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Can eastern wisdom resolve western epidemics? Traditional Chinese medicine therapies and the opioid crisis

Journal of Integrative Medicine 2021年第4期19卷 295-299页

作者： thomas Efferth An-long Xu Roxana Damiescu Mita Banerjee Norbert W.Paul David Y.W.lee Department of Pharmaceutical Biology Institute of Pharmacy and BiochemistryJohannes Gutenberg University55128 MainzGermany School of Life Science Beijing University of Chinese MedicineBeijing 100029China Obama Institute of Transnational American Studies Department of English and LinguisticsJohannes Gutenberg University55128 MainzGermany Institute for the History Philosophyand Ethics of MedicineJohannes Gutenberg University Medical Center55131 MainzGermany Harvard Medical School McLean HospitalBostonMA 02115USA

The widespread use of opioids to treat chronic pain led to a nation-wide crisis in the United States. Tens of thousands of deaths annually occur mainly due to respiratory depression, the most dangerous side effect of opioids. Non-opioid drugs and non-pharmacological treatments without addictive potential are urgently required. Traditional Chinese medicine(TCM) is based on a completely different medical theory than academic Western medicine. The scientific basis of acupuncture and herbal treatments as main TCM practices has been considerably improved during the past two decades, and large metaanalyses with thousands of patients provide evidence for their efficacy. Furthermore, opinion leaders in the United States favor non-pharmacological techniques including TCM for pain management to fight the opioid crisis. We advocate TCM as therapeutic option without addictive potential and without lifethreatening side effects(e.g., respiratory depression) to treat chronic pain patients suffering from opioid misuse. The evidence suggests that:(1) opioid misuse cannot be satisfactorily managed with standard medication;(2) opinion leaders in the United States favor to consider non-opioid and nonpharmacological treatment strategies including those from TCM to treat acute and chronic pain conditions;(3) large meta-analyses provide scientific evidence for the clinical activity of acupuncture and herbal TCM remedies in the treatment of chronic pain. Future clinical trials should demonstrate the safety of TCM treatments if combined with Western medical practices to exclude negative interactions between both modalities.

关键词： Traditional Chinese medicine Acupuncture Addiction Opioid crisis Pain

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Third assessment on impacts of climate change on tropical cyclones in the Typhoon Committee Region-Part Ⅱ:Future projections

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Tropical Cyclone Research and Review 2020年第2期9卷 75-86页

作者： Eun Jeong Cha thomas R.Knutson Tsz-Cheung lee Ming Ying Toshiyuki Nakaegawa National Typhoon Center Korea Meteorological AdministrationJejuRepublic of Korea Geophysical Fluid Dynamics Laboratory/NOAA PrincetonNJUSA Hong Kong Observatory Hong KongChina Shanghai Typhoon Institute China Meteorological AdministrationShanghaiChina Meteorological Research Institute/Japan Meteorological Agency TsukubaJapan

This paper assesses published findings on projections of future tropical cyclone(TC)activity in the ESCAP/WMO Typhoon Committee Region under climate change *** assessment also estimates the projected changes of key TC metrics for a 2℃anthropogenic global warming scenario for the western North Pacific(WNP)following the approach of a WMO Task Team,together with other reported findings for this *** projections of TC genesis/frequency,most models suggest a reduction of TC frequency,but an increase in the proportion of very intense TCs over the WNP in the ***,some individual studies project an increase in WNP TC *** studies agree on a projected increase of WNP TC intensity over the 21 st *** available projections for TC related precipitation in the WNP indicate an increase in TC related precipitation rate in a warmer *** warming may also lead to changes in TC prevailing tracks.A further increase in storm surge risk may result from increases in TC *** most confident aspect of forced anthropogenic change in TC inundation risk derives from the highly confident expectation of further sea level rise,which we expect will exacerbate storm inundation risk in coastal regions,assuming all other factors equal.

关键词： Tropical cyclones Climate change Westerm North Pacifie Typhoon Comitte Projections

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Third assessment on impacts of climate change on tropical cyclones in the Typhoon Committee Region——Part Ⅰ:Observed changes, detection and attribution

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Tropical Cyclone Research and Review 2020年第1期9卷 1-22页

作者： Tsz-Cheung lee thomas R.Knutson Toshiyuki Nakaegawa Ming Ying Eun Jeong Cha Hong Kong Observatory Hong KongChina Geophysical Fluid Dynamics Laboratory/NOAA PrincetonNJUSA Meteorological Research Institute/Japan Meteorological Agency TsukubaJapan Shanghai Typhoon Institute China Meteorological AdministrationShanghaiChina National Typhoon Center Korea Meteorological AdministrationJejuRepublic of Korea

