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Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5404-5416页

作者： Catarina Macedo-Silva Vera Miranda-Gonçalves Nuno tiago Tavares Daniela Barros-Silva Joana Lencart João Lobo Ângelo Oliveira Margareta PCorreia Lucia Altucci Carmen Jerónimo Cancer Biology&Epigenetics Group Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal Department of Precision Medicine University of Campania“Luigi Vanvitelli”80138NaplesItaly Department of Pathology and Molecular Immunology ICBAS-School of Medicine&Biomedical SciencesUniversity of PortoR.Jorge de Viterbo Ferreira 2284050-313PortoPortugal Medical Physics Radiobiology and Radiation Protection Group-Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal Department of Medical Physics Portuguese Oncology Institute of Porto4200-072PortoPortugal Department of Pathology Portuguese Oncology Institute of PortoPortoPortugal Department of Radiation Oncology Portuguese Oncology Institute of PortoPortoPortugal BIOGEM Molecular Biology and Genetics Research Institute83100AvellinoItaly IEOS Institute of Endocrinology and Oncology80100NaplesItaly

External beam radiotherapy(RT)is a leading first-line therapy for prostate cancer(PCa),and,in recent years,significant advances have been ***,RT resistance can arise and result in long-term recurrence or disease progression in the worst-case ***,making crucial the discovery of new targets for PCa ***,we generated a radioresistant PCa cell line,and found p53 to be highly expressed in radioresistant PCa cells,as well as in PCa patients with recurrent/disease progression submitted to *** dissection revealed that RT could promote p53 expression via epigenetic ***,a decrease of H3K27me3 occupancy at TP53 gene promoter,due to increased KDM6B activity,was observed in radioresistant PCa ***,p53 is essential for efficient DNA damage signaling response and cell recovery upon stress induction by prolonged fractionated ***,KDM6B inhibition by GSK-J4 significantly decreased p53 expression,consequently attenuating the radioresistant phenotype of PCa cells and hampering in vivo 3D tumor ***,this work contributes to improve the understanding of p53 as a mediator of signaling transduction in DNA damage repair,as well as the impact of epigenetic targeting for PCa radiosensitization.

关键词： TP53 damage cancer

Correlation between Rainfall and Mass Movements in North Coast Region of Sao Paulo State, Brazil for 2014-2018

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International Journal of Geosciences 2018年第12期9卷 669-679页

作者： Daniel Metodiev Marcio Roberto Magalhaes de Andrade Rodolfo Moreda Mendes Marcio Augusto Ernesto de Moraes Tehrrie Konig Cassiano Antonio Bortolozo tiago Bernardes Rafael Alexandre ferreira Luiz Juliano Oliveira Martins Coelho National Center for Monitoring and Early Warning of Natural Disasters (CEMADEN) Sao Jose dos Campos Sao Paulo Brazil

The monitoring of related hourly and accumulated rainfall index requires that critical thresholds of accumulated 72 hours rainfall are updated frequently according with the factors and local conditions (natural and anthropic) of each specific risk area. The importance of empirical methods is fundamental to confirm the relationship between rainfall intensity and accumulated rainfall with the mass movement events, in order to establish the critical threshold values. The present work performs an evaluation of the record data of mass movement events occurred in Sao Paulo State North coast region for a 4-year period (2014 to 2018) considering different mass movement characteristics (slope type, magnitude and impact level). Some rainfall values were obtained to show that within these parameters an event related to natural and anthropic features was triggered. A database was created, sorting source of information and municipalities monitored, to implement the correlation between the mass movement events and the rainfall values. To elaborate the event’s map, reliable record data of localization of the mass movement events was selected, as well as the nearest possible raingauges of CEMADEN (National Center for Monitoring and Early Warning of Natural Disasters);also the exact event triggering time, selection by the slope type, the magnitude and the impact level of the mass movement event. The rainfall values of these raingauges allowed the calculation of the accumulated rainfall index for 1, 3, 6, 24, 48, 72 and 96 hours, with the adoption of the 72 hours index for this work. The correlation graphics are divided by the slope type, the magnitude and the impact level of the mass movement event. Different critical thresholds appear, classifying such event by the influence level of triggering factors, natural and/or anthropic.

