检索结果-南通市图书馆

Microstructure and formation mechanism of SHS joining between C_f/Al composites and tial intermetallic with Al–Ni–CuO interlayer

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2015年第1期34卷 17-21页

作者： Zhuo-Ran Li Guang-jie Feng Kai Xu Xiang-Long Zhang State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology

In this study, it was reported a novel approach for joining Cf/A1 composites and tia1 intermetallic by self- propagating high-temperature synthesis （SHS）. Mixed powders of 14A1-2Ni-3CuO were used as the SHS inter- layer, and differential thermal analysis test of A1-Ni-CuO interlayer was conducted to analyze the exothermic char- acteristic. Sound joint was got by SHS joining under the conditions of 600 ℃, 30 min, and 5 MPa. The joint was characterized by scanning electron microscopy （SEM）, energy dispersive spectroscopy （EDS）, and X-ray diffrac- tion （XRD）. tia13 and NiA13 are, respectively, formed in the tia1/interlayer and Cf/A1/interlayer interfaces. Reac- tion products of Ni2Al3, NiAl3, A1203, and Cu were observed in the interlayer. And the formation mechanism of SHS joining was investigated.

关键词： SHS Joining Microstructure Formationmechanism A1-Ni-CuO interlayer

Comparison of ultrasound biomicroscopy and spectraldomain anterior segment optical coherence tomography in evaluation of anterior segment after laser peripheral iridotomy

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2016年第3期9卷 417-423页

作者： Xiao-Yun Ma Dan Zhu Jun Zou Wen-jie Zhang Yi-Lin Cao Department of Plastic and Reconstructive Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Tissue EngineeringNational Tissue Engineering Center of China Department of Ophthalmology Shanghai Guanghua Integrative Medicine Hospital Department of Ophthalmology Shanghai Tenth People's HospitalTongji University

AIM：To quantitatively assess narrow anterior chamber angle using spectral-domain anterior segment optical coherence tomography（SD-AS-OCT） and ultrasound biomicroscopy（UBM）,and to evaluate the correlations and consistency between SD-AS-OCT and UBM.· METHODS：Fifty-five eyes from 40 patients were *** were diagnosed with primary angleclosure glaucoma（PACG） remission（11 eyes from 8patients）,primary angle closure（PAC,20 eyes from 20patients） and PAC suspect（24 eyes from 12 patients）.Each eye was examined by SD-AS-OCT and UBM after laser peripheral iridotomy（LPI）.The measurements of SD-AS-OCT were angle open distance（AOD）,anterior chamber angle（ACA）,trabecular iris angle（tia）,and trabecular iris space area（TISA）.UBM measurements were AOD and *** of AOD500 and tia500 between UBM and AS-OCT were *** parameters were analysed by SPSS 16.0 and MedCalc.· RESULTS：ACA,tia and AOD measured by SD-ASOCT reached a maximum at the temporal quadrant and minimum at the nasal *** parameters of AOD500 and AOD750 showed a linear positive correlation,and AOD750 had less *** outcomes of AOD500 and tia500 were significantly smaller than those of *** results of the two techniques were correlated at the superior,nasal and inferior ***：Both UBM and SD-AS-OCT are efficient tools for follow-up during the course of *** recommended using parameters at 750 μm anterior to the sclera spur for the screening and follow-up of PACG and *** two methods might be alternatives to each other.

关键词： primary angle-closure glaucoma ultrasoundbiomicroscopy spectral-domain anterior segment opticalcoherence tomography laser peripheral iridotomy

Minimally invasive thoracoscopic left atrial appendage occlusion compared with transcatheter left atrial appendage closure for stroke prevention in recurrent nonvalvular atrial fibrillation patients after radiofrequency ablation:a prospective cohort study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2021年第11期18卷 877-885页

作者： Jian-Long WANG Kuo ZHOU Zheng QIN Wan-Jun CHENG Ling-Zhi ZHANG Yu-jie ZHOU Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Interventional Department Luanzhou People’s HospitalTangshanChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerot1ic DiseaseClinical Center for Coronary Heart DiseaseBeijingChina

