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Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia

World Journal of Gastroenterology 2010年第4期16卷 479-483页

作者： Imen Sfar Walid ben Aleya Leila Mouelhi Houda Aouadi thouraya ben rhomdhane Mouna Makhlouf Salwa Ayed-Jendoubi Houda Gargaoui Taoufik Najjar Taieb ben Abdallah Khaled Ayed Yousr Gorgi Laboratory of Immunology Charles Nicolle HospitalTunis 1006Tunisia Department of Gastroenterology Charles Nicolle HospitalTunis 1006Tunisia

AIM:To assess the possible association between PTPN22(R620W) gene polymorphism and inflammatory bowel disease(IBD).METHODS:One hundred and sixty-four patients with IBD 105 Crohn's disease(CD) and 59 ulcerative colitis(UC) and 100 healthy controls were *** of the PTPN22 gene 1858C→T polymorphism was performed by restriction fragment length polymorphism-polymerase chain reaction with Rsa Ⅰ ***:The genotypic and allelic frequencies of(R620W) PTPN22 gene polymorphism reveal a significant association of the PTPN22 620-W allele with IBD,compared to the healthy control group(OR:17.81,95% CI:4.18-21.86,P = 0.00001).Nevertheless,nodifference in this polymorphism was found between CD and UC *** significant association was found between the frequencies of genotypes of the PTPN22 gene with either the clinical features such as sex,age,age at disease onset,and extent of colitis,or the production of serological markers(anti-Saccharomyces cerevisiae antibody in CD and perinuclear anti-neutrophil cytoplasmic antibody in UC).CONCLUSION:These observations confirm the association of IBD susceptibility with the PTPN22 1858T(620-W) allele in Tunisian patients.

关键词： Inflammatory bowel disease PTPN22 Genetic polymorphism Genetic susceptibility

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Deep Water Status in Southwestern Tunisia

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Journal of Water Resource and Protection 2016年第6期8卷 657-664页

作者： thouraya Zemni Mohsen ben Alaya Fouad Zargouni Lahmaidi Moumni Department of Geology University of Sciences Tunis Tunisia Agriculture and Water Resources Ministry Tunis Tunisia

Due to the water demand growth in southwestern Tunisia, particularly in Segui Gafsa-Tozeur area, the Tunisian Government launched a research program for new water resources in the lower Cretaceous layers within the Hauterivian and Barremian age. The present study highlights the major results of this project and defines the ability of the Barremian and Hauterivian series to be or not as good usable aquifers in this region. Seismic data show that the studied levels are located in deep trough with a very high depth. The water collected from the drilled wells in this region shows a very high salinity (80 g/l to 130 g/l) with a very low water level (끪 m/TN). These water levels are in hydrological isolation by faulting (faults trending NE-SW and NW-SE) with the Jerid area, where these layers are good water bearing. Thus, the studied series can't be considered as encouraging usable aquifers in the future. These results are crucial to make a decision and represent the guideline for research strategies in South-West Tunisia. Consequently, the government focuses on water search within the Turonian level which showed much more encouraging signs.

关键词： Southwestern Tunisia Barremian Hauterivian Aquifers Salinity

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Donnan Dialysis Removal of Nitrate from Water: Effects of Process Parameters

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American Journal of Analytical Chemistry 2015年第6期6卷 569-576页

作者： thouraya Turki Raghda Hamdi Mohamed Tlili Mohamed ben Amor Laboratory of Natural Water Treatment Centre of Water Researches and Technologies Borj Cedria Science and Technology Park Soliman Tunisia

Excess or lack of levels of nitrate in drinking water is harmful to the human health, the concentration of NO-3 ions must be maintained at 50 mg/l. Donnan dialysis (DD) used as a driving force of the concentration gradient is an effective and simple technique for nitrate removal. In this paper, the transport of nitrate through an AMX anion-exchange membrane has been studied as a function of driving ion nature, receiver phase concentration, flow rate, temperature and agitation rate under Donnan dialysis condition. It was observed that the hydrodynamic conditions and temperature were the main variables affecting the transmembrane flow. As the driving ion, the chloride ion is more efficient than the hydrogeneocarbonate ion. The systematic study of the different parameters involved showed that the nitrate removal efficiency obtained with a feed synthetic nitrate solution (62 ppm) was off 96%. This efficiency slightly decreases for a tap water containing the same nitrate concentration;it was about 84%. This can be attributed to the complex ionic composition of the natural water.

关键词： Nitrate Natural Water Donnan Dialysis Anion Exchange Membrane

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