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Risk factors for postpartum posttraumatic stress disorder after emergency admission

World Journal of Emergency Medicine 2024年第2期15卷 121-125页

作者： Fengxia Du Jun zha Yan Li Lichao Fang Shuyu Xia Youjia yu Department of Obstetrics Suzhou Xiangcheng People’s HospitalSuzhou 215131China Department of Anesthesiology the Second Affiliated Hospital of Wannan Medical CollegeWuhu 241000China Department of Anesthesiology Suzhou Xiangcheng People’s HospitalSuzhou 215131China Department of Emergency and Intensive Care Unit Suzhou Xiangcheng People’s HospitalSuzhou 215131China

BACKGROUND:Postpartum posttraumatic stress disorder(PTSD)can occur in women who give birth after emergency *** identification of risk factors for this condition is crucial for developing effective preventive *** retrospective study aimed to explore the incidence and risk factors for postpartum PTSD in women who give birth after emergency ***:Medical records of women who gave birth after emergency admission were collected between March 2021 and April *** patients’general conditions and perinatal clinical indicators were *** puerperae were divided into PTSD group and control group based on symptom occurrence at six weeks *** logistic regression analysis was performed to identify risk ***:A total of 276 puerperae were included,with a PTSD incidence of 20.3% at six weeks *** logistic regression analysis identified emergency cesarean section(odds ratio[OR]=2.102;95%confidence interval[CI]:1.114-3.966,P=0.022),admission to the emergency department after midnight(12:00 AM)(OR=2.245;95%CI:1.170-4.305,P<0.001),and cervical dilation(OR=3.203;95%CI:1.670–6.141,P=0.039)as independent risk factors for postpartum *** pump use(OR=0.500;95%CI:0.259–0.966,P=0.015)was found to be a protective factor against postpartum ***:Emergency cesarean section,admission to the emergency department after midnight,and cervical dilation were identified as independent risk factors for postpartum PTSD,while analgesic pump use was a protective *** findings provide insights for developing more effective preventive measures for women who give birth after emergency admission.

关键词： Risk factors Posttraumatic stress disorder Emergency Delivery

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Polydopamine-modified metal-organic frameworks nanoparticles enhance the corrosion resistance and bioactivity of polycaprolactone coating on high-purity magnesium

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Journal of Magnesium and Alloys 2024年第5期12卷 2070-2089页

作者： Qingyun Fu Shaojie He Junjie Yang Ziyu Su Ping Li Xincheng yu Weihong Jin Shulan Xu Zhentao yu Dingsheng zha Center of Oral Implantology Stomatological HospitalSouthern Medical UniversityGuangzhouChina Panyu Hospital of Chinese Medicine Guangzhou 511400China Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou 510632China First Affiliated Hospital of Jinan University Guangzhou 510630China

Biodegradable magnesium(Mg)and its alloys exhibit excellent biocompatibility and mechanical compatibility,demonstrating tremendous potential for applications in ***,the rapid degradation rate has limited their clinical ***(PCL)is commonly employed as a polymer coating to impede the rapid degradation of ***,its long-term anti-corrosion capability and bioactivity are *** address these issues,polydopamine(PDA)-modified zeolitic imidazolate framework-8(PZIF-8)bioactive nanoparticles are fabricated and incorporated into the PCL *** PZIF-8 particles,featuring catechol motifs,can enhance the compactness of the PCL coating,reduce its defects,and possess biomineralization ability,thereby effectively improving its anti-corrosive and bioactive ***,the active substances released from the degradation of the PZIF-8 particles such as Zn^(2+)and PDA are beneficial for *** corrosion tests indicate that the corrosion current density of PCL-treated sample decreases by more than one order of magnitude and the amount of H_(2)released decreases from 0.23±0.12 to 0.08±0.08 ml cm^(-2)after doping with the ***,the improved corrosion resistance and released PDA and Zn^(2+)from the coating can promote osteogenic differentiation by up-regulating the expression of alkaline phosphatase activity,related osteogenic genes,and *** addition,in vivo implantation experiments in rabbit femur defects further offer strong evidence that the doping of PZIF-8 nanoparticles accelerates bone reconstruction of the PCL *** summary,this work implies a new strategy to fabricate a PCL-based coating on Mg-based implants by introducing the PZIF-8 particles for orthopedic applications.

