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Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis

Bioactive Materials 2023年第9期27卷 231-256页

作者： Akriti Nepal huong D.N.Tran Nam-Trung nguyen Hang thu Ta Queensland Micro-and Nanotechnology Centre Griffith UniversityNathanQueensland4111Australia Australian Institute for Bioengineering and Nanotechnology University of QueenslandSt LuciaQueensland4072Australia Bioscience Discipline School of Environment and ScienceGriffith UniversityNathanQueensland4111Australia

In traumatized patients, the primary cause of mortality is uncontrollable continuous bleeding and unexpected intraoperative bleeding which is likely to increase the risk of complications and surgical failure. High expansion sponges are effective clinical practice for the treatment of wound bleeding (irregular/deep/narrow) that are caused by capillaries, veins and even arterioles as they possess a high liquid absorption ratio so can absorb blood platelets easily in comparison with traditional haemostasis treatments, which involve compression, ligation, or electrical coagulation etc. When in contact with blood, haemostatic sponges can cause platelet adhesion, aggregation, and thrombosis, preventing blood from flowing out from wounds, triggering the release of coagulation factors, causing the blood to form a stable polymerized fibre protein, forming blood clots, and achieving the goal of wound bleeding control. Haemostatic sponges are found in a variety of shapes and sizes. The aim of this review is to facilitate an overview of recent research around haemostatic sponge materials, products, and technology. this paper reviews the synthesis, properties, and characteristics of haemostatic sponges, together with the haemostasis mechanisms of haemostatic sponges (composite materials), such as chitosan, cellulose, gelatin, starch, graphene oxide, hyaluronic acid, alginate, polyethylene glycol, silk fibroin, synthetic polymers silver nanoparticles, zinc oxide nanoparticles, mesoporous silica nanoparticles, and silica nanoparticles. Also, this paper reviews commercial sponges and their properties. In addition to this, we discuss various in-vitro/in-vivo approaches for the evaluation of the effect of sponges on haemostasis .

关键词： Haemostatic sponge Characteristics Mechanism Haemostasis Nanoparticles

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Polygonatum kingianum rhizome extract alleviates collagen antibody-induced arthritis by modulating proinflammatory cytokine production in mice

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Asian Pacific Journal of Tropical Biomedicine 2020年第11期10卷 490-495页

作者： Huyen Do thi Thanh Phuong Ngo thi Hien nguyen thi thu Nga nguyen thi Hung Le Ngoc Thao Dothi Ha Le Minh Graduate University of Science and Technology Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Institute of Natural Products Chemistry Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Hanoi Open University101 nguyen Hien str Hai Ba Trung Dist.HanoiVietnam Laboratory of Bioassay Institute of BiotechnologyVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Chemistry Lab Project Center for Research and Technology transferVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam

Objective: To evaluate the anti-arthritic effects of Polygonatum kingianum rhizome extract using both in vitro and in vivo ***: Lipopolysaccharide-induced RAW 264.7 macrophages were treated with an ethanol extract of Polygonatum kingianum rhizomes at different concentrations to determine nitric oxide and prostaglandin E2(PGE2) production. For in vivo study, Polygonatum kingianum ethanol extract was further investigated for its antiinflammatory effect in a mouse model with collagen antibodyinduced arthritis. Phytochemical study of Polygonatum kingianum ethanol extract was also ***: Saponins(142 mg/g total yield) was the main component in the Polygonatum kingianum ethanol extract. 5α,8α-ergosterol peroxide,(E,E)-9-oxooctadeca-10,12-dienoic acid and 3-(2?-hydroxy-4?-methoxy-benzyl)-5,7-dihydroxy-8-methyl-chroman-4-one were isolated from the extract. Polygonatum kingianum ethanol extract exhibited potential anti-inflammatory effects by inhibiting nitric oxide and PGE2 production in RAW 264.7 cells in a dosedependent manner. The level of arthritis in mice with collagen antibody-induced arthritis was significantly reduced(P<0.01) after treatment with Polygonatum kingianum ethanol extract, particularly at a dose of 1 000 mg/kg body weight. Besides, the extract demonstrated the regulatory effects on serum tumor necrosis factoralpha, interleukin-6, and interleukin-10 in treated ***: Polygonatum kingianum ethanol extract has beneficial effects on inflammatory cytokine regulation and PGE2 inhibition in an experimental mouse model with collagen antibody-induced arthritis. The phytochemical screening reveals that the saponin, as the main component, and sterols(daucosterol and 5α,8α-ergosterol peroxide) from Polygonatum kingianum ethanol extract may contribute to its promising in vitro and in vivo anti-inflammatory activities.

