusion between Al and Mg,resulting the significant reduction in Al/Mg intermetallic compounds in the *** Al/Mg bimetal interface with composite treatment is composed of Al_(3)Mg_(2)and Mg_(2)Si/AlxFeCoNiCrCu+FeCoNiCrCu/δ-Mg+Al_(12)Mg_(17)eutectic *** interface resulting from the composite treatment has a lower hardness than that without *** acoustic cavitation and acoustic streaming effects generated by ultrasonic vibration promote the diffusion of Al elements within the HEA coating,resulting in a significant improvement in the metallurgical bonding quality on the Mg *** fracture position shifts from the Mg side of the Al/Mg bimetal only with HEA coating to the Al side with composite *** shear strength of the Al/Mg bimetal increases from 32.16 MPa without treatment to 63.44 MPa with ultrasonic vibration and HEA coating,increasing by 97.26%.

关键词： ultrasonic vibration FeCoNiCrCu HEA coating Al/Mg bimetal interfacial microstructure shear strength compound casting

CD147 facilitates cisplatin resistance in ovarian cancer through FOXM1 degradation inhibition

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Genes & Diseases 2024年第5期11卷 122-125页

作者： Miao Wang Lin Chen Yu Wang tian fan Chunyu Zhu Zhixian Li Lei Mou Hong Yang Airong Qian Yu Li School of Life Sciences Northwestern Polytechnical UniversityXi’anShaanxi 710072China Xi’an Key Laboratory of Stem Cell and Regenerative Medicine Institute of Medical ResearchNorthwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Oncology Air Force Medical CenterPLABeijing 100142China Department of Obstetrics and Gynecology The First Affiliated Hospital of Air Force Medical UniversityXi’anShaanxi 710032China

Currently,the major therapy for patients with ovarian cancer includes post-cytoreductive surgery followed by chemotherapy of carboplatin or cisplatin plus *** rise of drug resistance is a substantial factor in cancer recurrence and mortality among ovarian cancer patients receiving cisplatin ***147 is widely expressed in a variety of cancer tissues1 and recognized as a drug target for its antibody drug Licartin which has been approved by China’s National Medicines and Pharmaceutical Administration.2 Even though many studies reported that CD147 is involved in the cisplatin resistance of varieties of cancers,3 its mechanism remains *** this investigation,we uncovered a distinctive mechanism by which CD147 regulates cisplatin resistance through the proteasomal degradation of the transcription factor FOXM1,which is associated with DNA damage repair,in ovarian cancer *** results suggest that targeting CD147 may have therapeutic implications for increasing cisplatin efficiency in the management of ovarian cancer.

关键词： FOXM1 cisplatin CD147

研究计划如何能够促进学科交叉研究——对国家自然科学基金重大研究计划的案例研究

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科学学与科学技术管理 2024年第6期45卷 35-51页

作者：樊春良樊天中国科学院科技战略咨询研究院北京100190 中国科学院大学公共政策与管理学院北京100049

研究计划如何促进学科交叉研究,是一个具有重要理论和实践意义的课题。论文以国家自然科学基金委重大研究计划为案例,从科学知识生产和制度构成的视角,以比较经济理论为理论框架,以“十五”和“十一五”期间实施的重大研究计划为基础,... 详细信息

研究计划如何促进学科交叉研究,是一个具有重要理论和实践意义的课题。论文以国家自然科学基金委重大研究计划为案例,从科学知识生产和制度构成的视角,以比较经济理论为理论框架,以“十五”和“十一五”期间实施的重大研究计划为基础,研究重大研究计划的制度构成是如何促进学科交叉研究的。研究发现:重大研究计划的设计和运行遵循学科交叉研究的规律,制度设置保障了学科交叉研究活动的开展,形成了促进学科交叉研究的整体机制。提出重大研究计划成功经验对于促进我国学科交叉研究四方面的启示和借鉴意义。

关键词：学科交叉重大研究计划比较经济理论国家自然科学基金

Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic Liver Disease by Network Pharmacology and Experiment

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 191-203页

作者： Ying-Ying Tan Ying-Ying Liu Yi-Yan Zhai Yi-Xuan Wang Zhi-Shan Wu Antony Stalin Guo-Liang Cheng Bing Li Chao Wu Zhi-Hong Huang Shan Lu Xiao-tian fan Zheng Zhao Jia-Rui Wu Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijingChina Department of Bioinformatics Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengduChina Department of Traditional Chinese Medicine State Key Laboratory of Generic Manufacture Technology of Chinese Traditional MedicineLinyiChina Department of Clinical Medicine Beijing Zest Bridge Medical Technology Inc.BeijingChina

Objective: Huazhi Rougan granules(HRGs) are a promising drug to improve alcoholic liver disease(ALD), but its mechanism remains unclear. Materials and Methods: Network pharmacology, molecular docking, and animal experiments were used to reveal the potential mechanism of HRG against ALD. Results: A total of 245 potential targets of HRG against ALD were obtained. Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD. Molecular docking showed that the key targets exhibited the good binding ability with the key compounds. The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue, improve blood lipid levels, antioxidant stress ability, and liver function, and reduce the release of inflammatory cytokines in the liver. Conclusions: This study reflects that HRG is an effective strategy for treating ALD, providing a basis for revealing the prevention and treatment mechanisms of ALD.

