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Exponentially Convergent Multiscale Finite Element Method

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Communications on Applied Mathematics and Computation 2024年第2期6卷 862-878页

作者： Yifan Chen thomas Y.Hou Yixuan Wang Applied and Computational Mathematics CaltechPasadena 91106USA

We provide a concise review of the exponentially convergent multiscale finite element method(ExpMsFEM)for efficient model reduction of pDEs in heterogeneous media without scale separation and in high-frequency wave *** ExpMsFEM is built on the non-overlapped domain decomposition in the classical MsFEM while enriching the approximation space systematically to achieve a nearly exponential convergence rate regarding the number of basis *** most generalizations of the MsFEM in the literature,the ExpMsFEM does not rely on any partition of unity *** general,it is necessary to use function representations dependent on the right-hand side to break the algebraic Kolmogorov n-width barrier to achieve exponential ***,there are online and offline parts in the function representation provided by the *** online part depends on the right-hand side locally and can be computed in parallel *** offline part contains basis functions that are used in the Galerkin method to assemble the stiffness matrix;they are all independent of the right-hand side,so the stiffness matrix can be used repeatedly in multi-query scenarios.

关键词： Multiscale method Exponential convergence Helmholtz's equation Domain decomposition Nonlinear model reduction

Ferroptosis mediators vary in metabolic syndrome,type-2 diabetes,and hypercholesterolemia:A meta-analysis report

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Genes & Diseases 2024年第3期11卷 109-112页

作者： Indra Kundu Ashlesha pande Tannishtha Das Susan Idicula-thomas Biomedical Informatics Centre Indian Council of Medical Research-National Institute for Research in Reproductive and Child HealthMumbaiMaharashtra 400012India Department of Biotechnology St.Xavier's CollegeKolkataWest Bengal 700016India

Metabolic syndrome(MetS)is a complex disorder characterized by the coexistence of phenotypes such as obesity,hypertension,hyperglycemia,high triglyceride level,and low level of high-density lipoprotein *** majorly dri... 详细信息

关键词： obesity cholesterol diabetes

How do neurons age?A focused review on the aging of the microtubular cytoskeleton

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Neural Regeneration Research 2024年第9期19卷 1899-1907页

作者： Brad Richardson thomas Goedert Shmma Quraishe Katrin Deinhardt Amritpal Mudher School of Biological Sciences University of SouthamptonSouthamptonUK Institute of Developmental and Regenerative Medicine University of OxfordOxfordUK

Aging is the leading risk factor for Alzheimer’s disease and other neurodegenerative diseases. We now understand that a breakdown in the neuronal cytoskeleton, mainly underpinned by protein modifications leading to the destabilization of microtubules, is central to the pathogenesis of Alzheimer’s disease. This is accompanied by morphological defects across the somatodendritic compartment, axon, and synapse. However, knowledge of what occurs to the microtubule cytoskeleton and morphology of the neuron during physiological aging is comparatively poor. Several recent studies have suggested that there is an age-related increase in the phosphorylation of the key microtubule stabilizing protein tau, a modification, which is known to destabilize the cytoskeleton in Alzheimer’s disease. This indicates that the cytoskeleton and potentially other neuronal structures reliant on the cytoskeleton become functionally compromised during normal physiological aging. The current literature shows age-related reductions in synaptic spine density and shifts in synaptic spine conformation which might explain age-related synaptic functional deficits. However, knowledge of what occurs to the microtubular and actin cytoskeleton, with increasing age is extremely limited. When considering the somatodendritic compartment, a regression in dendrites and loss of dendritic length and volume is reported whilst a reduction in soma volume/size is often seen. However, research into cytoskeletal change is limited to a handful of studies demonstrating reductions in and mislocalizations of microtubule-associated proteins with just one study directly exploring the integrity of the microtubules. In the axon, an increase in axonal diameter and age-related appearance of swellings is reported but like the dendrites, just one study investigates the microtubules directly with others reporting loss or mislocalization of microtubule-associated proteins. Though these are the general trends reported, there are clea

关键词： age-related changes aging cytoskeleton microtubules neuronal morphology

Modelling of the elastoplastic behaviour of the bio-cemented soils using an extended Modified Cam Clay model

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2184-2197页

作者： Xuerui Wang Christian B.Silbermann thomas Nagel Udo Nackenhorst Institute of Mechanics and Computational Mechanics Leibniz UniversitätHannoverAppelstr.9aHannover30167Germany Gesellschaft für Anlagen-und Reaktorsicherheit(GRS)gGmbH Theodor-Heuss-Straße 4Braunschweig38122Germany Geotechnical Institute Technische Universität BergakademieFreibergGustav-Zeuner-Str.1Freiberg09599Germany