Published findings on climate change impacts on tropical cyclones(TCs)in the ESCAP/WMO Typhoon Committee Region are *** focus on observed TC changes in the western North Pacific(WNP)basin,including frequency,intensity,precipitation,track pattern,and storm *** from an updated survey of impacts of past TC activity on various Members of the Typhoon Committee are also *** TC datasets continue to show substantial interdecadal variations in basin-wide TC frequency and intensity in the *** has been encouraging progress in improving the consensus between different datasets concerning intensity trends.A statistically significant northwestward shift in WNP TC tracks since the 1980s has been *** is low-to-medium confidence in a detectable poleward shift since the 1940s in the average latitude where TCs reach their peak intensity in the WNP.A worsening of storm inundation levels is believed to be occurring due to sea level rise-due in part to anthropogenic influence-assuming all other factors ***,we are not aware that any TC climate change signal has been convincingly detected in WNP sea level extremes *** also consider detection and attribution of observed changes based on an alternative Type II error avoidance perspective.

关键词： Tropical cyclones Typhoons Climate change Typhoon Committee Western North Pacific

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A randomized controlled trial of topical tea tree preparation for MRSA colonized wounds

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International Journal of Nursing Sciences 2014年第1期1卷 7-14页

作者： Rainbow L.P.lee Polly H.M.Leung thomas K.S.Wong School of Nursing The Hong Kong Polytechnic UniversityHong Kong Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong Faculty of Health and Social Sciences The Hong Kong Polytechnic UniversityHong Kong

Background:The prevalence of MRSA(Methicillin-resistant Staphylococcus aureus)colonized wounds in home care residents is expected to grow continuously as a result of the substantial proportion of older people requiring institutionalized care due to chronic disease and declining functional status,which contribute to more frequent skin breakdown and wound *** tree oil has been claimed to have anti-bacterial,analgesic and anti-inflammatory effects that have been suggested in many in-vitro studies to have good efficacy against *** aims of this study were to evaluate the effectiveness of 10%topical tea tree preparation to eradicateMRSA and to ascertain its influence on wound healing forMRSA-colonized ***:It was a randomized controlled trial,single-blind *** with stage II or above MRSA-colonized wounds and who had given their informed consent formed the *** determined sample sizewasbasedonthe effect size of our previouspilot study,whichwas *** outcome measurements were taken for the MRSA bacterial count and wound healing condition at baseline and at 1-week intervals during the 4-week dressing intervention ***:Thirty-two participants were recruited from two non-government nursing homes,16 in the control group and 16 in the tea tree oil *** control group residents received routine saline gauze dressing,while the tea tree oil group residents received the 10%topical tea tree preparation *** the tea tree oil group,all chronic wounds that had previously been delayed in healing were healed within 28 days without adverse *** was also completely eradicated in 14(87.5%)out of 16 wounds in the group receiving the 10%topical tea tree preparation.

关键词： MRSA Topical tea tree preparation Wounds

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722 V670-4

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汽车测试报告 2009年第7期 72-73页

作者： Bill thomas lee Brimble（图）

接下来看看Murcielago那凶悍的V12能否用嗓门吓住迈凯轮一奔驰的V8。清路!

关键词： 722 V670-4 轿车车型发动机性能

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Targeted Blue Nanoparticles as Photoacoustic Contrast Agent for Brain Tumor Delineation

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Nano Research 2011年第11期4卷 1163-1173页

作者： Aniruddha Ray Xueding Wang Yong-Eun Koo lee Hoe Jin Hah Gwangseong Kim thomas Chen Daniel A. Orringer Oren Sagher Xiaojun Liu Raoul Kopelman Biophysics University of Michigan Ann Arbor MI 48109 USA Department of Radiology University of Michigan Ann Arbor MI 48109 USA Department of Chemistry University of Michigan Ann Arbor MI 48109 USA Department of Neurosurgery University of Michigan Ann Arbor MI 48109 USA Institute of Acoustics Naniing University Nanjing 210093 China

把一个肿瘤与非肿瘤的组织区分开来在癌症外科期间是一项挑战性的任务。几次尝试被做了使用可见或荧光灯的代理人在外科期间帮助一个肿瘤的可视化。我们描述一个新奇方法描出大脑肿瘤，用一种高度敏感的 photoacoustic 成像技术，那被... 详细信息

把一个肿瘤与非肿瘤的组织区分开来在癌症外科期间是一项挑战性的任务。几次尝试被做了使用可见或荧光灯的代理人在外科期间帮助一个肿瘤的可视化。我们描述一个新奇方法描出大脑肿瘤，用一种高度敏感的 photoacoustic 成像技术，那被用作一个对比代理人的指向肿瘤的蓝 nanoparticles 提高。幽灵并且在老鼠大脑上的实验，前 vivo，在描出表明 photoacoustic 成像的高敏感在集中包含对比代理人的肿瘤很比由肉眼为可视化需要降低。为 nanoparticles 的系统的察觉的限制是水(到 0.84 mol/L Coomassie 蓝染料的等价物) 里的大约 0.77 g/mL。当与强烈光的吸收对比代理人使用了时，现在的探索学习建议那 photoacoustic 成像，能由揭示肿瘤的分发和程度 intraoperatively 便于癌症外科。

