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Asian Herpetological Research 2020年第1期11卷 63-70页

作者： Victor Mendes LIPINSKI Andre Passaglia SCHUCH tiago gomes dos santos Post Graduation Program of Animal Biodiversity Federal University of Santa MariaLaboratory of HerpetologyDepartment of BiologyAv.Roraima no 1000 building 17room 1140Camobi97105-900Santa MariaRSBrazil Universidade Federal do Pampa Av.Antonio Trilha1847Centro973000000 Sao GabrielRSBrasil Southern Regional Space Research Center CRS/INPE-MCTIP.O.Box 5021room 104197110-970Santa MariaRSBrazil

For decades the ecologists are using the same methods in order to determine the environmental health of a community,however,the crescent need on defining how these processes act,triggered the development of new methods that could classify the organisms and their function at the *** we used the anuran larvae to understand the effects of an environmental gradient on the structure and organization of the anuran assemblages along it,and to access in a realistic form,the actual state of preservation of the la rgest remnant of Atlantic Rainforest on the Southernmost portion of *** found that despite the higher diversity of species and the conservation unit status of the place,the ecosystem itself is still in danger,given the low number of functional groups and thus a higher number of ecosystem services that can be lost.

关键词： Anuran ecosystem function conservation unities tadpoles

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Cardiovascular risk burden and disability:findings from the International Mobility in Aging Study(IMIAS)

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Journal of Geriatric Cardiology 2024年第3期21卷 331-339页

作者： Juan-David Martinez-Aristizábal Carmen-Lucia Curcio Juliana Fernandes Afshin Vafael Cristiano dos santos gomes Fernando Gomez Internal Medicine Critical Care DepartmentPablo Tobón Uribe HospitalMedellínColombia Research Group in Geriatrics and Gerontology Faculty of Health SciencesUniversidad de CaldasManizalesColombia Laboratory of Physical Therapy and Collective Health Physical Therapy DepartmentFederal University of PernambucoJornalista Aníbal Fernandes Avenue RecifeBrazil Department of Public Health Sciences Queen’s UniversityKingstonONCanada Department of Physiotherapy University of PernambucoBR 203KmBrazil

BACKGROUND The association of cardiovascular risk burden with disability is *** examined the association between trajectories of the Framingham general cardiovascular disease risk score(FGCRS)with the trajectories of limitations of physical function in older *** A total of 1219 participants with no disabilities from the International Mobility in Aging Study(IMIAS)study who had up to three repeated measures of FGCRS between 2012–2016 and without a history of stroke or coronary heart disease at baseline and follow-up were *** at baseline was assessed and categorized into *** function was evaluated with the Short Physical Performance Battery(SPPB).The data were analyzed using linear mixed-effects *** At baseline,FGCRS ranged between 3–94(mean score:24±15.8),participants were 32(2.6%),502(41.2%)and 685(56.2%)in lowest,middle,and highest tertiles,*** the trajectories of limitations of physical function,the lowest FGCRS had no differences,while the middle and highest had a decrease in physical performance between 2012–2014(P=0.0001).Age,being female,living in Andes Mountains,having middle and highest FGCRS,higher alcohol consumption,being obese,lack of exercise and cognitive impairment increase the probability of disability(P<0.05).Alternatively,living in more developed regions and having a higher educational level reduced the probability of disability during the follow-up time(P<0.05).CONCLUSIONS Higher cardiovascular risk burden is associated with decreased physical performance,especially in *** suggest SPPB may provide a measure of cardiovascular health in older adults.

关键词： finding Battery burden

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Is magnesium deficiency the major cause of needle chlorosis of Pinus taeda in Brazil?

