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Molecular Dynamics Simulation of Xe Behavior in U-Mo Alloys Fuel

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Chinese Physics Letters 2014年第4期31卷 130-133页

作者： xiao Hong-Xing TANG Rui tian xiao-feng LONG Chong-Sheng Science and Technology on Reactor Fuel and Materials Laboratory Nuclear Power Institute of China Chengdu 610041 The College of Nuclear Technology and Automation Engineering Chengdu University of Technology Chengdu 610059

Classical molecular dynamics simulations are used to investigate the fission gas Xe behavior in a U-Mo alloy fuel matrix. The embedded atom method potential proposed by Smirnova et al. is used to describe the U-Mo-Xe system. The results show that the initial configuration of interstitial Xe atoms in U-Mo alloys is very instable and has a strong tendency to get together and to form a Xe bubble by ejecting the adjacent U atoms and Mo atoms from their former normal lattice sites. The pressure in Xe bubbles is initially quite high and then drops with increasing Xe concentration obviously. The matrix swelling of U-Mo alloys associated with the Xe bubble growth follows approximately a linear relationship with the ratio of Xe to U at low Xe concentration while the rate of swelling increases rapidly at high Xe concentration. The simulation results are in good agreement with the experimental data. The recovery of the damaged structure in the U-Mo alloys matrix is also investigated. It is shown that a damaged structure cannot be recovered completely after a system is relaxed for a long time while still having lots of defects.

关键词： MOLECULAR dynamics -- Simulation methods XENON THERMAL properties FISSION gases SWELLING of materials NUCLEATION

Effect of HMGA2 shRNA on the Cell Proliferation and Invasion of Human Colorectal Cancer SW480 Cells In vitro

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Chemical Research in Chinese Universities 2012年第2期28卷 264-268页

作者： XU Guang-meng ZHANG Hai-na tian xiao-feng SUN Mei FANG Xue-dong The Second Hospital of Jilin University Changchun 130041P.R.China

High mobility group A2（HMGA2） protein is a small nonhistone chromosomal protein that can modulate transcription of an ample number of *** previous studies demonstrate that up-regulation of HMGA2 expression occurrs in many kinds of cancers including colorectal cancer,suggesting that HMGA2 might play a critical role in the progression of various ***,the exact role of HMGA2 in colorectal cancer has not been *** verify the essential role of HMGA2 in the growth and invasiveness of colorectal cancer,HMGA2 expression was down-regulated by RNA interference（RNAi） in SW480 *** observed that the knockdown of HMGA2 led to the significant inhibition of proliferation and invasion of SW480 cells in *** results suggest that HMGA2 might play a crucial role in the progression of colorectal cancer,and be a potential therapeutic target for human colorectal cancer.

关键词： High mobility group A2(HMGA2) RNA interference(RNAi) Proliferation Invasion Colorectal cancer

Inhibitory Effects of Phenylacetic Acid on Proliferation of Human Pancreatic Carcinoma BXPC-3 Cells by the Regulation of Adenosine Deaminases Acting on RNA

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Chemical Research in Chinese Universities 2010年第6期26卷 964-968页

作者： JIANG Yao REN Hui ZHANG Guang ZHANG Ling tian xiao-feng JIA Hui-jie HAN Li-ying tian Yu Department of General Surgery China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China Department of General Surgery the Second Hospital of Jilin University Changchun 130041 P R. China Department of Thyroid Gland Surgery China-Japan Union Hospital of Jilin University Changehun 130033 P. R. China Prostate Diseases Prevention and Treatment Research Centre and Department of Pathophysiology Norman Bethune Medical School Jilin University Changchun 130021 P. R. China Department of Obstetrics and Gynecology the Second Hospital of Jilin University Changchun 130041 P. R. China Department of Neurosurgery China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China