关键词： inflammatory cytokine PGE2

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Research on The Development Trend and Countermeasures of Vietnam-China Trade Deficit

Research on The Development Trend and Countermeasures of Vie...

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作者： nguyen thi THANH thu 合肥工业大学

学位级别：硕士

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Implementation and assessment of diverse strategies for physical activity promotion in Vietnam--A case report

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Journal of Sport and Health Science 2018年第1期7卷 42-49页

作者： Gabriella Beckvid-Henriksson thu Hoai nguyen Julia Kilhed Agnes Nordstrom Sofie Svensson thi Thanh huong Tran Ingeborg Van Der Ploeg Carl Johan Sundberg Department of Physiology & Pharmacology Karolinska Instituter Stockholm 17177 Sweden Department of Neurobiology Care Sciences' and Society Division of Physiotherapy Karolinska Institutet Huddinge 14183 Sweden National Geriatric Hospital Ha Noi 100000 Vietnam department of Ethics & Social Medicine Hanoi Medical University Ha Noi 100000 Vietnam Unit for Bioentrepreneurship Department of Learning Informatics Management and Ethics Karolinska Instituter Stockholm 17177 Sweden

Background: Regular physical activity(PA) has documented effects in prevention and treatment of many non-communicable diseases(NCDs).Physical inactivity is recognized as the fourth leading risk factor for premature death, worldwide. Despite these facts, physical inactivity is increasing,not only in high-income, but also in middle-and low-income countries. To address this negative trend, evidence-based methods to increase PA are needed. The purpose of this paper is to describe the implementation and assessment of 4 strategies designed to increase PA in ***: Four strategies were used: i) introduction and evaluation of an education and training program on the Swedish method of Physical Activity on Prescription(PAP) among health care professionals, ii) translation of the PAP evidence-based handbook, Physical Activity in the Prevention and Treatment of Disease(called FYSS in Swedish) into Vietnamese, iii) launch of a mass-media campaign to promote PA, and iv)advocacy to support development of PA guidelines in ***: The evaluation indicated that the participating health care professionals had a positive attitude to PAP. However, they also reported uncertainty in prescribing PA. FYSS was translated and disseminated successfully to health care professionals. A mass-media campaign identified the beneficial effects of PA to health care professionals, journalists, policy makers, and the public. Last, the process of developing national guidelines on PA was ***: this project led to enhanced awareness and appreciation of PA in the prevention and treatment of NCDs among health care professionals as well as initiation of national PA guidelines. Important lessons also were learned in the presentation of PAP, which will be considered when designing similar projects in the future.

关键词： Exercise prescription Guidelines and recommendations Health promotion Lower middle-income country Non-communicable diseases Physicalactivity

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Anti-inflammatory effects of alkaloid enriched extract from roots of Eurycoma longifolia Jack

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Asian Pacific Journal of Tropical Biomedicine 2019年第1期9卷 18-23页

作者： Dao thi Thanh Hien Tran Phi Long Tran Phuong Thao Jeong-Hyung Lee Duong thu Trang nguyen thi thu Minh Pham Van Cuong Do thi Ngoc Lan nguyen Hai Dang nguyen Tien Dat Deparment of Traditional Pharmacy Hanoi University of Pharmacy Department of Biochemistry College of Natural Sciences Kangwon National University Advanced Center for Bio-organic Chemistry Institute of Marine Biochemistry Vietnam Academy of Science and Technology National Institute of Drug Quality Control Center for Research and Technology Transfers

Objective: To examine the in vitro and in vivo anti-inflammatory effects of the alkaloid enriched extract(ELA) from the roots of Eurycoma longifolia. Methods: The in vitro antiinflammatory effects of ELA were evaluated by examining its inhibitory activities against nitric oxide(NO) production and inducible nitric oxide synthase(iN OS) and cyclooxygenase2(COX-2) expressions in lipopolysaccharide(LPS)-stimulated RAW264.7 cells. The level of NO produced in the culture media was determined by Griess method. The i NOS and COX-2 protein expressions were analyzed by Western blot. The in vivo effect of ELA was evaluated on LPS-induced septic shock in mice model. Mice mortality was monitored for5 days after injection of LPS. The chemical contents of the ELA were determined by using various chromatographic and spectroscopic techniques. Results: The ELA was found to exhibit a significant anti-inflammatory effect in both in vitro and in vivo models. The results demonstrated that ELA dose-dependently inhibited LPS-induced NO production as well as the protein iN OS and COX-2 expressions. In the septic shock model, ELA dose-dependently protected mice from LPS-induced mortality. Further study on the isolated components of ELA indicated that 9,10-dimethoxycanthin-6-one may contribute significantly to the antiinflammatory effects of the extract. Conclusions: These results suggest that ELA exhibits the anti-inflammatory activity via suppression of pro-inflammatory mediators such as NO, iN OS,and COX-2 and protects mice from LPS-induced mortality in septic shock model.