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Journal of Forestry Research 2024年第2期35卷 209-221页

作者： Antônio Carlos Vargas Motta Shizuo Maeda Valdécio dos santos dos santos Rodrigues Tamires Maiara Ercole Stephen Arthur Prior Ana Elisa Lyra Brumat Amanda Pacheco Cardoso Moura Julierme Zimmer Barbosa João Bosco Vasconcellos gomes Department of Soil Sciences and Agriculture Engineering Federal University of ParanáR.dos Funcionários1540.CuritibaParanáCEP 80035‑050Brazil Brazilian Agricultural Research Company Embrapa FlorestasEstr.da Ribeira–Br‑476Km 111–Parque Monte Castelo.ColomboParanáCEP 83411‑000Brazil United States Department of Agriculture‑Agricultural Research Service USDA-ARS National Soil Dynamics Laboratory411 South Donahue DriveAuburnAL 36832USA Reforestation Remasa Rodovia PR 170–Km 522.BiturunaParanáCEP 84640‑000Brazil Federal Institute of Southeast of Minas Gerais R.Luz Interior360.Juiz de ForaMinas Gerais CEP 36030‑713Brazil

Needle chlorosis(NC)in Pinus taeda *** in Brazil becomes more frequent after second and third harvest rotation *** a study to identify factors contributing to yellowing needle chorosis(YNC),trees were grown in soils originating from contrasting parent materials,and soils and needles(whole,green and chlorotic portions)from 1-and 2-year-old branches and the first and second needle flush release at four sites with YNC on *** were analyzed for various elements and *** soils had very low base levels(Ca^(2+),Mg^(2+)and K^(+))and P,suggesting a possible lack of multiple *** symptoms started at needle tips,then extended toward the needle base with *** flush needles had longer portions with YNC than second flush needles *** from the lower crown also had more symptoms along their length than those higher in the *** were similar to those reported for *** chlorotic portions,Mg and Ca concentrations were well below critical values;in particular,Mg levels were only one third of the critical value of 0.3 g kg^(-1).Collectively,results suggest that Mg deficiency is the primary reason for NC of *** in various parent soils in Brazil.

关键词： Nutritional deficiency Forest management Soil depletion Pine foliar analysis Needle chlorosis

Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer:A case report

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 234-243页

作者： João Gramaça Isabel gomes Fernandes Carolina Trabulo Joana Gonçalves Rita Gameiro dos santos Adriano Baptista Idília Pina Centro Hospitalar Barreiro Montijo Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal Medical Oncology Unit Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal

BACKGROUND In patients with metastatic colorectal cancer(mCRC),the treatment options are limited and have been proved to be affected by rat sarcoma virus(RAS)mutational *** RAS wild-type(wt)patients,the combination of antiepidermal growth factor receptor(EGFR)monoclonal antibodies with chemotherapy(CT)is more effective than CT *** the other hand,RAS-mutated patients are not eligible for treatment with anti-EGFR *** SUMMARY Eleven patients with initially RAS-mutated mCRC were followed from diagnosis to May *** the time of cell-free DNA determination,five patients had undergone one CT line,five patients had undergone two CT lines,and one patient had undergone three CT lines(all in combination with bevacizumab).At the second and third treatment lines[second line(2L),third line(3L)],patients with neo-RAS wt received a combination of CT and *** neo-RAS wt patients treated with anti-EGFR,our findings indicated an increase in progression-free survival for both 2L and 3L(14.5 mo,P=0.119 and 3.9 mo,P=0.882,respectively).Regarding 2L overall survival,we registered a slight increase in neo-RAS wt patients treated with anti-EGFR(33.6 mo vs 32.4 mo,P=0.385).At data cut-off,two patients were still alive:A RAS-mutated patient undergoing 3L treatment and a neo-RAS wt patient who received 2L treatment with anti-EGFR(ongoing).CONCLUSION Our case series demonstrated that monitoring RAS mutations in mCRC by liquid biopsy may provide an additional treatment line for neo-RAS wt patients.

关键词： Metastatic colorectal cancer Rat sarcoma virus mutational status Liquid biopsy Rat sarcoma virus wild-type Neo-rat sarcoma virus wild-type Anti-epidermal growth factor receptor therapy Case report

Experimental evidence of pressure effects on spinel dissolution and peridotite serpentinization kinetics under shallow hydrothermal conditions

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Geoscience Frontiers 2024年第2期15卷 236-250页

