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Exponentially Convergent Multiscale Finite Element Method

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Communications on Applied Mathematics and Computation 2024年第2期6卷 862-878页

作者： Yifan Chen thomas Y.Hou Yixuan Wang Applied and Computational Mathematics CaltechPasadena 91106USA

We provide a concise review of the exponentially convergent multiscale finite element method(ExpMsFEM)for efficient model reduction of PDEs in heterogeneous media without scale separation and in high-frequency wave *** ExpMsFEM is built on the non-overlapped domain decomposition in the classical MsFEM while enriching the approximation space systematically to achieve a nearly exponential convergence rate regarding the number of basis *** most generalizations of the MsFEM in the literature,the ExpMsFEM does not rely on any partition of unity *** general,it is necessary to use function representations dependent on the right-hand side to break the algebraic Kolmogorov n-width barrier to achieve exponential ***,there are online and offline parts in the function representation provided by the *** online part depends on the right-hand side locally and can be computed in parallel *** offline part contains basis functions that are used in the Galerkin method to assemble the stiffness matrix;they are all independent of the right-hand side,so the stiffness matrix can be used repeatedly in multi-query scenarios.

关键词： Multiscale method Exponential convergence Helmholtz's equation Domain decomposition Nonlinear model reduction

Ferroptosis mediators vary in metabolic syndrome,type-2 diabetes,and hypercholesterolemia:A meta-analysis report

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Genes & Diseases 2024年第3期11卷 109-112页

作者： Indra Kundu Ashlesha Pande Tannishtha Das Susan Idicula-thomas Biomedical Informatics Centre Indian Council of Medical Research-National Institute for Research in Reproductive and Child HealthMumbaiMaharashtra 400012India Department of Biotechnology St.Xavier's CollegeKolkataWest Bengal 700016India

Metabolic syndrome(MetS)is a complex disorder characterized by the coexistence of phenotypes such as obesity,hypertension,hyperglycemia,high triglyceride level,and low level of high-density lipoprotein *** majorly dri... 详细信息

关键词： obesity cholesterol diabetes

How do neurons age?A focused review on the aging of the microtubular cytoskeleton

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Neural Regeneration Research 2024年第9期19卷 1899-1907页

作者： Brad Richardson thomas Goedert Shmma Quraishe Katrin Deinhardt Amritpal Mudher School of Biological Sciences University of SouthamptonSouthamptonUK Institute of Developmental and Regenerative Medicine University of OxfordOxfordUK

Aging is the leading risk factor for Alzheimer’s disease and other neurodegenerative diseases. We now understand that a breakdown in the neuronal cytoskeleton, mainly underpinned by protein modifications leading to the destabilization of microtubules, is central to the pathogenesis of Alzheimer’s disease. This is accompanied by morphological defects across the somatodendritic compartment, axon, and synapse. However, knowledge of what occurs to the microtubule cytoskeleton and morphology of the neuron during physiological aging is comparatively poor. Several recent studies have suggested that there is an age-related increase in the phosphorylation of the key microtubule stabilizing protein tau, a modification, which is known to destabilize the cytoskeleton in Alzheimer’s disease. This indicates that the cytoskeleton and potentially other neuronal structures reliant on the cytoskeleton become functionally compromised during normal physiological aging. The current literature shows age-related reductions in synaptic spine density and shifts in synaptic spine conformation which might explain age-related synaptic functional deficits. However, knowledge of what occurs to the microtubular and actin cytoskeleton, with increasing age is extremely limited. When considering the somatodendritic compartment, a regression in dendrites and loss of dendritic length and volume is reported whilst a reduction in soma volume/size is often seen. However, research into cytoskeletal change is limited to a handful of studies demonstrating reductions in and mislocalizations of microtubule-associated proteins with just one study directly exploring the integrity of the microtubules. In the axon, an increase in axonal diameter and age-related appearance of swellings is reported but like the dendrites, just one study investigates the microtubules directly with others reporting loss or mislocalization of microtubule-associated proteins. Though these are the general trends reported, there are clea

关键词： age-related changes aging cytoskeleton microtubules neuronal morphology

Modelling of the elastoplastic behaviour of the bio-cemented soils using an extended Modified Cam Clay model

