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Do we need a new levodopa?

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Neural Regeneration Research 2016年第5期11卷 731-732页

作者： thomas müller Department of Neurology St.Joseph Hospital Berlin-Wei?ensee

Idiopathic Parkinson＇s disease（PD）is classified as a chronic progressive neurodegenerative *** each other complementing,still hypothetical aetiologies describe the predominant dopaminergic neuronal *** include gene... 详细信息

关键词： RGma COmT Do we need a new levodopa PLP GSH

Biochemical indicators for neuronal regeneration during intrathecal triamcinolone application in multiple sclerosis

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Neural Regeneration Research 2015年第3期10卷 377-379页

作者： thomas müller Sven Lütge Department of Neurology St.Joseph Hospital Berlin-Weiβensee

multiple sclerosis （mS） is a chronic inflammatory disease of the central nervous system （CNS）. Essential charac- teristics are demyelination, inflammation and neurode- generation. This process affects the white and grey matter in the CNS. mS patients experience various progression subtypes in association with the cerebral or spinal, acute inflammatory or glial sclerotic lesions （mtiller, 2009）. most patients end up in a progressive, smouldering, chronic inflammatory process （mUller, 2009）. Current predominantly used 1.5 respectively 3 Tesla mRI with Gadolinium~ application visualize the various old and acute lesions. They serve as a biological marker in com- bination with standardised assessment of brain atrophy, black holes, etc. However, mRI with a stronger magnetic 7 Tesla field with better sensitivity gave hints on an on- going, acute inflammatory, smouldering process even with Gadolinium~ enhancing acute lesions in the brain and the spinal cord in progressive, so-called relapse free mS patients （mtiller, 2009; Sinnecker et al., 2012）. Ad- ditionally, progress of mS is determined with subjective standardised clinical ratings （Sinnecker et al., 2012）. Both methods are used for the evaluation of the efficacy of relapse rate reducing drugs. These compounds, i.e., in- terferons, teriflunamide, glatiramer acetate, fingolimod, fumarate or monoclonal antibodies, preponderantly weaken the malfunction of the peripheral immune system in relapse remitting mS patients. These mS drugs share one common disadvantage. They do not stop progression or improve mS within a framework of a regenerative process. They do not enable reversal of symptoms, for in- stance functional deficits or spasticity （mtiller, 2009）.

关键词： RGma Biochemical indicators for neuronal regeneration during intrathecal triamcinolone application in multiple sclerosis EDSS

Commentary on 'Depression severity and its predictors among multiple sclerosis patients in Saudi Arabia: a cross-sectional study'

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Neuroimmunology and Neuroinflammation 2018年第6期5卷 7-9页

作者： thomas müller Department of Neurology St.Joseph Hospital Berlin-WeissenseeBerlin 13088Germany

multiple sclerosis (mS) is looked upon as chronic autoimmune *** therapeutic research focus on the prevention of relapses in association with morphological magnet resonance imaging (mRI) *** paper again describes that depression is one of the most common symptoms in *** of depression for manifestation in mS are exogenous,such as disability,or endogenous,i.e.,due to localisation of lesions,which predispose for onset of *** paper points out that depression and related neuropsychiatric symptoms,i.e.,apathy and fatigue,should not be underestimated in the clinical maintenance of mS *** paper supports the view,that further research is warranted beyond past and future ongoing trials on cognitive deficits,which frequently disregard the impact of apathy and fatigur on standardised neuropsychological testing in association with chronic intake immune system modulating *** it is promising that efforts are undertaken on standardisation of neuropsychological assessment tools,*** cognition,in trials[1],whereas the minimental State Examination score have a considerable bias by the educational level of the *** repeatedly point out,that non-cognition related signs are often essential limiting for quality of *** a result,they investigate the efficacy of already available compounds often in observational or naturalistic small trials,like in this *** point out that non-cognition related signs are often essential limiting for quality of *** a result,they investigate the efficacy of already available compounds often in observational or naturalistic small *** outcomes are frequently considered as less essential by the authorities driven evidence-based-medicine classification of *** must consider that most of the used assessment instruments are not *** are biased by the attitude and habits of the investigator.

关键词： Commentary on a cross-sectional study Depression severity

Welcome to Neuroimmunology and Neuroinflammation:a new open access journal for neuroscience

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Neuroimmunology and Neuroinflammation 2014年第1期1卷 1-2页

作者： Gang Zhao thomas müller Department of Neurology Xijing HospitalForth Military Medical UniversityXi’an 710032ShaanxiChina Department of Neurology St.Joseph Hospital Berlin-Weissensee13088 BerlinGermany

BACKGROUND The nervous and the immune system are two essential components of the human *** developing research in neuroscience and immunology demonstrated that these two systems complement and interact with each other... 详细信息

关键词： journal neuroscience cooperation

Quantitative EEG Changes in Patients with Parkinson’s Disease during Therapy with Rasagiline

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Advances in Parkinson's Disease 2014年第3期3卷 22-34页

作者： Wilfried Dimpfel Christian Oehlwein Josef Anton Hoffmann thomas müller Justus-Liebig-University Giessen c/o NeuroCode AG WetzlarGermany Neurological Ambulance GeraGermany TEVA Pharma GmbH BerlinGermany St.Joseph-Krankenhaus Berlin-WeissenseeGermany