作者： Yuri de Melo Portella Rommulo Vieira Conceição tiago Abreu Siqueira Lucas Bonan gomes Rodrigo Sebastian Iglesias Programa de Pós-Graduação em Geociências(PPGGEO) Universidade Federal do Rio Grande do SulPorto AlegreBrazil Petrobras–Petróleo Brasileiro S.A. Avenida Henrique Valadares 28CentroRio de Janeiro(RJ)20231-030Brazil Instituto do Petróleo e dos Recursos Naturais-PUCRS–Pontifícia Universidade Católica do Rio Grande do Sul 90619-900Porto AlegreBrazil Universidade Federal do Rio Grande do Sul Instituto de GeociênciasLaboratório de Difratometria de Raios XPorto AlegreBrazil Escola Politécnica–PUCRS-Pontifícia Universidade Católica do Rio Grande do Sul 90619-900 Porto AlegreBrazil

Serpentinization reactions are paramount to understand hydro-geothermal activity near plate boundaries and mafic–ultramafic massifs,as well as fluid and element transfer between the Earth’s mantle and ***,fluid-rock element exchange and serpentinization kinetics under shallow hydrothermal conditions is still largely *** we present two constant temperature(230℃)time-series of natural peridotite(77.5%olivine;13.7%enstatite;6.8%diopside;2%spinel)serpentinization experiments:at 13.4 MPa;and 20.7 ***-enriched lizardite was the main secondary mineral in all runs after olivine(olv)and orthopyroxene(opx)serpentinization(without any detectable brucite,talc or magnetite),while primary spinel and diopside partially dissolved during the *** serpentinization stages comprises intrinsically coupled reactions between olivine and enstatite,as Al and Si are progressively transferred from orthopyroxene-derived to olivine-derived serpentine,while the opposite is true for Mg and Fe,with homogenization of serpentines compositions after 40 *** Ni/Cr ratios of serpentines,however,remain diagnostic of the respective primary *** average serpentine content indicates fast serpentinization rates of 0.55 wt.%·day^(-1)(0.26 mmol·day^(-1))and 0.26 wt.%·day^(-1)(0.13 mmol·day^(-1))at 13.4 and 20.7 MPa,*** 2x faster serpentinization kinetics at lower pressure is likely linked to enhanced spinel dissolution leading to one order of magnitude higher available Al,which accelerates olivine serpentinization while delays orthopyroxene ***,time-dependent increase in solid products masses suggests rock volume expands linearly 0.37%±0.01%per serpentine wt.%independently of *** balance constrains suggests olv:opx react at~5:2 and~3:2 M ratios,resulting in Si-deficient and Si-saturated serpentines at the end of the low-pressure series(13.4 MPa)and high-pressure series(20.7 MPa),***

关键词： Serpentine Volume expansion Serpentinization fluids Lost City hydrothermal field Serpentinite-hosted hydrothermal systems Hydrogen(H_(2))generation

The Colíder Paleoproterozoic felsic volcanism:New insights into stratigraphy and petrogenesis in the southern Amazonian Craton

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Geoscience Frontiers 2024年第2期15卷 274-303页

作者： André Massanobu Ueno Kunifoshita Felipe Holanda dos santos Maria JoséMesquita Instituto de Geociências Universidade Estadual de Campinas(UNICAMP)Rua Carlos Gomes250CEP:13083-855 CampinasSão PauloBrazil Departamento de Geologia Universidade Federal do CearáCampus do PiciBloco 912CEP:60440-554 FortalezaCearáBrazi

The eastern side of Alta Floresta Mineral Province(AFMP)(União do Norte region)comprises an effusive/-subvolcanic phase,explosive phase,and epiclastic *** effusive/subvolcanic phase comprises massive porphyritic rhyolite with different degrees of crystallinity,porphyritic rhyolite with flow structure,and microcrystalline *** explosive phase is characterized by welded lapilli tuff,lapilli tuff with flow structure,stratified lapilli tuff,and tuff with accretionary *** and siltstones characterize epiclastic *** are porphyritic rhyolite dikes that cut the volcanic *** rocks of the Colíder Group are rhyolites(>70%SiO2)with calcic-alkaline to alkaline-calcic affinity.A rhyolitic rock is predominantly ferroan and metaluminous,while a pyroclastic rock is predominantly magnesian to ferroan and meta-to peraluminous in *** rocks have a high LREE content,and slight fractionation of HREE suggests they have hybrid geochemical characteristics of high potassium calc-alkaline,shoshonitic,and suggestive affinities of A-type magmas,probably produced in a post-collisional orogenic *** rocks have a relatively high level of Ba and Rb and a negative anomaly for Sr,P,Nb,Ta,and Ti,suggesting an intra-plate mantle source with contributions from a metasomatized mantle *** rocks do not have adakitic characteristics nor fertility for Cu-Au(Sr/Y<1.9 and LaN/YbN<38.0)as in other regions of the *** welded lapilli tuff rocks show U-Pb age of 1838±17 Ma and 1817±2 Ma and are the older explosive *** effusive/subvolcanic phase has U-Pb ages of 1800±3 Ma and 1792±3 Ma obtained in the massive porphyritic *** age interval of approximately 46 Ma(1838–1792 Ma)suggests the presence of two or more volcanic cycles or distinct volcanic *** on the interpretation of volcanic and epiclastic deposits and remote sensing products,the paleoenvironmental reconstruction includes subaerial with effusive/subvolcani

