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Dysregulated neutrophilic cell death in SLE:a spotlight on ferroptosis

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3375-3376页

作者： kim Ohl thomas Rauen Klaus Tenbrock Dept.of Pediatrics RWTH Aachen University52074 AachenGermany Division of Nephrology and Clinical Immunology RWTH Aachen University52074 AachenGermany

In the recent issue of Nature Immunology,Li et *** a mechanistic insight into neutrophilic cell death and its role in systemic lupus erythematosus(SLE).1 Several groups reported an altered neutrophil function and enhanced neutrophilic cell death in SLE patients that provoke a sustained interferon(IFN)production.2 In a recent issue of Nature they report that enhanced ferroptosis in neutrophils results in a breakdow. of immune tolerance in SLE.1 Ferroptosis has recently been identified as a novel type of regulated cell death that is driven by lipid *** is implicated in a variety of pathological contexts such as cancer,(neuro-)degenerative diseases,but also in immune-mediated diseases such as non-alcoholic steatohepatitis(NASH),diabetes,multiple sclerosis(MS),and asthma.3 Nevertheless,cell-specific functions of ferroptosis remained less *** are know. to spontaneously undergo cell death,w.ich is partially related to their high ROS production.

关键词： death neutrophil peroxidation

Animal plant w.rfare and secondary metabolite evolution

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Natural Products and Bioprospecting 2013年第1期3卷 1-7页

作者： Steffen w.LL Sun Hee kim Henry Johannes GRETEN thomas EFFERTH Department of Pharmaceutical Biology Institute of Pharmacy and BiochemistryJohannes Gutenberg-UniversityMainzGermany Institute of Biomedical Sciences(ICBAS) University of PortoPortugal

The enduring discussion,w.y plants produce secondary metabolites w.th pharmacologically and toxicologically active tow.rds mammals traces back to the eminent role of medicinal plants in the millennia-old history of *** recent years,the concept of an animal plant w.rfare emerged,w.ich focused on the co-evolution betw.en plants and *** a reaction to herbivory,plants developed mechanical defenses such as thorns and hard shells,w.ich paved the w.y for adapted animal *** evolved further defense systems by producing chemicals that exert toxic effects on the animals that ingest *** a result of this selective pressure,animals developed special enzymes,*** P450 monooxigenases(CYP450)that metabolize xenobiotic *** a next step in the evolutionary competition betw.en plants and animals,plants evolved to produce non-toxic pro-drugs,w.ich become toxic only after ingestion by animals through metabolization by enzymes such as *** these sequestered evolutionary developments call to mind an arms race,the term animal plant w.rfare has been *** evolutionary competition betw.en plants and animals may help to better understand the modes of action of medicinal plants and to foster the efficient and safe use of phytotherapy now.days.

关键词： natural products phytochemicals liver metabolism cytochrome P450 monooxigenase ABC-transporter herbivore

Adult hippocampal neurogenesis and its impairment in Alzheimer's disease

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Zoological Research 2022年第3期43卷 481-496页

作者： thomas A.kim Michelle DSyty Kaitlyn w. Shaoyu Ge Department of Neurobiology&Behavior SUNY at Stony BrookStony BrookNY 11794USA Medical Scientist Training Program(MSTP) Renaissance School of Medicine at SUNYStony BrookStony BrookNY 11794USA

Adult neurogenesis is the creation of new.neurons w.ich integrate into the existing neural circuit of the adult *** evidence suggests that adult hippocampal neurogenesis(AHN)persists throughout life in mammals,including *** new.orn neurons have been implicated to have a crucial role in brain functions such as learning and ***,studies have also found that hippocampal neurogenesis is impaired in neurodegenerative and neuropsychiatric ***’s disease(AD)is one of the most common forms of dementia affecting millions of *** dysfunction is a common symptom of AD patients and progressive memory loss has been attributed to the degeneration of the ***,there has been grow.ng interest in identifying how.hippocampal neurogenesis is affected in ***,the link betw.en cognitive decline and changes in hippocampal neurogenesis in AD is poorly *** this review.w. summarized the recent literature on AHN and its impairments in AD.

关键词： Hippocampal function Adult hippocampal neurogenesis Cognitive function Alzheimer’s disease Alzheimer’s disease animal models

thomasine Logia： A Collection of Sapiential Traditions

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History Research 2013年第3期3卷 165-179页

作者： David w. kim Seoul National University Seoul ROK

This paper argues the sapiential characteristic of an ancient text in the history of early Christianity. Although thomas is a creative and distinctive text for its ow. community, the major framew.rk of the Logia in a textual-statistic w.y w.s based on the traditional Sophia literature that had affected the culture, custom, and authority of the Hellenised Jew.sh societies. Then, w.at kind of scrolls, books, and w.itings could be the religio-historical sources for thomas？ How.w.s thomas transformed from those sapiential manuscripts？ w.ile three data of ＂the Pauline Sophia concept＂, ＂the sapiential Logia of Q＂, and ＂the sapiential themes of the Jew.sh apocalyptic w.itings＂ are quite relevant, the Greek fragment of Papyrus Oxyrhynchus （P. Oxy.） 654 and NHC II, 2.32：10-51：28 w.ll evince the new.insight that the ancient Logia of the thomasine community w.s not ＂the traditional Q＂, but could be ＂a new.Q＂ coming from the common （oral, or w.itten, or both） Sophia tradition, as an independently developed one.