It has been suggested that in patients with Parkinson’s disease (PD) metabolism of the mAO-B inhibitor selegiline to methamphetamine may contribute and/or exacerbate sleep problems, possibly leading to deficits of cognition. This open-label exploratory study included 30 PD patients currently being treated with selegiline (7.5 mg/day) and complaining of sleep disturbances. The aim of the study was to determine whether switching from selegiline to another mAO-B inhibitor without amphetamine-like metabolites, namely rasagiline, would improve sleep behaviour and cognitive function in PD patients. Pathologic aberrations as determined by comparison of the frequency pattern of patients to a database consisting of healthy subjects revealed an approximation of electric brain activity to normality. For verification of efficacy, a combination of questionnaires, quantitative source density EEG recording with CATEEmò and performance of two psychometric tasks (d2-test of attention and reading) during the EEG recording were done on the last day of selegiline treatment (7.5 mg/day) as well as 2 and 4 months later, during which the patients were treated with rasagiline (1 mg/day). In addition, performance of the mental tasks revealed a statistically significant (p mproved cognitive abilities at the end of the treatment period. At the same time evaluation of the psychometric test results indicated a statistical improvement with respect to the score of the d2-test (increase from 6.54 to 7.37;p m levels of methamphetamine were measured before and after intake of selegiline or rasagiline. They were correlated to alpha2 power, which is under dopaminergic control, within the temporal lobe. From these results it is concluded that the switch from selegiline to rasagiline not only improved sleep behaviour as reported separately but also had a positive effect on electric brain activity and on cognition in these patie

关键词： Rasagiline Selegiline Quantitative EEG CATEEm^(■) Parkinson’s Disease Cognition

Wavefronts and Light Cones for Kerr Spacetimes

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Journal of modern Physics 2012年第12期3卷 1882-1890页

作者： Francisco Frutos-Alfaro Frank Grave thomas müller Daria Adis Department of Physics University of Costa Rica San Pedro Costa Rica Institute for Visualization und Interactive Systems University of Stuttgart Stuttgart Germany Theoretical Astrophysics University of Tübingen Tübingen Germany

We investigate the light propagation by means of simulations of wavefronts and light cones for Kerr spacetimes. Simulations of this kind give us a new insight to better understand the light propagation in presence of massive rotating black holes. A relevant result is that wavefronts are backscattered with winding around the black hole. To generate these visualizations, an interactive computer program with a graphical user interface, called JWFront, was written in Java.

关键词： General Relativity Wavefronts Lightcones Simulations

Direct laser interference patterning of nonvolatile magnetic nanostructures in Fe60Al40 alloy via disorder‐induced ferromagnetism

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Opto-Electronic Advances 2020年第1期3卷 1-7页

作者： Philipp Graus thomas Bmöller Paul Leiderer Johannes Boneberg Nikolay I.Polushkin Department of Physics University of Konstanz78457 KonstanzGermany Institute for Physics of microstructures of RAS 603950 GSP-105 Nizhny NovgorodRussian

Current magnetic memories are based on writing and reading out the domains with opposite orientation of the magnetization ***,information can be encoded in regions with a different value of the saturation *** latter approach can be realized in principle with chemical order-disorder transitions in intermetallic ***,we study such transformations in a thin-film(35 nm)Fe60Al40 alloy and demonstrate the formation of periodic magnetic nanostructures(PmNS)on its surface by direct laser interference patterning(DLIP).These PmNS are nonvolatile and detectable by magnetic force microscopy(mFm)at room temperature after DLIP with a single nanosecond *** provide different arguments that the PmNS we observe originate from increasing magnetization in maxima of the interference pattern because of chemical disordering in the atomic lattice of the alloy at temperatures T higher than the critical temperature Tc for the order(B2)-disorder(A2)***,our simulations of the temporal evolution of a partially ordered state at T>Tc reveal that the disordering rate is significant even below the melting ***,we find that the PmNS are erasable with standard thermal annealing at T

关键词： thin films laser patterning magnetic dots magnetic memory

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大型桨轮嬉戏湖中

工业设计 2009年第6期 56-57页

作者： michael Lawton thomas müller

位于德国波恩以北莱茵河畔蒙多夫的Lux-Werft造船厂二战结束以来一直在建造游船。但是在德国西部建造战后第一艘明轮船可是不同寻常的挑战。

关键词：造船厂德国游船明轮船轴承座

前向渠道整合与绩效——交易成本经济学应用和误差概念

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四川建材 2012年第6期38卷 287-294页

作者：罗文志 malte Brettel Andreas Engelen thomas müller 中国中铁二院工程集团有限责任公司四川成都610031 德国亚琛工业大学(RWTH) ***有限公司

在分销有关文献中关于渠道整合("直接"整合的分销队伍与"间接"非整合的分销队伍)研究主要基于交易成本经济学(TCE)。一些研究已经证实,交易成本经济学在渠道整合中关键的几个交易成本因素,如交易频率等方面能预测成功。不过,也没有交易... 详细信息

在分销有关文献中关于渠道整合("直接"整合的分销队伍与"间接"非整合的分销队伍)研究主要基于交易成本经济学(TCE)。一些研究已经证实,交易成本经济学在渠道整合中关键的几个交易成本因素,如交易频率等方面能预测成功。不过,也没有交易成本经济学对公司绩效的明确影响。本研究探讨依据误差观点的交易成本经济学规律得到的绩效成果,其中误差是借用相关研究的成果。研究模式已经经过196家新公司的样本测试。研究结果表明,与早期研究结论相一致,一些渠道整合的决定,其他理论不支持的可以由交易成本经济学解释。结果也证实交易成本经济学规范价值在于与交易成本经济学的规律相一致(如资源特定性的情况下采用直接分销渠道)并对公司绩效给予积极的影响。

关键词：分销渠道整合交易成本经济学规范性观点