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Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical management

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Journal of Pharmaceutical Analysis 2024年第1期14卷 16-38页

作者： nguyen Quang Thu nguyen Tran Nam Tien nguyen Thi Hai Yen thuc-Huy Duong nguyen Phuoc Long Huy Truong nguyen Department of Pharmacology and PharmacoGenomics Research Center Inje University College of MedicineBusan47392Republic of Korea Department of Chemistry University of EducationHo Chi Minh City700000Viet Nam Faculty of Pharmacy Ton Duc Thang UniversityHo Chi Minh City700000Viet Nam

The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB *** strategies to facilitate drug combinations,including pharmacokinetics-guided dose optimization and toxicology studies of first-and second-line anti-TB drugs have also been introduced and *** chromatography-mass spectrometry(LC-MS)has arguably become the gold standard in the analysis of both endo-and exo-genous *** technique has been applied successfully not only for therapeutic drug monitoring(TDM)but also for pharmacometabolomics *** improves the effectiveness of treatment,reduces adverse drug reactions,and the likelihood of drug resistance development in TB patients by determining dosage regimens that produce concentrations within the therapeutic target *** on TDM,the dose would be optimized individually to achieve favorable *** is essential in generating and validating hypotheses regarding the metabolism of anti-TB drugs,aiding in the discovery of potential biomarkers for TB diagnostics,treatment monitoring,and outcome *** article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two ***,we discussed the advantages and disadvantages of this technique in practical *** pressing need for non-invasive sampling approaches and stability studies of anti-TB drugs was ***,we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies(pharmacometrics,drug and vaccine developments,machine learning/artificial intelligence,among others)to encapsulate in an all-inclusive approach to improve treatment outcomes of TB patients.

关键词： Tuberculosis Therapeutic drug monitoring LC-MS MIPD Pharmacometabolomics Precision medicine

Photocatalytic degradation of antibiotic sulfamethizole by visible light activated perovskite LaZnO_(3)

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Journal of Environmental Sciences 2024年第10期144卷 212-224页

作者： Bui The Huy XCuong nguyen Vu Khac Hoang Bui nguyen Ngoc Tri Iqra Rabani nhu Hoa Thi Tran Quang Viet Ly Hai Bang Truong Major of Biomedical Engineering Division of Smart HealthcareCollege of Information Technology and ConvergencePukyong National UniversityBusan 48513Korea Center for Advanced Chemistry Institute of Research and DevelopmentDuy Tan UniversityDa Nang 550000Viet Nam Faculty of Environmental and Chemical Engineering Duy Tan UniversityDa Nang 550000Viet Nam Department of Environment and Energy Sejong UniversitySeoul 05006Korea Lab of Computational Chemistry and Modelling Department of ChemistryFaculty of Natural SciencesQuy Nhon UniversityQuy NhonViet Nam Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Korea Faculty of Materials Science and Technology University of ScienceHo Chi Minh City 700000Viet Nam Vietnam National University Ho Chi Minh City 700000Viet Nam Department of Environmental Engineering Seoul National University of Science and TechnologySeoul 01811Korea Optical Materials Research Group Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityViet Nam Faculty of Applied Technology School of TechnologyVan Lang UniversityHo Chi Minh CityViet Nam

In thiswork,the perovskite LaZnO_(3) was synthesized via sol-gel method and applied for photocatalytic treatment of sulfamethizole(SMZ)antibiotics under visible light *** was almost completely degraded(99.2%±0.3%)within 4 hr by photocatalyst LaZnO3 at the optimal dosage of 1.1 g/L,with amineralization proportion of 58.7%±0.4%.The efficient performance of LaZnO_(3) can be attributed to itswide-range light absorption and the appropriate energy band edge levels,which facilitate the formation of active agents such as·O_(2)^(−),h^(+),and·*** integration of RP-HPLC/Q-TOF-MS and DFT-based computational techniques revealed three degradation pathways of SMZ,which were initiated by the deamination reaction at the aniline ring,the breakdown of the sulfonamidemoieties,and a process known as Smile-type rearrangement and SO2 *** toxicity of SMZ and the intermediateswere analyzed by quantitative structure activity relationship(QSAR),indicating the effectiveness of LaZnO_(3)-based photocatalysis in preventing secondary pollution of the intermediates to the ecosystem during the degradation *** visible-light-activated photocatalyst LaZnO_(3) exhibited efficient performance in the occurrence of inorganic anions and maintained high durability across multiple recycling tests,making it a promising candidate for practical antibiotic treatment.