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2184-2197页

作者： Xuerui Wang Christian B.Silbermann thomas Nagel Udo Nackenhorst Institute of Mechanics and Computational Mechanics Leibniz UniversitätHannoverAppelstr.9aHannover30167Germany Gesellschaft für Anlagen-und Reaktorsicherheit(GRS)gGmbH Theodor-Heuss-Straße 4Braunschweig38122Germany Geotechnical Institute Technische Universität BergakademieFreibergGustav-Zeuner-Str.1Freiberg09599Germany

An elastoplastic constitutive model based on the Modified Cam Clay(MCC)model is developed to describe the mechanical behaviour of soils cemented via microbially induced calcite precipitation(MICP).It considers the increase of the elastic stiffness,the change of the yield surface due to MICP cementation and the degradation of calcium carbonate bonds during ***,to capture the typical contraction-dilation transition in MICP soils,the original volumetric hardening rule in the MCC model is modified to a combined deviatoric and volumetric hardening *** model could reproduce a series of drained triaxial tests on MICP-treated soils with different calcium carbonate ***,we carry out a parametric study and observe numerical instability in some *** combination with an analytical analysis,our numerical modelling has identified the benefits and limitations of using MCCbased models in the simulation of MICP-cemented soils,leading to suggestions for further model development.

关键词： Microbially induced calcite precipitation(MICP) Elastoplasticity Modified cam clay(MCC) OpenGeoSys MFront Contraction-dilation transition

Paraneoplastic retinopathies: an update on pathogenesis, diagnosis and management

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Annals of Eye Science 2024年第1期9卷 34-42页

作者： Akshay S.thomas Tennessee Retina NashvilleTNUSA

The paraneoplastic retinopathies are a heterogeneous group of disorders with significant visual consequences occuring in the setting of a systemic *** conditions may be characterized by the presence of antiretinal antibodies and may predate or follow the diagnosis of an underlying *** I review the clinical findings,pathophysiology,laboratory testing and management of the paraneoplastic retinopathies:cancer-associated retinopathy(CAR),melanoma-associated retinopathy(MAR),bilateral diffuse uveal melanocytic proliferation(BDUMP)and paraneoplastic vitelliform maculopathy(PVM).The pathophysiology of the paraneoplastic retinopathies varies from molecular mimicry resulting in anti-retinal antibody production(CAR,MAR)to relases of soluble factors either by the primary tumor(BDUMP)and/or immune system in response to the primary tumor(PVM)which result in retinal and/or retinal pigment epithelium *** each condition,structural and functional multimodal retinal testing can be helpful in establishing the *** for the paraneoplastic retinopathies involves a combination of treating the underlying malignancy plus additional local and/or systemic immunosuppressive agents though no systemic therapeutic protocols *** these interventions,the retinopathy may be progressive or the retinopathy may be a harbinger of poor ***,prompt diagnosis may help identify an underlying malignancy earlier and may thus improve cancer-related survival.

关键词： Paraneoplastic retinopathy bilateral diffuse uveal melanocytic proliferation(BDUMP) cancer-associated retinopathy(CAR) vitelliform

James Hogarth Pringle and his time-honored maneuver

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 391-392页

作者： thomas M.van Gulik Department of Surgery Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

The classical method to control blood loss during parenchymal transection of the liver is the Pringle *** his landmark article in the Annals of Surgery in 1908,James Hogarth Pringle occluded the afferent vessels to the liver by compressing the hepatoduodenal ligament between his thumb and index finger(1).He applied this maneuver in eight patients who required emergency laparotomy for major hemorrhage after severe liver *** he succeeded in controlling blood loss,the eight patients he described unfortunately all *** outcome did not prevent the Annals of Surgery from publishing his report after which James Hogarth Pringle was ready to enter the‘Hall of Fame’.Vascular inflow occlusion,applied in a continuous or intermittent fashion,became the mainstay technique for reducing blood loss during liver transection,and has remained so in the present era of laparoscopic and robotic liver resection(2).