关键词： Polydopamine ZIF-8 High-purity magnesium Polycaprolactone coating Anticorrosion Bone regeneration

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Predictive visual field outcomes after optic chiasm decompressive surgery by retinal vessels parameters using optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 365-373页

作者： Wen-Juan yu Jin Xiao Guang-Xin Wang Chang Jiang Wei zha Rong-Feng Liao Department of Ophthalmology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Neurosurgery the First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Ophthalmology the First People’s Hospital of HefeiHefei 230061Anhui ProvinceChina

AIM:To evaluate the predictive value of superficial retinal capillary plexus(SRCP)and radial peripapillary capillary(RPC)for visual field recovery after optic cross decompression and compare them with peripapillary nerve fiber layer(pRNFL)and ganglion cell complex(GCC).METHODS:This prospective longitudinal observational study included patients with chiasmal compression due to sellar region mass scheduled for decompressive *** estimating equations were used to compare retinal vessel density and retinal layer thickness preand post-operatively and with healthy *** regression models were used to assess the relationship between preoperative GCC,pRNFL,SRCP,and RPC parameters and visual field recovery after ***:The study included 43 eyes of 24 patients and 48 eyes of 24 healthy *** RPC and SRCP vessel density and pRNFL and GCC thickness were lower than healthy controls and higher than postoperative *** best predictive GCC and pRNFL models were based on the superior GCC[area under the curve(AUC)=0.866]and the tempo-inferior pRNFL(AUC=0.824),and the best predictive SRCP and RPC models were based on the nasal SRCP(AUC=0.718)and tempo-inferior RPC(AUC=0.825).There was no statistical difference in the predictive value of the superior GCC,tempo-inferior pRNFL,and tempo-inferior RPC(all P>0.05).CONCLUSION:Compression of the optic chiasm by tumors in the saddle area can reduce retinal thickness and blood *** reduction persists despite the recovery of the visual field after decompression ***,pRNFL,and RPC can be used as sensitive predictors of visual field recovery after decompression surgery.

关键词： sellar region mass retinal vessels optic chiasm optical coherence tomography angiography visual field decompressive surgery

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Human pluripotent stem cell-derived kidney organoids:Current progress and challenges

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World Journal of Stem Cells 2024年第2期16卷 114-125页

作者： Hong-Yan Long Zu-Ping Qian Qin Lan Yong-Jie Xu Jing-Jing Da Fu-Xun yu Yan zha Graduate School Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Laboratory Medicine Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina Department of Nephrology Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina Key Laboratory of Diagnosis and Treatment of Pulmonary Immune Diseases National Health CommissionGuizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

Human pluripotent stem cell(hPSC)-derived kidney organoids share similarities with the fetal ***,the current hPSC-derived kidney organoids have some limitations,including the inability to perform nephrogenesis and lack of a corticomedullary definition,uniform vascular system,and coordinated exit path-way for urinary ***,further studies are required to produce hPSC-derived kidney organoids that accurately mimic human kidneys to facilitate research on kidney development,regeneration,disease modeling,and drug *** this review,we discussed recent advances in the generation of hPSC-derived kidney organoids,how these organoids contribute to the understanding of human kidney development and research in disease ***,the limitations,future research focus,and applications of hPSC-derived kidney organoids were highlighted.

