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Jejunitis and brown bowel syndrome with multifocal carcinogenesis of the small bowel

World Journal of Gastroenterology 2015年第36期21卷 10461-10467页

作者： Martin Raithel Tilman T Rau Alexander F Hagel Heinz Albrecht thomas de Rossi thomas kirchner Eckhart G Hahn Department of Medicine 1 Friedrich-Alexander-University Erlangen-Nuremberg Department of Pathology Friedrich-Alexander University Erlangen-Nuremberg Department of Pathology Ludwig-Maximilians-University Munich

This is the first report describing a case where prolonged,severe malabsorption from brown bowel syndrome progressed to multifocally spread small bowel adenocarcinoma. This case involves a female patient who was initially diagnosed with chronic jejunitis associated with primary diffuse lymphangiectasia at the age of 26 years. The course of the disease was clinically,endoscopically,and histologically followed for 21 years until her death at the age 47 due to multifocal,metastasizing adenocarcinoma of the small bowel. Multiple lipofuscin deposits(so-called brown bowel syndrome) and severe jejunitis were observed microscopically,and sections of the small bowel showed dense lymphoplasmacytic infiltration of the lamina propria as well as blocked lymphatic vessels. After several decades,multifocal nests of adenocarcinoma cells and extensive,flat,neoplastic mucosal proliferations were found only in the small bowel,along with a loss of the mismatch repair protein MLH1 as a long-term consequence of chronic jejunitis with malabsorption. No evidence was found for hereditary nonpolyposis colon carcinoma syndrome. This article demonstrates for the first time multifocal carcinogenesis in the small bowel in a malabsorption syndrome in an enteritis-dysplasia-carcinoma sequence.

关键词： Brown bowel syndrome Carcinogenesis of the small b

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Translational research in pancreatic ductal adenocarcinoma: current evidence and future concepts

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World Journal of Gastroenterology 2014年第31期20卷 10769-10777页

作者： Stephan Kruger Michael Haas Steffen Ormanns Sibylle Bchmann Jens T Siveke thomas kirchner Volker Heinemann Stefan Boeck Department of Internal Medicine Ⅲ and Comprehensive Cancer Center Klinikum Grosshadern Ludwig-Maximilians-University of Munich Department of Pathology Ludwig-Maximilians-University of Munich Department of Internal Medicine Ⅱ Klinikum Rechts der Isar Technical University of Munich

Pancreatic ductal adenocarcinoma(PDA) is one of the major causes for cancer death worldwide. Treatment of metastatic disease remains challenging as only certain patients benefit from advances made with the intensified chemotherapy regimen folinic acid, irinotecan and oxaliplatin, the epidermal growth factor receptor inhibitor erlotinib or the recently FDA-approved nab-paclitaxel. Up to date, no established approach for prediction of treatment response or specific treatment allocation exists. Translational research was able to identify a number of potential biomarkers that might help to improve the dismal prognosis of PDA by facilitating upfront treatment allocation. This topic highlight is focused on current evidence on potential biomarkers for tumor biology, prognosis and prediction of treatment efficacy.

关键词： Biomarker Erlotinib Gemcitabine Human equilibrative nucleoside transporter 1 KRAS Nab-paclitaxel p53 Pancreatic cancer SMAD4 SPARC

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柔性可靠的链式传动

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现代制造 2006年第7期 45-45页

作者： thomas M.kirchner

链式运输系统在直喷柴油发动机油泵组装时的快速运输中起到关键作用。

关键词：链式传动可靠柔性快速运输运输系统机油泵直喷

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Mental health status in veterans residing in rural versus non-rural areas: results from the veterans’ health study

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Military Medical Research 2021年第1期8卷 79-89页

作者： Joseph J.Boscarino Charles R.Figley Richard E.Adams thomas G.Urosevich H.Lester kirchner Joseph A.Boscarino Clinical Psychology Department William James CollegeNewtonMA 02459USA School of Social Work Tulane UniversityNew OrleansLA 70112USA Department of Sociology Kent State UniversityKentOH 44242USA Ophthalmology Service Geisinger ClinicMount PoconoPA 18344USA Department of Population Health Sciences Geisinger Clinic100 N.Academy Avenue44-00DanvillePA 17822USA

Background: The majority of Veterans Affair(VA) hospitals are in urban areas. We examined whether veterans residing in rural areas have lower mental health service use and poorer mental health ***: Veterans with at least 1 warzone deployment in central and northeastern Pennsylvania were randomly selected for an interview. Mental health status, including posttraumatic stress disorder(PTSD), major depression, alcohol abuse and mental health global severity, were assessed using structured interviews. Psychiatric service use was based on self-reported utilization in the past 12 months. Results were compared between veterans residing in rural and non-rural areas. Data were also analyzed using multivariate logistic regression to minimize the influence by confounding ***: A total of 1730 subjects(55% of the eligible veterans) responded to the survey and 1692 of them had complete geocode information. Those that did not have this information(n=38), were excluded from some analyses. Veterans residing in rural areas were older, more often of the white race, married, and experienced fewer stressful events. In comparison to those residing in non-rural areas, veterans residing in rural areas had lower global mental health severity scores;they also had fewer mental health visits. In multivariate logistic regression, rural residence was associated with lower service use, but not with PTSD, major depression, alcohol abuse, and global mental health severity score after adjusting confounding factors(e.g., age, gender, marital status and education).Conclusions: Rural residence is associated with lower mental health service use, but not with poor mental health in veterans with former warzone deployment, suggesting rural residence is possibly protective.