关键词： Eurycoma longifolia Anti-inflammation Alkaloid 9,10-dimethoxycanthin-6-one

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N4-methylcytidine ribosomal RNA methylation in chloroplasts is crucial for chloroplast function,development,and abscisic acid response in Arabidopsis

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Journal of Integrative Plant Biology 2021年第3期63卷 570-582页

作者： Le nguyen Tieu Ngoc Su Jung Park Trinh thi huong Kwang Ho Lee Hunseung Kang Department of Applied Biology College of Agriculture and Life SciencesChonnam National UniversityGwangju 61186Republic of Korea Faculty of Forestry Agriculture Tay Nguyen UniversityBuonMaThuotDakLak63000Vietnam Center for Research Facilities Chonnam National UniversityGwangju 61186Republic of Korea

Although the essential role of messenger RNA methylation in the nucleus is increasingly understood,the nature of ribosomal RNA(rRNA)methyltransferases and the role of rRNA methylation in chloroplasts remain largely unknown.A recent study revealed that CMAL(for Chloroplast mraW-Like)is a chloroplast-localized rRNA methyltransferase that is responsible for N4-methylcytidine(m^(4)C)in 16S chloroplast rRNA in Arabidopsis *** this study,we further examined the role of CMAL in chloroplast biogenesis and function,development,and hormone *** cmal mutant showed reduced chlorophyll biosynthesis,photosynthetic activity,and growth-defect phenotypes,including severely stunted stems,fewer siliques,and lower seed *** cmal mutant was hypersensitive to chloroplast translation inhibitors,such as lincomycin and erythromycin,indicating that the m^(4)C methylation defect in the 16S rRNA leads to a reduced translational activity in ***,the stunted stem of the cmal mutant was partially rescued by exogenous gibberellic acid or *** cmal mutant grew poorer than wild type,whereas the CMAL-overexpressing transgenic Arabidopsis plants grew better than wild type in the presence of abscisic ***,these results indicate that CMAL is an indispensable rRNA methyltransferase in chloroplasts and is crucial for chloroplast biogenesis and function,photosynthesis,and hormone response during plant growth and development.

关键词： abiotic stress Arabidopsis chloroplast CMAL RNA methylation rRNA methylation

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A study implementing real-time PCR to identify Strongyloides species of third-stage larvae in human stool samples from Southern Vietnam

Infectious Medicine

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Infectious Medicine 2023年第3期2卷 229-236页

作者： Le Duc Vinh nguyen Kim Thach Huynh Hong Quang Do Nhu Binh Tran thi Duc Hanh nguyen Minh Toàn nguyen Trung Tuyen nguyen thu huong Department of Medical Parasitology Pham Ngoc Thach University of MedicineHo Chi Minh City 700000Vietnam Department of Fundamental Chemistry-Biochemistry Pham Ngoc Thach University of MedicineHo Chi Minh City 700000Vietnam Clinical Epidemiology Research Unit Institute of MalariologyParasitologyand Entomology Quy NhonBinh Dinh 55000Vietnam Department of Infectious Disease Military Hospital 103Hanoi 100000Vietnam Department of Epidemiology Hanoi University of Public HealthHanoi 100000Vietnam Department of Microbiology-Parasitology Hanoi University of Public HealthHanoi 100000Vietnam Department of Medicine University of Medicine and PharmacyVietnam National UniversityHanoi100000 Vietnam