An elastoplastic constitutive model based on the Modified Cam Clay(MCC)model is developed to describe the mechanical behaviour of soils cemented via microbially induced calcite precipitation(MICp).It considers the increase of the elastic stiffness,the change of the yield surface due to MICp cementation and the degradation of calcium carbonate bonds during ***,to capture the typical contraction-dilation transition in MICp soils,the original volumetric hardening rule in the MCC model is modified to a combined deviatoric and volumetric hardening *** model could reproduce a series of drained triaxial tests on MICp-treated soils with different calcium carbonate ***,we carry out a parametric study and observe numerical instability in some *** combination with an analytical analysis,our numerical modelling has identified the benefits and limitations of using MCCbased models in the simulation of MICp-cemented soils,leading to suggestions for further model development.

关键词： Microbially induced calcite precipitation(MICp) Elastoplasticity Modified cam clay(MCC) OpenGeoSys MFront Contraction-dilation transition

Heterocyclic Molecules Tethered Branched polymers with Innate Immune Stimulating Activity

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CCS Chemistry 2024年第5期6卷 1278-1288页

作者： Jiayu Zhao Liping Liu Yibo Wang Zichao Huang Yu Zhang Ruirui Qiao thomas p.Davis Zhaohui Tang Wantong Song Xuesi Chen Key Laboratory of polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026 Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 Jilin Biomedical polymers Engineering Laboratory Changchun 130022 Australian Institute of Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueensland 4072

We report herein an interesting finding that heterocyclic molecules tethered branched polymers exhibit innate immune stimulating *** we conjugated a series of five-,six-,or seven-membered heterocyclic molecules to branched polyethylenimine(bpEI),over 70%of them could induce the secretion of interferon-β(IFN-β)from murine dendritic and human leukemia monocytic(DC2.4 and THp-1)cells through activating the stimulator of interferon genes(STING)*** further proved that this kind of innate stimulating activity was dependent on the macromolecular architecture as heterocyclic molecules tethered linear pEI(lpEI)or dendritic polyamidoamine(pAMAM)induced no or much less IFN-β***,we prepared a series of poly-L-lysine(pLL)-derivatives with different branches to tether with heterocyclic molecules and proved that this kind of bpEI-like structure was important in en hancing the binding affinity with STING proteins and for exhibiting innate stimulating activity.

关键词： bioactive materials polymers heterocycles branched structure immunity

paraneoplastic retinopathies: an update on pathogenesis, diagnosis and management

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Annals of Eye Science 2024年第1期9卷 34-42页

作者： Akshay S.thomas Tennessee Retina NashvilleTNUSA

The paraneoplastic retinopathies are a heterogeneous group of disorders with significant visual consequences occuring in the setting of a systemic *** conditions may be characterized by the presence of antiretinal antibodies and may predate or follow the diagnosis of an underlying *** I review the clinical findings,pathophysiology,laboratory testing and management of the paraneoplastic retinopathies:cancer-associated retinopathy(CAR),melanoma-associated retinopathy(MAR),bilateral diffuse uveal melanocytic proliferation(BDUMp)and paraneoplastic vitelliform maculopathy(pVM).The pathophysiology of the paraneoplastic retinopathies varies from molecular mimicry resulting in anti-retinal antibody production(CAR,MAR)to relases of soluble factors either by the primary tumor(BDUMp)and/or immune system in response to the primary tumor(pVM)which result in retinal and/or retinal pigment epithelium *** each condition,structural and functional multimodal retinal testing can be helpful in establishing the *** for the paraneoplastic retinopathies involves a combination of treating the underlying malignancy plus additional local and/or systemic immunosuppressive agents though no systemic therapeutic protocols *** these interventions,the retinopathy may be progressive or the retinopathy may be a harbinger of poor ***,prompt diagnosis may help identify an underlying malignancy earlier and may thus improve cancer-related survival.

关键词： paraneoplastic retinopathy bilateral diffuse uveal melanocytic proliferation(BDUMp) cancer-associated retinopathy(CAR) vitelliform

BLE beacon-based floor detection for mobile robots in a multi-floor automation laboratory

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Transportation Safety and Environment 2024年第2期6卷 114-121页

作者： Haiping Wu Hui Liu thomas Roddelkopf Kerstin Thurow Institute of Artificial Intelligence&Robotics(IAIR) Key Laboratory of Traffic Safety on Track of Ministry of EducationSchool of Traffic and Transportation EngineeringCentral South UniversityChangshaHunan 410075China Center of Life Science Automation(celisca) 18119 Rostoc kGerman y Institute of Automation(IAT) University Rostock18119 RostockGermany

