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Osteomodulin downregulation is associated with osteoarthritis development

Bone Research 2023年第4期11卷 721-736页

作者： Jérémie Zappia Qiao Tong Renée Van der Cruyssen Frederique MFCornelis Cécile Lambert tiago pinto coelho Juliane Grisart Erika Kague Rik JLories Marc Muller Dirk Elewaut Chrissy LHammond Christelle Sanchez Yves Henrotin MusculoSKeletal Innovative Research Lab Center for Interdisciplinary Research on MedicinesUniversitéde LiègeLiègeBelgium School of Physiology Pharmacologyand NeuroscienceUniversity of BristolBristolUK Department of Biomedical Molecular Biology Ghent UniversityGhentBelgium Laboratory for Molecular Immunology and Inflammation Department of RheumatologyGhent University HospitalGhentBelgium Laboratory of Tissue Homeostasis and Disease Skeletal Biology and Engineering Research CenterDepartment of Development and RegenerationKU LeuvenLeuvenBelgium Cardiovascular Sciences Groupe Interdisciplinaire de Génoprotéomique AppliquéeUniversitéde LiègeLiègeBelgium Division of Nephrology CHU of LiègeUniversitéde LiègeLiègeBelgium Artialis SA Tour GIGACHU Sart-TilmanLiègeBelgium Division of Rheumatology University Hospitals LeuvenLeuvenBelgium Laboratoire d’Organogenèse et Régénération Groupe Interdisciplinaire de Génoprotéomique AppliquéeUniversitéde LiègeLiègeBelgium Physical Therapy and Rehabilitation Department Princess Paola HospitalVivaliaMarche-en-FamenneBelgium

Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis(OA), and osteomodulin(OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the sclerotic phenotype. However, the functions of OMD remain poorly understood, specifically in vivo. We used Omd knockout and overexpressing male mice and mutant zebrafish to study its roles in bone and cartilage metabolism and in the development of OA. The expression of Omd is deeply correlated with bone and cartilage microarchitectures affecting the bone volume and the onset of subchondral bone sclerosis and spontaneous cartilage lesions. Mechanistically, OMD binds to RANKL and inhibits osteoclastogenesis, thus controlling the balance of bone remodeling. In conclusion, OMD is a key factor in subchondral bone sclerosis associated with OA. It participates in bone and cartilage homeostasis by acting on the regulation of osteoclastogenesis. Targeting OMD may be a promising new and personalized approach for OA.

关键词： metabolism conclusion homeostasis

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Physico-chemical characterization of acid base disorders in patients with COVID-19:A cohort study

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World Journal of Nephrology 2024年第2期13卷 16-23页

作者： Sergio pinto de Souza Juliana R Caldas Marcelo Barreto Lopes Marcelo Augusto Duarte Silveira Fernanda Oliveira coelho Igor Oliveira Queiroz Pedro Domingues Cury Rogério da Hora Passos Department of Nephrology Hospital São RafaelSalvadorBA 41253190Brazil Department of Nephrology D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil Faculty of Medicine Escola Bahiana de Medicina e Saúde Pública-EBMSPSalvadorBA 40290000Brazil Department of Intensive Care D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil Hospital São Rafael D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil Department of Intensive Care Unit Hospital Israelita Albert EinsteinSao PauloSP 05652900Brazil

BACKGROUND Acid-base imbalance has been poorly described in patients with coronavirus disease 2019(COVID-19).Study by the quantitative acid-base approach may be able to account for minor changes in ion distribution that may have been over-looked using traditional acid-base analysis *** a cohort of critically ill COVID-19 patients,we looked for an association between metabolic acidosis surrogates and worse clinical outcomes,such as mortality,renal dialysis,and length of hospital *** To describe the acid-base disorders of critically ill COVID-19 patients using Stewart’s approach,associating its variables with poor *** This study pertained to a retrospective cohort comprised of adult patients who experienced an intensive care unit stay exceeding 4 days and who were diagnosed with severe acute respiratory syndrome coronavirus 2 infection through a positive polymerase chain reaction analysis of a nasal swab and typical pulmonary involvement observed in chest computed tomography *** and clinical data were obtained from electronic *** variables were compared using Fisher’s exact *** data were presented as median and interquartile *** Mann-Whitney U test was used for *** In total,211 patients were *** mortality rate was 13.7%.Overall,149 patients(70.6%)presented with alkalosis,28 patients(13.3%)had acidosis,and the remaining 34 patients(16.2%)had a normal arterial pondus *** those presenting with acidosis,most had a low apparent strong ion difference(SID)(20 patients,9.5%).Within the group with alkalosis,128 patients(61.0%)had respiratory *** non-survivors were older,had more comorbidities,and had higher Charlson’s and simplified acute physiology score *** did not find severe acid-base imbalance in this *** analyzed Stewart’s variables(effective SID,apparent SID,and strong ion gap and the effect of albumin,lactate,phosphorus,and chloride)were not d