The effect and mechanism of phenylacetic acid on the proliferation of pancreatic carcinoma cells were investigated in cultured pancreatic carcinoma BXPC-3 cells by means of 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide assay and flow cytometry *** results show that the treatment of pancreatic carcinoma cells with phenylacetic acid significantly inhibited the cell proliferation in time-dependent and dose-dependent *** proliferation of BXPC-3 cells was inhibited at the stage of S phase,the cells at the end stage of S phase were accumulated abundantly,and thus DNA synthesis could not be accomplished *** addition,the expression of adenosine deaminases acting on RNA（ADARs） mRNA in BXPC-3 cells and pancreatic carcinoma specimen were detected by *** been treated with phenylacetic acid,ADAR2 mRNA in BXPC-3 cells was significantly decreased,the differences were of statistical significance（P0.01）.Taken together,these results suggest that phenylacetic acid may likely regulate the proliferation of pancreatic carcinoma cells through the regulation of ADAR2 mRNA expression.

关键词： Pancreatic carcinoma Phenylacetic acid ADAR2 RNA editing

Molecular Dynamics Simulations of Thermal Properties of Solid Uranium Dioxide

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Chinese Physics Letters 2010年第3期27卷 243-246页

作者：李久楷田晓峰 Institute of Atomic and Molecular Physics Sichuan University Chengdu 610065

Molecular dynamics simulations are performed with the recently developed empirical interaction potential by Morelon et al. Thermodynamics properties of solid UO2 that have been assessed include melt point, density, enthalpy, heat capacity, lattice parameter variation with temperature, mean-square-displacement and diffusion coefficients of oxygen ion. The results are compared with the data in literature and it is suggested that the rigid ionic potential provides perfect results below the superionic range. The data showing thermodynamics properties will become unacceptable when the temperature is higher than 2500 K. Compared with the previous empirical potentials, the empirical potential developed by Morelon et al. improves the agreement of these data with the recommend ones.

关键词： Nuclear physics Condensed matter: structural mechanical & thermal

Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway

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World Journal of Gastroenterology 2010年第24期16卷 3002-3010页

作者： Zhao, Hai-Dong Zhang, feng Shen, Gang Li, Yu-Bing Li, Ying-Hua Jing, Hui-Rong Ma, Ling-Fei Yao, Ji-Hong tian, xiao-feng Dalian Med Univ Affiliated Hosp 2 Dept Gen Surg Dalian 116023 Liaoning Prov Peoples R China Dalian Med Univ Dept Pharmacol Dalian 116044 Liaoning Prov Peoples R China

AIM: To investigate the effect of sulforaphane (SFN) on regulation of NF-E2-related factor-2 (Nrf2)-antiox-idant response element (ARE) pathway in liver injury induced by intestinal ischemia/reperfusion (I/R). METHODS: Rats were divided randomly into four ex-perimental groups: control, SFN control, intestinal I/R and SFN pretreatment groups (n = 8 in each group). The intestinal I/R model was established by clamping the superior mesenteric artery for 1 h and 2 h reperfu-sion. In the SFN pretreatment group, surgery was performed as in the intestinal I/R group, with intraperitoneal administration of 3 mg/kg SFN 1 h before the op-eration. Intestine and liver histology was investigated. Serum levels of aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured. Liver tissue superoxide dismutase (SOD), myeloperoxidase (MPO), glutathione (GSH) and glutathione peroxidase (GSH-Px) activity were assayed. The liver transcription factor Nrf2 and heme oxygenase-1 (HO-1) were determined by immunohistochemical analysis and Western blotting ***: Intestinal I/R induced intestinal and liver injury, characterized by histological changes as well as a signif icant increase in serum AST and ALT levels (AST: 260.13 ± 40.17 U/L vs 186.00 ± 24.21 U/L, P < 0.01; ALT: 139.63 ± 11.35 U/L vs 48.38 ± 10.73 U/L, P < 0.01), all of which were reduced by pretreatment with SFN, respectively (AST: 260.13 ± 40.17 U/L vs 216.63 ± 22.65 U/L, P < 0.05; ALT: 139.63 ± 11.35 U/L vs 97.63 ± 15.56 U/L, P < 0.01). The activity of SOD in the liver tissue decreased after intestinal I/R (P < 0.01), which was enhanced by SFN pretreatment (P < 0.05). In ad-dition, compared with the control group, SFN markedly reduced liver tissue MPO activity (P < 0.05) and elevat-ed liver tissue GSH and GSH-Px activity (P < 0.05, P < 0.05), which was in parallel with the increased level of liver Nrf2 and HO-1 ***: SFN pretreatment attenuates liver injury induced by intestinal I

