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A Transfer Function Design for Medical Volume Data Using a Knowledge Database Based on Deep Image and Primitive Intensity Profile Features Retrieval

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Journal of Computer Science & Technology 2024年第2期39卷 320-335页

作者： Younhyun jung Jim Kong 盛斌 Jinman Kim School of Computing Gachon UniversitySeongnam 13120Korea School of Computer Science The University of SydneySydney 2006Australia Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Direct volume rendering(DVR)is a technique that emphasizes structures of interest(SOIs)within a volume visually,while simultaneously depicting adjacent regional information,e.g.,the spatial location of a structure concerning its *** DVR,transfer function(TF)plays a key role by enabling accurate identification of SOIs interactively as well as ensuring appropriate visibility of *** generation typically involves non-intuitive trial-and-error optimization of rendering parameters,which is time-consuming and *** at mitigating this manual process have led to approaches that make use of a knowledge database consisting of pre-designed TFs by domain *** these approaches,a user navigates the knowledge database to find the most suitable pre-designed TF for their input volume to visualize the *** these approaches potentially reduce the workload to generate the TFs,they,however,require manual TF navigation of the knowledge database,as well as the likely fine tuning of the selected TF to suit the *** this work,we propose a TF design approach,CBR-TF,where we introduce a new content-based retrieval(CBR)method to automatically navigate the knowledge *** of pre-designed TFs,our knowledge database contains volumes with SOI *** an input volume,our CBR-TF approach retrieves relevant volumes(with SOI labels)from the knowledge database;the retrieved labels are then used to generate and optimize TFs of the *** approach largely reduces manual TF navigation and fine *** our CBR-TF approach,we introduce a novel volumetric image feature which includes both a local primitive intensity profile along the SOIs and regional spatial semantics available from the co-planar images to the *** the regional spatial semantics,we adopt a convolutional neural network to obtain high-level image feature *** the intensity profile,we extend the dynamic time warping technique to address subtle alignment

关键词： data retrieval direct volume rendering ray analysis transfer function

Significance of dysplasia in bile duct resection margin in patients with extrahepatic cholangiocarcinoma:A retrospective analysis

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World Journal of Clinical Cases 2022年第10期10卷 3078-3087页

作者： jung Wan Choe Hyo jung Kim Jae Seon Kim Department of Internal Medicine Korea University Ansan HospitalKorea University College of MedicineAnsan 15355South Korea Department ofInternal Medicine Korea University Guro HospitalKorea University College of MedicineSeoul 08308South Korea Department ofInternal Medicine Korea University Guro Hospital2

BACKGROUND Radical resection is the only indicator associated with survival in extrahepatic cholangiocarcinoma(EHCC).However,limited data are available regarding the implications of dysplasia at the resection margin following *** To evaluate the prognostic significance of dysplasia-positive margins in patients diagnosed with *** We reviewed the records of patients who had undergone surgery for EHCC with curative intent between January 2013 and July *** retrospectively analyzed the clinicopathological data of 116 patients followed for longer than 3 *** status of resection margin was used to classify patients into negative low-grade dysplasia(LGD)and high-grade dysplasia(HGD)/carcinoma in situ(CIS)*** Based on postoperative status,72 patients underwent resection with negative margins,19 had LGD-positive margins,and 25 showed HGD/CIS-positive *** mean survival rates of the patients with negative margins,LGD margins,and HGD/CIS margins were 49.1±4.5,47.3±6.0,and 20.8±4.4 mo,respectively(P70 years and HGD/CIS-positive margins were significant independent factors for survival(hazard ratio=1.90 and 2.47,respectively).CONCLUSION HGD/CIS margin in resected EHCC is associated with a poor ***,the LGDpositive resection margin is not a significant indicator of survival in patients with EHCC.

