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Quality of Life in Living Kidney Donors Grenoble Teaching Hospital (France)

Open Journal of Nephrology 2024年第3期14卷 313-323页

作者： Manzan edwige Anastasie Wognin Abdoul Yannick Gonan Kéhi Jonathan Kpan Monlet Cyr Guei Konan Nguessan Michel Christ Ziahy Reine Marie tia weu melan.e Bourhaïma Ouattara Lionel Rostaing Department of Internal Medicine Nephrology Hemodialysis Teaching Hospital of Bouak Bouak Ivory Coast Medical Sciences Training and Research Unit Alassane Ouattara University Bouak Ivory Coast Nephrology Hemodialysis and Kidney Transplantation Department Yopougon Teaching Hospital Abidjan Ivory Coast Medical Sciences Training and Research Unit Flix Houphouet Boigny University Abidjan Ivory Coast Department of Internal Medicine Teaching Hospital of Abidjan Abidjan Ivory Coast Department of Nephrology Hemodialysis Apheresis and Renal Transplantation Grenoble Teaching Hospital Grenoble France

Context: Kidney transplantation is today the standard treatment for patients suffering from chronic end-stage renal failure. Living kidney donation offers many advantages for the recipient, but requires a subject without comorbidities to undergo surgery. The aim of this study was to assess the quality of life and psychosocial experience of living kidney donors after donation. Methods: This was a cross-sectional study with an analytical aim, involving living kidney donors during the period from January 2016 to April 2019 at CHUGA. (University Hospital Center of Grenoble Alpes in France). Results: Our study shows that out of 88 donors, 70 responded to our questionnaires, representing a prevalence of 80.5%. The average age of our donors was 55.6 years with a female predominance. Seven out of eight domains of the SF36 score had a good quality of life after donation and the donation did not alter their psychosocial experience. The majority of our donors expressed their pride and enthusiasm, did not regret having saved a life, and this experience was considered positive. Conclusion: Kidney donation does not have a negative impact on quality of life and psychosocial life. The majority of donors do not regret their donation. The dissemination of such results could make it possible to increase the number of kidney transplants from living donors in France, especially in our African countries where the management of eSRD remains a real public health problem.

关键词： Quality of Life Kidney Donors Psychosocial Life

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Phenazines:Natural products for microbial growth control

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hLife 2024年第3期2卷 100-112页

作者： Cátia A Sousa Marta Ribeiro Francisca Vale Manuel Simões ISeP/P.PORTO School of EngineeringPolytechnic of PortoPortoPortugal LePABe-Laboratory for Process engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoPortoPortugal ALiCe-Associate Laboratory in Chemical engineering Faculty of EngineeringUniversity of PortoPortoPortugal

The unprecedented problem of antibiotic resistance has become a major challenge for public health,which has contributed to an increase in infections caused by such *** microbial infections,typically biofilm-related,are alsocoupled to an increase in human mortality and ***,the demand for new antimicrobial agents hasincreased along with the evolution of microbial resistance *** products produced by bacteria,such as phenazines,have been recognized as an important source for the development of new antimicrobial agents,through the exploitation of their capacity to increase oxidative stress in other *** are a large groupof nitrogen-containing heterocyclic compounds and are essential for several cellular processes including iron acquisition,signaling events,enzymatic processes,and biofilm ***-inspired antibiotics(i.e.,2-bromo-1-hydroxyphenazine,2,4-dibromo-1-hydroxyphenazine,bromophenazine-21,phenazine-13,and phenazine-14)are veryactive against a wide range of gram-positive and gram-negative bacteria,including those associated with severe *** this study,mechanisms of phenazine-inspired antibiotics in the cellular processes of planktonic and sessilebacteria are ***,the application of phenazine-inspired antibiotics for the eradication of multidrugresistant planktonic and biofilm bacterial infections is also reviewed.

关键词： antimicrobial agents biofilms multidrug-resistant natural products phenazines

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香椿的树木年轮宽度与超年生殖行为的相互关系:对树轮学研究的警示

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Journal of Plant ecology 2024年第1期17卷 165-171页

作者： Monique Silva Costa Thaís Jorge de Vasconcellos Claudio Sergio Lisi Arno Fritz Neves Brandes Mario Tomazello-Filho Cátia Henriques Callado Instituto de Aplicação Fernando Rodrigues da Silveira Universidade do Estado do Rio de JaneiroRua Barão de Itapagipe96.Rio Comprido 20261-005Rio de JaneiroBrazil Laboratório de Anatomia Vegetal Universidade do Estado do Rio de JaneiroRua São Francisco Xavier524Maracanã20550-013Rio de JaneiroBrazil Departamento de Biologia Universidade Federal de SergipeAv.Marechal Rondon s/n-Rosa Elze.São Cristóvão 49100-000SergipeBrazil Departamento de Biologia Geral Universidade Federal FluminenseRua Prof.Marcos Waldemar de Freitas ReisS/N.Gragoatá24210-201Rio de JaneiroBrazil escola Superior de Agricultura Luiz de Queiroz Universidade de São PauloAv.Pádua Dias11.Piracicaba 13418-900São PauloBrazil