关键词： Sulforaphane Liver injury Intestinal isch-emia reperfusion NF-E2-related factor-2 Antioxidant response element

Ancient DNA unravels species identification from Laosicheng site,Hunan Province,China,and provides insights into maternal genetic history of East Asian leopards

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Zoological Research 2024年第1期45卷 226-229页

作者： Ming Zhang Cai-Hui Wang Yu-Xin Zheng Qi-Gao Jiangzuo Ye-Mao Hou Peng Cao Qing-Yan Dai Ruo-Wei Yang feng Liu xiao-tian feng Lin-Heng Mo Qiao-Mei Fu China-Central Asia"the Belt and Road"Joint Laboratory on Human and Environment Research Key Laboratory of Cultural Heritage Research and ConservationSchool of Culture HeritageNorthwest UniversityXi’anShaanxi 710127China Shanghai Qi Zhi Institute Shanghai 200232China College of Life Sciences Northwest UniversityXi’anShaanxi 710127China Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyCenter for Excellence in Life and PaleoenvironmentChinese Academy of SciencesBeijing 100044China Cultural Relics and Archaeology Institute of Hunan ChangshaHunan 410083China University of the Chinese Academy of Sciences Beijing 100049China

DEAR EDITOR,The Laosicheng site in Yongshun County,Hunan Province,China,plays an important role in elucidating the animal population composition of the region prior to the middle Qing Dynasty(approximately 300 years ago).This site has yielded a substantial number of animal bones,11960 of which have been identified to the species level,serving as direct evidence of ancient animal populations(Hunan Provincial Institute of Cultural Relics and Archaeology,2018).

关键词： Hunan Ancient insight

Comparative analysis of DNA extraction protocols for ancient soft tissue museum samples

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Zoological Research 2021年第3期42卷 280-286页

作者： Ming Zhang Peng Cao Qing-Yan Dai Yong-Qiang Wang xiao-tian feng Hong-Ru Wang Hong Wu Albert Min-Shan Ko xiao-Wei Mao Yi-Chen Liu Li Yu Christian Roos Tilo Nadler Wen xiao E.Andrew Bennett Qiao-Mei Fu Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China University of Chinese Academy of Sciences Beijing 100049China Institute of Cultural Relics and Archaeology in Xinjiang UrumqiXinjiang 830011China State Key Laboratory for Conservation and Utilization of Bioresource in Yunnan Yunnan UniversityKunmingYunnan 650091China Gene Bank of Primates and Primate Genetics Laboratory German Primate CenterLeibniz Institute for Primate ResearchGottingen 37077Germany Wildlife Consultant Cuc Phuong CommuneNho QuanNinh Binh 430000Vietnam Institute of Eastern-Himalaya Biodiversity Research Dali UniversityDaliYunnan 671003China

DNA studies of endangered or extinct species often rely on ancient or degraded *** majority of ancient DNA(aDNA)extraction protocols focus on skeletal elements,with skin and hair samples rarely *** to that found in bones and teeth,DNA extracted from historical or ancient skin and fur samples is also extremely fragmented with low endogenous content due to natural degradation ***,the development of effective DNA extraction methods is required for these ***,we compared the performance of two DNA extraction protocols(commercial and custom laboratory aDNA methods)on hair and skin samples from decades-old museum specimens to Iron Age archaeological *** found that apart from the impact sample-specific taphonomic and handling history has on the quantity and quality of DNA preservation,skin yielded more endogenous DNA than hair of the samples and protocols *** both methods recovered DNA from ancient soft tissue,the laboratory method performed better overall in terms of DNA yield and quality,which was primarily due to the poorer performance of the commercial binding buffer in recovering aDNA.