关键词： Dysplasia Cholangiocarcinoma Survival Extrahepatic cholangiocarcinoma Low-grade dysplasia High-grade dysplasia

Physicochemical and in-vitro release characteristics of vitamin C-loaded antioxidant orally disintegrating films with different catechin levels

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FOOD BIOSCIENCE 2023年第3期53卷 2211-2219页

作者： Shin, Hye-jung Chang, Jin-Hee Han, jung-Ah Sangmyung Univ Dept Food & Nutr Seoul 03016 South Korea

To develop a convenient food formulation for supplying antioxidants, hyaluronic acid (HA)-based orally dis-integrating film (ODF) containing vitamin C (Vit C) and catechin (CAT) with various molar ratios (Vit C:CAT, 1:0, 1:0.2, 1:0.4, 1:0.6, 1:0.8 and 1:1.0, by name of CAT0, CAT0.2, CAT0.4, CAT0.6, CAT0.8 and CAT1.0, respec-tively) were prepared, and the physico-chemical, and sensory properties of the films were analyzed. In addition, the release properties of the Vit C and CAT in the films were also evaluated. In the results, there was no sig-nificant difference in the moisture content among the films, but the thickness significantly increased with the CAT amount. The water vapor permeability (WVP) started decreasing at CAT0.4. For texture, the addition of CAT decreased tensile strength, and showed inverse relationship with film thickness. Also higher the CAT content was, the more brittle and fragile the texture obtained film. The vitamin C content in the film significantly decreased as the CAT content increased, whereas the antioxidant effects continued to increase with CAT content. In a sensory evaluation, CAT0.2 was the most preferred, followed by CAT0 and CAT0.4, and for those samples containing over 0.6 M ratio CAT, the acceptability dramatically decreased. Based on the above results, the most suitable molar ratio of Vit C:CAT was 1:0.4. As a result of the analysis of the release pattern of the optimized ODF (CAT0.4), both Vit C and CAT exhibited rapid release of over 70% within 30 and 20 min, respectively, in all simulated body fluids. So the prepared ODF can be considered as a suitable delivery formulation for convenient and fast-acting antioxidant.

关键词： Orally disintegrating film Vitamin C Catechin Antioxidant effects Sensory evaluation

A Sensor Network Web Platform Based on WoT Technology

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Computer Systems Science & Engineering 2021年第8期38卷 197-214页

作者： Shun-Yuan Wang Yun-jung Hsu Sung-jung Hsiao Wen-Tsai Sung Department of Electrical Engineering National Taipei University of TechnologyTaipei10608TaiwanChina Department of Information Technology Takming University of Science and TechnologyTaipei11451TaiwanChina Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung41170TaiwanChina

This study proposes a Web platform,the Web of Things(WoT),whose Internet of Things(IoT)architecture is used to develop the technology behind a new standard Web *** a remote sensor passes data to a microcontroller for processing,the protocol is often not *** study proposes a WoT platform that enables the use of a browser in a mobile device to control a remote hardware *** optimized code is written using an artificial intelligencebased algorithm in a *** data convergence technology is adopted to process the packets of different protocols and place them on the Web platform for access by other mobile *** platform has high efficiency and cross-platform advantages,with no limitation on the operating *** queueing telemetry transport(MQTT)technology is used to simplify the original HTTP *** that the mobile device is a subscriber,i.e.,the controller,and a microcontroller that connects the sensing device is the *** publishers and subscribers of MQTT need not know each other if they share a message *** intermediate agent role is much like a *** and subscribers do not need to interact,and publishers do not have to wait for subscriber confirmation to cause interactive permission be *** must publishers and subscribers be online at the same time,and they are free to choose when to get *** proposed WoT method is compared with the traditional IoT method regarding data *** results show that the proposed method can save time in processing large amounts of data,as the traditional IoT method wastes time,especially in data format transfer.

