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Long-chain acyl-CoA synthetase regulates systemic lipid homeostasis via glycosylation-dependent lipoprotein production

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Life Metabolism 2024年第2期3卷 38-54页

作者： Jie Li Yue Dong tianxing Zhou he tian Xiahe Huang Yong Q.Zhang Yingchun Wang Sin Man Lam Guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Lipidall Technologies Company Limited ChangzhouJiangsu 213000China

Interorgan lipid transport is crucial for organism development and the maintenance of physiological ***,we demonstrate that Drosophila long-chain acyl-CoA synthetase(dAcsl),which catalyzes the conversion of fatty acids into acyl-coenzyme As(acyl-CoAs),plays a critical role in regulating systemic lipid *** deficiency in the fat body led to the ectopic accumulation of neutral lipids in the gut,along with significantly reduced lipoprotein contents in both the fat body and *** aberrant phenotypes were rescued by fat body-specific overexpression of apolipophorin.A multi-omics investigation comprising lipidomics,metabolomics,and proteomics in conjunction with genetic screening revealed that glycosylation processes were suppressed in dAcsl knockdown *** of CG9035,human ortholog of which is implicated in the congenital disorder of glycosylation,ame-liorated gut lipid accumulation in *** lipoprotein glycosylation led to accelerated proteasome-related degradation and induced ER stress in dAcsl knockdown flies,impairing lipoprotein release into the circulation which compromised interorgan lipid transport between the fat body and the *** of ubiquitin-proteasome-dependent degradation alleviated the phenotype of gut ectopic fat accumulation in dAcsl knockdown ***,we verified that ACSL4,the human homolog of dAcsl,also regulated lipoprotein levels in hepG2 cells,indicating that the role of dAcsl in modulating lipoprotein secretion and systemic lipid homeostasis is possibly conserved in humans.

关键词： lipid homeostasis apolipoprotein glycosylation lipidomics metabolomics proteomics

Macrophage polarization disorder in the endometrial immune microenvironment may contribute to recurrent implantation failure

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Reproductive and Developmental Medicine 2024年第3期8卷 162-168页

作者： Yun Liu Xian-Ming Tan tian-tian he Department of Obstetrics and Gynecology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518000China School of Medicine Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518000China Department of Obstetrics The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510000China

Objective:To investigate the role and mechanisms by which macrophages(MΦ)contribute to the immune environment of the endometrium in cases of recurrent implantation failure(RIF).Methods:Endometrial transcriptome data from women with and without RIF(control group)were *** CIBERSORT software was used to determine the abundance of immune cells within the endometrial tissue based on expression *** gene co-expression network analysis was used to identify crucial regulatory genes and ***:Application of CIBERSORT confirmed significant infiltration of macrophages in the RIF ***6,TTC21A,KLHL31,NFIA,TNNT1,TPM1,CPVL,FUS,PEX5,and SLC43A3 were all closely correlated with M2 and M0 *** and DisNor analyses revealed that these genes contribute to the regulation of macrophage polarization via the Wnt signaling ***:This study identified dysregulation of macrophage polarization within the immune microenvironment of the endometrium in patients with RIF.A comprehensive analysis was conducted to investigate the potential mechanisms underlying this *** of macrophage polarization in the endometrium of patients with RIF is strongly associated with the Wnt signaling pathway.

关键词： Macrophage Polarization disorder Immune microenvironment Recurrent implantation failure Assisted reproductive technology

Bidirectional rectifier with gate voltage control based on Bi_(2)O_(2)Se/WSe_(2)heterojunction

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Journal of Semiconductors 2024年第1期45卷 63-70页

作者： Ruonan Li Fangchao Lu Jiajun Deng Xingqiu Fu Wenjie Wang he tian North China Electric Power University and hebei Key Laboratory of Physics and Energy Technology Beijing 102206China School of Integrated Circuits&Beijing National Research on Information Science and Technology(BNRist) Tsinghua UniversityBeijing 100084China

