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Stroke Epidemiological Study at the Centre Hospitalier Universitaire (CHU) de Cocody in Abidjan, Côte D’Ivoire

Journal of Biosciences and medicines 2023年第12期11卷 287-303页

作者： Abdoulaye Bâ tiémélé eugène atayi Amonchyépo Ablan Berth Assi UFR Biosciences Université Félix Houphou&eumlt-Boigny Abidjan C&ocircte d’Ivoire UFR Sciences médicales Université Félix Houphou&eumlt-Boigny Abidjan C&ocircte d’Ivoire

Background: Recent literature reported a recurrent increase in hemorrhagic stroke (HS) rates in low- and middle-income countries. However, the causes and mechanisms of the rising HS rates are unknown. To address these issues, the present epidemiological study was carried out in the neurovascular unit of the neurology department at the Centre Hospitalier Universitaire (CHU) de Cocody in Abidjan (Africa). methods: The study included 60 patients hospitalized from January 1 to December 31, 2016, who underwent brain CT (computerized tomography) scans. We examined the medical records and survey forms in these patients with acute stroke (within 7 days) admitted to the neurovascular Unit receiving only stroke patients. In these patients, we explored stroke distribution according to socio-demographic variables: age, gender and socio-professional categories. In addition, common risk factors were assessed. Results: In Côte d’Ivoire, our studies showed an ischemic stroke (IS) rate of 66.67% and a hemorrhagic stroke (HS) rate of 33.33%. Our studies indicated that stroke particularly affects the 40 - 60 age group. Then, stroke frequency has fallen in the 30 - 40 and 60 - 70 age groups, becoming rare in relatively young (70 years) subjects. In the sample analyzed, stroke occurred in women (56.67%) compared with men (43.33%). However, there was no gender-specific predilection for stroke. In addition, 90% of strokes occur in the working population and 10% in the non-working population. Arterial hypertension was the highest medical risk factor among patients (66.13%), compared with the other risk factors i.e. alcohol (17.42%), smoking (12.90%), previous stroke (9.67%), diabetes (6.65%), heart disease (6.65%) and dyslipidemia (3.23%). Specifically, hypertension was the main risk factor causing HS (45%) and IS (21.66%) in patients. Conclusion: Stroke particularly affected socio-economically active subjects (aged 40 - 60) in Africa, which were subjected to high prevalence of hemorrhagic

关键词： Hemorrhagic Stroke Ischemic Stroke Age Gender Hypertension Alcohol African Studies

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Effects of Ovariectomy and 17β-Estradiol Replacement on the Activity of Dopamine D2 Receptors in the Selection of macronutrients Carbohydrates, lipids and Proteins in Females Rats

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Journal of Biosciences and medicines 2023年第5期11卷 76-110页

作者： Brahima Bamba Seydou Silué tiémélé eugène atayi Antoine Némé Tako laboratoire de neurosciences UFR Biosciences Université Félix Houphou&eumlt-Boigny Abidjan C&ocircte d’Ivoire Service de neurologie UFR Des Sciences Médicales Centre Hospitalier et Universitaire (CHU) de Cocody Abidjan C&ocircte d’Ivoire

17β-estradiol modulates the activity of D2 receptors in the regulation of food intake and body weight. The functional lack of 17β-estradiol in postmenopausal women could create a dietary imbalance and cause body weight gain. This study aimed to better understand the interferences that could exist between 17β-estradiol, D2 receptors and the selection of carbohydrate, fat and protein consumption, as well as their consequences on body weight gain by using an animal model of the menopause. Ovariectomy exacerbates the consumption of foods rich in lipids. Thus confirming an inhibitory action of 17β-estradiol (E2) on the consumption of these types of foods. This consumption stimulates body weight gain, which is promoted by the high caloric content of these foods and not by the amount consumed. Our results showed a direct involvement of D2 receptors in food choice. This choice would be made according to the two (2) isoforms of the D2 receptors. The D2/BR isoform directs towards a high carbohydrate consumption, without causing a gain in body weight. While D2/SUl, promotes high fat food consumption, causing an increase in body weight. In women, 17β-estradiol modulates the activity ratio between these two D2 receptor isoforms to ensure energy and homeostatic balance, stabilizing food intake and body weight.

关键词： 17β-Estradiol D2 Receptors Bromocriptine Sulpiride Carbohydrates lipids Proteins Body Weight menopause Obesity

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Crosstalk between androgen signaling and the chemokine receptor CXCR4:a novel strategy to promote myelin regeneration

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neural Regeneration Research 2025年第9期20卷 2581-2582页

作者： marianne Bardy-lagarde Narimène Asbelaoui Abdel mouman Ghoumari UmR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

multiple sclerosis(mS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).mS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

关键词： myelin CXCR4

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High voltage electrical treatments can eco-efficiently promote the production of high added value peptides during chymotryptic hydrolysis of β-lactoglobulin

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Food Bioscience 2022年第3期47卷 197-210页

作者： Rock-Seth Agoua laurent Bazinet Jacinthe Thibodeau eugène Vorobiev Nabil Grimi Sergey mikhaylin Institute of Nutrition and Functional Foods (INAF) Dairy Research Center (STELA)Food Science DepartmentUniversité LavalQuébecQCCanada laboratory of Food Sustainability (EcoFoodlab) Food Science DepartmentUniversité LavalQuébecQCCanada laboratoire de Transformation Alimentaire et Procédés Électro-membranaires (lTAPEm) Food Science DepartmentUniversité LavalQuébecQCCanada University of Technology of Compiègne Laboratory of Agro-industrial technologiesCompiègneFrance