关键词： Alcoholic liver disease Huazhi Rougan granules inflammatory response network pharmacology

改进的局部最值分段多项式拟合算法精确校正拉曼光谱基线

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光谱学与光谱分析 2024年第4期44卷 1073-1080页

作者：田超凡李剑君翁国军朱键赵军武西安交通大学生命科学与技术学院教育部生物医学信息工程重点实验室陕西西安710049

基线校正作为拉曼光谱预处理极为关键的步骤之一,对进一步拉曼光谱数据分析和实现拉曼成像等有重要意义。目前,最常用的基线校正算法基于多项式拟合,由于其采用手动或半手动的形式,因此依赖人工经验,对用户的专业性要求较高,处理过程繁... 详细信息

基线校正作为拉曼光谱预处理极为关键的步骤之一,对进一步拉曼光谱数据分析和实现拉曼成像等有重要意义。目前,最常用的基线校正算法基于多项式拟合,由于其采用手动或半手动的形式,因此依赖人工经验,对用户的专业性要求较高,处理过程繁琐,处理结果差异较大。同时,在使用过程中,多项式阶数及移动分段窗口难以选择确定,因此处理的结果常出现欠拟合或过拟合现象。针对传统多项式拟合算法的此类局限性,改进了局部最值分段多项式拟合(NPPF)算法用于精确校正拉曼光谱基线。首先采用了改进的基于分段的局部最值算法,选取光谱中最宽峰底部轮廓的近似横向宽度作为背景点窗口宽度,依次选取窗口内的最小两个值作为需要拟合的背景基线点,避免直接比较或者人工选取导致的背景点选取困难,实现更准确地选取每个背景轮廓基线点。然后通过每个窗口三次拟合迭代覆盖的方式,得到三个拟合曲线函数,选取窗口内每个点对应三个曲线函数值,分别计算与前一拟合值的差值绝对值,取绝对值最小的曲线函数值作为此点拟合曲线值,从而较好地避免了传统分段多项式拟合(PPF)算法中的欠拟合和过拟合现象,同时也确定了拟合过程中的阶数和分段窗口。模拟了两种不同背景类型的拉曼光谱,将NPPF与PPF算法分别对两种模拟光谱进行处理比较,发现NPPF处理结果均方根误差(RMSE)小,证实NPPF较于PPF的优越性。最后,对实际样品(烯啶虫胺、罗丹明6G)的拉曼光谱进行了NPPF和PPF对比处理,发现NPPF的拟合基线较为准确,证实该算法NPPF在拉曼光谱基线校正预处理中具有广泛的实际应用价值和前景。

关键词：拉曼光谱多项式拟合基线校正局部最值

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浅析矿山测绘工程中特殊地形测量方法

世界有色金属 2024年第11期 148-150页

作者：田璠齐三和数码测绘地理信息技术有限公司甘肃天水741000

矿山测绘工程中难免会遇到特殊地形,影响测绘的精确度,因此要选择合适的技术加强质量控制工作,高效完成测绘工作。因此开展本文的研究工作,分析矿山测绘工程中特殊地形的情况,探究应用到的测绘技术和测量方法,以供相关工程参考,提高测... 详细信息

矿山测绘工程中难免会遇到特殊地形,影响测绘的精确度,因此要选择合适的技术加强质量控制工作,高效完成测绘工作。因此开展本文的研究工作,分析矿山测绘工程中特殊地形的情况,探究应用到的测绘技术和测量方法,以供相关工程参考,提高测绘质量。

关键词：矿山测绘工程特殊地形测量方法

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GREEDY NON-DOMINATED SORTING IN GENETIC ALGORITHM-ⅡFOR VEHICLE ROUTING PROBLEM IN DISTRIBUTION

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Chinese Journal of Mechanical Engineering 2008年第6期21卷 18-24页

作者： WEI tian fan Wenhui XU Huayu National CIMS Engineering Research Center Tsinghua University Beijing 100084 China

Vehicle routing problem in distribution （VRPD） is a widely used type of vehicle routing problem （VRP）, which has been proved as NP-Hard, and it is usually modeled as single objective optimization problem when modeling. For multi-objective optimization model, most researches consider two objectives. A multi-objective mathematical model for VRP is proposed, which considers the number of vehicles used, the length of route and the time arrived at each client. Genetic algorithm is one of the most widely used algorithms to solve VRP. As a type of genetic algorithm （GA）, non-dominated sorting in genetic algorithm-Ⅱ （NSGA-Ⅱ） also suffers from premature convergence and enclosure competition. In order to avoid these kinds of shortage, a greedy NSGA-Ⅱ （GNSGA-Ⅱ） is proposed for VRP problem. Greedy algorithm is implemented in generating the initial population, cross-over and mutation. All these procedures ensure that NSGA-Ⅱ is prevented from premature convergence and refine the performance of NSGA-Ⅱ at each step. In the distribution problem of a distribution center in Michigan, US, the GNSGA-Ⅱ is compared with NSGA-Ⅱ. As a result, the GNSGA-Ⅱ is the most efficient one and can get the most optimized solution to VRP problem. Also, in GNSGA-Ⅱ, premature convergence is better avoided and search efficiency has been improved sharply.