关键词：光声成像脑肿瘤造影剂纳米颗粒手术过程纳米粒子考马斯亮蓝肿瘤组织

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Covariance estimation via fiducial inference

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Statistical Theory and Related Fields 2021年第4期5卷 316-331页

作者： W.Jenny Shi Jan Hannig Randy C.S.Lai thomas C.M.lee Financial Planning&Analysis MassMutualBostonMAUSA Department of Statistics&Operations Research University of North CarolinaChapel HillNCUSA Department of Statistics University of CaliforniaDavisCAUSA

As a classical problem,covariance estimation has drawn much attention from the statistical com-munity for *** work has been done under the frequentist and Bayesian *** to quantify the uncertainty of the estimators without having to choose a prior,we have developed a fiducial approach to the estimation of covariance *** upon the Fiducial Berstein-von Mises Theorem,we show that the fiducial distribution of the covariate matrix is consistent under our ***,the samples generated from this fiducial distri-bution are good estimators to the true covariance matrix,which enable us to define a meaningful confidence region for the covariance ***,we also show that the fiducial approach can be a powerful tool for identifying clique structures in covariance matrices.

关键词： covariance estimation sparsity fiducial inference cliques

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Pathological findings following radical prostatectomy in patients who are candidates for active surveillance： impact of varying PSA levels

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Asian Journal of Andrology 2011年第6期13卷 838-841页

作者： Dong Il Kang thomas L. Jang Jeongyun Jeong Eun Young Choi Kelly Johnson Dong Hyeon lee Wun-Jae Kim Isaac Yi Kim Section of Urologic Oncology and Dean and Betty Gallo Prostate Cancer The Cancer Institute of New Jersey Robert Wood Johnson Medical School New Brunswick NJ 08903 USA Department of Urology Inje University Medical School Busan 614-735 Korea Department of Urology Ewha Womans University Seoul 158-710 Korea Department of Urology Chungbuk National University College of Medicine Cheongju 361-711 Korea

Active surveillance is an acceptable treatment option in men with a low-risk prostate cancer. In the present study, we have retrospectively reviewed the outcomes of 509 men who fit the criteria for active surveillance but selected radical prostatectomy. Then, the impact of varying prostate-specific antigen （PSA） levels on the risk of upstaging and upgrading in these patients was assessed. Pathological characteristics of patients who fulfilled the inclusion criteria under three active surveillance criteria--those of the University of California-San Francisco, the National Cancer Institute and the European Association of Urology--were examined. The proportion of men who were deemed candidates for active surveillance but were subsequently upstaged or upgraded was determined. Of 509 patients, 186 （36.5%）, 132 （25.9%） and 88 （17.3%） men fulfilled the active surveillance criteria, respectively. Upgrading （Gleason scores 7-10） ranged from 32.8% to 38.6%, while upstaging （≥ pT3） ranged from 10.2% to 12.5%, depending on the three active surveillance criteria. After a median follow-up of 24 months, three patients developed a biochemical recurrence. When the impact of varying PSA levels was examined using a test for trend analysis in the context of PSA for each protocol, rates of upstaging were lower in men with PSA 〈4 ng m1-1. However, there was no impact of varying PSA levels on upgrading. In conclusion, commonly used active surveillance protocols carry the risks of upgrading and upstaging. More reliable and accurate markers are needed to better stratify the risks of men who are appropriate candidates for active surveillance.

关键词： prostatectomy prostate-specific antigen prostatic neoplasm risk

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An Integrated Systems Biology Approach Identifies ZIKV and DENV Replication

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Genomics, Proteomics & Bioinformatics 2021年第1期19卷 108-122页

作者： Guang Song Emily M.lee Jianbo Pan Miao Xu Hee-Sool Rho Yichen Cheng Nadia Whitt Shu Yang Jennifer Kouznetsova Carleen Klumpp-thomas Samuel G.Michael Cedric moore Ki-Jun Yoon Kimberly M.Christian Anton Simeonov Wenwei Huang Menghang Xia Ruili Huang Madhu Lal-Nag Hengli Tang Wei Zheng Jiang Qian Hongjun Song Guo-li Ming Heng Zhu Department of Pharmacology&Molecular Sciences Johns Hopkins School of MedicineBaltimoreMD 21205USA Department of Biological Science Florida State UniversityTallahasseeFL 32306USA Department of Ophthalmology Johns Hopkins School of MedicineBaltimoreMD 21205USA National Center for Advancing Translational Sciences National Institutes of HealthBethesdaMD 20892USA Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310016China Institute for Cell Engineering Johns Hopkins University School of MedicineBaltimoreMD 21205USA Department of Neuroscience and Mahoney Institute for Neurosciences Perelman School for MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Cell and Developmental Biology Perelman School for MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Institute for Regenerative Medicine Perelman School for MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA The Epigenetics Institute Perelman School for MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