关键词： Mass Movement Events Rainfall Intensity Accumulated Rainfall Critical Thresholds Sao Paulo State-Brazil

Soil Physical Properties and Grain Yield Influenced by Cover Crops and Crop Rotation

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American Journal of Plant Sciences 2018年第4期9卷 584-598页

作者： Cesar tiago Forte Amauri Nelson Beutler Leandro Galon Camile Thais Castoldi Fábio Luís Winter Cinthia Maethe Holz Felipe Bianchessi Germani Concenco Leonardo Chechi Matheus Martins ferreira Andre Andres Giovane Matias Burg Plant Science Department Federal University of Santa MariaBrazil Agronomy Department Federal University of PampaItaquiBrazil Agronomy Department Federal University of Fronteira SulErechimBrazil Agronomy Department Embrapa Temperate AgriculturePelotasBrazil

The crop yield is related to several factors, among these, soil tillage, soil compaction and crop rotation. This study aimed to evaluate the winter cover crops and crop rotation influence on soil physical properties and grain yield of dry beans, maize and soybean for two growing seasons. Three experiments were conducted, corresponding to dry beans, maize and soybean crops. It was used the randomized block design with three treatments and four replications consisted by 3 × 10 m plots. The treatments were: two cover crops systems and crop rotation in no-till, and the control, consisting of winter fallow and conventional tillage. The cover crop dry matter, soil physical properties and grain yield for dry beans, maize and soybean in the two growing seasons were evaluated. Crop rotation systems and cover crops showed a trend to increase maize and soybean yields. Crop rotation in no-till increases soil compaction in the superficial layer compared to conventional tillage, but does not reduce the dry beans, maize and soybean yields.

关键词： No-Till Tillage Dry Matter Intercropped Bulk Density Soil Compaction

Comparison of Experimental Methods to Assess the Competitive Ability of Weed Species

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American Journal of Plant Sciences 2015年第13期6卷 2185-2196页

作者： Leandro Galon Germani Concenco Gismael Francisco Perin Alexandre ferreira da Silva Cesar tiago Forte Felipe de Adelio David Lauri Lourenco Radüz André Luiz Radunz André Andres Siumar Pedro Tironi Samara Emerim Concenco Plant Science Department Federal University of the Southern Border Erechim Brazil Weed Science Embrapa Western Agriculture Dourados Brazil Embrapa Maize and Sorghum Sete Lagoas Brazil Weed Science Embrapa Temperate Agriculture Pelotas Brazil Plant Science Department Federal University of the Southern Border Chapecó Brazil Federal Institute of Santa Catarina at Santa Rosa do Su-SC Santa Rosa do Sul Brazil

Competition between crops and weeds interfere on growth and development with harm to one or both, in different ways. To quantify these differences in competition, additive and replacement series study methods are most often used, each with different characteristics and goals. Therefore, we aimed with this work to study inter-specific competition between plants of soybean and corn against the weeds Bidens pilosa (beggartick) and Digitaria insularis (sourgrass), by two experimental methods of study: additive and replacement series (substitutive) experiments. Initial tests were performed prior to the installation of replacement series experiments to describe the intra-specific competition features for all species. For additive experiments these are unnecessary. To compare the methods of study, there were two sets of trials (an additive and a substitutive) installed under greenhouse, during the growing season 2013/14. Variables analyzed were leaf area and dry weight of shoots of crops and weeds, at 50 days after emergence. The results were analyzed according to the methods used, these being compared. It was found that the additive method supplied results most prone to be applied in the field, while the replacement series (substitutive) method was more appropriate for studies that aimed to provide detailed scientific information regarding the proportions of plants and coefficients describing the behavior of the species community.

关键词： Interference Zea mays Glycine max Weeds

Clinical Follow-Up Nursing Quality in Child Health

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Health 2015年第10期7卷 1235-1242页

作者： Fábia Barbosa de Andrade Tainara Lorena dos Santos ferreira tiago Jose Barbosa de Andrade Jéssica Isabelle dos Santos Dutra Dídia de Oliveira Pereira Brenda Kalyny Silva Brenda Kalyny Silva Ingrid Katianne Marques Araújo Faculty of Health Sciences of Trairi(FACISA) Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil University Center of Joao Pessoa(UNIPe) Joao PessoaBrazil

Objective: The present work aims to evaluate the impact of the activities of nursing consultations on health conditions of children served in Clínica de Enfermagem Salvando Vidas com Educa??o. Methods: This is an exploratory, descriptive study with a quantitative approach, realized from January through December 2012, at the Clínica de Enfermagem (Nursing Clinic), in the Santa Cruz County, rio Grande do Norte’s countryside, Brazil. Results: The obtained results showed a significant correlation between the type of pathology and final treatment proven by the value of p = 0.000;as for assessed 60%, more than half were discharged;the most prevalent diseases were the association between cutaneous and gastric with 11% who were discharged and, lastly, the association between gastric and respiratory with 7% discharged. Conclusion: Thus, the activities developed by the project are not restricted to the examination during the nursing consultation, since educational activities are planned from the data obtained in those consultations.