关键词： Kidney Organoids Human pluripotent stem cell Development Vascular system Disease modeling

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Myricetin induces M2 macrophage polarization to alleviate renal tubulointerstitial fibrosis in diabetic nephropathy via PI3K/Akt pathway

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World Journal of Diabetes 2024年第1期15卷 105-125页

作者： Wei-Long Xu Pei-Pei Zhou Xu yu Ting tian Jin-Jing Bao Chang-Rong Ni Min zha Xiao Wu Jiang-Yi yu Department of Endocrinology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pharmacy Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pneumology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKGROUND Development of end-stage renal disease is predominantly attributed to diabetic nephropathy(DN).Previous studies have indicated that myricetin possesses the potential to mitigate the pathological alterations observed in renal ***-theless,the precise molecular mechanism through which myricetin influences the progression of DN remains *** To investigate the effects of myricetin on DN and explore its potential therapeutic *** Db/db mice were administered myricetin intragastrically on a daily basis at doses of 50 mg/kg or 100 mg/kg for a duration of 12 ***,blood and urine indexes were assessed,along with examination of renal tissue *** morphology and fibrosis were evaluated using various staining techniques including hematoxylin and eosin,periodic acid–Schiff,Masson’s trichrome,and ***,high-glucose culturing was conducted on the RAW 264.7 cell line,treated with 25 mM myricetin or co-administered with the PI3K/Akt inhibitor LY294002 for a period of 24 *** both in vivo and in vitro settings,quantification of inflammation factor levels was conducted using western blotting,real-time qPCR and *** In db/db mice,administration of myricetin led to a mitigating effect on DN-induced renal dysfunction and ***,we observed a significant reduction in expressions of the kidney injury markers kidney injury molecule-1 and neutrophil gelatinase associated lipocalin,along with a decrease in expressions of inflammatory cytokine-related ***,myricetin treatment effectively inhibited the up-regulation of tumor necrosis factor-alpha,interleukin-6,and interluekin-1βinduced by high glucose in RAW 264.7 ***,myricetin modulated the M1-type polarization of the RAW 264.7 *** docking and bioinformatic analyses revealed Akt as the target of *** protective effect of myricetin was nullified upon blocking the polarization of RAW 264.7 via inh

关键词： Myricetin Diabetic nephropathy PI3K/Akt pathway Renal tubulointerstitial fibrosis Macrophage Polarization

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Tet methylcytosine dioxygenase 2(TET2)deficiency elicits EGFR-TKI(tyrosine kinase inhibitors)resistance in non-small cell lung cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1706-1720页

作者： Jian zhang Kejia zhao Wenjing Zhou Ran Kang Shiyou Wei yueli Shu Cheng yu Yin Ku Yonghong Mao Hao Luo Juqin Yang Jiandong Mei Qiang Pu Senyi Deng Zhengyu zha Gang yuan Shensi Shen Yaohui Chen Lunxu Liu Department of Thoracic Surgery and Institute of Thoracic Oncology West China Hospital of Sichuan UniversityChengdu 610097China Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer Sichuan UniversityChengdu 610097China Biobank of West China Hospital Sichuan UniversityChengdu 610041China

Despite epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKl)have shown remarkable efficacy in patients with EGFR-mutant non-small cell lung cancer(NSCLC),acquired resistance inevitably develops,limiting clinical *** found that TET2 was poly-ubiquitinated by E3 ligase CUL7^(FBXW11) and degraded in EGFR-TKI resistant NSCLC *** perturbationof TET2 rendered parental cells more tolerant to TKI ***2 was stabilized by MEK1 phosphorylation at Ser 1107,while MEK1 inactivation promoted its proteasome degradation by enhancing the recruitment of CUL7^(FBXW11),Loss of TET2 resulted in the upregulation of TNF/NF-kB signaling that confers the EGFR-TKI *** or pharmacological inhibition of NF-kB attenuate the TKI resistance both in vitro and in *** findings exemplified how a cell growth controlling kinase MEK1 leveraged the epigenetic homeostasis by regulating TET2,and demonstrated an alternative path of non-mutational acquired EGFR-TKI resistance modulated by TET2 ***,combined strategy exploiting EGFR-TKI and inhibitors of TET2/NF-κB axis holds therapeutic potential for treating NSCLC patients who suffered from this resistance.

