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Effectiveness of omega-3 polyunsaturated fatty acids against microbial pathogens

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第4期19卷 253-262页

作者： Warren CHANDA thomson p.joseph Xue-fang GUO Wen-dong WANG Min LIU Miza S.VUAI Arshad A.pADHIAR Min-tao ZHONG Department of Microbiology College of Basic Medical Sciences Dalian Medical University

Microorganisms provide both beneficial and harmful effects to human beings. Beneficial effects come from the symbiotic relationship that exists between humans and microbiota, but then several human illnesses have turned some friendly microbes into opportunistic pathogens, causing several microbial-related diseases. Various efforts have been made to create and utilize antimicrobial agents in the treatment and prevention of these infections, but such efforts have been hampered by the emergence of antimicrobial resistance. Despite extensive studies on drug dis- covery to alleviate this problem, issues with the toxicity and tolerance of certain compounds and continuous microbial evolution have forced researchers to focus on screening various phytochemical dietary compounds for antimicrobial activity. Linolenic acid and its derivatives （eicosapentaenoic acid and docosahexaenoic acid） are omega-3 fatty acids that have been studied due to their role in human health, being important for the brain, the eye, the cardiovascular system, and general human growth. However, their utilization as antimicrobial agents has not been widely appreciated, perhaps due to a lack of understanding of antimicrobial mechanisms, toxicity, and route of administration. Therefore, this review focuses on the efficacy, mechanism, and toxicity of omega-3 fatty acids as alternative therapeutic agents for treating and preventing diseases associated with pathogenic microorganisms.

关键词： Linolenic acid Omega-3 fatty acid Eicosapentaenoic acid (EpA) Docosahexaenoic acid (DHA) Antimicrobial agent Fatty acid

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Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders joseph Nelson Siewe Fodjo Olivia Kamoen Luis-Jorge Amaral Amber Hadermann Chiara Trevisan Mark J.Taylor Julia Gauglitz Achim Hoerauf Yasuaki Sato Katja polman Maria-Gloria Basanez Dan Bhwana thomson Lakwo Gasim Abd-Elfarag Sebastien D.pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for Sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease prevention Ivermectin Epilepsy Nodding syndrome Treatment Children policy

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Configurable Low-power Arrays for Real-Time Recursive Filtering

Configurable Low-Power Arrays for Real-Time Recursive Filter...

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1996 3rd International Conference on Signal processing(ICSp’96)

作者： joseph Thomas SGS-thomson Microelectronics 38019 Grenoble Cedex France

＜正＞This paper explains how a linear array of a fixed number of multiply-accumuJate modules may be configured for real-time recursive filtering over a wide range of sample rates,by trading the latter for filter *** is effected by projecting the computations of multiple recursive and nonrecursive multiply-accumulate operations in infinite impulse response filtering for example,onto one physical multiply-accumulate *** projected multiply-accumulate operations are scheduled in the same sample period using a system clock mat is faster than the sample clock by a factor that equals the projection order,so that the resulting structure is maximally *** projection order（hence the system clock rate） is made configurable,and the supply voltage autoregulates correspondingly so that the system operates economically in respect of the power dissipated.

关键词： IIR filters Delay Filtering Digital signal processing Clocks Nonlinear filters processor scheduling VLIW Registers Sampling methods

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Handbook of Stem Cells

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丛书名： v. 1

2004年

作者： Robert Lanza John Gearhart Brigid Hogan Douglas Melton Roger pedersen James thomson Michael West

ISBN: (数字)9780080533735

ISBN: (纸本)9780124366435

New discoveries in the field of stem cell research have frequently appeared in the news and in scientific literature. Research in this area promises to lead to new therapies for cancer, heart disease, diabetes, and a wide variety of other diseases. This two-volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system. The editors of the Handbook of Stem Cells include: Robert Lanza, Helen Blau, John Gearhart, Brigid Hogan, Douglas Melton, Malcolm Moore, Roger pedersen, E. Donnall Thomas, James thomson, Catherine Verfaillie, Irving Weissman, and Michael West. The Editorial Board includes: W. French Anderson, peter Andrews, Anthony Atala, Jose Cibelli, Giulio Cossu, Robert Edwards, Martin Evans, Elaine Fuchs, Margaret Fuller, Fred Gage, Richard Gardner, Margaret Goodell, Ronald Green, William Haseltine, joseph Itskovitz-Eldor, Rudolf Jaenisch, Ihor Lemischka, Dame Anne McLaren, Richard Mulligan, Stuart Orkin, Martin pera, Benjamin Reubinoff, Janet Rossant, Hans Scholer, Austin Smith, Evan Snyder, Davor Solter, Alan Trounson, and Leonard Zon. This comprehensive set should be a much-needed addition to the library of students and researchers alike.

关键词： Stem cells.

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小婴儿腰椎穿刺脑脊液参考值

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中国循证儿科杂志 2019年第4期14卷 317-318页

作者： Joanna thomson Heidi Sucharew Andrea T. Cruz Lise E. Nigrovic MD, MpH Stephen B. Freedman Aris C. Garro Fran Balamuth Rakesh D. Mistry joseph L. Arms paul T. Ishimine Dina M. Kulik Mark I. Neuman Samir S. Shah 郑继翠(译) 李凯(校) Divisions of Hospital Medicine Cincinnati Children's Hospital Medical CenterCincinnatiOhio Departments of Emergency Medicine and pediatrics School of MedicineUniversity of CaliforniaSan Diego and Rady Children's Hospital-San DiegoSan DiegoCalifornia University of Toronto TorontoCanada 不详 Biostatistics and Epidemiology and lInfectious DiseasesCincinnati Children's Hospital Medical CenterCincinnatiOhio Sections of Emergency Medicine and Infectious Diseases Baylor College of MedicineHoustonTexas Division of Emergency Medicine Boston Children's HospitalBostonMassachusetts Sections of pediatric Emergency Medicine and Gastroenterology Department of PediatricsAlberta Children's Hospital Research InstituteAlberta Children's HospitalCumming School of MedicineUniversity of CalgaryCalgaryCanada Warren Alpert Medical School Brown UniversityProvidenceRhode Island perelman School of Medicine University of PennsylvaniaPhiladelphiaPennsylvania School of Medicine University of ColoradoAuroraColorado Children's Hospitals and Clinics of Minnesota MinneapolisMinnesota

研究背景既往有关脑脊液(CSF)参考值的研究为单中心研究,且样本量较小,因此其应用价值有限。研究新知这项多中心横断面调查研究确定了不同日龄段婴儿的CSF参考值,并且提供了日龄相关CSF百分位参考曲线。

关键词：参考值脑脊液小婴儿腰椎穿刺横断面调查 CSF 样本量多中心

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专家系统原理与编程 4

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丛书名：计算机科学丛书

2000年

作者：（美）（J.贾拉塔诺）joseph Giarratano （美）（G.赖利）Gary Riley 印鉴等译

附光盘 ISBN 7-980007-34-4:经美国thomson公司授权:本书介绍了专家系统的基本理论，包括知识表示、推理方法、不确定性推理及不精确推理(基于模糊逻辑)，如何使用CLIpS程序设计语言来设计基于规则的专家系统等内容。

ISBN: (数字)7111075811

ISBN: (纸本)7111075811

关键词：理论专家系统程序设计

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