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不同磷肥使用量对油菜产量和品质的影响

农业技术与装备 2024年第3期 42-44页

作者：田丽娟徽县伏家镇农业科技服务中心甘肃徽县742308

以甘杂1号为试验材料,设置了30、60、90、120 kg/hm^(2)等4个磷肥处理及对照,比较了不同处理油菜产量、品质和种植经济效益。结果表明:适量磷肥的施入可提高油菜产量、品质及种植经济效益,综合考虑各个因素,在徽县伏家镇推荐磷肥用量为9... 详细信息

以甘杂1号为试验材料,设置了30、60、90、120 kg/hm^(2)等4个磷肥处理及对照,比较了不同处理油菜产量、品质和种植经济效益。结果表明:适量磷肥的施入可提高油菜产量、品质及种植经济效益,综合考虑各个因素,在徽县伏家镇推荐磷肥用量为90 kg/hm^(2)。

关键词：磷肥油菜产量品质

An Overview of Quality Management of Therapeutic Vaccines in Clinical Trials in China

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Asian Journal of Social Pharmacy 2024年第1期19卷 50-57页

作者： Lin Hansen tian lijuan School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To provide suggestions and a reference for improving the quality management system of clinical trials of therapeutic vaccines and promoting the development of therapeutic vaccines in *** Literature research,case study and comparative study were used to analyze the quality management system of clinical trials of therapeutic *** and Conclusion From the perspective of the sponsor,investigators and the thirdparty technical service company,the problems such as the low efficiency of clinical trial sample preparation and the lax implementation of the protocol by hospital departments in the quality management of clinical trials of therapeutic vaccines in China were ***,the optimization plan for the quality management of clinical trials of therapeutic vaccines is proposed,including optimizing the preparation process of therapeutic vaccines and strengthening the training of hospital department personnel.

关键词： therapeutic vaccine clinical trial quality management good clinical practice(GCP)

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三阶段质量管理在药物研发中的应用

化工管理 2024年第14期 29-32页

作者：万平安田丽娟沈阳药科大学辽宁沈阳110016 慕恩(广州)生物科技有限公司广东广州510530

文章对比分析了二阶段质量管理与四阶段质量管理的局限性,研究三阶段质量管理的优越性,并以某微生态活菌制药企业在非临床研究模块实施三阶段质量管理的情况作为实践案例进行分析。该企业实施三阶段质量管理后方案偏离率从60%降至25%。... 详细信息

文章对比分析了二阶段质量管理与四阶段质量管理的局限性,研究三阶段质量管理的优越性,并以某微生态活菌制药企业在非临床研究模块实施三阶段质量管理的情况作为实践案例进行分析。该企业实施三阶段质量管理后方案偏离率从60%降至25%。通过问卷调研,结果显示有70.59%的员工认为三阶段质量管理对自身工作有较大的促进作用,实施三阶段质量管理达到了良好的效果。基于此,文章分析三阶段质量管理在制药企业质量管理中的可行性应用,为制药企业提升研发质量管理水平提供参考。

关键词：制药企业药品研发三阶段质量管理风险管理

Th17/Treg失衡在银屑病发病中的作用研究进展

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皮肤病与性病 2024年第2期46卷 86-89页

作者：田丽娟王思农牛凡琪郭惠甘肃中医药大学甘肃兰州730000 甘肃中医药大学附属医院皮肤科甘肃兰州730000

银屑病作为一种皮肤科常见病,给个人和社会带来了沉重的负担,其诊断与治疗一直是我们关注的重点。CD4^(+)T淋巴细胞及其它亚群参与机体细胞免疫反应,在自身免疫性疾病中发挥重要作用。辅助性T细胞17(Th17)和调节性T细胞(Treg)在银屑病... 详细信息