关键词： Paleoproterozoic volcanism Eroded volcanic caldera Lithofacies analysis Colíder Group Amazonian Craton

Is magnesium deficiency the major cause of needle chlorosis of Pinus taeda in Brazil?

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Journal of Forestry Research 2024年第2期 213-225页

作者： Ant?nio Carlos Vargas Motta Shizuo Maeda Valdécio dos santos dos santos Rodrigues Tamires Maiara Ercole Stephen Arthur Prior Ana Elisa Lyra Brumat Amanda Pacheco Cardoso Moura Julierme Zimmer Barbosa Jo?o Bosco Vasconcellos gomes Department of Soil Sciences and Agriculture Engineering Federal University of Paraná Brazilian Agricultural Research Company Embrapa Florestas 3. United States Department of Agriculture-Agricultural Research Service USDA-ARS National Soil Dynamics Laboratory 4. Reforestation Remasa 5. Federal Institute of Southeast of Minas Gerais

Needle chlorosis(NC) in Pinus taeda L. systems in Brazil becomes more frequent after second and third harvest rotation cycles. In a study to identify factors contributing to yellowing needle chorosis(YNC), trees were grown in soils originating from contrasting parent materials, and soils and needles(whole, green and chlorotic portions) from 1-and 2-year-old branches and the first and second needle flush release at four sites with YNC on P. taeda were analyzed for various elements and properties. All soils had very low base levels(Ca2+, Mg2+and K+) and P, suggesting a possible lack of multiple elements. YNC symptoms started at needle tips, then extended toward the needle base with time. First flush needles had longer portions with YNC than second flush needles did. Needles from the lower crown also had more symptoms along their length than those higher in the canopy. Symptoms were similar to those reported for Mg. In chlorotic portions, Mg and Ca concentrations were well below critical values; in particular, Mg levels were only one third of the critical value of 0.3 g kg-1. Collectively, results suggest that Mg deficiency is the primary reason for NC of P. taeda in various parent soils in Brazil.

关键词：

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In Silico and in Vitro Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 Methyltransferase Inhibitors by Molecular Docking

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Journal of Biosciences and Medicines 2024年第7期12卷 214-229页

作者： Luciene Soares Silva tiago Soares Barbosa Maria Leonisa Sanchez-Nuñez Aldenise Mont Serrat Rosa da Silva Vitor Won-Held Rabelo Leonardo dos santos Corrêa Amorim Leonardo Alves Miceli Percilene Fazolin Vegi Alice Bernardino Helena Carla Castro Izabel Christina Nunes de Palmer Paixão Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niteri Brazil Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Antibiotics Biochemistry Teaching and Molecular Modeling Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Organic Chemistry at the Institute of Chemistry Institute of Biology Fluminense Federal University Niterói Brazil

Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complications. Although many efforts have been made to control ZIKV infection, approved vaccines or antiviral drugs are still lacking. Consequently, the development of new effective anti-ZIKV agents is urgently needed. In this context, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replication using in silico and in vitro methods. The four pyrazolone derivatives evaluated (1a, 1b, 1c, and 1d) inhibited over 50% of ZIKV replication with low cytotoxicity. Among them, compound 1b exhibited the most potent activity (EC50 = 4.3 μM) and the highest selectivity (SI = 342). Mechanism of action studies indicated that these compounds act at early stages of virus replication, and compound 1b can also directly inactivate ZIKV particles. Molecular docking studies suggested that these compounds can bind to and block the activity of ZIKV NS5 methyltransferase. Finally, pharmacokinetic and toxicological predictions have reinforced the safety and drug-like profiles of these derivatives. In conclusion, the pyrazolone scaffold proved to be valuable for anti-ZIKV drug development, and the derivatives studied deserve further investigation.

