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Perception of the COVID-19 Epidemic and Acceptance of Vaccination Among Healthcare Workers Prior to Vaccine Licensure——Beijing Municipality,China,May-July 2020

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China CDC weekly 2021年第27期3卷 569-575页

作者： Luodan Suo Rui Ma Zhongzhan Wang tian tang Haihong Wang Fang Liu Jinfeng tang Xinghui Peng Xue Guo Li Lu Xinghuo Pang Beijing Center for Disease Prevention and Control Beijing Research Center for Preventive MedicineBeijingChina Fengtai District Center for Disease Preventionand and Control BeijingChina Changping District Center for Disease Prevention and Control BeijingChina Chaoyang District Center for Disease Prevention and Control BeijingChina Daxing District Center for Disease Prevention and Control BeijingChina Miyun District Center for Disease Prevention and Control BeijingChina Huairou District Center for Disease Prevention and Control BeijingChina

Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)vaccine development has been progressing,but acceptance of the new vaccines by healthcare workers(HCWs)was not well known prior to a... 详细信息

关键词： vaccine Vaccine vaccines

牛支原体感染牛巨噬细胞对线粒体途径介导凋亡的影响

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中国畜牧兽医 2024年第8期51卷 3625-3634页

作者：唐恬王振余梦环徐坤何瑞丽秦田哲陈创夫马忠臣王勇石河子大学动物科技学院石河子832003 动物健康养殖国际联合研究中心石河子832003 动物疾病防控兵团重点实验室石河子832003

[目的]探究牛支原体石河子分离株感染牛巨噬细胞(BoMac)能否通过线粒体凋亡途径影响细胞增殖活力和凋亡。[方法]通过培养基培养及测定颜色变化单位(CCU)绘制牛支原体菌株生长曲线,确定其最高活力的培养时间;使用处于活力最高时的牛支原... 详细信息

[目的]探究牛支原体石河子分离株感染牛巨噬细胞(BoMac)能否通过线粒体凋亡途径影响细胞增殖活力和凋亡。[方法]通过培养基培养及测定颜色变化单位(CCU)绘制牛支原体菌株生长曲线,确定其最高活力的培养时间;使用处于活力最高时的牛支原体以不同感染复数(MOI)和不同感染时间感染牛巨噬细胞,分别利用实时荧光定量PCR和Western blotting试验检测线粒体凋亡通路核心分子Bax和Bcl-2的表达情况,通过CCK8试验检测细胞增殖活力水平,流式细胞术检测细胞凋亡率。[结果]生长曲线分析结果显示,牛支原体石河子分离株12~54 h处在对数生长期,54~84 h处在平台期(滴度为109 CCU/mL),因此,选用培养54 h的牛支原体石河子分离株感染细胞。实时荧光定量PCR与Western blotting检测结果一致,即随感染时间和MOI的增加,促凋亡蛋白Bax基因及其蛋白表达量呈现上升趋势,抑凋亡蛋白Bcl-2基因及其蛋白表达量呈现下降趋势,其中牛支原体石河子分离株感染24 h时,Bax基因表达量极显著增加(P<0.01),Bcl-2基因表达量显著降低(P<0.05),Bcl-2/Bax显著下降(P<0.05);当MOI为1000时Bax蛋白表达量极显著增加(P<0.01),Bcl-2蛋白表达量显著降低(P<0.05),Bcl-2/Bax极显著下降(P<0.01)。CCK8试验结果显示,随着感染时间和MOI的增加,牛巨噬细胞活力极显著降低(P<0.01),增殖抑制率为35%~45%。流式细胞术检测结果显示,感染后,牛巨噬细胞凋亡率为25%~45%。[结论]随着感染时间和MOI的增加,牛支原体石河子分离株可通过线粒体凋亡途径标志因子Bax和Bcl-2的表达诱导牛巨噬细胞凋亡,为进一步解析牛支原体的致病机制提供理论基础。

关键词：牛支原体牛巨噬细胞线粒体凋亡途径细胞增殖

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Bioinspired sensing-memory-computing integrated vision systems: biomimetic mechanisms, design principles, and applications

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Science China(Information Sciences) 2024年第5期67卷 5-27页

作者： Yujie HUANG Yinlong TAN Yan KANG Yabo CHEN Yuhua tang tian JIANG Institute for Quantum Information and State Key Laboratory of High Performance Computing College of Computer National University of Defense Technology College of Advanced Interdisciplinary Studies National University of Defense Technology Institute for Quantum Science and Technology College of ScienceNational University of Defense Technology

