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Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang Ding-Yue Shang Ying Chen Meng tian Cheng-Yu Jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

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改进TD3算法的机械臂三维路径规划方法

电光与控制 2025年第1期32卷 100-105页

作者：马天李超杨嘉怡西安科技大学计算机科学与技术学院西安710000

在军事航空领域中,复杂任务对机械臂路径规划提出了挑战。针对双延迟深度确定性策略梯度(TD3)算法学习效率低、样本利用率低的问题,提出了一种改进的TD3算法(Recurrent-TD3算法)。首先,将LSTM结合到策略网络与价值网络中,捕获航空控制... 详细信息

在军事航空领域中,复杂任务对机械臂路径规划提出了挑战。针对双延迟深度确定性策略梯度(TD3)算法学习效率低、样本利用率低的问题,提出了一种改进的TD3算法(Recurrent-TD3算法)。首先,将LSTM结合到策略网络与价值网络中,捕获航空控制任务中的时间序列信息,增强对时间序列变化的响应能力,使其能够在决策时考虑历史动作和状态,提高网络的表达能力;然后,将事后经验回放(HER)技术集成到TD3算法中,以解决任务中稀疏奖励难以学习的问题,通过将未达到目标的经验转化为达到新目标的经验,从而更有效地利用样本;最后,设计了一种基于包围盒的碰撞检测流程,以提高机械臂在军用航空任务中的安全性。实验表明,该算法相比于其他算法能够更快地找到一条无碰撞的路径,且平均路径长度最短。

关键词：机械臂路径规则 TD3 长短期记忆网络事后经验回放技术

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干细胞的趋电性迁移及机制

中国组织工程研究 2025年第23期29卷 4984-4992页

作者：韩芳舒晴贾绍辉田峻武汉体育学院运动医学院湖北省武汉市430079 武汉大学中南医院骨科康复科湖北省武汉市430071

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,... 详细信息

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,同时综述可能的作用机制。方法:通过检索Pub Med和中国知网数据库,收集截至2024年3月的相关文献,英文检索词:“stem cells,direct current electric field,pulsed electric field,migration,electric field device,mechanism”;中文检索词:“干细胞,直流电场,脉冲电场,迁移,电场装置,机制”。排除不能获取全文和与主题无关的文献。结果与结论:根据筛选要求共纳入58篇文献,包括中文文献15篇及英文文献43篇。文献以脂肪间充质干细胞、骨髓间充质干细胞、神经干细胞、表皮干细胞、人胚胎干细胞和人诱导性多功能干细胞为研究对象,在迁移装置中研究电场的不同参数对上述干细胞迁移的影响及其机制。(1)电场作为一种简单、无创且稳定的干预方式在指导干细胞定向迁移的过程中起着积极作用;(2)不同类型的干细胞发生趋电性迁移的方向不同,同时大部分干细胞的迁移速度和定向性是随着电场强度增加而增加的;(3)不同的电场装置在观测干细胞迁移时的侧重点不同,可根据实验目的而择优选择相关装置;(4)不同干细胞趋电性迁移的机制不完全相同,多数干细胞迁移过程中有MAPK通路、ROCK活化以及PI3K功能的参与,同时还有其他蛋白质复合物与信号通路参与调控该过程;(5)除电场参数不同之外,细胞本身的衰老情况和培养环境也会对趋电性迁移的结果产生影响。总而言之,电场作为一种影响干细胞迁移特性的重要信号,与其他新兴材料结合在组织工程应用中展现出了一定的潜力,有望在指导干细胞归巢方面发挥更加重要的作用,促进骨组织再生和修复以及神经系统、自身免疫系统以及肿瘤等疾病的研究取得更大的突破。

关键词：干细胞电场趋电性迁移机制归巢效应物理因子电场装置细胞衰老培养环境

国际学界关于ChatGPT语言能力的争论与思考

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语言战略研究 2025年第1期10卷 75-86页

作者：时仲田英慧司富珍北京语言大学语言学系/乔姆斯基研究所/生物语言学与脑科学实验室北京100083 北京华文学院招生办公室北京102206

随着ChatGPT为代表的大语言模型在应用方面取得极大成功,语言官能是否为人类独有的问题引起热议,国际学界形成两个对立的阵营。一方认为,大语言模型语言理解和产出方面达到了媲美人类的水准,对乔姆斯基的语言学理论提出了挑战,甚至足以... 详细信息