As an important task of multi-floor localization,floor detection has elicited great *** infrastructures like Wi-Fi and Bluetooth Low Energy(BLE)play important roles in floor ***,most floor detection research tends to focus on data modelling but pays little attention to the data collection system,which is the basis of wireless infrastructure-based floor *** fact,the floor detection task can be greatly simplified with proper data collection system *** this paper,a floor detection solution is developed in a multi-floor life science automation lab.A data collection system consisting of BLE beacons,a receiver node and an Internet of Things(IoT)cloud is *** features of the BLE beacon under different settings are evaluated in detail.A mean filter is designed to deal with the fluctuation of the received signal strength indicator data.A simple floor detection method without a training process was implemented and evaluated in more than 100 floor detection *** time delay and floor detection accuracy under different settings are ***,floor detection is evaluated on the H20 multi-floor transportation *** sensor nodes are installed on the robot at different *** floor detection performance with different installation heights is *** experimental results indicate that the proposed floor detection method provides floor detection accuracy of 0.9877 to 1 with a time delay of 5s.

关键词： BLE beacon floor detection multi-floor automation transportation robot

Applying Machine Learning Approach to Explore Childhood Circumstances and Self-Rated Health in Old Age-China and the US,2020-2021

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China CDC weekly 2024年第11期6卷 213-218,I0008-I0013页

作者： Shutong Huo Derek Feng thomas M.Gill Xi Chen Department of Health Society&BehaviorPublic HealthUniversity of CaliforniaIrvineCAUSA Department of Statistics and Data Science Yale UniversityNew HavenCTUS Department of Internal Medicine Yale School of MedicineNew HavenCTUS Department of Health policy and Management Yale School of Public HealthNew HavenCTUS Department of Economics Yale UniversityNew HavenCTUS.

Introduction:Childhood circumstances impact senior health,prompting the introduction of machine learning methods to assess their individual and collective contributions to senior ***:Using health and retirement study(HRS)and China Health and Retirement Longitudinal Study(CHARLS),we analyzed 2,434 American and 5,612 Chinese participants aged 60 and *** inference trees and forests were employed to estimate the influence of childhood circumstances on self-rated health(SRH).Results:The conventional method estimated higher inequality of opportunity(IOp)values in both China(0.039,accounting for 22.67%of the total Gini coefficient 0.172)and the US(0.067,accounting for 35.08%of the total Gini coefficient 0.191).In contrast,the conditional inference tree yielded lower estimates(China:0.022,accounting for 12.79%of 0.172;US:0.044,accounting for 23.04%of 0.191),as did the forest(China:0.035,accounting for 20.35%of 0.172;US:0.054,accounting for 28.27%of 0.191).Childhood health,financial status,and regional differences were key determinants of senior *** conditional inference forest consistently outperformed others in predictive accuracy,as demonstrated by lower out-of-sample mean squared error(MSE).Discussion:The findings emphasize the need for early-life interventions to promote health equity in aging *** learning showcases the potential in identifying contributing factors.

关键词： collective inequality estimates

MARS and RNAcmap3:The Master Database of All possible RNA Sequences Integrated with RNAcmap for RNA Homology Search

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Genomics, proteomics & Bioinformatics 2024年第1期22卷 143-150页

作者： Ke Chen thomas Litfin Jaswinder Singh Jian Zhan Yaoqi Zhou Institute of Systems and physical Biology Shenzhen Bay LaboratoryShenzhen 518055China peking University Shenzhen Graduate School Shenzhen 518055China University of Science and Technology of China Hefei 230026China Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China Institute for Glycomics Griffith UniversitySouthportQLD 4222Australia

sequences found in the huge,integrated database of protein sequences(Big Fantastic Database).In contrast,the existing nucleotide databases were not consolidated to facilitate wider and deeper homology ***,we built a comprehensive database by incorporating the non-coding RNA(ncRNA)sequences from RNAcentral,the transcriptome assembly and metagenome assembly from metagenomics RAST(MG-RAST),the genomic sequences from Genome Warehouse(GWH),and the genomic sequences from MGnify,in addition to the nucleotide(nt)database and its subsets in National Center of Biotechnology Information(NCBI).The resulting Master database of All possible RNA sequences(MARS)is 20-fold larger than NCBI’s nt database or 60-fold larger than *** new dataset along with a new split-search strategy allows a substantial improvement in homology search over existing state-of-the-art *** also yields more accurate and more sensitive multiple sequence alignments(MSAs)than manually curated MSAs from Rfam for the majority of structured RNAs mapped to *** results indicate that MARS coupled with the fully automatic homology search tool RNAcmap will be useful for improved structural and functional inference of ncRNAs and RNA language models based on *** is accessible at https://***/omix/release/OMIX003037,and RNAcmap3 is accessible at http://***/download/.

关键词： RNA sequence database Homology search Secondary structure MARS RNAcmap3