关键词： Perovskite Antibiotics Photocatalysis Density functional theory Toxicity

Prevalence and outcomes of neonates with severe COVID-19:An observational study at Children’s Hospital 1 in Ho Chi Minh City,Vietnam

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Asian Pacific Journal of Tropical Medicine 2024年第9期17卷 392-399,I0001页

作者： Phung nguyen The nguyen Tran Thanh thuc nguyen Thanh Hung Ngo Ngoc Quang Minh Dang Quoc Duy Tran Minh nhut nguyen Hoang Dung Tran nguyen Ai Nuong Dinh nguyen Cam Tu Department of Pediatrics University of Medicine and Pharmacy at Ho Chi Minh cityHo Chi Minh CityVietnam Children’s Hospital 1 Ho Chi Minh CityVietnam Pediatric Department School of MedicineVietnam National University Ho Chi Minh CityVietnam

Objective:To evaluate the impact of the severe COVID-19 pandemic on neonates and develop strategies to improve their ***:We conducted an observational cross-sectional study at Children's Hospital 1(CH1)from July 25,2021,to May 31,*** neonates who had fever or respiratory symptoms or were born from mothers with COVID-19 and had a positive RT-PCR SARS-CoV-2 result would be *** classified neonates with COVID-19 into 2 groups:mild/moderate and severe for *** between groups were analyzed using Fisher's exact test/Chi-square test for categorical variables and Student's t-test/Wilcoxon Rank Sum test for continuous ***:This study included 88 newborns who had positive RT-PCR SARS-CoV-2 *** severity COVID-19 rate among neonatal cases was found to be 13.6%(12/88),with a corresponding mortality rate of 1.1%(1/88).All severe cases showed lung abnormalities as evident on chest X-ray *** addition to respiratory symptoms,a higher incidence of gastrointestinal manifestations,such as vomiting and diarrhea,was observed in the severe group,indicating a compelling *** administration of anticoagulant and anti-inflammatory drugs in the study group resulted in a satisfactory outcome with no significant ***:The COVID-19 pandemic has had a substantial impact on the well-being of *** management of COVID-19 in this population presents significant challenges.

关键词： COVID-19 Neonate Anti-inflammatory Anticoagulant

Effect of Freeze-Thaw and Urea in Solubility of GPC3-Csub Protein Expressed in Escherichia coli

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Journal of Biosciences and Medicines 2024年第4期12卷 288-297页

作者： Xuan-Truc Chu-Dao Kim-Tuyen Huynh-Dam Dang-thuc Ngo-Luong Quang-Luan Le Thanh-Thao Vo-nguyen Department of Medical Biotechnology Biotechnology Center of Ho Chi Minh City Ho Chi Minh City Vietnam

Glypican-3 is a protein encoded by the Glypican-3 gene located on human X chromosome (Xq26), composed of two subunits, a 40 kDa N-terminal subunit, and a 30 kDa C-terminal subunit. Glypican-3 is a currently potential target molecule for liver cancer treatments because of its over-expression and growth effects on hepatocellular carcinoma (HCC). This study examined the expression and purification of a C-terminal subunit of Glypican-3 protein (GPC3-Csub) due to its application in both diagnosis and therapy for hepatocellular carcinoma. The gene encoding for GPC3-Csub was successfully cloned into plasmid pET28a fused with an affinity tag composed of six consecutive histidine residues (His-tag). Recombinant protein GPC3-Csub was expressed in Escherichia coli BL21 (DE3) in the condition of adding 3% ethanol with IPTG induction. GPC3-Csub was extracted using repeated freeze-thaw cycles with lysozyme, and inclusion bodies were solubilized by 8M Urea, SDS 10% in pH 12. His-tag fused GPC3-Csub proteins allowed it to be purified by affinity chromatography method using the Nickel-nitrilotriacetic acid (Ni-NTA) column. High expression of GPC3-Csub was confirmed by Coomassie staining and western-blot. GPC3-Csub could be isolated with a Ni-NTA column and have a purity of about 90%.

