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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao mei tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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NONLINEAR WATER WAVES IN LAGRANGIAN COORDINATES:SHALLOW FLUIDS

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Journal of Hydrodynamics 1996年第4期8卷 25-34页

作者： tian, mei Zhu, Yong Shanghai Univ Shanghai China

In this paper the KdV equation has been derived by using the Lagrangian coordinates and the head-on collision between solitary waves was studied without the assumption of irrotational motion condition. It is found tha... 详细信息

关键词： Computer simulation Flow of water Hydrodynamics Nonlinear equations Numerical analysis Water wave effects

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Systemic lupus erythematosus with visceral varicella:A case report

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World Journal of Clinical Cases 2022年第25期10卷 9168-9175页

作者： Jing Zhao mei tian Department of Rheumatology Affiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina

BACKGROUND As an autoimmune disease,systemic lupus erythaematosus(SLE)can affect multiple systems of the body and is mainly treated by steroids and immunosuppressive *** results in a long-term immunocompromised state with the potential of infection complications(e.g.,bacterial,fungal and viral infections).Abdominal pain or acute abdomen are frequently the only manifestations of SLE at disease onset or during the early stage of the disease ***,multidisciplinary collaboration is required to identify these patients because timely diagnosis and treatment are crucial for improving their *** SUMMARY Herein,we reported a case of an SLE patient with visceral varicella that was identified after the onset of abdominal *** 16-year-old female patient with SLE was admitted to our hospital due to initial attacks of abdominal pain and intermittent *** patient’s condition rapidly became aggravated within a short time after admission,with large areas of vesicular rash,severe pneumonia,respiratory failure,shock,and haematologic system and hepatic function *** on multidisciplinary collaboration,the patient was diagnosed with visceral disseminated varicella and was administered life support,antiviral(acyclovir),immunomodulatory(intravenous injection of human immunoglobulin),anti-infection(vancomycin)and anti-inflammatory(steroid)*** treatment,her clinical symptoms and laboratory indicators gradually improved,and the patient was *** SLE patients long treated with steroids and immunosuppressive agents are susceptible to various *** that visceral varicella with abdominal pain as the initial presentation is characterized by rapid progression and often coexists with serious complications,prompt diagnosis and early antiviral therapy are critical to prevent severe life-threatening complications.

关键词： Systemic lupus erythematosus Visceral varicella Severe pneumonia Tacrolimus Mycophenolate mofetil Case report

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Ab initio Study of the Potential Energy Surface and Product Branching Ratios for Reaction of O（^1D） with C2H5CI

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Chinese Journal of Chemical Physics 2009年第1期22卷 87-96页

作者： Chong-fu Song Zhi-mei tian Quan-xin Li tian-jing He Department of Chemistry Fuyang Teacher's College Fuyang 236041 China Department of Chemical Physics University of Science and Technology of China Hefei 230026 China

The potential energy surface of O（^1D）＋C2H5Cl reaction was studied using QCISD（T）/6- 311＋＋G（d,p）//MP2/6-31G（d,p） method. The calculations reveal an insertion-elimination mechanism. The insertion reaction of O（^1D） and C2H5Cl produces two energy-rich intermediates, IM1 and IM2, which subsequently decompose into various products. The calculations of the branching ratios of various products formed through the two intermediates were carried out using RRKM （Rice-Ramsperger-Kassel-Marcus） theory at the collision energies of 0, 20.9, 41.8, 62.7, 83.6, 104.5, and 125.4 kJ/mol. HCl is the main decomposition product for IM1; CH2OH is the main decomposition product for IM2. Since IM1 is more stable than IM2, HCl is probably the main product of the O（^1D）＋C2H5Cl reaction.

关键词： C2H5Cl Branching ratio Rate constant

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Glucocorticoids combined with tofacitinib in the treatment of Castleman’s disease:A case report

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World Journal of Clinical Cases 2022年第29期10卷 10794-10802页

作者： Xiao-Rui Liu mei tian Department of Rheumatology and Immunology Affiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina

BACKGROUND Castleman’s disease(CD),also known as vascular follicular lymphadenopathy is a rare proliferative disease of lymphoid tissue of unknown etiology that is clinically classified as unicentric CD(UCD) or multicentric CD(MCD) depending on lymph node *** present,idiopathic MCD(iMCD) is treated with interleukin-6 inhibitors,but some patients have poor clinical *** paper reports on a case of iMCD that achieved a good therapeutic effect after treatment with glucocorticoids combined with *** relevant data are summarized and reported *** SUMMARY This paper reports on a case of MCD in a 49-year-old female with persistent peritoneal effusion as the first manifestation and combined with multiple *** node biopsy showed Castleman’s disease-like *** ascites subsided after treatment with glucocorticoids and tofacitinib,indicating that the treatment was *** The combination of glucocorticoids with tofacitinib is an effective regimen for the treatment of CD.

