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A nanoagent for concurrent therapy of breast cancer bone metastasis and cancer-induced bone pain through SLC7A11 interruption and photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 295-299页

作者： Qi Fu Zhongming Lian Mengya Niu Yaru Huang Yanqiu Ai Long He Dandan Zhang Cuixia Zheng Jian-Jun Yang Lei Wang Dandan tian Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Translational Medical Center of Huaihe Hospital Henan UniversityKaifeng 475004China key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and *** concurrent treatment of bone metastases and CIBP remains a clinical challenge because the therapeutic options are *** this study,we construct a near-infrared light-activated nano-therapeutic system to meet this *** detail,sorafenib(SRF)and photosensitizer(chlorin e6,Ce6)are encapsulated into mesoporous hydroxyapatite nanoparticles(HANPs),which are further functionalized with hyaluronic acid(HA)to obtain HA-SRF/Ce6@HANPs *** designed nanoplatform destroys tumor cells in vitro and in vivo via the synergism of SRF(interrupting the exchange of cystine/glutamate by inhibiting SLC7A11)and photodynamic therapy(PDT,inducing reactive oxygen species generation).The decrease in tumor burden and reduction of extracellular glutamate significantly attenuate CIBP in mice model with developing bone ***,the combination of HA-SRF/Ce6@HANPs and PDT inhibit osteoclasts activation,promote osteoblast differentiation and accelerate bone ***,the nanoagent with good biocompatibility may provide an effective therapy method for the concurrent treatment of breast cancer bone metastasis and CIBP.

关键词： Breast cancer bone metastasis Cancer-induced bone pain Cystine/glutamate antiporter Sorafenib Photodynamic therapy

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本科层次职业教育的功能定位与发展路径研究——基于德国应用科学大学与职业学院的差异分析

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天津中德应用技术大学学报 2024年第3期 4-9页

作者：鄂甜北京教育科学研究院北京100036

明确界定本科层次职业教育的人才培养目标,特别是厘清应用技术本科与本科层次职业教育两种不同高等教育机构之间的差异化定位,对于当前本科层次职业教育的发展至关重要。借鉴德国应用科学大学与职业学院的成功经验,分析它们在培养目标... 详细信息

明确界定本科层次职业教育的人才培养目标,特别是厘清应用技术本科与本科层次职业教育两种不同高等教育机构之间的差异化定位,对于当前本科层次职业教育的发展至关重要。借鉴德国应用科学大学与职业学院的成功经验,分析它们在培养目标、专业设置、课程体系、教学模式等方面存在的差异,提出我国本科职业教育的功能定位应聚焦职业实践相关的能力培养,通过面向企业需求的专业设置、职业实践导向的课程体系、双元合作的教学模式,以及企业参与的录取标准,形成一套与应用技术本科差异化的发展路径。

关键词：本科层次职业教育应用技术大学德国职业学院

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激发企业主体作用的核心要素一一基于英国“雇主主导模式”学徒制改革的借鉴

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职业教育研究 2024年第3期 77-82页

作者：鄂甜北京教育科学研究院北京100036

强化企业主体地位是我国职业教育实现产教融合育人的关键。英国政府近几年实施的“雇主主导模式”学徒制度改革经验值得借鉴。通过学徒税改革,雇主成为主要融资者、资金支配者;通过雇主主导的学徒标准改革,雇主成为教学标准的开发者、... 详细信息

强化企业主体地位是我国职业教育实现产教融合育人的关键。英国政府近几年实施的“雇主主导模式”学徒制度改革经验值得借鉴。通过学徒税改革,雇主成为主要融资者、资金支配者;通过雇主主导的学徒标准改革,雇主成为教学标准的开发者、掌舵人;通过实施“ePA改革”,雇主成为评价标准的制定者、评价过程的参与者及评价结果的受益者。借鉴英国“雇主主导模式”的学徒制改革经验,建议我国将“资金”“标准”和“评价”三个要素作为关键突破口,强化企业在产教融合育人过程中的主体地位:一是重塑企业主体的职业教育融资体系,撬动企业核心利益,激发企业参与职业教育的内在动力;二是完善企业主导的专业教学标准开发与审批制度,保障教育培训质量;三是围绕企业选人用人需求,建立整体规范、权威有效的考试评价与资格认证制度。