BACKGROUND Tanscatheter left atrial appendage(LAA)closure and minimally invasive thoracoscopic LAA occlusion are local interventions of LAA for stroke prevention in patients with nonvalvular atrial fibrillation(NVAF).However,the safety and efficacy of these methods have not been *** prospective cohort study aimed to assess the safety and efficacy of those two treatment approaches for stroke prevention in NVAF *** Two hundred and nine recurrent NVAF patients who received radiofrequency ablation were *** pa-tients were treated with transcatheter LAA closure or thoracoscopic LAA *** patients were followed up from the first postoperative day and evaluated for efficacy endpoints(stroke/transient ischemic attack(tia),systemic embolism(SE),and death)and a safety endpoint(bleeding events).Perioperative complications were *** After a median follow-up of 1.8 years(383 patient-years),the overall rate of the composite efficacy endpoints was similar between the two groups(3.8 vs.2.7 events per 100 patient-years;HR=0.71;95%CI:0.225−2.237;P=0.559).However,regarding primary safety endpoint,there were 1.5 bleeding events per 100 patient-years in the thoracoscopic LAA occlusion group,com-pared with 6.4 in transcatheter LAA closure group(HR=0.246;95%CI:0.074−0.819;P=0.022).The incidence of operative com-plications was 3/138(2.17%)in thoracoscopic LAA occlusion group and 1/71(1.41%)in transcatheter LAA closure *** Thoracoscopic LAA occlusion and transcatheter LAA closure have similar efficacy in preventing stroke in NVAF ***,the thoracoscopic group had fewer bleeding events than the transcatheter group,but the former group required a longer hospital stay.

关键词： prevention patients transcatheter

Muscular involvement of extranodal natural killer/T cell lymphoma misdiagnosed as polymyositis: A case report and review of literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第5期8卷 963-970页

作者： Li-Hui Liu Qing Huang Yun-Hai Liu jie Yang Han Fu Lin Jin Department of Neurology Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina Department of Geriatrics Stroke Center Cerebrovascular disease clinical research center of Hunan provinceChangsha 410008Hunan ProvinceChina Department of Dermatology Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND Natural killer(NK)/T cell lymphoma is a rare and highly aggressive malignant tumor,and is a special form of non-Hodgkin's *** extranodal involvement is frequently found in tissues such as the skin,testicular and gastrointestinal tract etc,its presence in skeletal muscle has scarcely been reported in the *** SUMMARY We report a case of extranodal NK/T cell lymphoma with muscle swelling as the first clinical manifestation.A 42-year-old man,who initially presented with localized swelling in the double lower extremities,demonstrated gradual facial and eyelid swelling,and his imaging results showed multiple sites of muscle damage throughout the *** final pathological results suggested NK/T cell lymphoma,and immunohistochemistry showed CD20(-),CD3(+),CD30(+),CD56(-),EBER(+),Ki67(60%),tia-1(+)and CD68(±)*** muscle swelling significantly improved after treatment with chemotherapy *** This disease is difficult to diagnose and highly invasive,and should be included in the differential diagnosis of unexplained muscle swelling.

关键词： Lymphoma Extranodal natural killer/T cell lymphoma Muscular Polymyositis Muscle swelling Case report

Intracellular accumulation of tau inhibits autophagosome formation by activating tia1-amino acid-mTORC1 signaling

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Military Medical Research 2023年第2期10卷 175-190页

作者： Meng-Zhu Li En-jie Liu Qiu-Zhi Zhou Shi-Hong Li Shi-jie Liu Hai-Tao Yu Qi-Hang Pan Fei Sun Ting He Wei-Jin Wang Dan Ke Yu-Qi Feng Jun Li Jian-Zhi Wang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurosurgery the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Department of Pathology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Chemistry Wuhan UniversityWuhan 430072China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226000JiangsuChina.