With the explosion of sensory data in the Internet of Things(Io T) era, conventional machine vision systems are becoming increasingly difficult to meet the requirements of high efficiency, low energy consumption, and low latency due to their inherent shortcomings of separate sensing, memory, and computing units. Inspired by the retina and neuromorphic computing, the sensing-memory-computing integrated vision system(SMCVS) that features low power consumption, low latency, and high parallelism has been considered a promising technology to surpass the von Neumann architecture and realize strong artificial ***, novel materials like two-dimensional semiconductors and quantum dots with novel optoelectronic performance provide hardware carriers for implementing integrated sensing-memory-computing architectures,attracting considerable attention. This paper reviews the recent research progress in bioinspired vision systems in terms of biomimetic mechanisms, design principles, computational architectures, and ***, the biomimetic mechanisms are illustrated to guide the design of high-performance artificial visual perception systems. Then the research progress of optoelectronic-synapse-based bioinspired vision systems in the device principles and applications including image filtering, color recognition, visual adaptation, and motion detection are summarized. Finally, the challenges and future developing directions of the SMCVS are provided regarding bionic application, architecture design, and device fabrication.

关键词： sensing-memory-computing architecture neuromorphic computing retinomorphic device image recognition visual system

Maternal inappropriate calcium intake aggravates dietary-induced obesity in male offspring by affecting the differentiation potential of mesenchymal stem cells

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World Journal of Stem Cells 2022年第10期14卷 756-776页

作者： Ping Li Yang Wang Pei Li Yuan-Lin Liu Wei-Jiang Liu Xiao-Yu Chen tian-tian tang Ke-Min Qi Yi Zhang Laboratory of Nutrition and Development Key Laboratory of Major Diseases in Children's Ministry of EducationBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Experimental Hematology and Biochemistry Beijing Institute of Radiation MedicineBeijing 100085China Department of Pediatrics General Hospital of Tianjin Medical UniversityTianjin Medical UniversityTianjin 300070China

BACKGROUND The effects of inappropriate dietary calcium intake in early life on later obesity have not been fully *** To raise the mechanism of maternal calcium intake on the multi-differentiation potential of mesenchymal stem cells among their male *** Four-week-old female C57BL/6N mice were fed by deficient,low,normal and excessive calcium reproductive diets throughout pregnancy and *** MSCs(BMSCs)were obtained from 7-day-old male offspring to measure the adipogenic differentiation potential by the Wnt/β-catenin signaling *** other weaning male pups were fed a high-fat diet for 16 wk,along with normalfat diet as the *** the serum was collected for the measurement of biochemical ***,the adipose tissues were excised to analyze the adipocyte sizes and inflammatory *** the target gene expressions on the adipogenic differentiation and Wnt/β-catenin signaling pathway in the adipose tissues and BMSCs were determined by real-time reverse transcription polymerase chain *** Compared with the control group,maternal deficient,low and excessive calcium intake during pregnancy and lactation aggravated dietary-induced obesity,with larger adipocytes,more serious inflammatory infiltration and higher serum metabolism indicators by interfering with higher expressions of adipogenic differentiation(PPARγ,C/EBPα,Fabp4,LPL,Adiponectin,Resistin and/or Leptin)among their male offspring(P<0.05).And there were significantly different expression of similar specific genes in the BMSCs to successfully polarize adipogenic differentiation and suppress osteogenic differentiation in vivo and in vitro,respectively(P<0.05).Meanwhile,it was accompanied by more significant disorders on the expressions of Wnt/β-catenin signaling pathway both in BMSCs and adulthood adipose tissues among the offspring from maternal inappropriate dietary calcium intake *** Early-life abnormal dietary calcium intak

关键词： Calcium Obesity Bone mesenchymal stem cells Wnt/β-catenin signaling pathway Adipogenic differentiation Male offspring

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模拟电子技术课程知识结构的复杂网络分析

电子技术（上海） 2024年第1期53卷 36-38页

作者：唐甜陈奕朋李旭琼王土央李晓冬桂林电子科技大学信息与通信学院广西541004 桂林电子科技大学电子电路国家级实验教学示范中心广西541004 桂林电子科技大学认知无线电与信息处理教育部重点实验室广西541004

阐述Gephi可视化复杂网络技术特点,它用于梳理知识点结构、生成知识点复杂网络体系。探讨网络结构和网络特征值,从而利用复杂网络知识构建模拟电子技术课程的知识结构。

关键词：模拟电子技术 Gephi可视化系统知识结构

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Fourth-Order Interference on Polarization Beats with Phase-Conjugation Geometry