关键词：学徒制雇主主导模式:职业教育企业主体地位资金标准评价

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High-silica faujasite zeolite-tailored metal encapsulation for the low-temperature production of pentanoic biofuels

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Journal of energy Chemistry 2024年第1期88卷 552-560,I0012页

作者： Wenhao Cui Yuanshuai Liu Pengfei Guo Zhijie Wu Liqun kang Huawei Geng Shengqi Chu Linying Wang Dong Fan Zhenghao Jia Haifeng Qi Wenhao Luo Peng tian Zhongmin Liu National engineering Research Center of Lower-Carbon Catalysis Technology Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101ShandongChina College of Chemistry and Chemical engineering Inner Mongolia UniversityHohhot 010021Inner MongoliaChina State.k.y Laboratory of Heavy Oil Processing and key Laboratory of Catalysis of CNPC China University of PetroleumBeijing 102249China Department of Inorganic Spectroscopy Max Planck Institute for Chemical Energy ConversionMülheim an der Ruhr 45470Germany Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Division of energy Research Resources Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Leibniz-Institut für katalyse Albert-Einstein-Straβe 29aRostock 18059Germany

Zeolite-encapsulated metal nanoclusters are at the heart of bifunctional catalysts,which hold great potential for petrochemical conversion and the emerging sustainable ***,efficient encapsulation of metal nanoclusters into a high-silica zeolite Y in particular with good structural integrity still remains a significant ***,we have constructed Ru nanoclusters(~1 nm)encapsulated inside a high-silica zeolite Y(SY)with a SiO_(2)/Al_(2)O_(3) ratio(SAR)of 10 via a cooperative strategy for direct zeolite synthesis and a consecutive impregnation for metal *** with the benchmark Ru/H-USY and other analogues,the as-prepared Ru/H-SY markedly boosts the yields of pentanoic biofuels and stability in the direct hydrodeoxygenation of biomass-derived levulinate even at a mild temperature of 180℃,which are attributed to the notable stabilization of transition states by the enhanced acid accessibility and properly sized constraints of zeolite cavities owing to the good structural integrity.

关键词： High-silica zeolite Y Metal encapsulation Bifunctional catalysis Hydrodeoxygenation Biofuels

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Identification of S-RNase genotype and analysis of its origin and evolutionary patterns in Malus plants

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Journal of Integrative Agriculture 2024年第4期23卷 1205-1221页

作者： Zhao Liu Yuan Gao kun Wang Jianrong Feng Simiao Sun Xiang Lu Lin Wang Wen tian Guangyi Wang Zichen Li Qingshan Li Lianwen Li Dajiang Wang Research Institute of Pomology Chinese Academy of Agricultural Sciences/Key Laboratory of Horticultural Crops Germplasm Resources UtilizationMinistry of Agriculture and Rural AffairsXingcheng 125100China College of Agriculture Shihezi University/Key Laboratory of Special Fruits and Vegetables Cultivation Physiology and Germplasm Resources Utilization of Xinjiang Production and Construction CorpsShihezi 832000China