关键词： COVID-19 Physicochemical approach Acid-base status Critically ill patients Acute respiratory syndrome

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Sifu-a cybersecurity awareness platform with challenge assessment and intelligent coach

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Cybersecurity 2018年第1期1卷 945-967页

作者： tiago Espinha Gasiba Ulrike Lechner Maria pinto-Albuquerque Siemens AG Corporate Technology Otto-Hahn-Rin 681379 MunichBavariaGermany Universitat der Bundeswehr München MunichGermany Instituto Universitario de Lisboa(ISCTE-IUL) ISTAR-IULLisbonPortugal

Software vulnerabilities,when actively exploited by malicious parties,can lead to catastrophic *** handling of software vulnerabilities is essential in the industrial context,particularly when the software is deployed in critical ***,several industrial standards mandate secure coding guidelines and industrial software developers’training,as software quality is a significant contributor to secure *** Challenges(CSC)form a method that combines serious game techniques with cybersecurity and secure coding guidelines to raise secure coding awareness of software developers in the *** cybersecurity awareness events have been used with success in industrial ***,until now,these coached events took place *** the present work,we briefly introduce cybersecurity challenges and propose a novel platform that allows these events to take place *** introduced cybersecurity awareness platform,which the authors call Sifu,performs automatic assessment of challenges in compliance to secure coding guidelines,and uses an artificial intelligence method to provide players with solution-guiding ***,due to its characteristics,the Sifu platform allows for remote(online)learning,in times of social *** CyberSecurity Challenges events based on the Sifu platform were evaluated during four online real-life CSC *** report on three surveys showing that the Sifu platform’s CSC events are adequate to raise industry software developers awareness on secure coding.

关键词： Cybersecurity Awareness Training Artificial intelligence Serious games Secure coding Static application security testing Capture-the-flag Software development in industry

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A Simulation of Market-based Non-frequency Ancillary Service Procurement Based on Demand Flexibility

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Journal of Modern Power Systems and Clean Energy 2023年第3期11卷 781-792页

作者： Ricardo Faia Fernando Lezama tiago pinto Pedro Faria Zita Vale José Manuel Terras Susete Albuquerque Research Group on Intelligent Engineering and Computing for Advanced Innovation and Development(GECAD) R.Dr.António Bernardino de Almeida4314249-015PortoPortugal E-REDES Distribuição de Eletricidade S.A.R.Camilo Castelo Branco43LisboaPortugal

This paper proposes a novel approach for the provision of non-frequency ancillary service(AS)by consumers connected to low-voltage distribution *** proposed approach considers an asymmetric pool-based local market for AS negotiation,allowing consumers to set a flexibility quantity and desired price to trade.A case study with 98 consumers illustrates the proposed market-based non-frequency AS provision ***,three different strategies of consumers’participation are implemented and tested in a real low-voltage distribution network with radial *** is shown that consumers can make a profit from the sale of their flexibility while contributing to keeping the network power losses,voltage,and current within pre-defined ***,the results demonstrate the value of AS coming directly from end-users.

关键词： Demand flexibility local electricity market ancillary service low-volatge distribution network

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Intimate partner violence against women. Does violence decrease after the entry of the alleged offender into the criminal justice system?

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Forensic Sciences Research 2022年第1期7卷 53-60页

作者： Paulo Vieira-pinto JoséIgnacio Muñoz-Barús tiago Taveira-Gomes Maria João Vidal-Alves Teresa Magalhães Department of Forensic Sciences PathologyGynaecology and ObstetricsPaediatricsInstitute of Forensic SciencesUniversity of Santiago de CompostelaSantiago de CompostelaSpain IINFAC TS-Institute of Research and Advanced Training in Health Sciences Department of SciencesCESPUUniversity Institute of Health Sciences(IUCS)GandraPortugal cFaculty of Medicine University of PortoPortoPortugal CINTESIS-Centre of Health Technology and Service Research University of PortoPortoPortugal Fernando Pessoa University PortoPortugal

Intimate partner violence(IPV)is simultaneously assumed as a serious crime and a major public health issue,having recurrences as one of its main characteristics and,consequently,re-entries of some alleged offenders in the criminal justice system(CJS).The main goal of this study is to assess if in cases of female victims of IPV,violence decreases after the first entry of the alleged offender in the CJS.A retrospective study was performed based on the analysis of police reports of alleged cases of IPV during a 4-year *** final sample(n=1488)was divided into two groups according to the number of entries in the CJS(single or multiple)followed by a comparative *** suggest that violence decreases after the first entry of alleged offenders in the ***-entries were found in only 15.5%of the cases but they were accountable for 3.3 times more crimes on ***,victims of recidivism presented more injuries and required more medical ***,a small group of alleged offenders seems to be more violent and accountable for most of the IPV crimes registered in the CJS suggesting that regardless of legal sanctions aiming to deter violence,these measures may not be enough for a certain group of *** study sustains the need for a predictive model to quantify the risk of repeated IPV cases within the Portuguese population.