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的... 详细信息

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的树木年轮宽度与超年生殖行为相关联。总体而言,生殖结构的发育发生在湿润的年份,在生长季初期没有出现水分亏缺。然而,在这些年份,树木年轮宽度较小。这些结果可能与树木年轮宽度与当地气候之间缺乏相关性有关。因此,我们强调在径向生长研究中纳入生殖数据的重要性,以扩大对热带森林生长变异性的理解。

关键词：植物生长策略树木年轮学树木生态学生殖权衡

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Proposals of SPT-CPT and DPL-CPT correlations for sandy soils in Brazil

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Journal of Rock Mechanics and Geotechnical engineering 2017年第6期9卷 1152-1158页

作者： Mirella Dalvi dos Santos Kátia Vanessa Bicalho Universidade Federal do espírito Santo VitóriaBrazil

Field tests in geotechnical engineering are fundamental for identification of the underground *** standard penetration test(SPT) is the most commonly used geotechnical approach. There has been an increase both in the use and application of the in situ tests: cone penetration test(CPT) and dynamic probing(DP). Several empirical SPT-CPT and dynamic probing light(DPL)-CPT correlations for sandy soils have been discussed in the literature. New SPT-CPT and DPL-CPT correlations for the sandy soils of the city of Vitoria, in the southeast of Brazil, are suggested in this paper. Statistical analyses to evaluate the quality of the data used are performed, and the suggested correlations are validated with several previous published datasets. The paper also provides some insights into SPT-CPT correlations and soil characteristics(i.e. the mean particle size and the fines fraction of the soil).

关键词： Standard penetration test(SPT) Cone penetration test(CPT) Dynamic probing light(DPL) Correlations Sands Statistical evaluations

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Prevalence of Chronic Kidney Disease and Associated Factors among HIV Patients in the era of HAART in Ivory Coast: A Cross Sectional, Analytical Study

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Open Journal of Nephrology 2023年第1期13卷 20-30页

作者： Wognin Manzan Anastasie Gonan Yannick Kpan Kehi Jonathan Koffi Reine Abdul Khatibat tia weu Mélanie Bourhaima Ouattara Internal Medicine Teaching Hospital of Bouaké Alassane Ouattara University Bouaké Ivory Coast

Background: Chronic kidney disease (CKD) may be common among HIV patients living in sub-saharan Africa due to the confluence of CKD risk factors and genetic predisposition. Preventive strategy through early detection and treatment has been advocated for CKD in Africa where majority of patients present late and cannot afford the cost of renal replacement therapy which is not widely available. The purpose of this study was to identify the prevalence and factors associated with CKD among HIV infected adults receiving HAART in a teaching hospital in Ivory Coast. Methods: This is a cross-sectional study of HIV patients on Highly Active Anti Retroviral Therapy followed at the HIV clinic of the medical out-patient department of the University teaching hospital of Bouaké from January to December 2021. CKD was defined as a serum creatinine-based estimated glomerular filtration rate ≤ 60 ml/min/1.73 m2. The collected data was analyzed by using epi Info 2002 software. Results: Four hundred and two HIV-infected adults 18 years and over were recruited during the study period. We noticed 123 (30.6%) males. The mean age was 40 years. CKD was observed in 42 (10.44) patients infected-HIV. eighty eight point three percent of patients had CD4 more than 500 cells. Low eGFR correlated with age more than 60 years old, worker in public sector, unemployed, no formal education and HIV type 2. Conclusion: Our study identified a prevalence of CKD of 10.44% by CKD ePI equations among HIV patients on HAART that attended the teaching hospital of Bouaké in Ivory Coast. early screening and follow up of renal functions is important to minimize the risk of developing end stage kidney disease.