The Zika virus(ZIKV)and dengue virus(DENV)flaviviruses exhibit similar replicative processes but have distinct clinical outcomes.A systematic understanding of virus–host protein–protein interaction networks can reveal cellular pathways critical to viral replication and disease *** we employed three independent systems biology approaches toward this ***,protein array analysis of direct interactions between individual ZIKV/DENV viral proteins and20,240 human proteins revealed multiple conserved cellular pathways and protein complexes,including proteasome ***,an RNAi screen of 10,415 druggable genes identified the host proteins required for ZIKV infection and uncovered that proteasome proteins were crucial in this ***,high-throughput screening of 6016 bioactive compounds for ZIKV inhibition yielded 134 effective compounds,including six proteasome inhibitors that suppress both ZIKV and DENV *** analyses of these orthogonal datasets pinpoint proteasomes as critical host machinery for ZIKV/DENV *** study provides multi-omics datasets for further studies of flavivirus–host interactions,disease pathogenesis,and new drug targets.

关键词： Protein–protein interaction RNAi screening Chemical genetics screening Multi-omics

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A Review of Arctic-Subarctic Ocean Linkages: Past Changes, Mechanisms, and Future Projections

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Ocean-Land-Atmosphere Research 2023年第1期2卷 134-172页

作者： Qiang Wang Qi Shu Shizhu Wang Agnieszka Beszczynska-Moeller Sergey Danilov Laura de Steur thomas W.N.Haine Michael Karcher Craig M.lee Paul G.Myers Igor V.Polyakov Christine Provost Øystein Skagseth Gunnar Spreen Rebecca Woodgate Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research(AWI) BremerhavenGermany First Institute of Oceanography and Key Laboratory of Marine Science and Numerical ModelingMinistry of Natural ResourcesQingdaoPeople’s Republic of China Shandong Key Laboratory of Marine Science and Numerical Modeling QingdaoPeople’s Republic of China Institute of Oceanology Polish Academy of SciencesSopotPoland Department of Mathematics and Logistics Jacobs UniversityBremenGermany Norwegian Polar Institute Fram CentreTromsøNorway Earth&Planetary Sciences The Johns Hopkins UniversityBaltimoreMDUSA .8Ocean Atmosphere Systems GmbH HamburgGermany Applied Physics Laboratory University of WashingtonSeattleWAUSA. Department of Earth and Atmospheric Sciences University of AlbertaEdmontonABCanada. International Arctic Research Center and College of Natural Science and Mathematics University of Alaska FairbanksFairbanksAKUSA. Finnish Meteorological Institute HelsinkiFinland. Laboratoire LOCEAN-IPSL Sorbonne Université(UPMCUniversity Paris 6)CNRSIRDMNHNParisFrance. Institute of Marine Research and Bjerknes Centre of Climate Research BergenNorway. Institute of Environmental Physics University of BremenBremenGermany.

Arctic Ocean gateway fluxes play a crucial role in linking the Arctic with the global ocean and affecting climate and marine *** reviewed past studies on Arctic-Subarctic ocean linkages and examined their changes and driving *** review highlights that radical changes occurred in the inflows and outflows of the Arctic Ocean during the ***,the Pacific inflow temperature in the Bering Strait and Atlantic inflow temperature in the Fram Strait hit record highs,while the Pacific inflow salinity in the Bering Strait and Arctic outflow salinity in the Davis and Fram straits hit record *** the ocean heat convergence from lower latitudes to the Arctic and the hydrological cycle connecting the Arctic with Subarctic seas were stronger in 2000-2020 than in ***6 models project a continuing increase in poleward ocean heat convergence in the 21st century,mainly due to warming of inflow *** also predict an increase in freshwater input to the Arctic Ocean,with the largest increase in freshwater export expected to occur in the Fram Strait due to both increased ocean volume export and decreased *** Strait sea ice volume export hit a record low in the 2010s and is projected to continue to decrease along with Arctic sea ice *** quantitatively attribute the variability of the volume,heat,and freshwater transports in the Arctic gateways to forcing within and outside the Arctic based on dedicated numerical simulations and emphasize the importance of both origins in driving the variability.

关键词： Arctic ocean Strait

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