关键词： Forensic sciences intimate partner violence women re-entry recidivism criminal justice system

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Sediment geochemistry of the urban Lake Paulo Gorski

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International Journal of Sediment Research 2018年第4期33卷 406-414页

作者： Marcelo Bevilacqua Remor Silvio César Sampaio Sacha de Rijk Marcio Antnio Vilas Boas Jackeline Tatiane Gotardo Everton tiago pinto Fábio Augusto Schardong Program in Agricultural Engineering State University of Western ParanaRua Universitária 2069 Jardim Universitário Department of Freshwater Ecology and Water Quality 3. Science and Technology Center State University of Western ParanáRua Universitária 2069 Jardim Universitário

The objective of this study was to evaluate the concentration and distribution of heavy metals in the sediments of Paulo Gorski Lake, as well as the metals’ bioavailability and potential ecological risk, and to define the anthropogenic and natural heavy metal contributions to the lake. The chemical elements calcium(Ca), cadmium(Cd), cobalt(Co), chromium(Cr), copper(Cu), iron(Fe), potassium(K), magnesium(Mg), manganese(Mn), sodium(Na), nickel(Ni), lead(Pb), and zinc(Zn) were quantified by flame atomic absorption spectrophotometry with two extraction methods to quantify the bioavailable and nonbioavailable fractions. The data were evaluated using multivariate statistics and sediment quality *** sediment collection points(S1, S2, S3, S4 and S5) are different in terms of the concentration of heavy metals, except for S4 and S5, which were statistically equal. The bioavailable fraction of the elements in the sediment follows the sequence Pb > Cu > Mn > Zn > Ni > Cr > phosphorus(P) for all points. The elements Co, Cr, Pb, and Zn showed moderate to considerable contamination at all points. Only points S3 and S5 had moderate ecological risk. Urbanization has been affecting Paulo Gorski Lake via the input of chemical elements, especially Co and Pb. The points most affected by heavy metal contamination are S3 and S5 when the sedimentological sensitivity factor is considered. The lake has high hydrodynamics,causing some of the contaminants that enter the system to leave it, leading to potential negative impacts downstream.

关键词： Bioavailability Heavy metals Paulo Gorski Lake Sediment Trace elements

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Synthesis and structure of a praseodymium (Ⅲ) complex with carboxylate ligand：A thermal and spectroscopic study

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Journal of Rare Earths 2018年第10期36卷 1090-1097页

作者： Kátia Veronica Tenório José Augusto Teixeira Leandro Moreira de Campos pinto Flávio Júnior Caires Oswaldo Treu-Filho Fáhio Alencar dos Santos tiago André Denck Colman Alexandre Cuin Cláudio Teodoro de Carvalho Federal University of Grande Dourados CP 364 79804-970 Dourados MS Brazil Institute of Chemistry State University of Sao Paulo 14.801-970 Araraquara SP Brazil Chemistry Institute Federal University of Mato Grosso do Sul 79074-460 Campo Grande MS Brazil Chemistry Department State University of Sao Paulo 17033-360 Bauru SR Brazil Federal University of Juiz de Fore 36036-330 Juiz de Fora MG Brazil

One Pr（Ⅲ） lanthanide ion complex was initially synthesized and characterized by TGA-DSC in air atmosphere, as well as characterized by CHN elemental analysis, defining the stoichiometric ratio as Pr（DMBz）3. The gaseous products evolved during the thermal decomposition were also monitored in N2 atmosphere employing TGA/FT-IR system. A crystal structure is obtained by state-of-the-art powder X-rays diffraction methods measured in conventional laboratory equipment and refined by the Rietveld method, which defined it as a monoclinic system of the space group P21/C with a polymeric crystal structure, [Pr（DMBZ）3]n. FT-IR theoretical spectrum and time-dependent density functional theory（TD-DFT） were calculated from TGA-DSC and crystalline system data. The experimental and theoretical FT-IR spectra present a high correlation degree when the main stretching bands are compared, while the energy transfer（HOMO - LUMO） in their neighborhoods suggests the main contributions of the light-emitting states.