Two-dimensional(2D)WSe_(2)has received increasing attention due to its unique optical properties and bipolar *** WSe_(2)-based heterojunctions exhibit bidirectional rectification characteristics,but most devices have a lower rectification *** this work,the Bi_(2)O_(2)Se/WSe_(2)heterojunction prepared by us has a typeⅡband alignment,which can vastly suppress the channel current through the interface barrier so that the Bi_(2)O_(2)Se/WSe_(2)heterojunction device has a large rectification ratio of about 10^(5).Meanwhile,under different gate voltage modulation,the current on/off ratio of the device changes by nearly five orders of magnitude,and the maximum current on/off ratio is expected to be achieved *** photocurrent measurement reveals the behavior of recombination and space charge confinement,further verifying the bidirectional rectification behavior of heterojunctions,and it also exhibits excellent performance in light *** the future,Bi_(2)O_(2)Se/WSe_(2)heterojunction field-effect transistors have great potential to reduce the volume of integrated circuits as a bidirectional controlled switching device.

关键词： Bi_(2)O_(2)Se WSe_(2) heterojunction bidirectional rectification optoelectronic devices

面向量产的高速公路智能换道系统决策规划方法研究

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汽车工程 2024年第3期46卷 418-430页

作者：何一超寇胜杰田贺李昊芦勇联创汽车电子有限公司上海201206 清华大学车辆与运载学院北京100084

高速公路智能换道是高级辅助驾驶系统(ADAS)的重要功能,现阶段算法难以在低算力硬件资源条件下兼顾换道安全性和平顺性。为解决此问题,本文提出一种高速公路智能换道系统决策规划方法。通过分级危险区域,检测碰撞风险做出换道决策,进而... 详细信息

高速公路智能换道是高级辅助驾驶系统(ADAS)的重要功能,现阶段算法难以在低算力硬件资源条件下兼顾换道安全性和平顺性。为解决此问题,本文提出一种高速公路智能换道系统决策规划方法。通过分级危险区域,检测碰撞风险做出换道决策,进而实施横纵向解耦规划。在横向规划中,设计两阶段五次多项式换道轨迹规划,提升换道途中安全性和平顺性。在纵向规划中,巡航工况采用类PID算法,可提升规划实时性,而跟车工况采用基于同步预测时域的模型预测控制(MPC)算法,通过关联横纵向规划时间可提升换道平顺性,并设计代价函数降低求解复杂度可满足低资源占用要求。通过实车对比试验,验证了该方法在高速公路换道多场景中具有较高的安全性、平顺性和体验感。此外,算法占用的静态区存储和栈区峰值存储测试对比结果表明了该方法具有较低的硬件资源占用率,可满足低算力控制器对资源占用的要求。

关键词：智能换道系统解耦规划两阶段换道模型预测控制同步时域面向量产

基于减速度包络线修正的新型防滑效率计算方法

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交通运输工程学报 2024年第2期24卷 193-206页

作者：翟耕慰田春马天和陈超王国壮同济大学铁道与城市轨道交通研究院上海201804 常州大学机械与轨道交通学院江苏常州213164

为解决现有防滑效率计算方法准确性低、评价效果差等问题,在深入分析列车制动防滑过程中轮轨黏着系数变化规律及特点的基础上,修正了列车制动防滑过程减速度峰值包络线,使其接近理想减速度曲线,进而提出一种新型防滑效率计算方法;结合... 详细信息