Background:Autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration in Alzheimer’s disease(AD).This study aimed to investigate whether and how the accumulating tau may in turn affect ***:The primary hippocampal neurons,N2a and HEK293T cells with tau overexpression were respectively starved and treated with vinblastine to study the effects of tau on the initiating steps of autophagy,which was analysed by Student’s two-tailed *** rapamycin and concanamycin A were employed to inhibit the mammalian target of rapamycin kinase complex 1(mTORC1)activity and the vacuolar H+-ATPase(v-ATPase)activity,respectively,which were analysed by One-way ANOVA with post hoc *** Western blotting,co-immunoprecipitation and immunofuorescence staining were conducted to gain insight into the mechanisms underlying the tau effects of mTORC1 signaling alterations,as analysed by Student’s two-tailed t-test or One-way ANOVA with post hoc *** autophagosome formation was detected by immunofuorescence staining and transmission electron *** amino acids(AA)levels were detected by high performance liquid chromatography(HPLC).Results:We observed that overexpressing human full-length wild-type tau to mimic AD-like tau accumulation induced autophagy *** studies revealed that the increased tau could bind to the prion-related domain of T cell intracellular antigen 1(PRD-tia1)and this association significantly increased the intercellular level of amino acids(Leucine,P=0.0038;Glutamic acid,P=0.0348;Alanine,P=0.0037;Glycine,P=0.0104),with concordant upregulation of mTORC1 activity[phosphorylated eukaryotic translation initiation factor 4E-binding protein 1(p-4EBP1),P<0.0001;phosphorylated 70 kD ribosomal protein S6 kinase 1(p-p70S6K1),P=0.0001,phosphorylated unc-51-like autophagyactivating kinase 1(p-ULK1),P=0.0015]and inhibition of autophagosome formation[microtubuleassociated protein light chain 3 II(LC3 II),P=0.0073;LC3 pun

关键词： Tau Autophagy Amino acid pathway Mammalian target of rapamycin kinase complex 1(mTORC1) T cell intracellular antigen 1(tia1)

不同来源铁皮石斛多糖，微量元素及氨基酸含量分析

在线全文

学校读者我要写书评

暂无评论

时珍国医国药 2014年第7期25卷 1728-1729页

作者：栾洁辛甜储智勇汪家春汤佳静海军医学研究所上海200433 辽宁中医药大学辽宁大连116600 上海汤振生物技术有限公司上海201900

目的比较不同来源铁皮石斛的有效物质含量。方法应用等离子体发射光谱仪、氨基酸自动分析仪等测定了不同来源铁皮石斛微量元素、氨基酸和多糖含量。结果铁皮石斛原球茎(DPs)液体培养物的多糖含量与市售铁皮枫斗相近,分别为15.42%和16.6... 详细信息

目的比较不同来源铁皮石斛的有效物质含量。方法应用等离子体发射光谱仪、氨基酸自动分析仪等测定了不同来源铁皮石斛微量元素、氨基酸和多糖含量。结果铁皮石斛原球茎(DPs)液体培养物的多糖含量与市售铁皮枫斗相近,分别为15.42%和16.67%,铁皮石斛原球茎固体培养物多糖含量相对较低,仅为11.57%。铁皮石斛原球茎固体培养物及液体培养物中总氨基酸含量分别达到14.61%和8.62%,均高于铁皮枫斗(2.11%)。微量元素含量测定结果显示,两种铁皮石斛原球茎培养物的10种微量元素含量,除Ca、Mg、Sr略低于市售铁皮枫斗外,其他微量元素含量均高于铁皮枫斗。结论两种铁皮石斛组织培养物的主要药用成分与市售铁皮枫斗相近,可作为野生铁皮石斛的替代资源加以开发。

关键词：铁皮石斛多糖氨基酸微量元素

A Longitudinal Functional Magnetic Resonance Imaging Study of Working Memory in Patients Following a Transient Ischemic Attack: A Preliminary Study

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2018年第6期34卷 963-971页

作者： Wei Su Jian Guo Yun Zhang jie Zhou Ning Chen Muke Zhou Rong Li Huafu Chen Li He Department of Neurology West China Hospital of Sichuan University Department of Science and Technology West China Hospital of Sichuan University Department of Neurology Mianyang Central Hospital Key Laboratory for Neuroinformation of The Ministry of Education School of Life Science and Technology University of Electronic Science and Technology of China

In this study, we used functional magnetic resonance imaging(fMRI) to investigate longitudinal changes in brain activation during a verbal working memory(VWM) task performed by patients who had experienced a transient ischemic attack(tia). Twenty-five first-ever tia patients without visible lesions in conventional MRI and 25 healthy volunteers were enrolled. VWM task-related fMRI was conducted 1 week and 3 months post-tia. The brain activity evoked by the task and changes over time were assessed. We found that, compared with controls, patients exhibited an increased activation in the bilateral inferior frontal gyrus(IFG), right dorsolateral prefrontal cortex(DLPFC), insula, inferior parietal lobe(IPL), and cerebellum during the task performed 1 week post-tia. But only the right IFG still exhibited an increased activation at 3 months post-tia. A direct comparison of fMRI data between 1 week and 3 months post-tia showed greater activation in the bilateral middle temporal gyrus, right DLPFC, IPL, cerebellum, and left IFG in patients at 1 week post-tia. We conclude that brain activity patterns induced by a VWM task remain dynamic for a period of time after a tia, despite the cessation of clinical symptoms. Normalization of the VWM activation pattern may be progressively achieved after transient episodes of ischemia in tia patients.