随着ChatGPT为代表的大语言模型在应用方面取得极大成功,语言官能是否为人类独有的问题引起热议,国际学界形成两个对立的阵营。一方认为,大语言模型语言理解和产出方面达到了媲美人类的水准,对乔姆斯基的语言学理论提出了挑战,甚至足以取代生成语法的语言学理论地位。另一方则认为,人类语言习得“刺激贫乏”但生成能力惊人,而大语言模型“学习”语言依靠输入海量数据,因此,它无法对人类语言的本质问题给出合理性解释,在语言的核心属性方面与人类语言官能存在本质区别。不少实证测试也对夸大大语言模型在语言学理论中的地位的观点进行了批判。本文认为,对这一问题的讨论,首先应思考如下问题:(1)区分科学理论建构与工程应用;(2)对“可能的语言”与“不可能的语言”的区分做出原则性的预测与解释;(3)探讨自然语言习得“刺激贫乏”与大语言模型依靠“豪华型”海量数据之对立背后的深层原因;(4)对句法在人类语言和大语言模型中的地位进行更多维度和更系统的对比评测。

关键词： ChatGPT 大语言模型刺激贫乏可能的语言不可能的语言

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富血小板血浆促进创面愈合的细胞和分子机制

中国组织工程研究 2025年第13期29卷 2793-2801页

作者：龙晨艳程飚田举广东医科大学第一临床医学院广东省湛江市524000 广东医科大学中山市人民医院烧伤整形美容科广东省中山市528400 南部战区总医院烧伤整形科广东省广州市510030

背景:尽管富血小板血浆在促进创面愈合方面显示出治疗潜力,但其临床应用仍需要进一步的研究和验证。此外,对于富血小板血浆作用的机制仍存在一些争议和不确定性。目的:通过对富血小板血浆促进创面愈合的机制进行概述和分析,以增进对该... 详细信息

背景:尽管富血小板血浆在促进创面愈合方面显示出治疗潜力,但其临床应用仍需要进一步的研究和验证。此外,对于富血小板血浆作用的机制仍存在一些争议和不确定性。目的:通过对富血小板血浆促进创面愈合的机制进行概述和分析,以增进对该治疗方法的理解,为未来的基础研究和临床应用提供有益的指导。方法:在中国知网、PubMed数据库检索2000年1月至2023年12月发表的相关文献。英文检索词为“platelet rich plasma,PRP,wound,wound healing,refractory wounds,chronic wounds,cellular and molecular mechanisms,signaling pathways,regenerative medicine”,中文检索词为“富血小板血浆,PRP,创面,伤口,创面愈合,难愈性创面,慢性创面,细胞和分子机制,信号通路,再生医学”。根据纳入和排除标准,最终对80篇文献进行综述。结果与结论:①富血小板血浆在创面愈合中具有许多潜在的优势,它能够提供丰富的生长因子和细胞因子等生物活性物质;②富血小板血浆可以调节参与创面愈合的各种细胞类型的功能,包括表皮细胞、血管内皮细胞、成纤维细胞、干细胞和炎症细胞等;③在富血小板血浆疗法中,细胞外囊泡、线粒体对于创面愈合可能扮演着重要角色;④负载富血小板血浆水凝胶可广泛用于增强组织再生和作为药物传递的功能性载体;⑤富血小板血浆对创面细胞外基质合成和降解起调节作用,从而影响伤口愈合过程中基质重建;⑥富血小板血浆可能通过动态调节多种信号通路和上皮间质转化来影响组织修复与再生,从而为创面愈合的研究提供了全新的视角。

关键词：富血小板血浆生长因子创面愈合细胞和分子机制信号通路再生医学

A New Method for Searching Cubes and Its Application to 815-Round Trivium

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Journal of Systems Science & Complexity 2023年第5期36卷 2234-2254页

作者： LIU Chen tian tian QI Wenfeng PLA Strategic Support Force Information Engineering University Zhengzhou 450001China