关键词： Embedded systems mobile Web servers big data analysis WoT IoT

Development and characterization of novel polymorphic microsatellite markers for the Korean freshwater snail Semisulcospira coreana and cross-species amplification using next-generation sequencing

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Journal of Oceanology and Limnology 2020年第2期38卷 503-508页

作者： Yeon jung PARK Mi Nan LEE Eun-Mi KIM jung Youn PARK Jae Koo NOH Tae-Jin CHOI jung-Ha KANG Biotechnology Research Division National Institute of Fisheries ScienceBusan 46083Republic of Korea Department of Microbiology Pukyoung National UniversityBusan 48513Republic of Korea

Korean freshwater snails of the genus Semisulcospira are widely distributed across East *** has been a very popular nutritional food in Korea,and is an ecologically important water quality indicator because it lives only in clean ***,no microsatellite markers have been generated to study the population genetic diversity of this *** the present study,we developed and characterized 18 novel microsatellite loci from Semisulcospira coreana genomic *** microsatellites were isolated using 454 GS-FLX titanium sequencing and 18 markers were used for genotyping in *** addition,we also tested the cross-species transferability of the microsatellite markers in four additional Semisulcospira *** identified 18 polymorphic loci and the number of alleles per loci,and their polymorphism information content values ranged from 2 to 17 and 0.203 to 0.902,*** observed and expected heterozygosities of the loci ranged from 0.063 to 0.924 and 0.226 to 0.924,*** to the analysis of the cross-species transferability of these markers,four species,***,***,***,and ***,showed a very high transferability(80%–85%).These results show that this set of nuclear markers could be useful for population genetics studies of this species and closely related species.

关键词： Semisulcospira next-generation sequencing(NGS) microsatellite markers cross-species transferability

Continuity control method of cutter posture vector for efficient five-axis machining

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Journal of Central South University 2011年第6期18卷 1969-1975页

作者： HWANG Jong-dae KIM Sang-myung jung Hyun-chul jung Yoon-gyo School of Mechatronics Changwon National University

During five-axis machining of impeller, the excessive local interference avoidance leads to inconsistency of cutter posture, low quality of machined surface and increase of processing time. Therefore, in order to improve the efficiency of five-axis machining of impellers, it is necessary to minimize the cutter posture changes and create a continuous tool path while avoiding interference. By using an MC-space algorithm for interference avoidance, an MB-spline algorithm for continuous control was intended to create a five-axis machining tool path with excellent surface quality and economic feasibility. A five-axis cutting experiment was performed to verify the effectiveness of the continuity control. The result shows that the surface shape with continuous method is greatly improved, and the surface roughness is generally favorable. Consequently, the effectiveness of the suggested method is verified by identifying the improvement of efficiency of five-axis machining of an impeller in aspects of surface quality and machining time.

关键词： five-axis control machining configuration-space B-spline continuity control method impeller interference

Selexipag as Add-on Therapy for Patients with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease:A Single-Center Retrospective Study

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Congenital Heart Disease 2021年第3期16卷 233-244页

作者： Se Yong jung Doyoung jung Ah Young Kim Jae Hee Seol jung Min Park Jo Won jung Jae Young Choi Division of Pediatric Cardiology Congenital Heart Disease CenterSeverance Cardiovascular HospitalDepartment of PediatricsYonsei University College of MedicineSeoulKorea

Purpose:This study examined the efficacy and safety of selexipag in treating pulmonary arterial hypertension(PAH)associated with congenital heart disease(CHD).Materials and Methods:We conducted a retrospective study of patients with CHD-associated PAH,treated with selexipag since December *** adult patients(mean age,45.4 years;women,77%)were treated with selexipag as add-on *** characteristics,World Health Organization functional class,6-minute walking distance(6MWD)test results,N-terminal pro-B-type natriuretic peptide levels,echocardiographic data,and incidence of side effects were ***:The majority of patients(12/13,92.3%)experienced more than one treatment-associated complication;one patient dropped out of the study due to intolerable *** results of 6MWD test(from 299.2±56.2 m to 363.8±86.5 m,p=0.039)and tricuspid regurgitation(TR)pressure gradient(from 84.7±20.5 mmHg to 61.6±24.0 mmHg,p=0.018)improved and remained improved after selexipag treatment in 12 *** on the results of a non-invasive risk assessment,8(66.7%)patients showed improvement,3(25.0%)showed no interval change,and the status of one patient(8.3%)***,compared to patients treated with a low dosage,patients treated with a medium-to-high dosage showed a greater increase in 6MWD results(88.3±26.4 m vs.55.3±27.6 m,p=0.043)and a greater reduction in the TR pressure gradient(-33.7±10.9 mmHg vs.-12.5±12.0 mmHg,p=0.015).Conclusion:Selexipag is an efficient pulmonary vasodilator as add-on therapy in treating CHD-associated PAH.

