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Efficacy and safety of ultrasound cycloplasty for the treatment of glaucoma: a Meta-analysis

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1317-1325页

作者： tian-hong Wu Xue Yin Jian-Qing Li Pei-Rong lu Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

AIM:To evaluate the efficacy and safety of ultrasound cycloplasty(UCP)for ***:A comprehensive search of PubMed,Embase,Web of Science,and Google Scholar databases was used to select studies met the inclusion *** was performed by Review Manager and StataCorp ***:A total of 19 articles met the inclusion ***,UCP is effective and safe in the glaucoma treatment,the risk ratio(RR)of the success rate was 2.28(95%CI,1.82-2.84).After UCP,patients had a significant reduction in intraocular pressure(IOP;mm Hg),the weighted mean difference(WMD)was 11.39(95%CI,9.88-12.90).In addition,UCP brings fewer postoperative complications with RR of 0.30(95%CI,0.19-0.49).Most of the complications were short-term and ***,patients’use of IOP-lowering medications reduced,the standardized mean difference(SMD)was 0.78(95%CI,0.40-1.17).However,best corrected visual acuity(BCVA;logMAR)did not have obvious improvement after UCP,the WMD was 0.01(95%CI,-0.06-0.09).This procedure does provide painfulness relief,with RR of 3.06(95%CI,1.95-4.81).CONCluSION:UCP is effective and safe for suitable *** can effectively decrease IOP in glaucoma patients,reduce the patients’dependence on IOP-lowering medications after surgery,relief the painfulness and has fewer long-term or severe postoperative complications,but the BCVA did not improve much.

关键词： ultrasound cycloplasty glaucoma efficacy safety

Crosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids

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Acta Pharmaceutica Sinica B 2016年第5期6卷 393-408页

作者： hong lu Department of Pharmacology SUNY Upstate Medical University

The liver is essential for survival due to its critical role in the regulation of metabolic *** of xenobiotics,such as environmental chemicals and drugs by the liver protects us from toxic effects of these xenobiotics,whereas metabolism of cholesterol,bile acids(BAs),lipids,and glucose provide key building blocks and nutrients to promote the growth or maintain the survival of the *** a wellestablished master regulator of liver development and function,hepatocyte nuclear factor 4 alpha(HNF4α)plays a critical role in regulating a large number of key genes essential for the metabolism of xenobiotics,metabolic wastes,and *** expression and activity of HNF4α is regulated by diverse hormonal and signaling pathways such as growth hormone,glucocorticoids,thyroid hormone,insulin,transforming growth factor-β,estrogen,and ***4α appears to play a central role in orchestrating the transduction of extracellular hormonal signaling and intracellular stress/nutritional signaling onto transcriptional changes in the *** have been a few reviews on the regulation of drug metabolism,lipid metabolism,cell proliferation,and inflammation by HNF4α.However,the knowledge on how the expression and transcriptional activity of HNF4α is modulated remains *** I provide comprehensive review on the regulation of expression and transcriptional activity of HNF4α,and how HNF4α crosstalks with diverse extracellular and intracellular signaling pathways to regulate genes essential in liver pathophysiology.

关键词： HNF4α Liver Drug metabolism Lipid metabolism Inflammation Hormone

Unifying logic rules and machine learning for entity enhancing

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Science China(Information Sciences) 2020年第7期63卷 142-160页

作者： Wenfei FAN Ping lu Chao tian School of Informatics University of Edinburgh Shenzhen Institute of Computing Sciences Shenzhen University Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang University Alibaba Group

This paper proposes a notion of entity enhancing, which unifies entity resolution and conflict resolution, to identify tuples that refer to the same real-world entity and at the same time, correct semantic inconsistencies. We propose to unify rule-based and machine learning(ML) methods for entity enhancing, by embedding ML classifiers as predicates in logic rules. We model entity enhancing by extending the chase. We show that the chase warrants correctness justification and the Church-Rosser property. Moreover, we settle fundamental problems associated with entity enhancing, including the enhancing, consistency, satisfiability,and implication problems, ranging from NP-complete and coNP-complete to Π~p-complete. Taken together,these provide a new theoretical framework for unifying entity resolution and conflict resolution.

