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Overweight and obesity in hip and knee arthroplasty:Evaluation of 6078 cases

World Journal of Orthopedics 2015年第1期6卷 137-144页

作者： Daniel Guenther Stefan Schmidl Till O Klatte Harald K Widhalm Mohamed Omar Christian Krettek thorsten gehrke Daniel Kendoff Carl Haasper Orthopaedic Department Helios-Endo Klinik Hamburg Trauma Department Hannover Medical School (MHH) Department of Trauma Handand Reconstructive SurgeryUniversity Medical Center Hamburg-Eppendorf Department of Trauma Surgery Medical University of Vienna

AIM: To evaluate a possible association between thevarious levels of obesity and peri-operative characteristics of the procedure in patients who underwent endoprosthetic joint replacement in hip and knee joints. METHODS: We hypothesized that obese patients were treated for later stage of osteoarthritis, that more conservative implants were used, and the intraand perioperative complications increased for such patients. We evaluated all patients with body mass index(BMI) ≥ 25 who were treated in our institution from January 2011 to September 2013 for a primary total hip arthroplasty(THA) or total knee arthroplasty(TKA). Patients were split up by the levels of obesity according to the classification of the World Health Organization. Average age at the time of primary arthroplasty, preoperative Harris Hip Score(HHS), Hospital for Special Surgery score(HSS), gender, type of implanted prosthesis, and intra-and postoperative complications were ***: Six thousand and seventy-eight patients with a BMI ≥ 25 were treated with a primary THA or TKA. Age decreased significantly(P < 0.001) by increasing obesity in both the THA and TKA. HHS and HSS were at significantly lower levels at the time of treatment in the super-obese population(P < 0.001). Distribution patterns of the type of endoprostheses used changed with an increasing BMI. Peri- and postoperative complications were similar in form and quantity to those of the normal population. CONCLUSION: Higher BMI leads to endoprosthetic treatment in younger age, which is carried out at significantly lower levels of preoperative joint function.

关键词： Adiposity Total knee arthroplasty Total hip arthroplasty Obesity Overweight Prosthesis

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Compartment syndrome of thigh and lower leg with disruption of the popliteal vascular bundle after being run over by a 25-ton truck

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Chinese Journal of Traumatology 2013年第5期16卷 308-310页

作者： Rolf D Burghardt thorsten gehrke Daniel Kendoff Ulrich Stockle Sebastian Siebenlist Department of Orthopaedics Helios-Endo KlinikHamburg Hamburg Germany Klinik for Unfall-und Wiederherstellungschirurgie Berufsgenossenschaftlichen Unfallklinik Eberhard-Karls-Universitat Tubingen Schnarrenbergstraβe 95 72076Tubingen Germany Department of Trauma Surgery Klinikum rechts der IsarTechnische Universitat M(3nchen Germany

Compartment syndrome of the thigh is a rare condition, potentially resulting in devastating functional outcome. Increasing intracompartmental pressure which suppresses microcirculation and capillary perfusion may lead to cellular anoxia and muscle ischemia. The muscle com- partments in the thigh have a more compliant fascia and blend anatomically into the open compartments of the pelvis, thus compensating higher volumes than the compartments in the lower leg. We present a previously unreported case in which the limb of a 36-year-old man was run over by a 25- ton truck. He presented with a sensomotor deficit in his left lower leg with full paralysis of the shank muscles and ab- sence of all foot pulses. CT scan showed a huge haematoma in the thigh with active bleeding out of the popliteal artery into the haematoma which has already expanded into the muscle compartments of the lower leg. The limb had a disas- trous compartment syndrome of the thigh and lower leg with disruption of the popliteal neurovascular bundle; however, no bones in the limb were fractured. A complete fasciotomy of all the lower limb muscle compartments was immediately performed. The artery was reconstructed with interposition of the smaller saphenous vein, which was al- ready interrupted through the initial trauma.

关键词： Compartment syndromes Thigh Hemorrhage Popliteal artery Peroneal nerve

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Effect of vaccinations and school restrictions on the spread of COVID-19 in different age groups in Germany

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Infectious Disease Modelling 2024年第4期9卷 1250-1264页

作者： Christiane Dings Dominik Selzer Nicola Luigi Bragazzi Eva Mohler Markus Wenning Thomas gehrke Ulf Richter Alexandra Nonnenmacher Folke Brinkmann Tobias Rothoeft Michael Zemlin Thomas Lücke thorsten Lehr Department of Clinical Pharmacy Saarland University66123SaarbrückenGermany Department of Child and Adolescent Psychiatry Saarland University Hospital66421HomburgGermany Medical Association Westfalen-Lippe48151MünsterGermany School of Education and Psychology Siegen University57072SiegenGermany University Children's Hospital Ruhr University44791BochumGermany University Children's Hospital Airway Research Center North(ARCN)German Center for Lung Research(DZL)LübeckGermany Department of General Pediatrics and Neonatology Saarland University Hospital66421HomburgGermany

With the emergence of SARS-CoV-2,various non-pharmaceutical interventions were adopted to control virus transmission,including school ***,the introduction of vaccines mitigated not only disease severity but also the spread of *** study leveraged an adapted SIR model and non-linear mixed-effects modeling to quantify the impact of remote learning,school holidays,the emergence of Variants of Concern(VOCs),and the role of vaccinations in controlling SARS-CoV-2 spread across 16 German federal states with an age-stratified *** highlight a significant inverse correlation(Spearman's ρ=0.92,p<0.001)between vaccination rates and peak incidence rates across all age ***-parameter estimation using the observed number of cases stratified by federal state and age allowed to assess the effects of school closure and holidays,considering adjustments for vaccinations and spread of VOCs over ***,modeling revealed significant(p<0.001)differences in the virus's spread among pre-school children(0-4),children(5-11),adolescents(12-17),adults(18-59),and the elderly(60+).The transition to remote learning emerged as a critical measure in significantly reducing infection rates among children and adolescents(p<0.001),whereas an increased infection risk was noted among the elderly during these periods,suggesting a shift in infection networks due to altered caregiving ***,during school holiday periods,infection rates among adolescents mirrored those observed when schools were *** exercises based on the model provided evidence that COVID-19 vaccinations might serve a dual purpose:they protect the vaccinated individuals and contribute to the broader community's safety.

关键词： COVID-19 Vaccination Non-pharmaceutical interventions Age Mathematical modeling

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