关键词： Child Nursing School Care

Bronchial Fibroepithelial Polyp: A Rare and Challenging Diagnosis

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Open Journal of Medical Imaging 2017年第4期7卷 163-168页

作者： Francisco Barbosa De Araújo Neto Ana Flávia Pina ferreira Ellen Caroline Toledo Do Nascimento Ricardo Francisco Cintra Zagatti Mark Wanderley Thiana Pozzatto Rogrigues tiago Castello Branco Lyra Vinícius Martins Valois Márcio Valente Yamada Sawamura Department of Radiology The Medical School The University of S&atilde o Paulo S&atilde o Paulo Brazil Department of Pathology The Medical School The University of S&atilde o Paulo S&atilde o Paulo Brazil Department of Radiology Hospital Heliópolis S&atilde o Paulo Brazil

Context: Bronchial fibroepithelial polyp is a very rare benign endobronchial tumor. Typically, it is a slow growing lesion, and the differential diagnosis includes other benign and malignant endobronchial tumors. Case Report: We report a case of a 75-year-old female who complained of intermittent productive cough. Computed tomography of the thorax showed a solid nodule with lobulated contours in the right main bronchus and subtotal atelectasis of the right lower lobe. Bronchoscopy with biopsy confirmed the diagnosis of a bronchial fibroepithelial polyp. Conclusion: This case is illustrative and demonstrates the importance of imaging methods and of histopathological correlation for the accurate diagnosis of this benign treatable lesion.

关键词： Tomography Bronchoscopy Bronchial Diseases Polyps

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最低能耗学校

世界建筑导报 2010年第1期25卷 44-47页

作者： Michael Laar Celio ferreira Filho Diniz Eduardo Franco Azeredo Canellas Eduardo Teixeira Pinto Dezouzart tiago Macedo Costa Gualda

项目地点:巴西里约热内卢项目类型:建筑(教育)开工日期:2006年初一个用于学校建筑的小型能源设计项目,包括自然通风装置、能够防御太阳直接辐射的自然照明装置以及屋顶花园。

关键词：学校建筑

Impact of infection in hospitalized cirrhotic patients in a university hospital

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Concentrations of Silver Nitrate in the In Vitro Development and Conservation of Passiflora gibertii ***

Open Journal of Gastroenterology（肠胃病学期刊） 2012年第3期

作者： tiago dos Santos ferreira tiago Sevá-Pereira Jazon Romilson de Souza Almeida Milena Fioravante Ademar Yamanaka Elza Cotrim Soares

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American Journal of Plant Sciences 2017年第12期8卷 2944-2955页

作者： Gláucia Amorim Faria Lucas Menezes Felizardo Antonio Flávio Arruda ferreira Paula Suares Rocha Aline Namie Suzuki Antonio da Silva Souza Tatiana Góes Junghans Maria Angélica Pereira de Carvalho Costa Ana Patricia Bastos Peixoto Augusto Ramalho de Morais Beatriz Garcia Lopes tiago Almeida de Oliveira Departmentof Mathematics School of EngineeringSao Paulo State University(Unesp)Ilha SolteiraBrazil Department of Civil Engineering School of EngineeringSao Paulo State University(Unesp)Ilha SolteiraBrazil Laboratory of Environmental Mutagenesis Institute of BiosciencesSao Paulo State University(Unesp)Rio ClaroBrazil Embrapa Cassava and Fruticulture Cruz das AlmasBrazil Center for Agrarian Biological and Environmental SciencesFederal University of the Recôncavo of Bahia(UFRB)Cruz das AlmasBrazil Department of Statistics State University of Paraíba(UEPB)Campina GrandeBrazil Department of Exact Sciences Federal University of Lavras(UFLA)LavrasBrazil

The aim of this study was to evaluate the effects of silver nitrate in the in vitro development and conservation of passion fruit plants. Experiments were carried out at the Laboratory of Culture and Tissues, in the National Cassava and Fruits Research Center (EMBRAPA), using microcuttings of Passiflora gibertii N. E. Br., previously cultivated in vitro. The microcuttings were placed in MS media supplemented with silver nitrate at concentrations of 0, 1, 2, 4 and 8 mg·L-1, and, during 30, 60 and 90 days, the following variables were identified: Shooting length (cm), number of roots, number and coloration of leaves. A completely randomized design with 30 replications in a split-plot scheme was employed. Polynomial regression equations were adjusted in analysis of variance to compare averages of treatments. The obtained results support the assumption of high sensitivity of passion fruit tissues to ethylene, which reflects in the lost of vigor and in the induction of culture senescence by its accumulation. Based on obtained results, and in order to mitigate this problem, it is possible to indicate an addition of 2 mg·L-1?of silver nitrate in culture media, for the micropropagation of passion fruit plant, allowing the controlling of the atmosphere inside the culture test tubes, during the establishment of explants and other steps of the process.

关键词： Passion Fruits Tropical Fruits Plant Propagation Reduced Growth Ethylene