银屑病作为一种皮肤科常见病,给个人和社会带来了沉重的负担,其诊断与治疗一直是我们关注的重点。CD4^(+)T淋巴细胞及其它亚群参与机体细胞免疫反应,在自身免疫性疾病中发挥重要作用。辅助性T细胞17(Th17)和调节性T细胞(Treg)在银屑病发病中紧密相关,是免疫耐受、体内平衡、致病性和病原体清除的关键T细胞类型。研究发现CD4+T淋巴细胞在银屑病的发生、发展、治疗和预后过程中起着重要作用,特别是Th17/Treg失衡在银屑病发病机制中扮演重要角色。本文旨在综述Th17/Treg失衡在银屑病发病过程中的作用,为银屑病的诊断与治疗提供新思路。

关键词：辅助性T细胞17 调节性T细胞银屑病进展

基于组合权重的Fisher最优分割法在水库汛期分期中的应用

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人民珠江 2024年第1期45卷 146-153页

作者：夏青青李英海刘芬劳嘉鹏田丽娟荆州市长江河道管理局测量队湖北荆州434000 三峡大学水利与环境学院湖北宜昌443002 荆州市荆州区水利工程移民服务中心湖北荆州434000

针对Fisher最优分割法中多指标赋权仅考虑单一客观赋权法的不足,将基于信息论的熵权法和基于统计学原理的变异系数法、CRITIC赋权法引入到指标权重计算中,提出基于组合权重的Fisher最优分割法进行水库汛期分期。以水布垭水库为例,选取... 详细信息

针对Fisher最优分割法中多指标赋权仅考虑单一客观赋权法的不足,将基于信息论的熵权法和基于统计学原理的变异系数法、CRITIC赋权法引入到指标权重计算中,提出基于组合权重的Fisher最优分割法进行水库汛期分期。以水布垭水库为例,选取能反映洪水变化规律的旬平均流量、最大洪峰流量出现次数、旬最大一日洪量、旬最大三日洪量、旬最大七日洪量5个指标,采用基于组合权重的Fisher最优分割法进行汛期分期,并将分期结果与采用单一客观赋权法的分期结果进行对比分析,最后确定汛期分为3期最优,前汛期为5月1日至6月10日、主汛期为6月11日至7月31日、后汛期为8月1日至9月30日。研究结果表明:采用组合权重法确定权重既兼顾了熵权法、变异系数法、CRITIC赋权法的优势,又能直观地区分不同指标对汛期分期的影响程度,该方法适用于Fisher最优分割法中多指标权重的确定。

关键词：汛期分期多指标权重组合权重法 Fisher最优分割法结果影响

以创新创业能力提升为导向的生物技术专业应用型人才培养路径研究

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创新创业理论研究与实践 2024年第6期7卷 91-93页

作者：申健刘德江薛春梅丛慧颖田立娟佳木斯大学生物与农业学院黑龙江佳木斯154007

为了提升高等教育人才培养与社会需求的匹配度,该文以生物技术专业人才培养为例,探讨了应用型人才培养的路径,通过培养方案的制定、课程教学融入创新创业训练、组建科研小组参加创新创业竞赛、开展专业实习和毕业论文等实践环节的实施,... 详细信息

为了提升高等教育人才培养与社会需求的匹配度,该文以生物技术专业人才培养为例,探讨了应用型人才培养的路径,通过培养方案的制定、课程教学融入创新创业训练、组建科研小组参加创新创业竞赛、开展专业实习和毕业论文等实践环节的实施,总结了如何在人才培养过程中全方位融入创新创业教育,提升大学生的创新创业能力。实践表明:创新创业训练对提高大学生创新创业能力,培养应用型人才,实现大学生顺利就业具有积极的促进作用。

关键词：创新创业能力培养生物技术应用型人才以赛促学培养路径

Microstructure and mechanical properties of TiAl castings produced by zirconia ceramic mould

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China Foundry 2011年第4期8卷 371-375页

作者： Chen Yanfei Xiao Shulong tian Jing Xu lijuan Chen Yuyong School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China

Owing to their low density and attractive high-temperature properties, gamma titanium aluminide alloys (TiAl alloys, hereafter) have significant potential application in the aerospace and automobile industries, in which these materials may replace the heavier nickel-based superalloys at service temperatures of 600-900℃. Investment casting of TiAl alloys has become the most promising cost-effective technique for the manufacturing of TiAl components. Ceramic moulds are fundamental to fabricating the TiAl casting components. In the present work, ceramic mould with a zirconia primary coat was designed and fabricated successfully. Investment casting of TiAl blades and tensile test of specimens was carried out to verify the correctness and feasibility of the proposed method. The tensile test results indicate that, at room temperature, the tensile strength and the elongation are about 450 MPa and 0.8%, respectively. At 700℃, the tensile strength decreases to about 410 MPa and the elongation increases to 2.7%. Microstructure and mechanical properties of investment cast TiAl alloy are discussed.