关键词： endogenous ancient primarily

金雀异黄素对人肝癌SMMC-7721细胞生长抑制和凋亡的影响

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吉林大学学报（医学版） 2009年第3期35卷 499-502,F0003页

作者：田晓丰曹宏田力吉林大学中日联谊医院腹腔镜外科吉林长春130033 吉林大学第二医院基本外科吉林长春130041

目的:探讨金雀异黄素(Gen)对人肝癌SMMC-7721细胞生长的抑制作用及凋亡调控的影响,明确Gen抗肿瘤的可能机制。方法:SMMC-7721细胞按Gen浓度分为5、10和20 mg.L-13个处理组和对照组(未加Gen),给药24和48 h后,透射电镜观察细胞超微结构变... 详细信息

目的:探讨金雀异黄素(Gen)对人肝癌SMMC-7721细胞生长的抑制作用及凋亡调控的影响,明确Gen抗肿瘤的可能机制。方法:SMMC-7721细胞按Gen浓度分为5、10和20 mg.L-13个处理组和对照组(未加Gen),给药24和48 h后,透射电镜观察细胞超微结构变化,MTT法检测细胞增殖抑制率,流式细胞仪(FCM)分析细胞时相,免疫组化法检测细胞内Caspases-3蛋白的表达水平。结果:Gen处理组细胞核内异染色质呈块状凝集,胞质内线粒体肿胀空化,随着Gen浓度增加,细胞核呈固缩状,核内异染色质趋边凝集,细胞质空化明显,对照组无改变;MTT法检测显示,随着Gen浓度增加,作用时间从24到48 h的延长,SMMC-7721细胞增殖抑制率升高,呈时间和剂量依赖性(P<0.01)。流式细胞术显示,随着Gen浓度增加,停滞在G2/M期细胞数增加(P<0.01),S期细胞减少(P<0.01),G0/G1期细胞减少(P<0.01)。免疫组化结果显示,随着Gen浓度增加,Caspases-3蛋白表达增强,呈剂量依赖性(P<0.01)。结论:Gen对人肝癌SMMC-7721细胞的生长具有明显抑制作用,上调Caspases-3蛋白表达和诱导细胞凋亡可能是其作用机制之一。

关键词：金雀异黄素肝肿瘤,实验性细胞凋亡

硅氧铝陶瓷纤维含量对半金属摩擦材料摩擦磨损性能的影响

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摩擦学学报 2008年第1期28卷 63-67页

作者：韩野田晓峰尹衍升中国海洋大学材料科学与工程研究院

采用冷压成型及热压固化工艺制备钢纤维/硅氧铝陶瓷纤维混杂增强酚醛树脂半金属摩擦材料,在DMS-150型定速摩擦磨损试验机上研究了不同硅氧铝陶瓷纤维含量对材料的摩擦热衰退性能、恢复性能以及磨损性能的影响,借助扫描电子显微镜观察磨... 详细信息

采用冷压成型及热压固化工艺制备钢纤维/硅氧铝陶瓷纤维混杂增强酚醛树脂半金属摩擦材料,在DMS-150型定速摩擦磨损试验机上研究了不同硅氧铝陶瓷纤维含量对材料的摩擦热衰退性能、恢复性能以及磨损性能的影响,借助扫描电子显微镜观察磨损表面形貌并分析其磨损机制.结果表明,添加质量分数5%以上硅氧铝陶瓷纤维,能够使摩擦材料的抗热衰退性能得到显著改善,但恢复性能有所下降,磨损率稍有升高,磨损机制由粘着磨损转变为粘着磨损与磨粒磨损的复合形式.

关键词：硅氧铝陶瓷纤维半金属摩擦材料摩擦磨损性能