关键词： logic rules machine learning entity enhancing entity resolution conflict resolution

A novel progressive wave gyroscope based on acousto-optic effects

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Microsystems & Nanoengineering 2022年第5期8卷 81-90页

作者： lu tian Qiang Shen honglong Chang Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospacea School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China

We propose and numerically investigate a brand-new,high-sensitivity progressive wave gyroscope based on acoustooptic effects for the measurement of rotational angular *** the traditional surface acoustic wave(SAW)gyroscope,which uses shifts in the SAW frequency to characterize the rotational angular velocity,this study uses acousto-optic effects to detect changes in refractive index caused by mechanical strain,measuring the angular velocity by the output optical power intensity of the optical *** three-dimensional finite element analysis method is utilized to build an SAW excitation model and optical detection *** show that the sensitivity of the SAW gyroscope is highly dependent upon geometric parameters of the structure and that the mechanical strain induced by the progressive wave of the SAW can be effectively measured by the optical power intensity under the action of external angular *** superiority of the proposed structure is substantiated by its achievement of a theoretical sensitivity of 1.8647(mW/m^(2))/(rad/s)and high impact resistance of 220,000 *** means of normalization,the sensitivity of the proposed structure can be enhanced by four orders of magnitude compared to the traditional SAW *** novel structure combines the advantages of both conventional microscale vibrating gyroscopes and optical gyroscopes,providing a powerful solution for performance enhancement of SAW gyroscopes and,thereby,enabling application in the field of inertial devices.

关键词： resistance wave structure

Organic optoelectronics:materials,devices and applications

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光学精密工程 2005年第5期13卷 525-534页

作者： IAU Yi CUI tian-hong Department of Mechanical Engineering University of Minnesota 111 Church Street SE Minneapolis MN 55455 USA

The interest in organic materials for optoelectronic devices has been growing rapidly in the last two decades. This growth has been propelled by the exciting advances in organic thin films for displays, low-cost electronic circuits, etc. An increasing number of products employing organic electronic devices have become commercialized, which has stimulated the age of organic optoelectronics. This paper reviews the recent progress in organic optoelectronic technology. First, organic light emitting electroluminescent materials are introduced. Next, the three kinds of most important organic optoelectronic devices are summarized, including light emitting diode, organic photovoltaic cell, and photodetectors. The various applications of these devices are also reviewed and discussed in detail. Finally, the market and future development of optoelectronic devices are also demonstrated.

关键词：光电子学 OLED PPV 显示器电路

The apparent state of droplets on a rough surface

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Science China(Physics,Mechanics & Astronomy) 2009年第2期52卷 233-238页

作者： CHEN XiaoLing lu tian Key Laboratory for Power Machinery and Engineering of Ministry of Education School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200030China

The factors influencing the state and wetting transition of droplets on a rough surface are both complex and obscure. The change in wetting is directly reflected by changes under the contact condition of the droplets with the surface. The recent study about the wettability of the superhydrophobic surface under the condensing condition arouses the new understanding about the apparent state of droplets on a rough surface. In this work, to validate the existence of droplets in an intermediate state, a microscale pillar topological polydimethylsiloxane (PDMS) surface was manufactured and its wettability under various conditions was studied. According to the experimental data, it is proposed that the wetting state of a rough surface may be embodied using the contact area ratio of a solid/liquid/gas droplet with the projective plane. A general calculation model for the apparent contact angle of droplets is given and expressed diagrammatically. It is found that the measured apparent contact angles of droplets at dif- ferent states on the surface falls within the range predicted by our proposed equation.

关键词： rough surface wettability apparent contact angle condensing condition

Comparison of Beijing MST Radar and Radiosonde Horizontal Wind Measurements

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Advances in Atmospheric Sciences 2017年第1期34卷 39-53页