为解决现有防滑效率计算方法准确性低、评价效果差等问题,在深入分析列车制动防滑过程中轮轨黏着系数变化规律及特点的基础上,修正了列车制动防滑过程减速度峰值包络线,使其接近理想减速度曲线,进而提出一种新型防滑效率计算方法;结合列车制动防滑系统实际工作原理,搭建了列车制动防滑效率仿真验证平台,在仿真层面验证了减速度包络线修正的正确性和新型防滑效率计算方法的准确性;在不同仿真工况下对比分析了6种防滑效率计算方法的合理性和防滑性能评价效果,并基于实车防滑试验验证了新方法的实用性。研究结果表明:搭建的列车制动防滑效率仿真验证平台所得列车制动时间、制动距离等计算结果与相同工况下实车防滑试验结果的相对误差不超过5%,可用来验证和分析防滑效率计算方法与防滑性能评价效果;修正后的减速度峰值包络线与理想减速度曲线的相对误差不超过4.5%;当防滑控制策略不变时,新型防滑效率计算方法对列车在不同制动级位和黏着水平下的仿真结果相差不超过1.1%,试验结果相差不超过3.5%,且防滑效率均小于100%,稳定性良好;采用不同防滑控制策略时,新型防滑效率计算方法的仿真结果存在明显差异,且不同控制策略对应的防滑效率与其防滑性能正相关,能体现出不同防滑系统间的性能差异;新型防滑效率计算方法能通过实车防滑试验计算防滑效率,为实车提供了一种新的防滑性能评价手段。

关键词：铁道车辆制动系统防滑效率减速度包络线联合仿真实车防滑试验

Single-center retrospective study of the diagnostic value of doubleballoon enteroscopy in Meckel’s diverticulum with bleeding

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1043-1054页

作者： tian he Chao Yang Jing Wang Ji-Sheng Zhong Ai-Hua Li Ya-Jing Yin Li-Ling Luo Chun-Mei Rao Nian-Fen Mao Qiang Guo Zan Zuo Wen Zhang Ping Wan Yunnan Digestive Endoscopy Clinical Medical Center Department of GastroenterologyThe First People’s Hospital of Yunnan ProvinceThe Affiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina Department of Medicine Kunming University of Science and TechnologyKunming 650093Yunnan ProvinceChina School of Medicine Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina Department of Gastroenterology Qujing Hospital of Traditional Chinese MedicineQujing 655000Yunnan ProvinceChina Department of Gastroenterology Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina

BACKGROUND The study aimed to analyze the characteristic clinical manifestations of patients with intestinal disease Meckel’s diverticulum(MD)complicated by digestive tract ***,we aimed to evaluate the value of double-balloon enteroscopy(DBE)in MD diagnosis and the prognosis after laparoscopic diverticula *** To evaluate the value of DBE in the diagnosis and the prognosis after laparoscopic diverticula resection for MD with *** The study retrospectively analyzed relevant data from 84 MD patients treated between January 2015 and March 2022 and recorded their clinical manifestations,auxiliary examination,and follow-up after laparoscopic resection of ***(1)Among 84 MD patients complicated with hemorrhage,77 were male,and 7 were female with an average age of 31.31±10.75 *** incidence was higher in men than in women of different ages;(2)Among the 84 MD patients,65(78.40%)had defecated dark red stools,and 50(58.80%)had no accompanying symptoms during bleeding,indicating that most MD bleeding appeared a dark red stool without accompanying symptoms;(3)The shock index of 71 patients(85.20%)washe blood loss of most MD patients was less than 20%–30%,and only a few patients had a blood loss of>30%;(4)The DBE-positive rate was 100%(54/54),99mTcpertechnetate-positive scanning rate was 78%(35/45)compared with capsule endoscopy(36%)and small intestine computed tomography(19%).These results suggest that DBE and 99mTc-pertechnetate scans had significant advantages in diagnosing MD and bleeding,especially DBE was a highly precise examination method in MD diagnosis;(5)A total of 54 MD patients with hemorrhage underwent DBE examination before *** endoscopy revealed many mucosal manifestations including normal appearance,inflammatory changes,ulcerative changes,diverticulum inversion,and nodular hyperplasia,with ulcerative changes being the most common(53.70%).This suggests that diverticular mucosal u

关键词： Meckel’s diverticulum with bleeding Double-balloon colonoscopy 99mTc-pertechnetate scanning Capsule endoscopy Ectopic gastric mucosa