关键词： TET2 TKI resistance

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碳排放权交易、数字经济与企业全要素生产率

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商业研究 2024年第1期 12-22页

作者：董雨袁雪查勇中国科学技术大学管理学院合肥230026

“双碳”战略目标的提出契合高质量发展的内在需要,碳排放权交易市场是实现该目标的关键工具,2013—2014年,我国建立了首批七个试点碳交易市场,近十年以来,此项政策的减排效果已经受到广泛认可,但其对经济发展的影响依然值得探究。基于2... 详细信息

“双碳”战略目标的提出契合高质量发展的内在需要,碳排放权交易市场是实现该目标的关键工具,2013—2014年,我国建立了首批七个试点碳交易市场,近十年以来,此项政策的减排效果已经受到广泛认可,但其对经济发展的影响依然值得探究。基于2010—2019年重污染行业A股上市公司的数据,本文以首批七个试点碳交易市场的正式启动为准自然实验,构建双重差分模型探讨该项政策对企业全要素生产率的影响,并从碳交易市场特征和数字经济发展的角度对作用机制进行分析。研究发现,碳交易政策能够显著提高企业的全要素生产率。机制分析表明,在碳交易政策对全要素生产率的作用过程中,企业数字化转型发挥了部分中介作用。此外,碳交易政策效果在非国有企业、风险承担水平高的企业中更强,并且碳市场的交易规模、流动性、数字基础设施、互联网普及率和数字普惠金融的发展都对碳交易政策效果发挥着正向调节效应,碳配额价格水平也具有一定的负向调节效应。

关键词：碳排放权交易市场全要素生产率双重差分模型数字经济

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晋西黄土小流域土壤有机碳空间分布特征及其影响因素

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生态学杂志 2024年第5期43卷 1373-1380页

作者：左启林于洋查同刚北京林业大学水土保持学院北京100083 北京林业大学山西吉县森林生态系统国家野外科学观测研究站北京100083

植被恢复影响土壤有机碳(SOC)空间分布。为阐明黄土丘陵沟壑小流域SOC的空间变异特征及其影响因素,以晋西蔡家川流域内的4个典型子流域(南北窑农地流域、北坡人工林流域、柳沟封禁流域、人祖山天然次生林流域)为研究对象,通过野外调查... 详细信息

植被恢复影响土壤有机碳(SOC)空间分布。为阐明黄土丘陵沟壑小流域SOC的空间变异特征及其影响因素,以晋西蔡家川流域内的4个典型子流域(南北窑农地流域、北坡人工林流域、柳沟封禁流域、人祖山天然次生林流域)为研究对象,通过野外调查与室内测定SOC含量,采用经典统计学和地统计学方法,分析流域尺度0~100 cm SOC的分布规律及其与环境因子的关系。结果表明:不同子流域SOC含量不同,柳沟封禁流域>天然次生林流域>北坡人工林流域>南北窑农地流域;相对于人工恢复,自然恢复能累积和储存更多的SOC;空间上,SOC呈自西向东逐渐降低的趋势,随深度增加,SOC的分布格局更具均一性;植被类型、土地利用方式、地形特征等因素影响小流域尺度SOC空间分布格局;灌草地SOC含量最高(14.43±8.91 g·kg^(-1)),其次是林地(13.11±6.98 g·kg^(-1)),农地SOC含量最低(8.48±2.98 g·kg^(-1));较之农地,灌草地和林地SOC含量分别提高70.2%和54.6%;在0~20 cm土层,坡度为15°~25°时SOC含量出现最大值;在0~20 cm土层,不同坡向对SOC含量大小排序为阴坡(15.82±7.63 g·kg^(-1))>半阴坡(12.94±7.53 g·kg^(-1))>半阳坡(11.48±6.28 g·kg^(-1))>阳坡(11.1±6.19 g·kg^(-1))。研究结果为评价黄土流域植被恢复的土壤生态效应提供依据。在植被恢复和重建过程中,要注意人工林天然化、对应的天然林进行封禁管理。