关键词： Pringle Surgery patients

The miracle transplantation of a black leg by the surgeon saints Cosmas and Damian

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 1-2页

作者： thomas M.van Gulik Department of Surgery Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

The miracle of the saints Cosmas and Damian refers to transplantation of a black leg onto a white man that took place in medieval Rome(Figure 1)(1).A sexton of a church in Rome was seriously affected by cancer in his right *** into a delirious fever,he dreamed that the holy surgeons,saint Cosmas and saint Damian,visited him and skilled as they were,decided to remove the affected leg and replace it with a healthy *** went to the grave of a recently deceased Ethiopian man and retrieved the right leg of this black man and took it to the *** sick leg of the sexton was amputated and they transplanted onto him the leg of the black *** their miracle operation,Cosmas and Damian have been elevated to patron saints of the surgical profession and many surgical societies have adopted their names in honor of them.

关键词： black Figure replace

BLE beacon-based floor detection for mobile robots in a multi-floor automation laboratory

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Transportation Safety and Environment 2024年第2期6卷 114-121页

作者： Haiping Wu Hui Liu thomas Roddelkopf Kerstin Thurow Institute of Artificial Intelligence&Robotics(IAIR) Key Laboratory of Traffic Safety on Track of Ministry of EducationSchool of Traffic and Transportation EngineeringCentral South UniversityChangshaHunan 410075China Center of Life Science Automation(celisca) 18119 Rostoc kGerman y Institute of Automation(IAT) University Rostock18119 RostockGermany

As an important task of multi-floor localization,floor detection has elicited great *** infrastructures like Wi-Fi and Bluetooth Low Energy(BLE)play important roles in floor ***,most floor detection research tends to focus on data modelling but pays little attention to the data collection system,which is the basis of wireless infrastructure-based floor *** fact,the floor detection task can be greatly simplified with proper data collection system *** this paper,a floor detection solution is developed in a multi-floor life science automation lab.A data collection system consisting of BLE beacons,a receiver node and an Internet of Things(IoT)cloud is *** features of the BLE beacon under different settings are evaluated in detail.A mean filter is designed to deal with the fluctuation of the received signal strength indicator data.A simple floor detection method without a training process was implemented and evaluated in more than 100 floor detection *** time delay and floor detection accuracy under different settings are ***,floor detection is evaluated on the H20 multi-floor transportation *** sensor nodes are installed on the robot at different *** floor detection performance with different installation heights is *** experimental results indicate that the proposed floor detection method provides floor detection accuracy of 0.9877 to 1 with a time delay of 5s.

关键词： BLE beacon floor detection multi-floor automation transportation robot

Applying Machine Learning Approach to Explore Childhood Circumstances and Self-Rated Health in Old Age-China and the US,2020-2021

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China CDC weekly 2024年第11期6卷 213-218,I0008-I0013页

作者： Shutong Huo Derek Feng thomas M.Gill Xi Chen Department of Health Society&BehaviorPublic HealthUniversity of CaliforniaIrvineCAUSA Department of Statistics and Data Science Yale UniversityNew HavenCTUS Department of Internal Medicine Yale School of MedicineNew HavenCTUS Department of Health Policy and Management Yale School of Public HealthNew HavenCTUS Department of Economics Yale UniversityNew HavenCTUS.

Introduction:Childhood circumstances impact senior health,prompting the introduction of machine learning methods to assess their individual and collective contributions to senior ***:Using health and retirement study(HRS)and China Health and Retirement Longitudinal Study(CHARLS),we analyzed 2,434 American and 5,612 Chinese participants aged 60 and *** inference trees and forests were employed to estimate the influence of childhood circumstances on self-rated health(SRH).Results:The conventional method estimated higher inequality of opportunity(IOP)values in both China(0.039,accounting for 22.67%of the total Gini coefficient 0.172)and the US(0.067,accounting for 35.08%of the total Gini coefficient 0.191).In contrast,the conditional inference tree yielded lower estimates(China:0.022,accounting for 12.79%of 0.172;US:0.044,accounting for 23.04%of 0.191),as did the forest(China:0.035,accounting for 20.35%of 0.172;US:0.054,accounting for 28.27%of 0.191).Childhood health,financial status,and regional differences were key determinants of senior *** conditional inference forest consistently outperformed others in predictive accuracy,as demonstrated by lower out-of-sample mean squared error(MSE).Discussion:The findings emphasize the need for early-life interventions to promote health equity in aging *** learning showcases the potential in identifying contributing factors.

关键词： collective inequality estimates