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《管子》政治哲学中的公私观念

古代文明（中英文） 2024年第3期18卷 72-79,158页

作者：曾筱琪田贺东北师范大学马克思主义学部吉林长春130024 东北师范大学马克思主义学部哲学院吉林长春130024

公私之辨是战国时期的焦点议题,《管子》作为战国中后期的重要文献,反映了诸子思想激烈争鸣与积极融合的特质,其公私观念一方面秉持法家立场,将公私对立的理论推向极致,以此诠释法的权威性、客观性;另一方面则吸收黄老道家思想,将天地... 详细信息

公私之辨是战国时期的焦点议题,《管子》作为战国中后期的重要文献,反映了诸子思想激烈争鸣与积极融合的特质,其公私观念一方面秉持法家立场,将公私对立的理论推向极致,以此诠释法的权威性、客观性;另一方面则吸收黄老道家思想,将天地之“无私”解释为人类社会应当遵循的法则,由此弥合了“道—法”之间的鸿沟。《管子》将“法”的精神特质定义为“公而无私”,推导出“去私立公”作为政治治理原则,并确立君主为此原则能否有效贯彻的首要责任人,进而从人性的视角以及天地无私的形上层面,诠释政治哲学“公而无私”的必然性、合理性、可行性。

关键词：《管子》公私政治哲学法

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中小学地理游戏化教学研究综述

地理教学 2024年第18期 54-59页

作者：汤依玲何甜湖南师范大学地理科学学院湖南长沙410081

游戏化教学具有促进学习的教育潜力。本文基于WOS数据库,梳理2013~2024年中小学地理游戏化教学的相关文献,从教学应用、设计与开发、教学评估三个方面进行归纳分析,揭示了国际中小学地理游戏化教学领域的研究重点,总结了特点和趋势,并... 详细信息

游戏化教学具有促进学习的教育潜力。本文基于WOS数据库,梳理2013~2024年中小学地理游戏化教学的相关文献,从教学应用、设计与开发、教学评估三个方面进行归纳分析,揭示了国际中小学地理游戏化教学领域的研究重点,总结了特点和趋势,并对未来的研究进行了展望。

关键词：中小学地理游戏化教学文献综述

Magnesium cantharidate suppresses PP2A and ERK1/2 pathway to inhibit hepatocellular carcinoma cells

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Toxicology Advances 2024年第1期6卷 16-27页

作者： Ze Wang Yu-Xi Huang tian-Mu he Xiang-Yu Tan Xiao-Fei Li Yun Liu Rong Yan School of Pharmacy Zunyi Medical UniversityZunyi 563000China School of Basic Medicine Zunyi Medical UniversityZunyi 563000China Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines Zunyi Medical UniversityZunyi 563000China

Background:Magnesium cantharidate(MC)is a protein phosphatase 2A(PP2A)inhibitor antitumor ***,its antitumor mechanism in hepatocellular carcinoma cell(HCC)remains ***:PP2A lentiviral vector over expression strategy was utilized both in vivo and in vitro to explore the antitumor effect in MC and okadaic acid(OA).Tumor weight was detected in mice after MC and OA *** proliferation,cell cycle,apoptosis rate,and western blotting were detected to explore the effects on MC and OA in human hepatocarcinoma SMMC-7721 ***:In vivo results demonstrated that MC inhibited HCC progression while OA promoted tumor *** vitro results demonstrated that MC effectively inhibited the growth of SMMC-7721 cells by arresting the cell cycle at the G2/M phase with inhibiting Cdc25C and activating the phosphorylation of the Cdc2 *** cytometry results further showed that MC increased ***,the expression of phosphorylated ERK1/2 was lower in the MC group but higher in the OA *** docking results showed that MC docked well with ERK1/***:MC inhibited HCC progression by suppressing the growth and activating the apoptosis of cancer cells and suppressing the expression of PP2A and ERK1/2.

关键词： magnesium cantharidate ERK1/2 HCC PP2A