作者： Yufang tian Daren lu Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

To determine the performance and data accuracy of the 50 MHz Beijing Mesosphere-Stratosphere-Troposphere （MST） radar, comparisons of radar measured horizontal winds in the height range 3-25 km with radiosonde observations were made during 2012. A total of 427 profiles and 15 210 data pairs were compared. There was very good agreement between the two types of measurement. Standard deviations of difference （mean difference） for wind direction, wind speed, zonal wind and meridional wind were 24.86° （0.77°）, 3.37 （-0.44）, 3.33 （-0.32） and 3.58 （-0.25） m s^-1, respectively. The annual standard deviations of differences for wind speed were within 2.5-3 m s^-1 at all heights apart from 10-15 km, the area of strong winds, where the values were 3-4 m s^-1. The relatively larger differences were mainly due to wind field variations in height regions with larger wind speeds, stronger wind shear and the quasi-zero wind layer. A lower MST radar SNR and a lower percentage of data pairs compared will also result in larger inconsistencies. Importantly, this study found that differences between the MST radar and radiosonde observations did not simply increase when balloon drift resulted in an increase in the real-time distance between the two instruments, but also depended on spatiotemporal structures and their respective positions in the contemporary synoptic systems. In this sense, the MST radar was shown to be a unique observation facility for atmospheric dynamics studies, as well as an operational meteorological observation system with a high temporal and vertical resolution.

关键词： MST radar radiosonde horizontal wind measurement comparison and analysis

Thermal hydraulic characteristics of helical coil once-through steam generator under ocean conditions

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Nuclear Science and Techniques 2022年第10期33卷 139-150页

作者： tian-Ze Bai Chang-hong Peng School of Nuclear Science and Technology University of Science and Technology of ChinaNo.96Jinzhai RoadBaohe DistrictHefei 230026China

Owing to its advantages of high heat transfer efficiency and compactness, the helical coil once-through steam generator(HCOTSG) can be used in floating nuclear power plants and has been widely used in the design of small modular reactors. The helical tubular geometric structure of the HCOTSG allows heat transfer and local flow changes to occur under complex ocean conditions. In this study, theoretical models of ocean conditions are added to the RELAP5/MOD3.3 code and verified. Using the modified RELAP5 code, the thermal–hydraulic characteristics of the HCOTSG under ocean conditions are simulated. The results show that under rolling conditions, the flow oscillation amplitudes of the single liquid-phase, twophase flow, and single gas-phase regions are different. A circular change in the horizontal position of the helical tube causes the fluctuation of the parameters to change periodically. A phase difference of approximately 3.9 s at a flow rate of 23 kg/s is observed in the flow fluctuation along the axial direction. The driving force, period, and amplitude of rolling significantly affect the flow fluctuation in the HCOTSG. In natural circulation, the flow in the HCOTSG is complex, and the primary-side flow fluctuation can reduce the trough of the flow oscillation at the helical tube by approximately 24.3%.

关键词： RELAP5 HCOTSG Ocean conditions Thermal–hydraulic analysis Flow oscillation

Spin effect on redox acceleration and regioselectivity in Fe-catalyzed alkyne hydrosilylation

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National Science Review 2024年第2期11卷 155-167页

作者： Peng He Meng-Yang Hu Jin-hong Li tian-Zhang Qiao Yi-Lin lu Shou-Fei Zhu Frontiers Science Center for New Organic Matter State Key Laboratory and Institute of Elemento-Organic Chemistry Nankai University

Iron catalysts are ideal transition metal catalysts because of the Earths abundant, cheap, biocompatible features of iron salts. Iron catalysts often have unique open-shell structures that easily undergo spin crossover in chemical transformations, a feature rarely found in noble metal catalysts. Unfortunately, little is known currently about how the open-shell structure and spin crossover affect the reactivity and selectivity of iron catalysts, which makes the development of iron catalysts a low efficient trial-and-error program. In this paper, a combination of experiments and theoretical calculations revealed that the iron-catalyzed hydrosilylation of alkynes is typical spin-crossover catalysis. Deep insight into the electronic structures of a set of well-defined open-shell active formal Fe(0) catalysts revealed that the spin-delocalization between the iron center and the 1,10-phenanthroline ligand effectively regulates the iron center's spin and oxidation state to meet the opposite electrostatic requirements of oxidative addition and reductive elimination, respectively,and the spin crossover is essential for this electron transfer process. The triplet transition state was essential for achieving high regioselectivity through tuning the nonbonding interactions. These findings provide an important reference for understanding the effect of catalyst spin state on reaction. It is inspiring for the development of iron catalysts and other Earth-abundant metal catalysts, especially from the point of view of ligand development.

关键词： spin effect spin-delocalization spin crossover iron-catalysis alkyne hydrosilylation