关键词： Glypican-3 Affinity Chromatography Inclusion Body Liver Cancer

Transfer Learning for Disease Diagnosis from Myocardial Perfusion SPECT Imaging

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Computers, Materials & Continua 2022年第12期73卷 5925-5941页

作者： Phung nhu Hai nguyen Chi Thanh nguyen Thanh Trung Tran Trung Kien Institute of Information Technology AMSTHanoi11307Vietnam Department of Medical Equipment 108 Military Central HospitalHanoi11610Vietnam

Coronary artery disease(CAD)is one of the most common pathological conditions and the major global cause of *** perfusion imaging(MPI)using single-photon emission computed tomography(SPECT)is a non-invasive method and plays an essential role in diagnosing ***,there is currently a shortage of doctors who can diagnose using SPECT-MPI in developing countries,especially *** on deploying machine learning and deep learning in supporting CAD diagnosis has been noticed for a long ***,these methods require a large dataset and are therefore time-consuming and *** study aims to develop a cost-effective and high-performance CAD classification model to support doctors in these *** this paper,we propose a transfer learning framework for a multi-stage training process with different learning *** process consists of two training stages:a warming up stage in which all layers of a pre-trained model(on ImageNet dataset)are frozen;and a finetuning stage in which a small amount of the top layers are unfrozen and then retrained with a lower learning *** dataset for this study consists of the polar maps from 218 *** popular CNN-based pre-trained models have been investigated,and ResNet152V2-based model has obtained the highest performances with an accuracy of 95.5%,area under the receiver operating characteristic curve(AUC)score 0.932,sensitivity 94.4%,precision 96.4%,and F1-score 95.2%.These performances are competitive or even better than all state-of-the-art approaches in terms of classification accuracy and *** also apply the class activation mapping technique to help explain the model’s predictions and increase the model’s reliability,proving capable of assisting the SPECT image readers in the CAD diagnosis.

关键词： Coronary artery disease deep learning transfer learning SPECTMPI polar maps

数字经济驱动下创新生态系统空间演化与迭代机制研究

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科技创业月刊 2024年第7期37卷 34-42页

作者：徐雪娇阮氏如龚众北华大学经济管理学院吉林省吉林市132013

数字经济的发展不仅改变了创新生态系统的理论基础和行为逻辑,也改变了创新生态系统的结构和特征,促使创新生态系统空间演化模式和迭代机制发生转变。基于数字经济理论和创新生态系统理论,探索了数字经济驱动下创新生态系统空间演化与... 详细信息

数字经济的发展不仅改变了创新生态系统的理论基础和行为逻辑,也改变了创新生态系统的结构和特征,促使创新生态系统空间演化模式和迭代机制发生转变。基于数字经济理论和创新生态系统理论,探索了数字经济驱动下创新生态系统空间演化与迭代机制,并构建理论模型,得出以下结论:第一,在数字经济的驱动下,创新生态系统的创新要素高匹配性、创新网络优化性、创新边界延展性、创新平台打造便捷性特征更加明显;第二,数字经济驱动下创新生态系统呈现放射状、凝聚状、网络状、点状的空间演化模式;第三,数字经济驱动下创新生态系统的迭代呈现出螺旋上升型、思维驱动型、技术引领型、周期扩张型4种机制。

关键词：数字经济创新生态系统空间演化迭代机制

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One and the same androgen for all?towards designer androgens

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Asian Journal of Andrology 1999年第1期1卷 21-28页

作者： Louis J G Gooren nhu Thanh nguyen Division of Andrology Department of Endocrinology Hospital of the Vrije Universiteit Amsterdam The NetherlandsDepartment of Urology Binh Dan Hospital Ho Chi Minh City Vietnam