关键词： Castleman’s disease Multicentric Castleman’s disease Idiopathic multicentric Castleman’s disease Abdominal dropsy Tofacitinib Glucocorticoids Case report

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Prevalence of color vision deficiency among Chinese college students and their quality of life

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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1542-1548页

作者： Jing-Ge Gao mei tian Department of Ophthalmology Wang Jiang Hospital of Sichuan UniversityChengdu 610065Sichuan ProvinceChina Department of Ophthalmology West China Healthcare Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To investigate the prevalence of color vision deficiency(CVD)among college students and their quality of life(QoL)in a Chinese ***:This cross-sectional study was performed in Sichuan University in Chengdu,*** questionnaire containing participants’demographic data,as well as CVD related QoL was distributed to students who were screened as CVD[by Color Vision Examination Plates(Version 6)]in 2022 freshman entrance *** blindness QoL(CBQoL)and utility analysis were used to evaluate the QoL of CVD ***:There were 381 of 17303(2.20%)students screened as CVD,including 368(4.11%)males and 13(0.16%)females.A total of 317 students completed the questionnaire,the response rate was 83.20%.Only 166 participants(52.3%)knew they have CVD before the physical examination for college entrance examination,while a total of 145 participants(45.74%)hoped to be diagnosed *** medians of CBQoL score and utility were 5.85(range 2.2-6)and 1(range 0-1),*** proportions of students whose QoL is affected by CVD were 67.63%(211/312)and 42.27%(134/317)measured by CBQoL and utility analysis ***:The prevalence of CVD in males is much higher than that in *** time when CVD students first became aware of their CVD is relatively *** QoL of the study population is quite high,while a large proportion of students’QoL are affected by *** is suggested that as a congenital defect,CVD screening in China should be earlier,and appropriate guidance and support are needed for CVD patients to help them better adapt to life,study,and work.

关键词： color vision deficiency prevalence quality of life utility analysis college student

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Synthesis of Nicotinic Acid by Potassium Dichromate Oxidation

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Chemical Research in Chinese Universities 2002年第3期18卷 330-333页

作者： tian mei ZHANG Heng bin CAO Xue jing College of Chemistry Jilin UniversityChangchun 130023P.R.China

Nicotinic acid was synthesized from 3 methylpyridine with potassium dichromate as the oxidant. The reaction conditions, the product separation and analysis were studied. The results indicate that under the certain reaction conditions, the yield of nicotinic acid can reach 67.4%, the conversion can reach 99.7% and the selectivity can be as high as 99.8%. The final product has a high purity.

关键词： Nicotinic acid Potassium dichromate 3 Methylpyridine Chemical oxidation.

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Phylomitogenomics of Malacostraca(Arthropoda: Crustacea)

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Acta Oceanologica Sinica 2015年第2期34卷 84-92页

作者： SHEN Xin tian mei YAN Binlun CHU Kahou Jiangsu Key Laboratory of Marine Biotechnology/College of Marine Science Huaihai Institute of Technology Beijing Institutes of Life Science Chinese Academy of Sciences Simon F.S.Li Marine Science Laboratory School of Life Sciences The Chinese University of Hong Kong