关键词： HIV CKD Prevalence Africa

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Deposition of nanoparticles on school eyeglasses in urban and rural areas:A methodology for a more real assessment of the possible impacts

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Geoscience Frontiers 2022年第1期13卷 498-505页

作者： Kátia Martinello James C.Hower Guilherme L.Dotto Claudete G.Ramos Carlos e.Schnorr Diana Pinto Instituto Inanís Rua Felizardo FurtadoPorto AlegreBrazil University of Kentucky Department of Earth&Environmental SciencesLexingtonKY 40506USA University of Kentucky Center for Applied Energy Research2540 Research Park DriveLexingtonKY 40511USA Chemical engineering Department Federal University of Santa Maria97105-900 Santa MariaBrazil Department of Civil and environmental Universidad de la CostaCUCCalle 58#55–66BarranquillaAtlánticoColombia

Because incomplete confirmation is available concerning the influential role of atmosphere contamination on conjunctivitis,myopia,asthma,and allergic rhinitis in Brazil,the focus of the present work is to explore the possible relations among atmosphere contamination and eye *** that a case study on eye diseases,by way of questionnaires supplemented by the investigation of nanoparticles(NPs)on eyeglasses,the study examines the mechanisms in which NPs and ultra-fine particles are deposited on the glasses of children up to 10 years of age in urban and rural *** important connection between atmosphere contaminants and individual protection equipment justifies improving indoor school properties in order could protect children’s eyes,particularly in high-pollution/high-particulate areas.

关键词： Indoor air pollution Nanoparticles eyes health Allergic reaction Schools

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Factors Associated with echocardiographic Abnormalities in Patients with Chronic Kidney Disease in a Tertiary Hospital in Ivory Coast

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Open Journal of Nephrology 2022年第1期12卷 36-47页

作者： weu M. tia Abdoulaye Togo Manzan A. Wognin Reine M. Koffi Jonathan Kpan Bourhaima Ouattara Dame A. Gnionsahe Department of Internal Medicine University Teaching Hospital (CHU) of Bouaké Bouaké C&ocirc te d'Ivoire Nephrology-Hemodialysis Department University Teaching Hospital (CHU) of Yopougon Abidjan C&ocirc te d'Ivoire

Background: Cardiovascular risk factors (CVRF) are very frequent in pa-tients with chronic kidney disease (CKD) and impose a new environment to which the heart must adapt. Cardiac ultrasound is a non-invasive and easy-to-perform examination that allows quantitative and qualitative assessment of the anatomy and function of the heart. The objectives of this study were to describe abnormalities observed on trans-thoracic Doppler-echocar-diography and to investigate the factors associated with them. Materials and Method: This was a monocentric retrospective cross-sectional study conducted in CKD patients hospitalized in a hospital center in Côte d'Ivoire from January 2017 to December 2018. Results: One hundred and four cases were collected with a mean age of 48.87 ± 14.47 years and a sex ratio of 1.7. Patients with end-stage-renal-disease (eSRD) represented 83.7% with 55.8% of cases of chronic glomerulonephritis. Cardiovascular risk factors were 100% anemia, 84.6% inflammatory profile, 77.9% hypertension, 76.9% hypocalcemia and in 67.3% oedema. Cardiac abnormalities were observed in 78.8% of patients. Left ventricular hypertrophy (LVH), accounting for 20.2% of cases, was associated with male gender (OR 0.127 CI 0.025 - 0.643;p = 0.013) and hypertensive nephropathy (OR 0.189 CI 0.056 - 0.637;p = 0.007). History of hypertension (OR 0.297 CI 0.084 - 1.050;p = 0.060) and diabetes (OR 5.315 CI 1.260 - 22.419;p = 0.023), hypertensive nephropathy (OR 0.174 CI 0.052 - 0.585;p = 0.005) and hypocalcemia (OR 6.094 CI 1.723 - 21.559;p = 0.005) are incriminated in the development of left ventricular dilatation (LVD) which accounted for 38.5% of cases. Conclusion: Left ventricular hypertrophy and dilatation are the main echocardiographic abnormalities observed in our population.

关键词： Chronic Renal Failure Left Ventricular Hypertrophy Ivory Coast

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Prevalence and Risk Factors for Albuminuria among HIV Ivorian Children, Using the Dipstick Method

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Open Journal of Nephrology 2018年第1期8卷 1-9页

作者： tia weu melan.e Messou K. eugene Lagou Delphine Amelie Cisse Lassina Grinmaud Mylene Coulibaly Pessa Albert N’Zoue Kanga Sita Department of Nephrology CHU Yopougon Abidjan C&ocirc te d’Ivoire CePReF Abidjan C&ocirc te d’Ivoire Department of Paediatrics Chu Treichville Abidjan C&ocirc te d’Ivoire