关键词： Complex Thermal analysis Powder diffraction state-of-art Polymeric structure Theoretical calculation Rare earths

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Initial medication adherence in newly diagnosed glaucoma patients:three adherence measures

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 630-637页

作者： Joana Menino Pedro Camacho Andrécoelho Escola Superior de Tecnologia da Saúde Instituto Politécnico de LisboaLisbon 1990-096Portugal H&TRC-Health&Technology Research Center ESTeSLEscola Superior de Tecnologia da SaúdeInstituto Politécnico de LisboaLisbon 1990-096Portugal iNOVA4Health NOVA Medical SchoolFaculdade de Ciências MédicasNMSFCMUniversidade NOVA de LisboaLisbon 1150-82Portugal Instituto de Oftalmologia Dr.Gama pinto Lisbon 1150-255Portugal

AIM:To determine initial medication adherence in newly diagnosed glaucoma patients treated with anti-glaucoma ***:This retrospective and observational study included all patients diagnosed with glaucoma in the Primary Health Care units in Portugal during the years 2012 and 2013,which in consequence received a first prescription for anti-glaucoma *** was collected from electronic prescribing records of the primary care units and from pharmacy claims *** of glaucoma treatment and early discontinuation were measured,and the combination of(non)-initiation and early discontinuation accounted for initial medication(non)-***:A total of 3548 new glaucoma patients(40.1%male;59.9%female)were *** 1133(31.9%)patients were initially classified as non-users,since there was no pharmacy claim found for their first prescription for glaucoma ***,277(11.5%)patients early discontinued their treatment,acquiring only their first ***,the initial medication non-adherence rate was 39.7%since 1410 patients either didn’t initiate treatment or discontinued it ***:This study,reveals a major opportunity to improve glaucoma treatment and its control,since a large proportion of patients fail to engage with their prescribed therapy,which implies that implementation of individual or group strategies that enable patients with glaucoma to correctly perform their treatment is still needed.

关键词： glaucoma glaucoma treatment initiation early discontinuation initial medication adherence

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Technical Evaluation of Hybrid Clones of Corymbia spp. to Produce Market Pulp

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Paper And Biomaterials 2022年第3期7卷 1-6页

作者： Marcelo Moreira da Costa Ricardo de Carvalho Bittencourt Thales Augusto pinto coelho Nogueira Larissa Soares Silva Weslley Henrique Martins da Silva Sebastião Renato Valverde Gleison Augusto Dos Santos Daniel Alexander Fernandes coelho Claudilene Aparecida Alves Pena Department of Forest Sciences Federal University of VicosaVicosaMinas Gerais36570900Brazil Aperam BioEnergia Co. CapelinhaMinas Gerais39680000Brazil

This study presents hybrid clones of Corymbia *** by Aperam BioEnergia as potential substitutes for Eucalyptus wood in the pulp *** biomass of Eucalyptus *** compared with that of Corymbia *** performing modified kraft pulping and basic density *** were made by analyzing their respective mean annual increments of cellulose(MAI_(cel))and specific wood consumption(SWC),estimated using a kappa number of(19±1).The results showed that one of the hybrid clones(Corymbia citriodora×Corymbia torelliana,ID 4)had higher basic wood density,higher screened yield,better MAI_(cel#k19),and lower SWC than the other samples,reaching values of 0.608 t/m^(3),54.1%,24.6 ADt/ha/year(i.e.,air dry ton/hectare/year),and 2.74 m^(3)/ADt,***,clone ID 4 had the highest MAI_(cel)/SWC ratio score(8.98).Given its high forest productivity and low industrial cost compared with other samples,as well as its advantages over Eucalyptus ***,we concluded that clone ID 4 has great potential as an alternative biomass for pulp production.

关键词： Corymbia hybrids modified kraft pulping mean annual increments of cellulose(MAIcel) specific wood consumption(SWC)

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Automatic Stamping Charger---Stamping of Blended Coal-Theorical Study and Practice Analysis at TKCSA

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Journal of Mechanics Engineering and Automation 2015年第10期5卷 573-579页

作者： Yan Samuel Ferreira Junqueira Leonardo de Souza pinto Robson coelho Jose Maria Clemente Technical Unit Iron Making ThyssenKrupp CSA Rio de Janeiro 23560-352 Brazil Coke Plant Maintenance Department ThyssenKrupp CSA Rio de Janeiro 23560-352 Brazil Independent Consult Vitoria Brazil

The coke plant of a steel plant corresponds to the area that transforms a blend of coal into coke for using in blast furnace and steam to power plant. The coking plant of ThyssenKrupp CSA uses the heat recovery technology with stamping charger for stamping and preparation a blend of coals for charging and coking. Stamping technology adds several benefits to the process, such as increased density, homogeneity and alignment of the coal cake charged into the oven, as well as provides better control of the coking process, improves parameters of coke quality and allows coal blending with lower coking power, thereby reducing the production cost of coke and power generation. Through the automation of stamping charger, it is possible to evaluate and calculate the stamped coal density charged and the productivity gains this system provides.

关键词： Stamping charger density automatic coke plant

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