关键词： sapiential traditions thomas Logia Sophia and Q

Semi-transparent,flexible,and electrically conductive silicon mesh by capillarity-driven w.lding of vapor-liquid-solid-grow. nanow.res over large areas

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Nano Research 2020年第5期13卷 1465-1471页

作者： thomas A.Celano Seokhyoung kim David J.Hill James F.Cahoon Department of Chemistry University of North Carolina at Chapel HillChapel HillNC 27599-3290USA

Bottom-up synthesis of semiconductor nanow.res(Nw.)by the vapor-liquid-solid(VLS)mechanism has enabled diverse technological applications for these *** metallic Nw.,how.ver,it has been challenging to form large-area interconnected Nw.***,w. generate centimeter-scale meshes of mechanically and electrically interconnected Si Nw. by sequentially grow.ng,collapsing,and joining the Nw. using a capillarity-driven w.lding *** fabricate meshes from VLS-grow. Nw. ranging in diameter from 20 to 100 nm and find that the meshes are three-dimensional w.th a thickness ranging from^1 to^10 microns depending on the Nw.*** extinction measurements reveal that the netw.rks are semi-transparent w.th a color that depends on the absorption and scattering characteristics of individual ***,active voltage contrast imaging of both centimeter-and micron-scale meshes reveals w.despread electrical *** a sacrificial layer,w. demonstrate that the mesh can be liberated from the grow.h substrate,yielding a highly flexible and transparent *** transport measurements both on the grow.h substrate and on liberated,flexible films reveal electrical conduction across a centimeter scale w.th a sheet resistance of^160-180 kΩ/square that does not change significantly upon *** the ability to encode complex functionality in semiconductor Nw. through the VLS process,w. believe these meshes of netw.rked Nw. could find application as neuromorphic memory,electrode scaffolds,and bioelectronic interfaces.

关键词： semiconductor nanow.re conductive netw.rk flexible electronics w.lding thermal annealing active-voltage contrast

Functional specialization of Nicotiana attenuata phytochromes in leaf development and flow.ring time

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Journal of Integrative Plant Biology 2017年第3期59卷 205-224页

作者： Variluska Fragoso Youngjoo Oh Sang-Gyu kim Klaus Gase Ian thomas Baldw.n Department of Molecular Ecology Max Planck Institute for Chemical Ecology Hans-Knoll-Straβe 8 D-07745 .lena Germany Center for Genome Engineering，Institute of Basic Science，Daejeon，South Korea

Phytochromes mainly function in photoau- totrophic organisms to adjust grow.h in response to fluctuating light signals. The different isoforms of plant phytochromes often display both conserved and divergent roles, presumably to fine-tune plant responses to environmental signals and optimize fitness. Here w. describe the distinct, yet partially redundant, roles of phytochromes NaPHYA, NaPHYB1 and NaPHYB2 in a w.ld tobacco species, Nicotiana attenuata using RNAi-silenced phytochrome lines. Consistent w.th results reported from other species, silencing the expression of NaPHYA or NaPHYB2 in N. attenuata had mild or no influence on plant develop- ment as long as NaPHYBI w.s functional; w.ereas silencing the expression of NaPHYB1 alone strongly altered flow.ring time and leaf morphology. Thecontribution of NaPHYB2 became significant only in the absence of NaPHYB1; plants silenced for both NaPHYB1 and NaPHYB2 largely skipped the rosette- stage of grow.h to rapidly produce long, slender stalks that bore flow.rs early： hallmarks of the shade- avoidance responses. The phenotyping of phyto- chrome-silenced lines, combined w.th sequence and transcript accumulation independent functional analysis, suggest the diversification of the phytochromes, and a dominant role of NaPHYB1 and NaPHYB2 in N. attenuata＇s vegetative and reproductive development.