Context: Human immunodeficiency virus (HIV) infected children are at risk of developing chronic kidney disease defined by decreased glomerular filtration rate and or proteinuria. Studies on the prevalence of and risk factors for proteinuria among HIV-infected children in sub-Saharan Africa are scarce and in Cote d’Ivoire, there is paucity of reported data. We determined the prevalence of and the risk factors for proteinuria among HIV-infected Ivorian children in both ART (antiretroviral therapy)-na?ve and ART-exposed children. Method: It was a cross-sectional bi-centric study, conducted from July 2013 to April 2014. each child’s urine was tested for proteinuria and microalbuminuria using multi test strips and mitral test, respectively. Proteinuria was defined as of significant of 1+ and above on the dipstick or the presence of microalbuminuria ≥ 20 mg/l. Results: Of the 155 HIV-infected children enrolled, there were 78 boys. Sixty seven point seven percent were treated with antiretroviral and 74.1% had treatment duration of less than 5 years. In the first dipstick test, the prevalence of proteinuria was 29% which persisted in 9.7% after 24 hour urinary protein examination. It was significantly different between the 2 groups treated and na?ve (2.8% versus 24%). The advanced CDC clinical stage emerged as the main independent determinant of proteinuria. Conclusion: Proteinuria is common in HIV-infected Ivorian children. Screening for proteinuria in HIV-infected children will help in early and treatment, and thus prevention and progression to chronic kidney disease to end-stage kidney disease.

关键词： Prevalence Proteinuria HIV Ivorian Child Antiretroviral Therapy

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Patterns of Acute Kidney Injury in a Medical emergency Department in Sub-Saharan Africa

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Open Journal of Nephrology 2022年第3期12卷 267-275页

作者： weu Mélanie tia Mélanie Anastasie Wognin Christ Zahe Reine Marie Koffi Nathanael Mey Kehi Jonathan Kpan Abdul Yannick Gonan Ouattara Bourhaima Department of Internal Medicine University Teaching Hospital of Bouaké University Alassane Ouattara of C&ocirc te d’Ivoire Bouaké C&ocirc te d’Ivoire

Background: Acute kidney injury (AKI) is a common in community and a serious outcome in hospital setting. Despite the progress of dialytic and non-dialytic therapeutic means, its mortality remains high. Our objective was to contribute to a better knowledge of how AKI managed in an emergency medical ward in an African country located in the southern part of the Sahara. Patients and Methods: We conducted a retrospective study from January 1 to December 31, 2019, conducted at the emergency department of the University Teaching Hospital of Bouake, on cases of AKI. Results: During the study period, we collected 221 cases of AKI out of a total of 1778 files giving a prevalence of 12.4%. The mean age was 54 ± 19 years. A male predominance with a sex ratio of 1.4 was observed. The main past histories were hypertension in 40.4%, cardiac disease in 16.9%, and diabetes in 14.3%. The patients in were classified in 63.8% of cases as stage I, in 22.1% as stage II and in 14.1% as stage III according to the AKIN criteria. AKI was functional in 93.2% of cases. Hemodialysis was indicated in 15 (6.8%) patients, but only 3 (1.4%) underwent it. The mortality rate was 45.2%. Factors associated with mortality were: creatinine level greater than or equal to 30 mg/l, sepsis and impaired vigilance. Conclusion: Acute renal failure was frequent in subjects under 60 years old. Its mechanism of occurrence is functional and therefore it can be prevented by vascular filling. The majority of patients were seen at AKIN Stage I. The outcome was favorable in more than one third of the cases and the mortality rate remains high.

关键词： AKI African Setting High Mortality

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Post Hepatitis C Cirrhosis in Sub-Sahara Kidney Transplant, Treated with Sofosbuvir/Ledipasvir: Report of Case and Review of Literature

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Open Journal of Nephrology 2017年第4期7卷 95-100页

作者： Tsevi Yawovi Mawufemo Lagou Amelie Delphine tia weu melan.e Coulibaly Pessa Nawo Albert Cherif Ibrahima Guei Monlet Cyr Ackoundou-N’Guessan Kan Clement Nephrology and Dialysis Department of Teaching Hospital Sylvanus Olympio University of LomeLomeTogo Nephrology Hemodialysis and Organ Transplant Departement of Yopougon Teaching HospitalUniversity Felix Houphouet BoignyAbidjanCote d’Ivoire

Background: Viral hepatitis C is a major public health problem in the world. The advent of direct-acting antivirals has revolutionized the taking in charge and prognosis of patients infected with the hepatitis C virus. The interest of this presentation is to draw attention to the problem of therapeutic care posed by viral hepatitis C in kidney transplant patients in C?te d’Ivoire, a country with limited resources where all direct-acting antivirals are not yet available. Patient observation: We report the case of a kidney transplant of 52 years old, chronic bearer of viral hepatitis C virus who after his kidney transplant presented, decompensated active cirrhosis. A treatment based on Sofosbuvir 400 mg/Ledipasvir 90 mg in this patient with genotype 2 for 12 weeks was initiated. A sustained virological response was observed 12 weeks after the end of treatment. Conclusion: Direct-acting antivirals offer the possibility of antiviral C treatment without interferon or ribavirin in cirrhotic renal transplant.

关键词： C?te D’Ivoire Direct-Acting Antivirals Kidney Transplantation Viral Hepatitis C

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