关键词： Veterans Rural Risk factors PTSD Alcohol abuse Depression Service use Census data

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Temperature effect on foamability, foam stability, and foam structure of milk

Temperature effect on foamability, foam stability, and foam ...

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中国化学会第十五届胶体与界面化学会议

作者： Martin kirchner Katrin Oetjen Christine Bilke-Krause Mania Madani thomas Willers KRüSS GmbH Institute of Chemical Engineering and Macromolecular Chemistry University of Hamburg

＜正＞Milk is a daily consumed product and the best known example of a natural colloidal *** intriguing foaming properties are important *** processing dairy-based foams such as whipped cream or cappuccino-style *** foams are colloidal systems formed by air bubbles,water,and surface active *** is a very important parameter influencing

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Tip-and Laser-based 3D Nanofabrication in Extended Macroscopic Working Areas

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Nanomanufacturing and Metrology 2021年第3期4卷 132-148页

作者： Ingo Ortlepp thomas Frohlich Roland FuBl Johann Reger Christoph Schaffel Stefan Sinzinger Steffen Strehle ReneTheska Lena Zentner Jens-Peter Zollner Ivo WRangelow Carsten Reinhardt Tino Hausotte Xinrui Cao Oliver Dannberg Florian Fern David Fischer Stephan Gorges Martin Hofmann Johannes kirchner Andreas Meister Taras Sasiuk Ralf Schienbein Shraddha Supreeti Laura Mohr-Weidenfeller Christoph Weise Christoph Reuter Jaqueline Stauffenberg Eberhard Manske Institute of Process Measurement and Sensor Technology Technische Universitat IlmenauEhrenbergstrasse 2998693 IlmenauGermany Control Engineering Group Technische Universitat IlmenauIlmenauGermany Optical Engineering Group.Technische Universitat Ilmenau IlmenauGermany Microsystems Technology Group.Technische Universitat Ilmenau IlmenauGermany Precision Engineering Group.Technische Universitat Ilmenau IlmenauGermany Compliant Systems Group Technische Universitat IlmenauIlmenauGermany Micro-and Nanoelectronic Systems Group Technische Universitat IlmenauIlmenauGermany Nanoscale Systems Group.Technische Universitat Ilmenau IlmenauGermany Division for Research Service and Technology Transfer Technische Universitat IlmenauIlmenauGermany Electronics Technology Group.Technische Universitat Ilmenau IlmenauGermany IMMS Institut flir Mikroelektronik-und Mechatronik-Systeme Gemeinniitzige GmbH(IMMS GmbH) IlmenauGermany Fachgebiet Technische Physik City University of Applied SciencesBremenGermany Lehrstuhl fiir Fertigungsmesstechnik Friedrich-Alexander-U niversitat(FAU)Erlangen-NiirnbergGermany JUMO GmbH&Co.KG FuldaGermany Asphericon GmbH JenaGermany

The field of optical lithography is subject to intense research and has gained enormous ***,the effort necessary for creating structures at the size of 20 nm and below is considerable using conventional *** effort and the resulting financial requirements can only be tackled by few global companies and thus a paradigm change for the semiconductor industry is conceivable:custom design and solutions for specific applications will dominate future development(Fritze in:Panning EM,Liddle JA(eds)Novel patterning *** society for optics and ***,Bellingham,***://***/10.1117/12.2593229).For this reason,new aspects arise for future lithography,which is why enormous effort has been directed to the development of alternative fabrication ***,the technologies emerging from this process,which are promising for coping with the current resolution and accuracy challenges,are only demonstrated as a proof-of-concept on a lab scale of several square *** scale is not adequate for the requirements of modern lithography;therefore,there is the need for new and alternative cross-scale solutions to further advance the possibilities of unconventional *** challenges arise because of the technical progress in various other fields,realizing new and unique functionalities based on nanoscale effects,e.g.,in nanophotonics,quantum computing,energy harvesting,and life *** platforms for basic research in the field of scale-spanning nanomeasuring and nanofabrication are necessary for these tasks,which are available at the Technische Universitiit Ilmenau in the form of nanopositioning and nanomeasuring(NPM)*** this equipment,the limits of technical structurability are explored for high-performance tip-based and laser-based processes for enabling real 3D nanofabrication with the highest precision in an adequate working range of several thousand cubic millimete

关键词： Nanomeasuring Nanopositioning Nanomanufacturing Scale-spanning Tip-based Laser-based Nanofabrication

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