Identification of the S genotype of Malus plants will greatly promote the discovery of new genes,the cultivation and production of apple,the breeding of new varieties,and the origin and evolution of self-incompatibility in Malus *** this experiment,88 Malus germplasm resources,such as Aihuahong,Xishuhaitang,and Reguanzi,were used as *** gene-specific primer combinations were used in the genotype *** amplification using leaf DNA produced a single S-RNase gene fragment in all *** results revealed that 70 of the identified materials obtained a complete S-RNase genotype,while only one S-RNase gene was found in 18 of *** homology comparison and analysis,13 S-RNase genotypes were obtained:S_(1)S_(2)(Aihuahong,etc.),S_(1)S_(28)(Xixian Haitang,etc.),S_(1)S_(51)(Hebei Pingdinghaitang),S_(1)S_(3)(Xiangyangcun Daguo,etc.),S_(2)S_(3)(Zhaiyehaitang,etc.),S_(3)S_(51)(Xishan 1),S_(3)S_(28)(Huangselihaerde,etc.),S_(2)S_(28)(Honghaitang,etc.),S_(4)S_(28)(Bo 11),S_(7)S_(28)(Jiuquan Shaguo),S_(10)S_e(Dongchengguan 13),S_(10)S_(21)(Dongxiangjiao)and S_(3)S_(51)(Xiongyue Haitang).Simultaneously,the frequency of the S gene in the tested materials was *** findings revealed that different S genes had varying frequencies in Malus resources,as well as varying frequencies between intraspecific and interspecific.S_(3) had the highest frequency of 68.18%,followed by S_(1)(42.04%).In addition,the phylogenetic tree and origin evolution analysis revealed that the S gene differentiation was completed prior to the formation of various apple species,that cultivated species also evolved new S genes,and that the S_(50) gene is the oldest S allele in Malus *** S_(1),S_(29),and S_(33) genes in apple-cultivated species,on the other hand,may have originated in ***,***,and ***,*** addition to ***,*** and *** may have also played a role in the origin and evolution of some Chine

关键词： Malus S-RNase genotype self-incompatibility origin and evolution

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Structural basis of negative regulation of CRISPR-Cas7-11 by TPR-CHAT

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2716-2725页

作者： tian Hong Qinghua Luo Haiyun Ma Xin Wang Xinqiong Li Chongrong Shen Jie Pang Yan Wang Yuejia Chen Changbin Zhang Zhaoming Su Haohao Dong Xiaodi Tang Department of Laboratory Medicine State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduChina Frontiers Medical Center Tianfu Jincheng LaboratoryWest China HospitalSichuan UniversityChengduChina

CRISPR‒Cas7-11 is a Type Ⅲ-e CRISPR-associated nuclease that functions as a potent RNA editing ***-peptide repeat fused with Cas/HeF1-associated signal transducer(TPR-CHAT)acts as a regulatory protein that interacts with CRISPR RNA(crRNA)-bound Cas7-11 to form a CRISPR-guided caspase complex(Craspase).However,the precise modulation of Cas7-11’s nuclease activity by TPR-CHAT to enhance its utility requires further ***,we report cryo-electron microscopy(cryo-eM)structures of Desulfonema ishimotonii(Di)Cas7-11-crRNA,complexed with or without the full length or the N-terminus of *** structures unveil the molecular features of the Craspase *** analysis,combined with in vitro nuclease assay and electrophoretic mobility shift assay,reveals that DiTPR-CHAT negatively regulates the activity of DiCas7-11 by preventing target RNA from binding through the N-terminal 65 amino acids of DiTPR-CHAT(DiTPR-CHAT_(NTD)).Our work demonstrates that DiTPRCHAT_(NTD) can function as a small unit of DiCas7-11 regulator,potentially enabling safe applications to prevent overcutting and offtarget effects of the CRISPR‒Cas7-11 system.

关键词： CRISPR crRNA TPR

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Interfacial molecular screening of polyimide dielectric towards high-performance organic field-effect transistors

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Chinese Chemical Letters 2024年第2期35卷 268-271页

作者： Yingshuang Zheng Huchao Li Ting Jiang Fei Jiao Jie Li Yong Lei Guofeng tian Jinshun Bi Yundong Xuan Liqiang Li Deyang Ji Wenping Hu Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic SciencesInstitute of Molecular Aggregation ScienceTianjin UniversityTianjin 300072China GPL Photonics Laboratory State Key Laboratory of Applied OpticsChangchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic SciencesSchool of ScienceCollaborative Innovation Center of Chemical Science and EngineeringTianjin UniversityTianjin 300072China Joint School of National University of Singapore and tianjin University Fuzhou 350207China Fachgebiet Angewandte Nanophysik Institut für Physik & IMN MacroNanoTechnische Universität IlmenauIlmenau 98693Germany State.k.y Laboratory of Chemical Resource engineering Beijing University of Chemical TechnologyBeijing 100029China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100101China