关键词： Selexipag congenital heart disease pulmonary arterial hypertension

Mobilization of monocytic myeloid-derived suppressor cells is regulated by PTH1R activation in bone marrow stromal cells

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Bone Research 2023年第2期11卷 354-367页

作者： Eun jung Lee Kyoung Jin Lee Seungpil jung Kyong Hwa Park Serk In Park Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoulRepublic of Korea The BK21 Graduate Program Department of Biomedical SciencesKorea University College of MedicineSeoulRepublic of Korea Division of Breast and Endocrine Surgery Department of SurgeryKorea University Anam HospitalSeoulRepublic of Korea Division of Oncology and Hematology Department of Internal MedicineKorea University Anam HospitalSeoulRepublic of Korea Vanderbilt Center for Bone Biology Vanderbilt University School of MedicineNashvilleTNUSA

Myeloid-derived suppressor cells(MDSCs)are bone marrow(BM)-derived immunosuppressive cells in the tumor microenvironment,but the mechanism of MDSC mobilization from the BM remains *** investigated how BM stromal cell activation by PTH1R contributes to MDSC ***1R activation by parathyroid hormone(PTH)or PTH-related peptide(PTHrP),a tumor-derived counterpart,mobilized monocytic(M-)MDSCs from murine BM without increasing immunosuppressive *** vitro cell-binding assays demonstrated thatα4β1 integrin and vascular cell adhesion molecule(VCAM)-1,expressed on M-MDSCs and osteoblasts,respectively,are key to M-MDSC binding to *** PTH1R activation,osteoblasts express VEGF-A and IL6,leading to Src family kinase phosphorylation in *** inhibitors suppressed PTHrP-induced MDSC mobilization,and Src activation in M-MDSCs upregulated two proteases,ADAM-17 and MMP7,leading to VCAM1 shedding and subsequent disruption of M-MDSC tethering to ***,our data provide the molecular mechanism of M-MDSC mobilization in the bones of tumor hosts.

关键词： MMP7 suppressor regulated

DAVS:Dockerfile Analysis for Container Image Vulnerability Scanning

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Computers, Materials & Continua 2022年第7期72卷 1699-1711页

作者： Thien-Phuc Doan Souhwan jung School of Electronic Engineering Soongsil UniversitySeoul06978Korea

Container technology plays an essential role in many Information and Communications Technology(ICT)***,containers face a diversity of threats caused by vulnerable packages within container *** vulnerability scanning solutions for container images are *** solutions entirely depend on the information extracted from package *** a result,packages installed directly from the source code compilation,or packages downloaded from the repository,etc.,are *** introduce DAVS–A Dockerfile analysis-based vulnerability scanning framework for OCI-based container images to deal with the limitations of existing *** performs static analysis using file extraction based on Dockerfile information to obtain the list of Potentially Vulnerable Files(PVFs).The PVFs are then scanned to figure out the vulnerabilities in the target container *** experimental shows the outperform of DAVS on detecting Common Vulnerabilities and Exposures(CVE)of 10 known vulnerable images compared to Clair–the most popular container image scanning ***,DAVS found that 68%of real-world container images are vulnerable from different image registries.

关键词： Container security vulnerability scanning OCI image analysis