关键词： Greedy non-dominated sorting in genetic algorithm-Ⅱ (GNSGA-Ⅱ) Vehicle routing problem (VRP) Multi-objective optimization

穿龙骨刺片联合玻璃酸钠治疗早中期膝骨关节炎的临床研究

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现代药物与临床 2024年第1期39卷 200-204页

作者：许瑞丽范田郭晓芳宋诗伟河南省胸科医院药剂科河南郑州450003 河南省胸科医院骨科河南郑州450003

目的探讨穿龙骨刺片联合玻璃酸钠注射液治疗早中期膝骨关节炎的临床效果。方法选择河南省胸科医院2019年6月到2021年6月收治的早中期膝骨关节炎患者160例,将入选的患者按照随机数字表法分为对照组和治疗组,各80例。对照组膝关节腔内注... 详细信息

目的探讨穿龙骨刺片联合玻璃酸钠注射液治疗早中期膝骨关节炎的临床效果。方法选择河南省胸科医院2019年6月到2021年6月收治的早中期膝骨关节炎患者160例,将入选的患者按照随机数字表法分为对照组和治疗组,各80例。对照组膝关节腔内注射玻璃酸钠注射液,1支/次,1次/周。治疗组患者在对照组治疗方法的基础上口服穿龙骨刺片,6~8片/次,3次/d。两组连续治疗5周。比较两组的临床疗效、临床症状、血清指标。结果治疗后,治疗组的总有效率(93.75%)高于对照组(80.00%,P<0.05)。治疗后,两组视觉模拟评分法(VAS)评分、西大略和麦克马斯特大学骨关节炎指数(WOMAC)评分均下降(P<0.05),治疗组VAS评分、WOMAC评分低于对照组(P<0.05)。治疗后,两组血沉(ESR)、C反应蛋白(CRP)、Ⅰ型胶原羧基端肽β降解产物(β-CTX)、前列腺素E_(2)(PGE_(2))、P物质(SP)、多巴胺(DA)、5-羟色胺(5-HT)水平下降,Ⅰ型前胶原羧基末端肽(PICP)、骨钙素(BGP)水平升高(P<0.05),治疗组ESR、CRP、β-CTX、PGE_(2)、SP、DA、5-HT水平低于对照组,PICP、BGP水平高于对照组(P<0.05)。结论穿龙骨刺片联合玻璃酸钠注射液治疗早中期膝骨关节炎可有效改善患者的临床症状,调节骨代谢和疼痛介质水平。

关键词：穿龙骨刺片玻璃酸钠注射液膝骨关节炎 VAS评分 WOMAC评分 C反应蛋白骨钙素

变形温度对塑性变形新方法加工的AZ31镁合金显微组织和织构的影响

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Transactions of Nonferrous Metals Society of China 2024年第7期34卷 2138-2152页

作者：范宇田卢立伟刘剑波马旻黄伟颖巫瑞智湖南科技大学材料科学与工程学院湘潭411201 湖南金峰机械科技有限公司娄底417700 长沙理工大学能源与动力工程学院高效清洁能源利用重点实验室长沙410114 哈尔滨工程大学材料科学与化学工程学院超轻材料与表面技术教育部重点实验室哈尔滨150001

提出一种新的反复镦挤变形(RUE)方法。采用光学显微镜(OM)、X射线衍射(XRD)、电子背散射衍射(EBSD)和维氏硬度计分析不同变形温度对RUE变形AZ31镁合金显微组织和织构的影响。结果表明:经RUE变形后,AZ31镁合金组织局部细化至0.8μm,细化... 详细信息

提出一种新的反复镦挤变形(RUE)方法。采用光学显微镜(OM)、X射线衍射(XRD)、电子背散射衍射(EBSD)和维氏硬度计分析不同变形温度对RUE变形AZ31镁合金显微组织和织构的影响。结果表明:经RUE变形后,AZ31镁合金组织局部细化至0.8μm,细化机制主要为连续动态再结晶(CDRX);随着温度的升高,首先形成平行于剪切面的基面织构,随后形成强度减弱的{11■0}织构,最后形成{0001}和{0001}织构。基面和锥面位错滑移导致织构分裂。经RUE变形后AZ31镁合金的最大硬度较初始状态提高42.4%,主要原因是细晶强化和位错强化。

关键词： AZ31镁合金反复镦挤变形动态再结晶织构硬度