关键词： James L. w.ller University of Tasmania Australia

Evaluation of Rice Seedling Tolerance to Constant and Intermittent Low.Temperature Stress

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Rice science 2012年第4期19卷 295-308页

作者： Sang-Ic kim Dong-min kim thomas H.TAI USDA-ARS Crops Pathology and Genetics Research Unit Department of Plant Sciences-Mail Stop 1University of CaliforniaDavisCA 95616USA Department of Agronomy Chungnam National UniversityDaejeon 305-764Republic of Korea

M202, IR50 and advanced backcross （BC4F6） lines carrying the cold tolerance QTLs qCTS4 and qCTS12 w.re evaluated using three low.temperature stress assays （constant, intermittent and constant w.th recovery period）. Under constant stress, tw. BC4F6 lines （MIb 4853-9 and MIb 6885-2） exhibited differences in seedling grow.h and accumulation of stress-related compounds although both carry the tw. QTLs in the IRS0 background. Differences betw.en these lines w.re also observed in the constant w.th recovery period assay, although both of them performed comparably under intermittent stress, MIb 6885-2 performed more similarly to M202 in the constant and constant w.th recovery period assays, suggesting that this line contains an introgressed region（s） not present in MIb 4853-9. The three assays w.re also applied to assess variations in cold tolerance in a set of diverse germplasms. Performance metrics and visual ratings w.re comparable for evaluating tolerance to constant stress. How.ver, differences in response to intermittent stress w.re more evident from grow.h and total chlorophyll measurements than from visual ratings. w.th regard to the constant w.th recovery period assay, about 15% of the germplasm accessions did not recover. How.ver, some lines w.ich exhibited chilling injuries of comparable severity w.re able to overcome them. This recovery phenotype may improve rice performance in the field and w.rrant further investigation.

关键词： rice seedling cold tolerance quantitative trait locus advanced backcross line low.temperature stress

Citrus black spot detection using hyperspectral imaging

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International Journal of Agricultural and Biological Engineering 2014年第6期7卷 20-27页

作者： Daegw.n kim thomas F.Burks Mark A.Ritenour Jianw.i Qin Asan Institute for Life Sciences Asan Medical CenterSongpa-guSeoul 138-736Korea Department of Agricultural&Biological Engineering University of FloridaGainesvilleFL 32611USA Indian River Research and Education Center(IRREC) University of FloridaFt.PierceFL 34945USA Environmental Microbial and Food Safety Laboratory(EMFSL) Agricultural Research ServiceU.S.Department of AgricultureBeltsvilleMD 20705USA

This paper describes the development of a hyperspectral imaging approach for identifying fruits infected w.th citrus black spot(CBS).Hyperspectral images w.re taken of healthy fruit and those w.th CBS symptoms or other potentially confounding peel conditions such as greasy spot,w.nd scar,or *** angle mapper(SAM)and spectral information divergence(SID)hyperspectral analysis approaches w.re used to classify fruit samples into tw. classes:CBS or *** classification accuracy for CBS w.th SAM approach w.s 97.90%,and 97.14% w.th *** combination of hyperspectral images and tw. classification approaches(SID and SAM)have proven to be effective in recognizing CBS in the presence of other potentially confounding fruit peel *** study result can be a reference for the non-destructive detection of fruits infected w.th citrus black spot.

关键词： citrus black spot hyperspectral imaging spectral angle mapper spectral information divergence imaging processing

Beneficial impact of lithium bis(oxalato)borate as electrolyte additive for high-voltage nickel-rich lithium-battery cathodes

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InfoMat 2023年第8期5卷 67-80页

作者： Fanglin w. Angelo Mullaliu thomas Diemant Dominik Stepien Tatjana NParac-Vogt Jae-Kw.ng kim Dominic Bresser Guk-Tae kim Stefano Passerini Helmholtz Institute Ulm(HIU) UlmGermany Karlsruhe Institute of Technology(KIT) KarlsruheGermany Department of Chemistry KU LeuvenLeuvenBelgium Department of Energy Convergence Engineering Cheongju UniversityCheongjuRepublic of Korea Chemistry Department Sapienza University of RomeRomeItaly

High-voltage nickel-rich layered cathodes possess the requisite,such as excellent discharge capacity and high energy density,to realize lithium batteries w.th higher energy ***,such materials suffer from structural and interfacial instability at high voltages(>4.3 V).To reinforce the stability of these cathode materials at elevated voltages,lithium borate salts are investigated as electrolyte additives to generate a superior cathode-electrolyte ***,the use of lithium bis(oxalato)borate(LiBOB)leads to an enhanced cycling stability w.th a capacity retention of 81.7%.Importantly,almost no voltage hysteresis is detected after 200 cycles at *** outstanding electrochemical performance is attributed to an enhanced structural and interfacial stability,w.ich is attained by suppressing the generation of micro-cracks and the superficial structural degradation upon *** improved stability stems from the formation of a fortified borate-containing interphase w.ich protects the highly reactive cathode from parasitic reactions w.th the ***,the decomposition process of LiBOB and the possible adsorption routes to the cathode surface are deduced and elucidated.

关键词： cathode electrolyte interphase electrolyte additive high voltage cathodes LiBOB nickel-rich cathodes