关键词： investment casting TiAl alloys ceramic moulds zirconia

Systematic analysis of DNA polymerases as therapeutic targets in pan-cancers

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BIOCELL 2024年第1期48卷 123-138页

作者： ZHENHUA LI HUILAI LV FAN ZHANG ZIMING ZHU QIANG GUO MINGBO WANG CHAO HUANG lijuan CHEN WENPAN ZHANG YUN LI ZIQIANG tian Department of Thoracic Surgery Fourth Hospital of Hebei Medical UniversityShijiazhuang050011China Department of Thoracic Surgery The First Hospital of XingtaiXingtai054001China Department of Thoracic Surgery Affiliated Hospital of Hebei UniversityBaoding050017China Shanghai OrigiMed Co. Ltd.Shanghai200000China Department of Thoracic Surgery The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Introduction:DNA polymerases are crucial for maintaining genome stability and influencing ***,the clinical implications of DNA polymerases in tumorigenesis and their potential as anti-cancer therapy targets are not well ***:We conducted a systematic analysis using TCGA Pan-Cancer Atlas data and Gene Set Cancer Analysis results to examine the expression profiles of 15 DNA polymerases(POLYs)and their clinical *** also evaluated the prognostic value of POLYs by analyzing their expression levels in relation to overall survival time(OS)using Kaplan-Meier survival ***,we investigated the correlations between POLY expression and immune cells,DNA damage repair(DDR)pathways,and *** sensitivity analysis was performed to assess the relationship between POLY expression and drug ***:Our analysis revealed that 14 out of 15 POLYs exhibited significantly distinct expression patterns between tumor and normal samples across most cancer types,except for DNA nucleotidylexotransferase(DNTT).Specifically,POLD1 and POLE showed elevated expression in almost all cancers,while POLQ exhibited high expression levels in all cancer *** POLYs showed heightened expression in specific cancer subtypes,while others exhibited low ***-Meier survival curves demonstrated significant prognostic value of POLYs in multiple cancers,including PAAD,KIRC,and *** analysis further validated these *** patterns of POLYs varied significantly among different cancer types and were associated with poorer survival *** correlations were observed between the expression of POLY members and immune cells,DDR pathways,and *** sensitivity analysis indicated an inverse relationship between POLY expression and drug ***:Our comprehensive study highlights the significant role of POLYs in cancer development and identifies them as promising prognostic and

关键词： DNA polymerases(POLYs) Prognostic biomarker The Cancer Genome Atlas(TCGA) Ubiquitination network

Improvement in collapsibility of ZrO2 ceramic mould for investment casting of TiAl alloys

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China Foundry 2011年第1期8卷 9-13页

作者： Chen Yanfei Xiao Shulong tian Jing Xu lijuan Kong Fantao Chen Yuyong School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China

Investment casting has been widely recognized as the best option in producing TiAl components with key benefits of accuracy,versatility and *** collapsibility of ceramic moulds for investment casting is critical in the manufacturing process of TiAl components due to TiAl's intrinsic brittleness at room *** aim of the present research is to provide a method for production of TiAl components by investment casting in ZrO2 ceramic moulds with improved *** prepared with high polymer additions were utilized during the preparation of ceramic *** stress/strain curves obtained from green and baked ceramic moulds demonstrate that the green strength was increased with the application of high polymer,while baked strength decreased,thus the collapsibility of ceramic moulds was *** is suggested that this result is related to the burn-out of high polymer which left a lot of *** experimental findings were also verified by the investment casting of "I"-shaped TiAl components.

关键词： collapsibility 改进 ZrO2 陶器的模子 TiAl 合金扔的投资