The introduction of designer oestrogens as a treatment modality in hormone replacement in women has invited toconsider the concept of compounds with selective androgenic effects for male hormone replacement therapy. The fullspectrum of the actions of testosterone may not be necessary of even undesired for certain indications for testosteronetreatment. To define for what indications certain androgenic properties are desired and undesired more insight in basicandrogen (patho)physiology is required. There is convincing evidence that aromatization of androgenic compounds tooestrogens might be an advantage for maintenance of bone mass and it might also mitigate negative effects of androgenson biochemical parameters of cardiovascular risks; the potentially negative effects of oestrogens on prostate pathology inageing men needs further elucidation. While the role of dihydro-testosterone (DHT) for the male sexual differentiationand for pubertal sexual maturation is evident, its role in mature and ageing males seems less significant or may even beharmful. It is, however, of note that a negative effect of DHT on prostate pathophysiology is certainly not *** male contraception a progestational agent with strong androgenic properties might be an asset. For most of theandrogenic actions the critical levels of androgens are not well established. The latter is relevant since the large amountof androgen molecules required for its biological actions (as compared to oestrogens)is an impediment in androgenreplacement modalities. There may be room for more biopotent androgens since delivery of large amounts of androgenmolecules to the circulation poses problems for treatment modalities.

关键词： androgens synthetic androgens designer drugs

DENSITY ESTIMATES FOR SOLUTIONS OF STOCHASTIC FUNCTIONAL DIFFERENTIAL EQUATIONS

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Acta Mathematica Scientia 2019年第4期39卷 955-970页

作者： nguyen Tien DUNG Ta Cong SON Tran Manh CUONG nguyen Van TAN Trinh nhu QUYNH Department of Mathematics FPT University Hoa Lac High Tech Park Hanoi Vietnam Department of Mathematics VNU Hanoi University of Science 334 Nguyen Trai Thanh Xuan Hanoi Vietnam Department of Foundation Academy of Cryptography Techniques Hl Chien Thang Thanh Tri Hanoi Vietnam Military Information Technology Institute 17 Hoang Sam Cau Giay Hanoi Vietnam

In this article, we investigate the density of the solution to a class of stochastic functional differential equations by means of Malliavin calculus. Our aim is to provide upper and lower Gaussian estimates for the d... 详细信息

关键词： Stochastic functional differential equations density estimates Malliavin calculus

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Process of establishing design requirements and selecting alternative configurations for conceptual design of a VLA

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Chinese Journal of Aeronautics 2017年第2期30卷 738-751页

作者： Bo-Young Bae Sangho Kim Jae-Woo Lee nhu Van nguyen Bong-Cheul Chung Department of Aerospaee Information Engineering Konkuk University Seoul 143-701 Republic of Korea Konkuk Aerospace Design Airworthiness Research Institute Konkuk University Seoul 143-701 Republic of Korea

In this study,a process for establishing design requirements and selecting alternative configurations for the conceptual phase of aircraft design has been *** proposed process uses system-engineering-based requirement-analysis techniques such as objective tree,analytic hierarchy process,and quality function deployment to establish logical and quantitative ***,in order to perform a logical selection of alternative aircraft configurations,it uses advanced decision-making methods such as morphological matrix and technique for order preference by similarity to the ideal *** addition,a preliminary sizing tool has been developed to check the feasibility of the established performance requirements and to evaluate the flight performance of the selected *** present process has been applied for a two-seater very light aircraft（VLA）,resulting in a set of tentative design requirements and two families of VLA configurations：a high-wing configuration and a low-wing *** resulting set of design requirements consists of three categories：customer requirements,certification requirements,and performance *** performance requirements include two mission requirements for the flight range and the endurance by reflecting the customer *** flight performances of the two configuration families were evaluated using the sizing tool developed and the low-wing configuration with conventional tails was selected as the best baseline configuration for the VLA.

关键词： Aircraft configuration Conceptional design Design requirements Requirement analysis Very light aircraft (VLA)

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