关键词： Zika Pyrazolone NS5 Methyltransferase Antivirals

Floristic composition and edaphic relationships in ferruginous campo rupestre reference ecosystems

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Journal of Mountain Science 2024年第3期21卷 719-733页

作者： G.Wilson FERNANDES Letícia RAMOS Dario C.PAIVA Jéssica CUNHA-BLUM Vanessa Matos gomes Daniel NEGREIROS Ecologia Evolutiva&Biodiversidade Departamento de GenéticaEcologia e Evolução/ICBUniversidade Federal de Minas Gerais31270-901Belo HorizonteMGBrazil Knowledge Center for Biodiversity 31270-901Belo HorizonteMGBrazil Department of Biological Sciences Institute of EnvironmentFlorida International UniversityMiamiFL 33199USA Programa de Pós Graduação em Biodiversidade e Uso dos Recursos Naturais Universidade Estadual de Montes ClarosMontes ClarosMGBrazil Laboratório de Estudo das Relações Solo-Planta Departamento de SolosUniversidade Federal Rural do Rio de JaneiroSeropédicaRGBrazil

Land use change and occupation have led to modifications in the environment causing loss of biodiversity and ecosystem services throughout the *** environments with high economic relevance,such as the ferruginous campo rupestre(rupestrian grassland known as Canga in Brazil),are even more susceptible to severe impacts due to their extreme habitat conditions and low *** determination of reference ecosystems based on the intrinsic characteristics of the ecosystem is essential for conservation as well as to the implementation of ecological *** proposed the reference ecosystem of the three main types of habitats of the ferruginous campo rupestre based on their floristic *** described the floristic composition of each habitat and evaluated the physicochemical properties of the soils and the relationship between plants and *** three habitats showed high diversity of plant species and many endemic species,such as Chamaecrista choriophylla,Cuphea pseudovaccinium,Lychnophora pinaster,and Vellozia *** distribution of vegetation was strongly related with the edaphic characteristics,with a set of species more adapted to high concentration of base saturation,fine sand,organic carbon,and iron,while another set of species succeeded in more acidic soils with higher S and silt *** provide support for the contention that the ferruginous campo rupestre is a mosaic of different habitats shaped by intrinsic local *** to recognize the floristic composition of each particular habitat can lead to inappropriate restoration,increased habitat homogenization and increased loss of biodiversity and ecosystem *** study also advances the knowledge base for building the reference ecosystem for the different types of ferruginous campo rupestre habitats,as well as a key database for highlighting those species contribute most to community assembly in this diverse and threatened tropical mountain ecosystem.

关键词： Canga Ecological restoration Extreme ecosystem Non-forest ecosystems Rupestrian grassland Taxon environment relationships

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Pseudo-discontinuum model to simulate hard-rock mine pillars

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Underground Space 2023年第4期11卷 81-95页

作者： Erick Ro genes Alessandra dos santos gomes Marcio Muniz de Farias Leandro Lima Rasmussen Faculty of Technology University of BrasiliaDF 70910-900BrasiliaBrazil

In this study,the pseudo-discontinuum modeling technique,called continuum Voronoi block model(CVBM),was applied to repre-sent the behavior of hard-rock pillars from underground mines subjected to high field *** CVBM’s ability to produce numerical results consistent with the observed behavior of pillars is demonstrated through the numerical analysis of a hypothetical case and a back analysis of the Creighton mine *** results show that the model can capture convergence displacements and explicitly show the formation of macro-fractures parallel to excavation walls,intact rock slabs,and V-shaped *** components are characteristics of brittle failure induced by highly stressed ground *** studies presented in this work confirm the CVBM as a convenient tool for the numerical modeling of intact rock pillars excavated in deep underground mines.

关键词： Brittle failure Spalling Bulking Voronoi tessellation