关键词：黄土高原小流域土壤有机碳空间分布地统计学

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Exploring the effect and mechanisms of Epimedium on diabetic testicular injury using network pharmacology,molecular docking,and cell experiments

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TMR Modern Herbal Medicine 2024年第2期7卷 19-27页

作者： Jun-Jun Wei Qiong-Yao Xu zhao-Wen Pan Yi-Wei Tu Wei yu Lan Huang Wen-Liang zha College of Pharmacy Hubei University of Science and TechnologyXianning 437100China Xianning Medical College Hubei University of Science and TechnologyXianning 437100China School of Stomatology and Ophthalmology Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China

Background:Studying the potential targets and mechanisms of Epimedium for anti-diabetic testicular injury using network pharmacology,molecular docking,and cell ***:Acquisition of major components and targets of Epimedium was based on TCMSP,TCMID,and Symmap databases and retrieval of diabetic testicular injury targets by OMIM,GeneCards,Pharmgkb,and Drugbank *** targets were obtained from the Venny 2.1.0 database and input SRTING data to construct a protein-protein interaction(PPI)network,and key targets were screened in Cytoscape 3.8.0 *** the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses of intersecting targets were conducted through the DAVID ***,AutoDock software was used to verify docking between the main components and the core target *** addition,a Cell Counting Kit-8(CCK-8)assay was used to determine the survival effect of quercetin,the main component of Epimedium,on TM4 sertoli-like cells exposed to palmitic acid(PA).Results:Quercetin,kaempferol and luteolin in epimedium were identified as the main components in the treatment of diabetic testicular *** has core target proteins including MMP9,AKT1,and *** biological process mainly involves the regulation of the apoptotic signaling *** key pathways of KEGG are the AGE-RAGE signaling pathway in diabetic complications,PI3K-Akt and MAPK signaling *** docking results showed that quercetin had the strongest binding ability to ***,PA-challenged cells had a lower survival rate,which was alleviated by the administration of ***:Our findings suggest that Epimedium attenuates diabetes mellitus(DM)-induced testicular injury through AGE-RAGE,PI3K-Akt and MAPK signaling *** insights offer a potential therapeutic strategy for managing DM-induced testicular injury,will be the basis for future clinical research.

关键词： Epimedium diabetic testicular injury network pharmacology molecular docking

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数字普惠金融对新质生产力的影响及作用机制研究

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农村金融研究 2024年第7期 54-66页

作者：庞加兰查雨城西安外国语大学经济金融学院

新质生产力是中国经济高质量发展的重要着力点,而数字普惠金融则是推动新质生产力发展的关键动力之一。将数字普惠金融融入到新质生产力的发展中,不仅能够有效提升金融服务的效率和质量,还能够为新质生产力的发展提供有力的金融支持,推... 详细信息

新质生产力是中国经济高质量发展的重要着力点,而数字普惠金融则是推动新质生产力发展的关键动力之一。将数字普惠金融融入到新质生产力的发展中,不仅能够有效提升金融服务的效率和质量,还能够为新质生产力的发展提供有力的金融支持,推动中国经济实现高质量发展。论文利用2012—2021年中国30个省(自治区、直辖市,不含西藏自治区与港澳台地区)的面板数据,系统考察了数字普惠金融对新质生产力的影响及其作用机制。研究表明:数字普惠金融显著推动了新质生产力发展,在进行了内生性检验后,结论仍然成立;机制检验表明,数字普惠金融通过推动产业结构升级对新质生产力产生影响,同时市场化程度在数字普惠金融与新质生产力发展之间发挥正向调节作用。此外,数字普惠金融作用于新质生产力时存在自身双重门槛效应。论文研究结论有助于深入理解数字普惠金融对新质生产力影响的内在机制,为实现高质量发展提供更加有效的路径选择与理论支撑。

关键词：数字普惠金融新质生产力产业结构升级市场化程度门槛效应

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