The cube attack proposed by Dinur and Shamir is one of the most important key-recovery attacks against *** division property based cube attacks have been extensively studied and significantly *** particular,the MILP modeling technique for the three-subset division property without unknown subset proposed by Hao,et *** EUROCRYPT 2020 and the new technique with nested monomial predictions proposed by Hu,et *** ASIACRYPT 2021 are best techniques to recover exact superpolies in division property based cube ***,at this state of the art,whether a superpoly can be recovered in division property based cube attacks is mainly decided by the scale of the superpoly,that is,the number of *** the choice for proper cubes corresponding to low-complexity superpolies is more critical *** effective cube construction methods were proposed for experimental cube attacks,but not applicable to division property based cube *** this paper,the authors propose a heuristic cube criterion and a cube sieve algorithm,which can be combined with the three-subset division property to recover a number of *** to815-round Trivium,the authors recovered 417 superpolies from 441 cubes obtained by our algorithm of sizes between 41 and *** success rate is 94.56%.There are 165 non-constant superpolies with degree less than *** order to demonstrate the significance of the new algorithm,the authors tested the best superpoly recovery technique at EUROCRYPT 2020 using random cubes of similar sizes on 815-round *** experimental result shows that no cube could be completely recovered within a given period of time because the superpolies for random cubes are too complex.

关键词： Cube attacks division property key-recovery attacks trivium

Differential Fault Attack on the Stream Cipher LIZARD

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Chinese Journal of Electronics 2021年第3期30卷 534-541页

作者： MA Zhen tian tian QI Wenfeng National Digital Switching System Engineering Technological Research Center

In this paper, we try to give a security evaluation of LIZARD stream cipher in regard to fault attacks, which, to the best of our knowledge, is the first fault analysis on LIZARD. We design a differential engine of LIZARD to track the differential trail of the keystreams. It is shown that the distributions of the keystream differences are heavily biased. Utilizing this characteristic, we propose an improved method to identify the fault location for LIZARD whose success probability approaches 1. Then we use the fault-free keystream and faulty keystreams to generate system of equations in internal state variables and solve it by SAT solver. The result shows that with 100 keystream bits, only 6 different faults are needed to recover the internal state. Finally,the comparison between LIZARD and Grain v1 shows that LIZARD is more resistable than Grain v1 in regard to fault attacks.

关键词： cryptography fault tolerant computing probability keystream differences faulty keystreams differential fault attack LIZARD stream cipher fault attacks fault analysis differential trail fault-free keystream fault location differential engine stream cipher LIZARD

Interactive Effect and Spatial Characteristics of Agricultural Development Level and Transport Superiority Degree in Main Grain-producing Areas of the Central Jilin Province,China

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Chinese Geographical Science 2022年第4期32卷 643-664页

作者： tian tian MA Yanji Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130102China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

To investigate the spatial synergy between agricultural development level and transport superiority degree in grain-producing areas of the central Jilin Province and the driving mechanism between them,22 counties in the central Jilin Province were used as the research units to calculate agricultural development level and transport superiority degree using the entropy weighting method,weighted travel time and raster cost *** spatial econometric model was used to analyze the mechanism of the mutual influence between the *** main conclusions are as follows.1)Agricultural development level around Changchun,the provincial capital city,and in the areas of Changchun-Jilin and Changchun-Gongzhuling is high,whereas the development level of the counties in the southwest is low.2)Transport superiority degree of each county has improved,the overall connectivity of the road networks has been optimized,and the level of transportation accessibility has shown the development trend of‘centralization’,exhibiting the characteristics of proximity diffusion.3)Locally,there is spatial heterogeneity in the mutual driving effects of the two,with six main patterns.4)The theoretical conditions of von Thunen’s agricultural location have changed under the conditions of market economy due to the improvement of the transport networks,the new model of agricultural development,and the changes of the market system.

关键词： main grain-producing areas agricultural development level transport superiority degree coordination spatial and temporal differentiation

Spectrally distinct near-infrared probes for multiplexed biomedical imaging

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Science China Chemistry 2021年第12期64卷 2057-2059页

作者： He tian Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center School of Chemistry and Molecular EngineeringEast China University of Science&TechnologyShanghai200237China

Our bodies contain a huge amount of anatomical,physiological,cellular or molecular *** understanding of how these pieces of information are organized has a significant impact on the progress of biology and *** present... 详细信息

关键词： probes organized pieces