Chymotryptic hydrolysis of β-lactoglobulin (β-lg) leads to the release of a wide range of biofunctional ***,the proteolysis of native β-lg is limited due to its compact globular structure,thus ending with low yields of *** our previous study showed that eco-efficient High Voltage Electric Treatments (HVET),namely Pulsed Electric Fields (PEF) and Electric Arc (ARC),of β-lg substantially improved its enzymatic hydrolysis,no information regarding the nature of released peptides is available up to ***,the time-dependent release of peptides and the dynamics of this release were discussed in the current *** analysis of the final hydrolysates showed that chymotrypsinolysis of HVET samples released 19% more peptides with higher concentration than the native and preheated ***,1-min HVET were found to be more efficient than 10-min ones as they led to the release of bioactive peptides (even without chymotrypsin) with higher eco-efficiency scores.

关键词： β-lactoglobulin Peptides High-voltage electrical treatments Eco-efficiency Chymotrypsin Hydrolysis.

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Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-Shou Kuo Kuan-Hsun lin Ying-Yi Chen Yuan-ming Tsai ti-Hui Wu Hsu-Kai Huang Tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUmmARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin lung transplantation Post-transplant complications Case report

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark l.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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Disaster Risk Resilience:Conceptual Evolution,Key Issues,and Opportunities

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International Journal of Disaster Risk Science 2022年第3期13卷 330-341页

作者： marie-Hélène Graveline Daniel Germain Institut des Sciences de l’Environnement(ISE) Universitédu QuébecàMontréalMontréalH3C 3P8Canada Department of Geography Universitédu QuébecàMontréalMontréalH3C 3P8Canada

Resilience has become a cornerstone for risk management and disaster ***,it has evolved extensively both etymologically and conceptually in time and across scientific *** concept has been(re)shaped by the evolution of research and practice *** the opposite of vulnerability for a long time,resilience was first defined as the ability to resist,bounce back,cope with,and recover quickly from the impacts of *** avoid the possible return to conditions of vulnerability and exposure to hazards,the notions of post-disaster development,transformation,and adaptation(build back better)and anticipation,innovation,and proactivity(bounce forward)were then ***,resilience is characterized by a multitude of components and several *** present a selection of 25 components used to define resilience,and an interesting linkage emerges between these components and the dimensions of risk management(prevention,preparedness,response,and recovery),offering a perspective to strengthen resilience through the development of *** its potential,resilience is subject to challenges regarding its operationalization,effectiveness,measurement,credibility,equity,and even its ***,it offers applicability and opportunities for local communities as well as an interdisciplinary look at global challenges.

关键词： Community Disaster risk Resilience Sustainable development

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SYNTHESIS OF SOlUBlE POlY(3,4-DIHYDROXY-o-TOlYlEne):REDOX POlYmER

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Chinese Journal of Polymer Science 2006年第1期24卷 41-46页

作者： Sad moulay Fatima m'zyène laboratoire de Chimie-Physique moléculaire et macromoléculaire Faculté des Sciences de l'Ingénieur Département de Chimie Industrielle Université de BlidaRoute de SoumèaB.P.270Blida 09000Algeria. laboratoire de Chimie-Physique moléculaire et macromoléculaire Faculté des Sciences de l'Ingénieur Département de Chimie Industrielle Université de BlidaRoute de SoumaB.P.270Blida 09000Algeria.

Conventional chloromethylation, paraformaldehyde/hydrogen chloride in acetic acid medium, was applied to 1,2- dimethoxybenzene. Chloroform-soluble poly（3,4-dimethoxy-o-tolylene） was obtained with an intrinsic viscosity of 0.034 dl g^-1. The polymer was evaluated as a condensation redox polymer precursor formed by a Friedel-Crafts reaction. Cleavage of the methoxy groups present in this polymer resulted in poly（3,4-dihydroxy-o-tolylene） which manifested a great air-oxidation resistance. The redox property of the latter polymer was found to be 1017 mV by potentiometric titration with 0.05 N ceric ammonium nitrate at 25℃. This midpotential was compared to that of catechol, a monomeric analogue, under the same titration conditions.

关键词： Poly(3,4-dimethoxy-o-tolylene) Poly(3,4-dihydroxy-o-tolylene) Redox polymer.

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal michele l Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

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Continuous leaderless synchronization control of multiple spacecraft on SO(3)

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Astrodynamics 2021年第3期5卷 279-291页

作者： ti Chen State Key laboratory of mechanics and Control of mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 211106China

This paper presents a solution to the leaderless consensus of multiple spacecraft on SO(3)under a connected undirected *** algorithm is proposed to generate an undirected tree graph from a connected undirected communication topology.A distributed observer is designed to estimate the desired attitude and angular velocity for each spacecraft under the generated tree *** adaptive controller with a general connected undirected graph is developed to complete the synchronization *** with zero and nonzero final angular velocities are *** proofs and numerical simulations are presented to demonstrate the effectiveness of the proposed controllers.

关键词： leaderless synchronization distributed observer SO(3) adaptive controller

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