Along with the sequencing technology development and continual enthusiasm of researchers on the mitochondrial genomes, the number of metazoan mitochondrial genomes reported has a tremendous growth in the past decades. Phylomitogenomics—reconstruction of phylogenetic relationships based on mitochondrial genomic data—is now possible across large animal groups. Crustaceans in the class Malacostraca display a high diversity of body forms and include large number of ecologically and commercially important species. In this study, comprehensive and systematic analyses of the phylogenetic relationships within Malacostraca were conducted based on 86 mitochondrial genomes available from Gen Bank. Among 86 malacostracan mitochondrial genomes, 54 species have identical major gene arrangement（excluding t RNAs） to pancrustacean ground pattern,including six species from Stomatopoda, three species from Amphipoda, two krill, seven species from Dendrobranchiata（Decapoda）, and 36 species from Pleocyemata（Decapoda）. However, the other 32 mitochondrial genomes reported exhibit major gene rearrangements. Phylogenies based on Bayesian analyses of nucleotide sequences of the protein-coding genes produced a robust tree with 100% posterior probability at almost all nodes. The results indicate that Amphipoda and Isopoda cluster together（Edriophthalma）（BPP=100）.Phylomitogenomic analyses strong support that Euphausiacea is nested within Decapoda, and closely related to Dendrobranchiata, which is also consistent with the evidence from developmental biology. Yet the taxonomic sampling of mitochondrial genome from Malacostraca is very biased to the order Decapoda, with no complete mitochondrial genomes reported from 11 of the 16 orders. Future researches on sequencing the mitochondrial genomes from a wide variety of malacostracans are necessary to further elucidate the phylogeny of this important group of animals. With the increase in mitochondrial genomes available, phylomitogenomics will emerge

关键词： Malacostraca Crustacea Phylomitogenomics gene arrangement mitochondrial genome

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Recent Advances in Organic Electrochemical C-H Functionalization

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Chinese Journal of Chemistry 2018年第4期36卷 338-352页

作者： qi-Liang Yang Ping Fan tian-Sheng mei State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry & Molecular Engineering East China University of Science and Technology 130 Meilong Road Shanghai 200237 China

Organic electrochemistry has a rich history in organic synthesis and has been considered as a promising alternative to traditional chemical oxidants and reductants because it obviates the use of stoichiometric amount of dangerous and toxic reagents. In particular, the electrochemical C-H bonds functionalization is one of the most desirable approaches for the construction of carbon-carbon （C-C） and carbon-heteroatom （C-X） bonds. This review summarizes the substantial progress made in the last few years in C-H functionalization via organic electrochemistry. It is divided into sections on C-C, C-N, C-O, C-S, C-Halogen and C-P bond formation.

关键词： organic electrochemistry C-H functionalization carbon-carbon bond formation carbon-heteroatom bond formation

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Current and emerging immunotherapeutic approaches for biliary tract cancers

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 440-449页

作者： Zhen-Gang Yuan tian-mei Zeng Chen-Jie Tao Department of Oncology Eastern Hepatobiliary Surgery HospitalSecond Military Medical University(Navy Medical University)Shanghai 200438China

Background:Biliary tract cancers(BTCs)comprise a heterogeneous group of aggressive malignancies with unfavorable *** benefit of chemotherapy seems to have reached a bottleneck and,therefore,new effective therapeutic strategies for advanced BTCs are *** targeted therapies in selected patients are rapidly changing the ***,the low frequency of specific driver alterations in BTCs limits their wide ***,immunotherapeutic approaches are also under active investigation in BTCs,but the role of immunotherapy in BTCs remains *** sources:Pub Med,Web of Science,and meeting resources were searched for relevant articles published from January 2017 to May *** search aimed to identify current and emerging immunotherapeutic approaches for *** on clinical trials was obtained from https://***/and http://***/.Results:Immunotherapy in BTC patients is currently under investigation,and most of the investigations focused on the application of immune checkpoint inhibitors(ICIs).However,only a subgroup of BTCs with microsatellite-instability high(MSI-H)/DNA mismatch repair-deficient(d MMR)or tumor mutational burden-high(TMB-H)benefit from monotherapy of ICIs,and limited activity was observed in the second or subsequent ***,promising results come from studies of ICIs in combination with other therapeutic approaches,including chemotherapy,in advanced BTCs,with a moderate toxicity *** studies demonstrated that compared to GEMCIS alone,durvalumab plus GEMCIS significantly improved patient survival(TOPAZ-1 trial)and that ICIs-combined chemoimmunotherapy is poised to become a new frontline therapy option,regardless of TMB and MMR/MSI *** cell therapy and peptide-or dendritic-based cancer vaccines are other immunotherapeutic options that are being studied in *** biomarkers have been investigated to define their predictive role in res

关键词： Biliary tract cancer Cholangiocarcinoma Gallbladder cancer Immunotherapy Immune checkpoint inhibitors

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