关键词： Functional magnetic resonance imaging Recovery Transient ischemic attack Verbal working memory

A Multi-Channel CMOS Analog Front-End Interface IC with 157.8 d B Current Detection Dynamic Range

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2024年第2期33卷 393-402页

作者： Kunyu WANG Wenjing XU Chengbin ZHANG Yanjun YANG Man-Kay LAW Li ZHOU jie CHEN Ming CHEN Institute of Microelectronics of the Chinese Academy of Science University of Chinese Academy of Sciences Zunyi Normal University Institute of Microelectronics and Dept.of ECE FST University of Macau

A high dynamic range and low-noise CMOS(complementary metal-oxide-semiconductor transistor)front-end interface integrated circuit(IC) with multi-channel detection is presented in this paper. Two different current detection channels, composed of a trans-impedance amplifier(tia) and an integrator-differentiator tia, are used to boost the current detection range. A capacitance-coupled instrument amplifier(CCIA) is also included to realize high precision voltage detection. A fourth-order sigma-delta modulator using a second-order loop filter and a second-order noise shaping integral quantizer is adopted to realize effective number of bits above 16 bits. The presented interface IC is implemented in 0.18-μm CMOS process with supply voltage of 3.3 V, and a proto-type electrochemical sensor platform with miniaturized sensor array is developed to verify the functionality of the interface IC. Measurement results indicate that the designed interface IC achieves 157.8 d B current detection dynamic range, and the measured input-referred current noise and voltage noise floor are 1.04 p A and 58.4 n V within 10 k Hz integration bandwidths,respectively.

关键词： Integrated circuits Sigma-delta modulation Semiconductor device measurement Voltage measurement Current measurement Noise Bandwidth

Primary study on imaging in transient ischemic attacks

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2005年第21期118卷 1812-1816页

作者： LU jie LI Kun-cheng HUA Yang Department of Radiology Xuanwu Hospital Capital University of Medical Sciences Beijing 100053 China

Background Although transient ischemic attacks （tia） is a clinical diagnosis, imaging findings are important for its diagnosis and treatment. This study evaluated the value and limitations of conventional CT, CT cerebral perfusion imaging and transcranial Doppler sonography （TCD） in patients with tia. Methods Conventional CT, CT cerebral perfusion imaging and TCD were performed in 20 patients with tia. After regular CT examination, d-0-second dynamic scans were performed on selected slice, while 40 ml of nonionic contrast materials was bolus-injected through antecubital vein with power injector. These dynamic images were processed with the perfusion software package on workstation. Cerebral blood flow （CBF） and time to peak （3~FP） were measured in specific regions of the brain. TCD was also performed in 20 patients with tia. Comparative analysis was made on the basis of the results of conventional CT, CT cerebral perfusion imaging and *** In the 20 patients with tia, conventional CT turned out to be normal. However, persisting abnormal perfusion changes corresponding to clinical symptoms were found in 13 cases with the prolonged TFP. The other 7 cases were normal. TFP of the affected side （ 11.6 ± 3.0） s was significantly prolonged （ t =4. 782 ,P 〈0. 01 ） in comparison with the contralateral side （8.8 ± 1.5 ） s. The difference in CBF was not statistically significant （t = 1. 912, P =0. 073） between the affected side [ （223.9 ±19.6） ml ·min^-1 ·L^-1 ] and the contralateral side [ （227.7 ± 19. 8） ml · min^-1· L^-1 ] . TCD revealed severe stenosis or occlusion of the carotid artery in 10 patients, arteriosclerosis in 6 patients, blood speed decrease in 2 patients, vasospasm in 1 patient. Conclusions Conventional CT can exclude intracerebral diseases. Perfusion CT provides valuable hemodynamic information and shows the extent of perfusion disturbances. TCD can demonstrate abnormalities of the involved arteries in patients with tia. The combination of these three

关键词： transient ischemic attacks computerized tomography perfusion transcranial Doppler sonography