Background:Strongyloidiasis,a neglected disease caused by intestinal nematodes of the genus,is endemic to tropical and subtropical areas such as *** methods only identify the genus,while DNA-molecular techniques are susceptible in Strongyloides *** study aims to determine the prevalence of dominant Strongyloides species among the population in Duc Hoa district,Long An,***:A cross-sectional study used 1190 stool specimens collected from July 2017 to November *** samples were transported within 2 h,stored at 2-8℃,and processed within 48 h for microscopy smear and culture at the Laboratory of Medical Parasitology,Pham Ngoc Thach University of Medicine(PNT).Then all positive samples with the above 2 methods were verified by real-time PCR ***-time PCR amplification was conducted at the Laboratory of Molecular Biology,***:Direct microscopy and modified Harada-Mori culture detected Strongyloides *** in 79/1190 sam-ples(6.6%).About 94.2%of the DNA samples were Strongyloides stercoralis,2.9%were co-infections with Strongy-loides ratti and ***,and 2.9%were patients with *** identity of 12/14 sequences was confirmed as *** with a high level of similarity(91.3%-100%)and over 98%for ***:DNA-molecular techniques and sequence analysis are highly suitable for identifying Strongyloides species isolated from stool *** is remarkable evidence of the presence of zoonosis *** disease in human,not just the known *** is likely to result in a certain proportion of people being infected by this animal-borne infectious pathogen.

关键词： Strongyloidiasis Strongyloides stercoralis Strongyloides ratti DNA-molecular techniques

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Studying Cosmological Time Variability of the Fine-Structure Constant from the Analysis of Quasar Spectra

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Journal of Modern Physics 2011年第6期2卷 533-537页

作者： Le Duc Thong nguyen thi thu huong 不详

The article has been retracted due to the investigation of complaints received against it. The substantial portions of the text came from Le Duc Thong’s former article, 'New method of searching for cos-mological time variation of the fine-structure constant', which has also been retraced by Prog. Theor. Phys. because of plagiarism. The scientific community takes a very strong view on this matter and we treat all unethical behavior such as plagiarism seriously. this paper published in Vol.2 No.6 533-537, 2011, has been removed from this site.

关键词： Determination of Fundamental Constants Observation Cosmology

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Strong limit on Δα/α from the analysis of feII absorp-tion line multiplets

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Natural Science 2011年第7期3卷 508-512页

作者： Le Duc Thong nguyen thi thu huong 不详

The article has been retracted due to the investigation of complaints received against it. The substantial portions of the text came from Le Duc Thong’s former article, 'New method of searching for cos-mological time variation of the fine-structure constant', which has also been retraced by Prog. Theor. Phys. because of plagiarism. The scientific community takes a very strong view on this matter and we treat all unethical behavior such as plagiarism seriously. this paper published in Vol.3 No.7 508-512, 2011, has been removed from this site.

关键词： Determination of Fundamental Constants Observation Cosmology

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Efficacy of 308-nm Monochromatic Excimer Lamp and Topical Tacrolimus Combination Therapy in Localized Vitiligo:A Study in Vietnam

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International Journal of Dermatology and Venereology 2023年第4期6卷 224-228页

作者： Hien thi thu Do Hao Thai Minh nguyen Takuro Kanekura National Hospital of Dermatology and Venereology Hanoi 100000Vietnam Department of Dermatology Kagoshima University Graduate School of Medical and Dental SciencesKagoshima 890-8544Japan.

Objective:Combination therapy of a 308-nm monochromatic excimer lamp and topical tacrolimus is widely used in the treatment of localized vitiligo;however,there are no published studies investigating this combination therapy in Vietnamese patients with *** study was performed to evaluate the efficacy of combined excimer lamp and topical tacrolimus therapy for patients with localized vitiligo in ***:We performed a pre-post clinical trial of 30 patients diagnosed with localized vitiligo in *** patients were treated with an excimer lamp twice weekly and with topical tacrolimus twice *** was evaluated based on the reduction rate of the vitiligo area scoring index (VASI).Data were analyzed using descriptive statistics,Fisher’s exact test,Kruskal-WallisH test,and Spearman correlation coefficient ***:After 12 weeks of treatment,response was excellent or good in 16 patients (53.3%),moderate in 8 patients (26.7%),and poor in 6 patients (20.0%).The excellent or good responses increased over time from 3 patients (10.0%) at 6 weeks to 16 patients (53.3%) at 12 weeks (P = 0.001).Earlier initiation of repigmentation was associated with a better response to treatment (r = -0.71;P = 0.020).Patients with a perifollicular repigmentation pattern responded better to treatment than those with combined or marginal repigmentation patterns (P = 0.003).Side effects occurred in 13 patients (43.3%),including burning (43.3%),pruritus (10.0%),and mild blistering (6.7%),and none of these interrupted the ***:Combination therapy with excimer lamp and topical tacrolimus appears to be effective and safe in treating patients with localized vitiligo in Vietnam.

关键词： localized vitiligo excimer lamp topical tacrolimus

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