The compatibility of the gate dielectrics with semiconductors is vital for constructing efficient conducting channel for high charge ***,it is still a highly challenging mission to clearly clarify the relationship between the dielectric layers and the chemical structure of semiconductors,especially vacuum-deposited small ***,interfacial molecular screening of polyimide.k.pton)dielectric in organic field-effect transistors(OFeTs)is comprehensively *** is found that the semiconducting small molecules with alkyl side chains prefer to form a high-quality charge transport layer on polyimide(PI)dielectrics compared with the molecules without alkyl side *** this basis,the fabricated transistors could reach the mobility of 1.2 cm^(2) V^(−1)s^(−1) the molecule with alkyl side chains on bare PI *** is more,the compatible semiconductor and dielectric would further produce a low activation energy(e_(A))of 3.01 meV towards efficient charge transport even at low temperature(e.g.,100 k,0.9 cm^(2) V^(−1)s^(−1)).Our research provides a guiding scheme for the construction of high-performance thin-film field-effect transistors based on PI dielectric layer at room and low temperatures.

关键词： Interfacial molecular screening Polyimide dielectrics Organic semiconductors Interface engineering Thin-film transistors

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Multiple metal sources in polymetallic W-Sn ore deposits revealed by mercury stable isotopes

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Science China earth Sciences 2024年第11期67卷 3465-3475页

作者： Zhendong tian Bernd LeHMANN Changzhou DeNG Xingchun ZHANG Anbo LUO Yinghua CHeN Runsheng YIN State.k.y Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences Mineral Resources Technical University of Clausthal Faculty of Land Resource engineering Kunming University of Science and Technology

Granite-related W-Sn ore systems are commonly associated with coeval Pb-Zn mineralization. It remains unclear whether these metals are derived from the same sources or not. Mercury（Hg） is a common minor component in such systems. Hg isotopes undergo unique mass-independent fractionation(expressed as Δ199Hg values), which is mainly generated during Hg photochemical reactions on earth's surface and not affected by magmatic-hydrothermal processes, offering an excellent opportunity to trace metal sources in hydrothermal systems. We observed near-zero Δ199Hg values in wolframite（-0.10‰ to0.08‰, n=11）, and in skarn-（-0.17‰ to 0.12‰, n=48） and greisen-type（-0.12‰ to 0.10‰, n=11） bulk tin-tungsten ore from eight major ore deposits in South China. These values are identical to those of coeval highly evolved granites（-0.13‰ to 0.12‰,n=49）, supporting that Hg in W-Sn ores were sourced from granite. However, sulfides（e.g., pyrite, chalcopyrite, arsenopyrite,galena, and sphalerite） in these deposits exhibit negative to near-zero Δ199Hg values（-0.42‰ to 0.09‰, n=124）, which indicates a contribution of Hg and by inference other metals from both Precambrian basement rocks(Δ199Hge-related *** study demonstrates that multiple sources of metals were involved in the formation of the polymetallic W-Sn deposits, and further highlights that extraction of metals from basement rocks may be a critical control on the formation of economically important mineralization of base metal sulfides（e.g., Pb, Zn） in granite-related magmatic-hydrothermal systems.

关键词： Tin-tungsten deposit Mercury isotope Metal source Metal zonation South China

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氮掺杂二硫化钼纳米催化剂的电催化析氢性能

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化工进展 2024年第1期43卷 465-472页

作者：杨成功黄蓉王冬娥田志坚中国科学院大连化学物理研究所辽宁大连116023 中国科学院大学北京100049

以钼酸钠为钼源,L-半胱氨酸为硫源和还原剂,双氰胺为氮源,采用水热法合成了一系列氮掺杂二硫化钼纳米催化剂(N-MoS_(2))。通过XRD、SeM、XPS、Raman等手段表征了不同N掺杂量的N-MoS_(2)催化剂的形貌、元素分布、晶体结构和电子性质。表... 详细信息