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Chinese Physics Letters 2000年第3期17卷 206-208页

作者： ZHANG Yau-Peng SUN Li-Qun tang tian-Tong ZHANG Lu FU Pan-Ming Department of Electronic Science and Technology Xi'an Jiaotong UniversityXi'an 710049 Institute of Physics Chinese Academy of SciencesBeijing 100080

The effect of fourth-order coherence on ultrafast modulation spectroscopy(UMS)with phase-conjugation geome-try(PCUMS)in a cascade three-level system is investigated using chaotic and phase-diffusion *** has been found that the modulation terms of the beat signal depend *** second-order coherence function,and different stochastic models of the laser field affect only the fourth-order coherence *** difference between the PCUMS and UMS is discussed from a physical viewpoint.

关键词： function. MS Polarization

Temperature Dependence of Optically Erased Two-Wave Mixing in Ce:KNSBN

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Chinese Physics Letters 1998年第5期15卷 345-347页

作者： LIU Jin-song LU Ke-qing LIANG Chang-hong ZHANG Du-ying tang tian-tong Department of Applied Physics Xidian UniversityXi’an 710071 Institute of Electronic and Information Engineering Jiaotong UniversityXi’an 710049

The intensity response of an optically erased photorefractive two-wave mixing to the erase beam is studied by using the coupling wave equation and the band-transport *** concepts of response strength and the minimum response intensity are introduced and their temperature dependence is investigated.A 2-fold increase in the response strength and 4-fold decrease in minimum response intensity have been experimentally observed in Ce:KNSBN at 633 nm when the crystal temperature is raised from 320 to *** experimental results are in agreement with theoretical analysis and show that the response property can be improved by changing the crystal temperature.

关键词： temperature crystal wave

Research on Financing Game Model of Small and Medium-sized Enterprises based on Different Risk Categories

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International Journal of Technology Management 2016年第9期 61-63页

作者： tian tang Economics and Management School Wuhan UniversityWuhan Hubei 430072 China

With the development of market economy and the deepening of economic system reform, some of the Small and medium-sized（SME） enterprises have become the most dynamic economic growth point in the national economy. Nevertheless, SMEs are facing a lot of problems in the market competition, such as technical backwardness, information lag, lack of talents, etc.. The healthy development of SMEs is very important, whereas, SMEs’ financing is a worldwide problem, and the result of financing game between banks and enterprises depends on a variety of decision-making factors. In this paper, from the point of view of bank, we analyze the diffi culties of external financing of SMEs, and establish a financing game model based on different risk categories, in order to better solve the problems that remain in the process of financing and promote the healthy and sustainable development of SMEs.

关键词： Financing Game Model Small and Medium-sized Enterprises Risk Categories Risk Management

情景式教学联合BOPPPS教学法在急诊科医患沟通教学中的应用研究

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中国中医急症 2024年第7期33卷 1286-1289,1312页

作者：闫美花陈新日覃玉珍班志红包一涵马艳唐甜罗显民唐日新唐华民广西中医药大学附属国际壮医医院广西南宁530201 广西中医药大学第一附属医院广西南宁530023

目的探讨情景式教学联合BOPPPS教学法在急诊科医患沟通教学的应用效果。方法采取便利抽样法,选取2021年5月至2023年5月在广西中医药大学附属国际壮医医院急诊科实习的70名中医学本科实习生为研究对象,按照实习时间的先后顺序分为对照组... 详细信息

目的探讨情景式教学联合BOPPPS教学法在急诊科医患沟通教学的应用效果。方法采取便利抽样法,选取2021年5月至2023年5月在广西中医药大学附属国际壮医医院急诊科实习的70名中医学本科实习生为研究对象,按照实习时间的先后顺序分为对照组和观察组,对照组采用传统的教学方法,观察组采用情景式教学联合BOPPPS的教学方法。比较两组实习生的医患沟通技能、临床模拟学习沉浸感及实习生对带教老师的教学满意度。结果观察组实习生医患沟通技能及临床模拟学习沉浸感均优于对照组,差异均有统计学意义(P<0.05);观察组实习生对带教老师的教学满意度优于对照组,差异均有统计学意义(P<0.05)。结论情景式教学联合BOPPPS教学方法应用于急诊科中医学本科实习生医患沟通教学活动中,能够提高实习生医患沟通技能和临床模拟学习沉浸感,同时能提高实习生对带教老师的教学满意度。

关键词：医患沟通技能情景式教学 BOPPPS教学中医学本科实习生临床模拟学习沉浸感

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