以钼酸钠为钼源,L-半胱氨酸为硫源和还原剂,双氰胺为氮源,采用水热法合成了一系列氮掺杂二硫化钼纳米催化剂(N-MoS_(2))。通过XRD、SeM、XPS、Raman等手段表征了不同N掺杂量的N-MoS_(2)催化剂的形貌、元素分布、晶体结构和电子性质。表征结果表明,合成的N-MoS_(2)催化剂均为纳米片层组成的花球,N原子均匀掺杂进了MoS_(2)晶格中。N掺杂使得N原子周围的Mo和S原子的电子密度增加,生成更多具有催化活性的不饱和配位点。采用电化学工作站在酸性介质中测试了催化剂的线性扫描伏安曲线和塔菲尔斜率,评价了N-MoS_(2)纳米催化剂的电催化析氢(HeR)性能。结果表明,MoS_(2)催化剂和N-MoS_(2)催化剂上的析氢反应均通过Volmer-Heyrovsky路径进行。MoS_(2)催化剂上析氢反应速控步骤为Volmer反应,N-MoS_(2)催化剂上析氢反应的速控步骤为Heyrovsky反应。与MoS_(2)催化剂相比,N-MoS_(2)催化剂的塔菲尔斜率较低,析氢反应速率较快,显示出更好的电催化析氢性能。尤其当N与Mo的原子为0.1时(N/Mo=0.1),制备的N-MoS_(2)-0.1催化剂表现出最好的电催化析氢性能,其塔菲尔斜率为60mV/dec。N-MoS_(2)催化剂的电催化活性提高可归结为不饱和配位点暴露量的增加和富电子的Mo对Mo-H*的弱化。

关键词：氮掺杂二硫化钼催化剂电化学氢

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Design of high-temperature superconductors at moderate pressures by alloying AlH3 or GaH3

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Matter and Radiation at extremes 2024年第1期9卷 94-103页

作者： Xiaowei Liang Xudong Wei eva Zurek Aitor Bergara Peifang Li Guoying Gao Yongjun tian Center for High Pressure Science(CHiPS) State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China School of Materials Science and engineering Henan University of TechnologyZhengzhou 450001China Department of Chemistry State University of New York at BuffaloBuffaloNew York 14260-3000USA Physics Department and eHU Quantum Center University of the Basque CountryUPV/EHU48080 BilbaoSpain Donostia International Physics Center(DIPC) 20018 DonostiaSpain Centro de Física de Materiales CFM Centro Mixto CSIC-UPV/EHU20018 DonostiaSpain extreme Conditions Physics Research Team College of Physics and Electronic InformationInner Mongolia Minzu UniversityTongliao 028043China

Since the discovery of hydride superconductors,a significant challenge has been to reduce the pressure required for their *** this context,we propose that alloying could be an effective strategy to achieve *** focus on a series of alloyed hydrides with the AMH_(6)composition,which can be made via alloying A15 AH_(3)(A=Al or Ga)with M(M=a group IIIB or IVB metal),and study their behavior under *** of them are predicted to maintain the A15-type structure,similar to AH_(3)under pressure,providing a platform for studying the effects of alloying on the stability and superconductivity of AH_(3).Among these,the A15-type phases of AlZrH_(6)and AlHfH_(6)are found to be thermodynamically stable in the pressure ranges of 40–150 and 30–181 GPa,***,they remain dynamically stable at even lower pressures,as low as 13 GPa for AlZrH_(6)and 6 GPa for AlHfH_(6).These pressures are significantly lower than that required for stabilizing A15 ***,the introduction of Zr or Hf increases the electronic density of states at the Fermi level compared with *** enhancement leads to higher critical temperatures(Tc)of 75 and 76 k for AlZrH_(6)and AlHfH_(6)at 20 and 10 GPa,*** the case of GaMH_(6)alloys,where M represents Sc,Ti,Zr,or Hf,these metals reinforce the stability of the A15-type structure and reduce the lowest thermodynamically stable pressure for GaH_(3) from 160 GPa to 116,95,80,and 85 GPa,*** noteworthy are the A15-type GaMH_(6)alloys,which remain dynamically stable at low pressures of 97,28,5,and 6 GPa,simultaneously exhibiting high Tc of 88,39,70,and 49 k at 100,35,10,and 10 GPa,***,these findings enrich the family of A15-type superconductors and provide insights for the future exploration of high-temperature hydride superconductors that can be stabilized at lower pressures.

关键词： alloying alloys superconductors

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